Cancer chemo(toxico)therapy revisited and alternative ways of healing.A thesis presented to the Anglo-American Institute of Drugless Therapy and leading to the Degree of Doctor of Naturopathy (N.D.).
© 1990 by Dr. Henri Rosenberg.
Introduction 2
Chapter I : Chemo(toxico)therapy 3
Chapter II : Amygdalin - Vitamin B 99
Chapter III : The Synthetic Physiatrons 128
Chapter IV : Trypanosoma Therapy 140
Chapter V : Selenium Therapy 146
Chapter VI : The beer's yeast cure 156
Chapter VII : Tumor related indicators 164
Chapter VIII : The Thymus Therapy 188
Chapter IX : The H-11 Therapy 194
Chapter X : Antineoplaston 202
Chapter XI : Gelum Oral RD® 205
Chapter XII : Neoblastine® 212
Chapter XIII : The WIEDERMANN cure 219
Chapter XIV : Beetroot (juice) as cancer therapy 225
Chapter XV : Integral Fasting Therapy 229
Chapter XVI : The Iron Cancer Cure 235
The Synthetic Physiatrons
of Jean SOLOMIDES (1)
Background
It was in 1947, when Dr Jean SOLOMIDES still worked at the Pasteur Institute in Paris, that the foundations of the discovery of the oncostatic (and even oncocitic) properties of what he then called synthetic peroxidases were laid. At that time SOLOMIDES was experimenting with these synthetic peroxi-dases on strains of tuberculosis, and he observed that they possessed the power to kill tubercolis bacteria. Shortly afterwards he discovered that they also possessed cancerstatic properties. This discovery was the final straw for the Pasteur Institute and he was dismissed. His exclusion from the Institute and consequently from the official scientific world - a world which had by then accepted no less than seventy articles for publication in the most authoritative journals (2) - was no mere exclusion, but had a sort of retroactive effect, because from that moment on it was as if he had never existed, as if he had never worked in the Pasteur Institute, as if he had never belonged to the official scientific elite, and consequently had never passed his medical examinations (3).
From 1952 on Dr SOLOMIDES adopted the undisputed anoxia theory of the Nobel Prize winner, Otto WARBURG (4), as the etiology of cancer, according to which a disturbance in cell respiration leads to the production of lactic acid in the cell (5). At the same time he assumed that the anti-carcinogenic (and carcinogenic) activity of X - rays was linked to the peroxides induced by radiation in the body (6) as a result of the breakdown of fermentation products of respiration, such as cytochromoxidase, and the acidification of the tissue.
Continuing with this working hypothesis, SOLOMIDES prepared certain synthetic peroxidases, which possessed the ability to peroxidize certain substances in vitro (and probably in vivo as well).These synthetic peroxidases consisted (and still do consist) of two parts:
1. a macromolecule with all the properties of an organic colloidal catalyst, which thus corresponds to the definition of enzymes of HALDANE and OPPENHEIMER (7), except that this is not secreted by the living cell, but compounded in the laboratory. At the Pasteur Institute Jean SOLOMIDES had originally used oil distillates for this purpose (cod-liver oil and later on vegetable oils, such as castor and geranium oil) in water emulsions or suspensions. The disadvantage, however, of this was that the oils, which were insoluble in water, gave rise to a turbid mixture that could only be injected with difficulty. His next step was to try EMULSOF O, a polyethylene etheroxide obtained from castor oil (ERP, Ether-oxide Ricino-Polyethylenique), which he used in all his preparations.
2. a peroxide such as hydrogen peroxide (H2O2), or a peroxide carrier as defined by MAISIN: an unsaturated substance which in the body has the property of oxidizing and producing an organic peroxide of H2O2. Ascorbic acid, some aldehydes, such as enanthol, citral (8), cod-liver oil (9), and linalyl and geranyl acetate (10) meet this definition. Polyphenols which upon oxidation produce quinones and peroxides should also be included.
Because SOLOMIDES upon announcing his discovery was refused admittance to the official research centres, as described above, he was reduced to doing research on his own in his cellar in Sceaux, following in the footsteps of the Curies in their garage (also in Sceaux!!), Pasteur in his attic, and Koch in his kitchen who also made great discoveries.
In 1957 HOLMAN (11) (re)discovered the anticarcinogenic effect of hydrogen peroxide, without, however, of making any mention of of the synthetic peroxidases of Jean SOLOMIDES. Since then the antineoplasmic properties of other peroxides have been investigated in the USA and in the Federal Republic of Germany.
The renewed interest and research since 1975 into lyposomes is somewhat reminiscent of the synthetic peroxidases (physiatrons of Jean SOLOMIDES. These lyposomes are oils in watery emulsions more intimately mixed not by ERP carriers but by physical treatments, such as short wave radiation, immediately before injection.The discoveries of the Japanese scientists OSOTO, ODIE, and KATARUMA, who achieved success with the treatment of cancers of the stomach and intestines with citronelal (a peroxidase) and cod-liver oil, and citral and soya oil emulsified using short wave or electrical techniques, point in the direction of SOLOMIDES discoveries.
The Birth of Physiatry
Originally Dr SOLOMIDES thought that the exceptional oncostatic properties of his synthetic peroxidases were exclusively due to their chemical characteristics. In accordance with WARBURG's theory on the anaerobic environment in which cancer cells thrived, SOLOMIDES assumed that the cancer cell were oxygenless microbes (anaerobes), that is to say microorganisms, similar to equally oxygenless poison cells, which draw their energy from the surrounding substances smothering them in the process. SOLOMIDES thought (in the early fifties) that the peroxides in his synthetic peroxidases supplied oxygen to the cancer cells, destroying them. These peroxides are unstable and give off oxygen under the influence of the peroxidase which starts off the oxidation of the cancer cells. This is why he originally called these drugs synthetic peroxidases, meaning synthetic oxidation stimulants.
However, further research, and particularly when passing from a basic chemical analysis to a physical-biological approach, he revised and refined his theory, though without denying his first findings. This led to the creation of the theory of physiatry (from the Greek words "Physos" meaning nature and "Iatros" meaning healer), which states that the physical properties of the synthetic properties of the synthetic peroxidases (now renamed physiatrons) are those which guide them to the cell membranes of the cancer cell. This selective behaviour was a point which had not been clearly stated in his original theory. The discovery of this essential link in his theory was entirely circumstantial. He had noticed that when a spider or an ant (of which there were so many in his basement laboratory) fell into synthetic peroxidase, which is quite harmless to human beings, it drowned immediately, whereas in water these creatures would not drown so quickly. The constituents of the membrane of these insects had therefore, like cancer cells, to be sensitive to peroxidase, in contrast to human beings. From this he drew the conclusion, which was later confirmed by American workers at the Warf Institute, that synthetic physiatrons were not toxic to healthy cells, though they were to cancer cells.
This immediately gave him the key to the selective properties of the synthetic physiatrons.
The cancer and cancer cell theory of Jean SOLOMIDES
Like SZILLARD, BURNET and BUSCH SOLOMIDES believed that cancer came about as the result of the aging of cells. Cell division is controlled by the more or less rapid destruction of peroxides which form during the cellular metabolism. Indeed cancer cells are incapable of using oxygen, causing peroxides to to created which cannot be broken down because of the shortage of catalase, cytochtomes and Vitamin E. Peroxides can form free radicals, which are able to engender carcinogenic mutations by alkylizing chromosomes.
Now when does cancer arise? In every cell which ages, is inadequately vascularized, or has been subjected to chemical or physical influences, the number of mitochondria falls causing a shortage of oxygen and causing the cell to produce lactate. This leads in turn to a fall in the pH of the cell, and the histones dissolve, which at normal pH's or alkaline pH's are insoluble, causing the suspension of the suppression of some genes, including the K genes. After being stripped the K gene undergoes a carcinogenic mutation.
There are two main causes of cell aging:1. Overnutrition
This leads to an increase in the number of mitoses and cell divisions. In cells with a low mitotic index this leads to intracellular peroxides. Some these peroxides are mutagenic. This is why a diet moderately low in fats is to be recommended.
2. Ionizing Radiation
Primarily X-rays (1). These cause peroxides to form locally as described above. Prophylactic measures must attempt to combat the peroxides. Magnesium chloride and copper acetate can easily destroy the peroxides, as well as the complex synthetic ERP-Cu, which behaves as a synthetic catalase (2).
Cancrons
SOLOMIDES called the cancer cell the cancron. This differs from the normal cell as follows:
1. Reduced adhesion to the surrounding cells, which is the result of a shortage in the mucoproteins of the cell wall leading to a lack of calcium bonds with other cells.
2. Disappearance of contact inhibition as a consequence of 1. When normal cells come in contact with one another, they inhibit each others cell division.
3. Cancer cells have no self-adhesion, making them extremely mobile, and are thus invasive and metastasive. They have a high mitosis index, which varies in accordance with the virulence of the cancer.
4. The membrane of a cancron is irregular.
5. Cancrons are highly negatively charged, hardly less than red blood cells.
6. Cancer cells are abnormally permeable. Some intracellular ferments like dipeptidase and cathepsin pass through more quickly. The cell membrane contains no antigens specific to cells. The changes in the membrane are the result of a change in the genome. The number of mitochondria and their volume is reduced. There is therefore less oxidation and glycolysis increases (WARBURG). Cancron membranes contain more lipids and are less rigid. They absorb all sorts of substances by mynocotose. This explains how cancrons capture blood proteins and even red blood cells. This process is the cause of cachexia and anemia.
7. Cancer cells do not only draw their energy from oxidation as their number of mitochondria is greatly reduced. They also make use of aerobic and anaerobic glycolysis, leading to the production of lactic acid and specific mitotic proteins.AMBROSE showed that cancer cells and normal cells have a different lipidoprotein structure, which explains the special properties summarized above.
A. Operation of Synthetic Physiatrons
1. ERP - Polyethylene etheroxide from castor oil
a. Chemical Formula
OH-CH2-CH2-(OH-CH2-CH2)11-CH2-CH2-O-C17-H32-COO-CH2
|
OH-CH2-CH2-(OH-CH2-CH2)11-CH2-CH2-O-C17-H32-COO-CH2
|
OH-CH2-CH2-(OH-CH2-CH2)11-CH2-CH2-O-C17-H32-COO-CH2b. Properties
It is a macromolecule with a molecular weight of 2448, viscous, with colloidal properties, dissolves easily in water, alcohol, ether and organic solvents, petroleum ether excepted. It is highly soluble in fats and oils and forms compounds with a number of substances.
c. Enzymatic Properties
ERP is a soluble organic colloidal synthetic substance. If it furthermore is a catalyst, it meets the requirements of the definition of an enzyme given by HALDANE, OPPENHEIMER and THOMAS (12). Using the auto-oxidation and heteroxidation of indigo blue and by demonstrating that small amounts of ERP are capable of hastening the loss of colour in indigo blue in a hydrogen peroxide milieu, where it in fact acts as a catalyst for the oxidization reaction, SOLOMIDES was able to show that ERP is also a catalyst. The optimal temperature is 40_·C.
There is also an optimal concentration of ERP: a high concentration with respect to water increases the stability and reduces the reactivity and the toxicity of the peroxides in circulation. In this way the peroxides are carried into the cell where by diluting the ERP to its optimal catalytic concentration, full activity is restored to the peroxide.
ERP has furthermore an optimal pH. A slightly alkaline milieu reduces its activity while a reduction in pH increases its activity.
All polyethylene glycols have the same effect as ERP; The chemical function has therefore nothing to do with the castor oil, but rather with the polyethylene chain, and the alcohol groups on it.ERP Compounds
ERP will not diffuse through porous membranes which are normally permeable for substances with a low molecular weight. ERP forms compounds with iodine, KI, urethane, H2O2, copper acetate, colloidal copper and bases such as KOH, which in turn cannot be dialyzed. ERP forms physiochemical compounds (Van der Waal forces, hydrogen bonds, etc.) with numerous substances which may or may not be soluble in water. The stereochemical configuration of these compounds differs from case to case and they determine the specific nature of the attachment of these compounds to the surface of the cancron and their penetration of the lysosomes. Substances which are not soluble in water, become soluble because of the bond with ERP. ERP is an amophile substance.
1. As a result of its hydrophilic side it is soluble in water and can therefore not penetrate the cell.
2. However, because of its lipophilic side it has the tendency to attach itself to the membranes and cannot penetrate the cell as long as the cell has an external protein layer. This is not the case in cancer cells, where according to AMBROSE and others the protein protective layer does not continuously cover the cell membrane. There is, nevertheless, an internal protective layer. The compound oxidizing substances on the ERP denature the lipids and the proteins of the cell membrane of the cancron.
2. The Peroxides
Peroxides act on cells as aging, carcinogenic agents, but they also possess anticarcinogenic properties which must be used therapeutically correctly in conjunction with the ERP.
HOLMAN (13), MAGAT (14), BARANGER and MARECHAL (15), and LEFEVRE have all pointed out the anti-carcinogenic properties of hydrogen peroxide. The H2O2 is, however, easily broken down by the natural catalase, peroxidase, and haemoglobin.
According to SCHUSTER (17) H2O2 works on the SH function of enzymes and proteins. WEITZEL and BUDDEKE (18) have also demonstrated this.
ZANGER (19) exposed methyllineolate to UV radiation and obtained lipoperoxides which too have an antineoplasmic effect. Many researchers have made all sorts of peroxides which, however, also affect normal cells. Some of them worked through alkalinization like the classic antimitotics.
By compounding these peroxides with ERP they settle on the cell membranes of a specific cancer cell (selectivity!), and oxidize the the membranoreticular structures there, causing proteolytic enzymes to be evolved with cellyse. At the same time enzymes with SH groups are oxidized and mutagenic radicals are created. WILBUR and others (20) demonstrated that cells with a low mitotic index form peroxides more rapidly than those with a higher mitotic index, which do not form peroxides or rapidly break them down, thanks to their abundance of anti-oxidizing substances such as vitamin E.
Highly differentiated cells break the lipoperoxides down more slowly as they become older, creating ceroid pigment and other polymerization products with proteins or haemoglobins, leading to the formation of atheromes.
Peroxides, therefore, lie at the root of the aging process.
ERP lowers the pH thus stimulating the production and secretion of antibodies (21). ERP has furthermore a destructive effect on organic peroxides. It has been shown in an experiment that ERP-Cu rapidly breaks down peroxides: ERP peroxides destroy peroxides in old cells, with an antineo-plasmic effect on these cells. Furthermore there is a synergic effect between X-rays and ERP peroxides as long the X-ray dose remains under the 2500 r. At this dose level the organism is still highly resistant with lesions in the cancer cells improving permeability and allowing the peroxide preparations to penetrate more smoothly. At the same time the ERP Peroxides provide a rapid breakdown of the peroxides formed by the X-rays, thus immediately eliminating the harmful (carcinogenic) effect of X-rays.
Composition of Synthetic Physiatrons
There are various sorts of physical preparations containing physiatrons, depending on whether peroxides or other substances are added to the ERP (EMULSOV).
The iodized synthetic physiatrons (22)
P.S 4A P.S.100 B P.S. 288 P.S. 410 P.S. 50 T
___________________________________________________________Emulsov Emulsov Emulsov Emulsov Methane
0.555 g 0.555 g 0.555 g 0.555 g 0.555 g
Urethane same formula Mg chloride iodine iodine
0.15g as P.S 4
iodine varies potassium potassium potassium
iodate
potassium comes from ethylene ethylene ethylene
ethylene iodine, which glycol glycol glycol
glycol appears in nipagine nipagine nipagine
nipagine "another copper geranyl testosterone
form" acetate acetate propionate
in deionized water, q.s. 5 ml.
___________________________________________________________P.S. with peroxidogene ascorbic acid
P.S. 90 A: urethane, basic chlorohydrate from quinines, ascorbic acid and deionized water, q.s. 5ml.
P.S. 120 C
This product contains a mild antimitoticum and thus requires care in administration.
T.E.M. 0.000138 g
Urethane 0.15 g
Sodium bicarbonate 0.0017 g
Ethylene glycol 0.05 g
Nipagine 0.5 g
Deionized water q.s. 5 mlAdministration : intramuscular or intravenuous perfusion for the above P.S. numbers.
Oral P.S.
P.S. 70 contains peroxides
P.S. 40 contains copper
P.S. 80 contains aldehydesAdministration : ampoules for oral use
Suppositories
Emulsov 3 g
Urethane 10 g
Geranyl acetate 6 g
Exc q.s. 100 gIndications
P.S. 4 A: breast, liver, and pancreatic tumors
P.S. 100B larynx, tongue, breast, stomach, colon, and bladder cancers, osteosarcoma, and fibro-sarcoma
P.S. 288 brain, skin, tongue, larynx, and stomach cancers
P.S. 410 tongue, larynx, intestinal, bladder, and kidney, cancers, osteo and fibrosarcoma, and lympho-sarcoma.
P.S. 50T breast tumors
P.S. 90A not in cancers
P.S. 120 C only when beginning therapy and for short periods.
cancers of the lung, tongue, testes, and thyroid, osteosarcoma, melonoma, myeloma, leukemia, and Hodkin's disease.
P.S. 70 not in cancers
P.S. 80 indicated for all IV treatments with P.S.
P.S. 40 combats inflammation
suppositories:
for cancers of the digestive tract (rectum, sigmoid, etc.)
Manufactured by :
OLEA-CENTRE
56,rue de la Marne
F-92330 SCEAUXphone: 661.10.84 and 661.28.84
Books by J. SOLOMIDES
"La Physiatrie et les physiatrons synthétiques", 1969, Institut Solomidès.
"Chimiothérapie du cancer considérée comme maladie à virus", Librairie Le François, Paris, 1952, 1976.
Book about SOLOMIDES
CONORD, A., L'Affaire Solomidès, J.J. Pauvert, 1977
This book and further information can be obtained from the
Institut J. Solomidès (I.J.S.)
Société Civile d'Etudes et de Recherches sans activité commerciale
56, Rue de la Marne
F-92330 SCEAUXThe Centre Scéen de la Recherche Biologique (C.S.R.B.) also publishes a journal in French entitled "REMEDES, Organe de défense des malades en péril".
Editorial Offices: 28, Av. Jean Jaurés; F-92330 SCEAUX.
Finally,
L.A.R.A., Ligue pour l'application prioritaire de l'article 63 du code pénal aux malades en péril, is an organization whose purpose it is to see article 63 of the French Penal Code, which punishes persons who fail to render assistance to persons in danger, also applied to persons suffering from disease and therefore ensure that these persons are also considered as persons in danger.
________________________________________________________________________________Foot-notes
(1) Originally he referred to his product as synthetic peroxidase. When he later refined his theory by introducing the concept of physiatry (see below) he changed the name from synthetic peroxidases to synthetic physiatrons.
(2) Articles by him appeared in journals such as, Compte-Rendu de la Société de Biologie, Bulletin Médical, Le Monde Médical, Annales de l'Institut Pasteur, Société d'études scientifiques sur la tuberculose, Revue de la Tuberculose, la Presse Médicale, La France Médicale, Revue Internationale de Vitaminologie, Société Française de Microbiologie, Compte Rendus de l'Académie des Sciences, Annales Pharmaceutiques, Journal of the American Medical Association, Société de Pathologie Comparée. The Ann. Inst. Pasteur and C.R. Soc. Biol. alone accepted 18 and 27 of his articles respectively. After 1951, the year of his excommunication, not one article by him appeared in the above publications.
(3) see the ISRAEL interview.
(4) WARBURG, O., The Metabolism of Tumors, Constable, London, 1930.
(5) see the chapter on lactic acid, page
(6) .........
(7)
(8) SOLOMIDES, J and RONSIN E. in Rev. Ann. Chimioth., page 11 (1953)
(9) SOLOMIDES, J., Le Distillat de huile de foie de morue. Propriétés antibiothiques et premières applications thérapeutiques, Ann. Inst. Pasteur, 78, page 227 (1950)
(10) SOLOMIDES, J., to C.R. Académie des Sciences, under sealed cover nos.
(11)
(12) THOMAS, P., Manuel de Biochimie, Masson (éd.), Paris, 1946, page 175.
(13) HOLMAN, op cit.
(14) MAGAT, in Ztschr. f. Krebsforschung, 27, page 378 (1928)
MAGAT, in Ztschr. f. Krebsforschung, 33, page 219 (1933)
MAGAT, First International Cancer Congress Madrid, II, page 1015. (1933)(15) BARANGER en MARECHAL, C.R., 231, Page 661 (1950)
(16) LEFEVRE, in le concour medical, 74, page 2497.(1952)
(17) SCHUSTER, in Pro. Soc. Exper. Biol. Med. 90 pages 443. (1955)
(18) WEITZEL and BUDDECKE, Hope Seyler's Physiol. Chem Deutsch, 317, page 150 (1959)
WEITZEL and BUDDECKE, ibid, 323, page 14 (1961)
WEITZEL, BUDDECKE and SCHNEIDER, ibid, 323, page 14 (1961)
WEITZEL, BUDDECKE and PFEIL, ibid, 323, page 14 (1961)
WEITZEL, BUDDECKE and PFEIL, ibid, 331, page 65 (1963)(19) ZANGER, in Ztschr. f. Krebsforschung, 65, page 220 (1963)
(20) WILBUR, KENASTSON, WOLFSON, OTTOLEGHI and GAULDEN, Anal. RecK 120, page 708. (1954)
(21) see chapter on Gelum Oral RD, page ....
(22) P.S. stands for Physiatron Synthetiques.
Dr. Henri ROSENBERG, LL.D., Ph.D., N.D.
Doctor of Naturopathy
Permanent Member of the British
Guild of Drugless Practitioners.
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