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Cancer chemo(toxico)therapy revisited and alternative ways of healing

Cancer & Biopsy

Cancer chemo(toxico)therapy revisited and alternative ways of healing.

A thesis presented to the Anglo-American Institute of Drugless Therapy and leading to the Degree of Doctor of Naturopathy (N.D.).

© 1990 by Dr.  Henri  Rosenberg.

 

TABLE OF CONTENTS

[Click on the Chapters' names  to reach them]
 
Introduction  2
Chapter I : Chemo(toxico)therapy 3
Chapter II : Amygdalin - Vitamin B 99
Chapter III : The Synthetic Physiatrons 128
Chapter IV : Trypanosoma Therapy 140
Chapter V : Selenium Therapy 146
Chapter VI : The beer's yeast cure 156
Chapter VII : Tumor related indicators 164
Chapter VIII : The Thymus Therapy 188
Chapter IX : The H-11 Therapy 194
Chapter X : Antineoplaston 202
Chapter XI : Gelum Oral RD® 205
Chapter XII : Neoblastine^® 212
Chapter XIII : The WIEDERMANN cure 219
Chapter XIV : Beetroot (juice) as cancer therapy 225
Chapter XV : Integral Fasting Therapy 229
Chapter XVI : The Iron Cancer Cure 235

Chapter IV

Trypanosoma Therapy

Background

In 1929 two Soviet biologists, ROSKIN and KLYUEVA (1) discovered the tumor-arresting qualities of trypanosoma and proceeded to carry out trials in animals and the clinic.  Trypanosoma cruzi is the trypanosome responsible for Chagas' disease, widespread in South America.  It had been observed that cancers in some people who survived the disease had been spontaneously cured, or that these survivors appeared to be immune to cancer.  This peculiarity first gave rise to the idea that trypanosoma might secrete a poison which is an antidote to cancer.
In the first stage of their investigation the Russia biologists implanted Crocker sarcoma in mice and then treated them with live trypanosoma.  They observed the lysis of the cancer cells.  Their next step was to use trypanosoma killed by heating.  They called the remaining active substance "endotoxin".  These endotoxins turned out to have the same oncolytic properties as the live preparation.  The Russians reported that more than 85% of their mice recovered after the 14th day.  Much encouraged by the successful trials in mice, they decided to carry out clinical tests.  Here again they met with considerable success.  They obtained either the complete regression of cancers of the larynx, esophagasus, breast, cervix, and lips with an exclusively biological treatment, or, where non-operable tumors were involved reductions in the size of the tumor to an operable level.
In the fifties Professor COUDERT, and his disciple Dr JUTTIN (2), both from Lyon in France, resumed experimentation with animals and clinical trials, and were able to confirm the findings of their Russian colleagues.

COUDERT and JUTTIN suspected that the undeniable biological properties of the active product (the Russians' endotoxin) obtained from trypanosoma could be ascribed to their enzymatic nature.  As enzymes are extremely sensitive to their milieu (temperature for example) the French researchers started using a freeze-dried preparation.  Using this they confirmed the selective oncolytic action, and furthermore demonstrated that the younger the tumor the greater was the preparation's effectiveness.  With large irreversible tumors the trypanosoma preparation was nevertheless observed to slow the development of the cancer.
In clinical trials the French experimenters obtained less spectacular, though nevertheless interesting therapeutic results.  There are great differences between trypanosoma types with respect to their tumor tropism, and this may be the explanation of the difference in success rates between the French and Russian trials.
This is why only titrated and stabilized types of trypanosoma extracts are used in humans nowadays.
The first clinical observation made COUDERT and JUTTIN was that pain was relieved.  This was reported both by the patients and confirmed by the nursing personnel, who were not informed of the trypansoma treatment.  The reduction or withdrawal of pain-killers were concrete evidence of this.
Significant increases in appetite and weight (patients tended to put on 8 to 10 kg from the second month of treatment), a sense of euphoria and a restoration of strength were not only reported by the patients themselves but were also observed with reference to objective criteria in virtually all patients by independent nursing staff.
In advanced tumors a slowdown and stabilization of tumor development could be observed at the very least, signi-ficantly increasing the period of survival.
The direct influence on the tumor which COUDERT also achieved in his clinical trials did not appear to be dependent on the histological nature of the neoplasm.
The most spectacular effect was the complete regression, with the formation of scar tissue, of cancers of the tongue and the larynx.  In other cancers a partial regression of the cancer body was obtained.
When these regressing tumors were surgically removed, anatomopathological examination revealed that they still contained neoplasmic cells, but, and an extremely important but, they were only very occasionally found to be in mitosis (3).

In clinical trials COUDERT also observed improved fibrosis, and a reduction of the likelihood of bleeding and metastasis as a result of tryponosoma therapy (4).
More recent are the clinical observations of SPITHAKIS (5) who writing in 1970 concluded that the trypanosoma extract therapy led to "very demonstrable results".
He also clinically confirmed the pain supressing properties of the preparation, the improvement of the patient's general condition (improved appetite, increase in weight, the sense of well-being, better nighttime rest, and even an improvement of the blood analysis, particularly the high red corpuscle count), the significant regression of tumors, and a significant reduction in hemoptoic events when cobalt therapy is started.
The influence of the preparation on metastasis was in SPITHAKIS's view only slight.  Other (French) cancer therapists such as VEYRIAS-NANTIAT (5) and LAGEZE, DURAND, and CHASSAGNON (6) reported (in 1960) that metastasis shown in X-ray plates of the lungs had been halted after trypanosoma treatment.
 

Action

The Soviet biologists reported at a conference in held in Berlin in 1960 that by using trypanosoma extract considerable reductions in the average size of cancer cells and a normalization of the ratio of nucleus to nucleolus could be achieved, as well as a reduction in the mitosis index (7).  They had also observed that RNA concentrations in the cell were lower, thus reducing protein synthesis, which in turn led to a slowdown of cancer cell proliferation.
MICHEL-BRUN (8) confirmed the Russian thesis in 1963.  He observed that the trypanosa-DNA appeared to penetrate the genetic system of the cancerous cell, where it restored the enzyme balance.
ROSKIN and KLYUEVA's trypanosoma extract therapy had more or less been forgotten (in fact it had never really received widespread international attention at all) because their discovery was announced at the peak of the excitement around the recently discovered chemo(toxico)therapy with mustard gas derivatives.

It was only when this euphoria began to subside as a result of the limited success of chemo(toxico)therapy and because of its numerous side effects that there was renewed interest in ways of stimulating the immune system and that such means again came into fashion (9).
At about this time trypanosoma extract therapy was rediscovered, as was BCG-Corynebacterium parvuum therapy, and other similar therapies.
The renewed interest was manifested in works by LISTON et al. (10), NOGUEIRA, GORDON, and COHN (11), SHIDUCA ITOW (12), WILLIAMS and REMINGTON (13), and WILLIAMS and SAWYER (14) which emphasized the non-specific immunostimulative properties of the trypanosoma extract by stimulating macrophage and the immunological defences by cell mediation.
Currently nothing more is known about how trypanosoma extract works.  Nevertheless it is difficult not to conclude that with its ability to suppress pain, encourage a sense of well-being, stimulate appetite, and promote weight gain, not to mention its ability, discovered in the seventies, to stimulate the immune system, there is no good reason why this non-toxic trypanosoma extract should not be used on a wide scale.
 

Composition

One ampoule contains

- freeze-dried schizotrypanum cruzi  3630 million
- lactose          50 mg
- methylpara-hydroxybenzoate         1 mg
- ampoules containing solvent for
  rehydrating the freeze-dried material          1.5 ml
 

Administration

Intramuscular

Indications

All tumors without histological distinction.  The best results are however obtained with cancers of the ear, nose and throat, and the breast.

Suppliers

Institute Merieux (since 1897)
17, rue Bourgelat
Boite postale 255
F-69223 Lyon Cedex 1
France
Tel. (07) 838. 06.10
Telex 310627 Merieux Lyon

________________________________________________________________________________

Foot-notes
 

(1) ROSKIN G. and EXEMPLARSKAYA E., Protozoinfection und experimenteller Krebs, Z. für Krebsforsch. 34, pps 628-645 (1931)
 ROSKIN G. and ROMONOVA K., Action des toxines sur le cancer expérimental, Acta cancerlogica, 1, page 323-334 (1935)
 ROSKIN G. and ROMONOVA K., Traitement du cancer expérimental par les endotoxins de Protozoaires, Arch. Int. Med. Exp. 13, page 379-384 (1938)
 ROSKIN G. Toxin Therapy of Experimental cancer, Cancer Research, 6,page 363-365 (1946)
 ROSKIN G. Le probléme de la carcinogèse à la lumière des recherches expérimentales de biothérapie des tumeurs malignes, Abhandl. der Deutsch. Akad. des Wissensch. z. Berlin no 3, pp. 334-354. (1960)
 KLYUEVA N. Procédés de biothérapie du cancer, Rev. Acad. Sciences Med. de l'URSS, 2-3, (1946)
 KLYUEVA N. Orientation de la biothérapie du cancer, Le Médecin Français, 1, pp. 8-9 (1947)
 KLYUEVA N. Les voies de la biothérapie du cancer, Amer. Journal of Soviet Medecine, June, page 408-411 (1947)
 KLYUEVA N. and ROSKIN G. I. Le probléme des antibiotiques anticancereux, Rev. Acad. des Sciences URSS, 41, pp. 55-73 (1956)
 KLYUEVA N. and ROSKIN G. I. Le probléme des antibiotiques anticancereux, 1, page 2 Moscow (1957).
 KLYUEVA N. and ROSKIN G. I. Biotherapy of Malignant Tumours, Pergamon Press, Oxford, London, New York, Paris (1963)

(2) COUDERT J. .............

(3) COUDERT J., BATTESTI M.R., and PAPAGEORGIOU, C., Modifications de l'indice mitotique des cellules néoplasiques en culture (souche KB) sous l'influence d'un extrait de trypanosoma cruzi, C.R. Soc. Biologie, 154, 3, pp. 612-615 (1960)
 COUDERT J., BATTESTI M.R., and PAPAGEORGIOU, C., Action d'un extrait de Trypanosoma cruzi sur l'indice mitotique des cellules néoplasiques en culture de la souche KB, Revue Lyonnaise de Médecine, t. 9,10, pp 745-750. (1960)

(4) compare the findings with the proteolytic enzymes on fibrosis, page

(5) SPITHAKIS R. Le trypanosa en cobalthérapie, Marseille Médical, 107, 11 (1970)

(6) in Lyon Médical, 21st of February 1960.

(7) see the findings of COUDERT above, and his publications, footnote .. p..

(8) MICHEL-BRUN J. Influence de l'extrait de Trypanosoma cruzi sur divers aspects métaboliques de la cellule sarcomateuse, Thèse de Doctorat en Pharmacie, Lyon (1963);

(9) Science is in fact very subject to fashion.  What yesterday was acclaimed as science, is out of date today.  And what was the blackest of heresy the day before yesterday is of course today's science.  The term "scientific" is therefore relative, strongly influenced by fashion, and should be taken with the necessary pinch of salt.

(10) LISTON A.J., BAKER J.R. and SELDEN L.F., Specific delayed-type hyper-sensitivity footpad response in mice artificially immunized with two trypanosoma (Schizotrypanum) species, Journal of General Microbiology, vol. 98, 2, pp 615-617 (1977)

(11) NOGUERIA N., GORDON S., COHN Z. Trypanosoma cruzi: modification of macrophage function during infection, The Journal of Experimental Medecine, vol 146, 2, pp. 157-171 (1977)
 NOGUERIA N., GORDON S., COHN Z. Trypanosoma cruzi: The immunological induction of macrophage plasminogen activator requires thymus-derived lymphocytes, The Journal of Experimental Medicine, vol 146, 2, pp. 177-183 (1977)

(12) SHIDUC ITOW, PLESSMAN CAMARGO E. Proteolytic activities in cell extracts of Trypanosoma cruzi, J. Protozoology, Vol 24, 4, pp 591-595 (1977)

(13) WILLIAMS D.M., REMINGTON J.S. Effect of Human monocytes and macrophages on Trypanosoma cruzi, Immunology, Vol 32, 1, pp. 19-23 (1977)

(14) WILLIAMS D.M., SAWYER S. and REMINGTON J.S. Role of activated macrophages in resistance of mice to infection with Trypanosoma cruzi, The Journal of Infectious Diseases, Vol 134, 6, pp 610-623.
 
 
 
 

Dr.  Henri  ROSENBERG, LL.D., Ph.D., N.D.
Doctor of Naturopathy
Permanent Member of the British
Guild of Drugless Practitioners.

 

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