Diet UltraSound Diabetes Cancer & Biopsy Germanium Heart Disease Free Radicals IV Chelation Therapy	Vibrant Life Home Web Family Of Three Chelation Formulas MSM Other VL Products The Wednesday Letter Frequently Asked Questions Testimonials	Karl Loren Web Shopping Cart	Separate Search Page or search below
Navigation Help	Oral Chelation Therapy Other	Ingredients Technical	Write To Karl Loren	Table Of Contents

Sucralose -- Splenda -- Substitute for Sugar.  Is It Safe?

Return To Main Page On Sucralose

Source

Back to Health/Nutrition Page. / Back to Aspartame / NutraSweet Toxicity Info Ctr..

Splenda, also known as sucralose, is artificial sweetener which is a chlorinated sucrose derivative. Facts about this artificial chemical follows:

 

• Pre-Approval Research
  Pre-approval research showed that sucralose caused shrunken thymus glands (up to 40% shrinkage) and enlarged liver and kidneys. The manufacturer put forth two arguments in an attempt to claim that sucralose is not toxic:
  
   
  1. The dose of sucralose in the experiments was high. However, for chemicals that do not have generations of safe use, the dosage tested must be adjusted for variations in potential toxicity within the human population and between humans and rodents. In order to this, toxicologists estimate a variation of effects in the human population of 10 times. In other words, one person may not have effects until a dose of 10 mg per kg of body weight (10 mg/kg) is reached, while another person may have chronic toxicity effects at 1 mg per kg of body weight (1 mg/kg). In addition, it is well known that many chemicals are much more toxic in humans than in rodents (or even monkeys). For example, the chemicals that the sweetener aspartame breaks down into vary from 5 to 50 times more toxic in humans than in rodents. Therefore, toxicologists estimate a further 10 times the dose for differences between human and rodent toxicity for a total of 100 times (10 * 10).
     
     In order to estimate a potential safe dose in humans, one must divide the lowest dose in given to rodents that was seen to have any negative effects on their thymus glands, liver or kidneys by 100. That dose is then known as the maximum Tolerable Daily Intake (TDI) for lifetime use. Keep in mind that the TDI is just an estimate. Some chemicals are much more than 10 times more toxic in humans than in rodents (or will cause cancer in humans in low-dose, long-term exposure and do not cause cancer in rodents at all). A person ingesting the TDI for some chemical may find that it causes cancer or immune system or neurological problems after many years or decades of use. So, if the manufacturer claims that the dose was equivalent to 50 diet sodas, then the TDI would be one half (1/2) of a diet soda, and even that dose may or may not be safe.
     
      
  2. The manufacturer claimed that the sucralose was unpleasant for the rodents to eat in large doses. They said that starvation caused the shruken thymus glands. From the New Scientist (23 Nov 1991, pg 13):
     
      

     [Toxicologist Judith] Bellin reviewed studies on rats starved under experimental conditions, and concluded that their growth rate could be reduced by as much as a third without the thymus losing a significant amount of weight (less than 7 percent). The changes were much more marked in rats fed on sucralose. While the animals' growth rate was reduced by between 7 and 20 percent, their thymuses shrank by as much as 40 percent.

  
   

• Recent Research
  A possible problem with caecal enlargement and renal mineralization has been seen in post approval animal research.
  
   
• Sucralose Breaks Down
  Despite the manufacturer's mis-statements, sucralose does break down into small amounts of 1,6-dichlorofructose, a chemical which has not been adequtely tested in humans.
  
   
• Independent, Long-Term Human Research
  None. Manufacturer's "100's of studies" (some of which show hazards) were clearly inadequate and do not demonstrate safety in long-term use.
  
   
• Chlorinated Pesticides
  The manufacturer claims that the chlorine added to sucralose is similar to the chlorine atom in the salt (NaCl) molecule. That is not the case. Sucralose may be more like ingesting tiny amounts of chlorinated pesticides, but we will never know without long-term, independent human research.
  
   
• Conclusion
  While it is unlikely that sucralose is as toxic as the poisoning people are experiencing from Monsanato's aspartame, it is clear from the hazards seen in pre-approval research and from its chemical structure that years or decades of use may contribute to serious chronic immunological or neurological disorders.
  
   
• Addendum (October 2, 2000)
  Ocassionally, persons emailing ask questions about sucralose research. What follows is a copy of a response one such question. The answer starts by summarizing the aspartame (NutraSweet) issue and then addresses the sucralose issue.
  
   

  Let me start by saying that, as you may know, there is a quickly growing body of evidence demonstrating the toxicity of aspartame. This includes:
  
   

  • Recent European research showing that ingesting aspartame leads to the accumulation of formaldehyde in the brain, other organs and tissues (Formaldehyde has been shown to damage the nervous system, immune system, and cause irreversible genetic damage in humans.)
     
  • An extremely large number of toxicity reactions reported to the FDA and other organizations
     
  • A recent report showing that nearly 100% of independent research has found problems with aspartame.
     

  
  Why is this relevent to the sucralose question? Similar to the aspartame situation 15 years ago:
  
   

  1. Pre-approval test indicated potential toxicity of sucralose.
  2. There are no *independent* controlled human studies on sucralose (similar to 15 years ago for aspartame).
  3. There are no long-term (12-24 months) human studies of sucralose's effects.
  4. There is no monitoring of health effects. It took government agencies decades to agree that there were countless thousands of deaths from tobacco. Why? Simply because there had been no monitoring or epidemiological studies. Without such monitoring and studies, huge effects can easily go unnoticed.

  
  So, without even addressing the pre-approval research showing potential toxicity, it is clear that sucralose has a) no long history (e.g., decades) of safe use, b) no independent monitoring of health effects, c) no long-term human studies, and d) no independent human studies. I would hope that the Precautionary Principal, now commonly used in Europe, would be a guiding force for people who are interested in health. Otherwise, we might as well just use any poorly-tested, artificial (lab-created) chemical that has shown potential for long-term toxicity.
  
  As far as the pre-approval research related to sucralose.... As you probably know, pre-approval research is rarely published. It is only available from the FDA by filing a Freedom of Information Act request. However, you can see a very short summary regarding sucralose and shrunken thymus glands in the "New Scientist" (23 November 1991, page 13).

It is very important that people who have any interest in their health stay aware from the highly toxic sweetener, aspartame and other dangerous sweeteners such as sucralose (Splenda), and acesulfame-k (Sunette, Sweet & Safe, Sweet One). Instead, please see the extensive resources for sweeteners on the Healthier Sweetener Resource List.


Back to Health/Nutrition Page. / Back to Aspartame / NutraSweet Toxicity Info Ctr..
 

SUBSCRIBE:  The Wednesday Letter is a free electronic monthly newsletter written and published by Karl Loren.  You can view more than 50 back issues of this publication by clicking here.  The Wednesday Letter subscription list is maintained on a secure server, no name is ever given or sold to anyone, and it is never used except for this Newsletter.  It is automatically published on the Tuesday night just before the first Wednesday of every month.  You can subscribe to this free monthly electronic letter by entering your eMail address and name below.  You will then automatically receive a request for confirmation, sent to whatever address you have entered.  If you do NOT receive this confirmation request, then you will not be subscribed.  There may have been an error with your address and you should resubmit.  The letter is never sent twice to the same address -- so you do not have to worry about a duplicate subscription.  When you receive this confirmation request you must reply to it, or your subscription will not become active.  No one can subscribe your name, and address, without you being notified, and if you get an unwanted notice of subscription you only need to DO NOTHING and the subscription will NOT be active.

REMOVAL:  You can remove yourself from the subscription list in several different ways.  Click here to read about this entire newsletter system.  Every edition of The Wednesday Letter is delivered to your address with YOUR name and address in view on the letter, with a link that allows you to remove THAT name from the subscription list.  If you try to send this removal message from an address different from the one you used to send in your original confirmation, then you will get a warning notice first, sent to the subscription address, asking you to confirm that you want to be removed from the list -- by replying to THAT request for confirmation, you will then be automatically removed.  Thus, no one else can unsubscribe you, from some other computer, without your knowledge.  But, if you send in the unsubscribe notice from the same machine used to receive the Letter, then the removal from the subscription list is automatic.

Personal Message:  When you send a personal message to Karl Loren, you will receive a personal reply as per his instructions.  Karl pledges that every personal message will get a personal answer. When you provide your mail address, we will send you free information including our free catalog and a cassette tape lecture by Karl Loren about heart disease, no charge, by mail, even if outside the US.  You can select particular information you would like to receive, along with the free cassette tape and catalog.