Cancer chemo(toxico)therapy revisited and alternative ways of healing.A thesis presented to the Anglo-American Institute of Drugless Therapy and leading to the Degree of Doctor of Naturopathy (N.D.).
© 1990 by Dr. Henri Rosenberg.
Introduction 2
Chapter I : Chemo(toxico)therapy 3
Chapter II : Amygdalin - Vitamin B 99
Chapter III : The Synthetic Physiatrons 128
Chapter IV : Trypanosoma Therapy 140
Chapter V : Selenium Therapy 146
Chapter VI : The beer's yeast cure 156
Chapter VII : Tumor related indicators 164
Chapter VIII : The Thymus Therapy 188
Chapter IX : The H-11 Therapy 194
Chapter X : Antineoplaston 202
Chapter XI : Gelum Oral RD® 205
Chapter XII : Neoblastine® 212
Chapter XIII : The WIEDERMANN cure 219
Chapter XIV : Beetroot (juice) as cancer therapy 225
Chapter XV : Integral Fasting Therapy 229
Chapter XVI : The Iron Cancer Cure 235
Selenium therapy
The element selenium (Se) was discovered and isolated in 1817 by the Swedish chemist and mineralogist Joens Jacob BERZELIUS(1). To emphasize its chemical relationship with tellurium, which derives its name from the earth (Greek : tellus = earth), the newly discovered element was called after the moon (Greek : Selene).Its atom number is 34 and its atom weight is 78.96.
In the table of Mendeleev, selenium is found in the sixth group with oxigen, sulphur, tellurium and polonium.
Albeit in varying concentrations, selenium is fould in the soil almost anywhere in the world. The Se-content depends on the nature of the rock, soil acidity, rainfall, temperature and other factors. Large selenium concentrations are found in certain areas of the U.S.A. (Western States), China, Venezuela, Cloumbia, Israel and Ireland. Selenium-poor areas however are much more frequent : the North-West and East of the U.S.A., South-America, New-Zealand, Australia, China, Japan, Great-Brittain, Canada, Scandinavia, Germany, France, Belkgium and Switzerland.
In addition to the above-mentioned relationship between selenium and tellurium, selenium shows even a more striking similarity to sulphur. Consequently, selenium is also found in volcanic sulphur androus applications in industry. The stablest thermo-dynamic form of selenium is metalic or grey selenium, which is a semi-conductor (conductibility increases as heating or lighting increases). Hence, selenium is used in electronic industry and as a volcanizer in rubber; it is used furthermore to improve processing of certain kinds of stainless steal and reduce the corrosivity of same steal sorts, such as chromic steal. The latter is caused by the anti-oxidant action of Se, which we will refer to again in rous applications in industry. The stablest thermo-dynamic form of selenium is metalic or grey selenium, which is a semi-conductor (conductibility increases as heating or lighting increases). Hence, selenium is used in electronic industry and as a volcanizer in rubber; it is used furthermore to improve processing of certain kinds of stainless steal and reduce the corrosivity of same steal sorts, such as chromic steal. The latter is caused by the anti-oxidant action of Se, which we will refer to again in the discussion of the possible mechanisms of action. Generally, both organic (3) and anorganic (4) chemistry show resemblances with sulphur and sulphuric substances.
Selenium in cancer.
The idea to adopt selenium in the fight against cancer was conceived by August von WASSERMANN (1866-1925), attached to the Rudolf Virchow Hospital in Berlin. In 1910, he concentrated on the problem of the life duration of cancer cells in serum suspensions and tried to find a test to measure the vitality of the cells. Basing himself on GOSIO's (5) research work, his attention was drawn to natrium selenite which is used for the same purpose in bacteriology. That is how it struck him that (vital in contradiction to necrotizing) cancer cells were capable of reducing selenite (as well as tellurium).
This encourages him to start studying this 'characteristic' of cancer cells in vivo (6). Intratumourous selenite injections as well as (later) intravenous administrations of selenium compounds to mice with Ehrlich carcinoma proved to be capable of making the tumour fluid and making it disappear without recidivism.
WALKER and KLEIN (7) also reported, in 1915, about the complete disappearance of small subcutaneous tumours after oral administration of selenite in subtoxic doses.
It is important to put emphasis on the theoretic approach of the physio-logical of the physiological role of selenium, which the authors ascribe to the 'hyperoxidation of the cells' - as they call it - by which they actually meant the consequences of the endogenic production of OH-radicals from H2O2 and hydroperoxides.
The publication of VON WASSERMANN's findings in 1911 was met with a lot of enthusiasm and aroused extremely great interest and expectations. Human tests were promptly carried out. Although VON WASSERMANN had released the composition of his therapeutic agents, he had not indicated the exact dosage. As a consequence, selenium poisoning caused the first deadly accidents (8) thereby diminishing the initial enthusiasm which had to make way for a fastly growing scepticism. This was the end of a first phase in the history of selenium therapy. A period of weakened and careful scientific interest followed, although research work had not decreased. The hoped-for breakthrough of selenium therapy however still failed to come because of the above-mentioned negative attitude on the part of the medical corps. In 1924, this scepticism was even enforced by the publication of research work by NELSON, FITZHUG and CALVEY (9) who claimed to have discovered a cancerigenic action in selenium. This obviously had political repercussions and influenced the Delaney-stipulation (a legal text for the improvement of Public Health) in the U.S., where the addition of selenium to animal food was strictly forbidden.
Similar legal measures were also adopted in other countries to protect people from selenium poisoning.
Nevertheless, selenium research continued even in these hard times.As soon as 1920, a study by WATSON-WILLIAMS (10) was published in which hopeful results were reported of cancer patients treated with colloidal selenium. TODD (11) who also used colloidal selenium, esta-blished significant survival figures with post-operative breast cancer patients.
After World War II, REVICI (12) (of the Institute for Applied Biology, New York and previously, attached to the Pasteur Institute, Paris) performed clinical tests. He preferred to carry out his human tests with organic selenium compounds, for fear of the possible toxic action of selenium. He reported about remissions of many years in a number of hopeless cancer patients.
WEIBERGER and SUHRLAND (13), on their part, informed in 1956 about therapy successes with selenocystine administered to leukaemic patients and Murphey-lymphosarcomas (14).
Other studies in the same period by SHAMBERGER and RUDOLPH (15) and SHAMBERGER and FROST (16) are worth mentioning.
However, only in the seventies, a renewed systematic and therapy-directed selenium research was initiated, at a time when VON WASSER-MANN's pioneer research with animals had long been forgotten. An experimental confirmation of VON WASSERMAN's work was brought by Soviet-Russian scientists ABDULLAEV, GASANOV, RAGIMOV, TEPYAKOVA, MEKHITIEV and DZAFAROV (17); they proved that only one injection with selenium is capable of restraining the growth of an Ehrlich-ascites-, Gueringcarcinoma and M-1-sarcoma. The recent finding of GREEDER and MILNER (18) and MILNER and HSU (19) - who could also demonstrate the tumourrestraining characteristics in both L1210 leukaemia cells in mice and in vitro , are in the same line.
IP and SINHA (20), furthermore, succeeded in stopping the growth of implanted breast tumours in rats by adding 2 ppm Se to their food. The numerous animal tests carried out by SCHRAUZER (21), who examined and proved the influence of selenium on the genesis of spontaneous tumours, must not remain unmentioned.
Selenium experiences were also conducted by environmental disciplines (such as environmental geochemistry ...). Hence, it was established that significantly high ages were reached in the Vilcabamba-Valley (Ecuador), South-Caucasus (S.U.) and the Hunza-area (Pakistan). An increasing number of scientific studies were carried out in this respect.
Doctor David DAVIES of the Gerontological Department at Londen Uni- versity, discovered, by means of fixed birth, baptism and death certifi-cates, tha in the Vilcabamba-Valley people tend to grow very old. In addition, he ascertained that these areas were free of environmental diseases such as cancer and heart diseases.
In the Soviet Union, Soviet, French and American scientists focused on the generally high ages obtained by the inhabitants of the Caucasus; at this moment a Russian Institute for Gerontology is still working on the case. The third area where Mathusalems are found, is the Hunza-area by which China, Pakistan and the S.U. are connected. Initially, scientists wanted to reduce this longevity to the way people fed themselves in the above-mentioned areas. The Americal Doctor Ronald PHILIPS has conducted a comparative study about the way Mormons and Adventists live and eat; they both abstain from smoking and liquor; the only distinction in their eating patterns is that the Mormons are vegetarians whereas the Adventists eat meatless food.
PHILIPS found that the frequency of cancer was significantly lower for the Adventists than for the Mormons, but more in particular he discovered that the Mormons, who lived in the State of Utah (rich in selenium), suffered considerably less cancer than their co-religionists in other states (poor in selenium) although they had a similar living and eating pattern.
This geographic determination as a function of the soil containing selenium or not, is a constant in the selenium research coming from the envirmental disciplines.
An example of this is the alcali disease, which impairs animals (horses and sheep in particular (22)), about which Marco Polo was the first, in 1295, to report in his Diaries from West-China.
In 1856 the American surgeon MADISON (23) gave a description of the disease, ascribing it initially to the high content of alcali in water and soil in the area of the Rocky Mountains. It was not until 1933 that ROBINSON (24) ascribed it to selenium poisoning.
Selenium poisoning is also found in cows (25), pigs and chickens (26).
On the other hand, if the soil is poor in selenium, other syndromes are caused in many animals such as chickens and cows (27), calve (28), sheep (29) and foal (30).
In 1977, a report of the British Ministry of economics, fishery and nutrition revealed that Great-Britain was largely poor in selenium, with the exception of the North of Norfolks, were high Se-concentrations had been established.
This phenomenon was attributed to glacier motions of millions of years ago. The report ascertained furthermore that the frequency of people over 75 is thrice as high in this area as in the rest of Great-Britain which is largely poor in selenium (31). The inhabitants of the questionable selenic area live according to a pattern which comes closer to that of the above-mentioned three countries with record-'long-living people', name-ly they eat a lot of fresh fruit and vegetables which they - and this seems to be essential - grow themselves on the spot, thus ensuring a high absorption of selenium.
Very recent findings are those of the Chinese Cancer Investigation Centre of the National Medical Academy of Peking Yü Shu Yü, which proposed a report at the Third International Conference about 'Anorganic and Alimentary Aspects with regard to Cancer and other Diseases'; their report contained some succusful animal tests with selenium on mice with implanted hepatoma cells : subcutaneous (2 mg/kg) or intraperitoneal ( 1 mg/kg) injections of natrium selenite increased the cAMP-level (32) and lowered the cAMP-phosphodiesterasis, which clearly illustrates the versatility of the way selenium acts on cancer.
Action
The nice thing about the mechanism of the anti-neoplastic action of selenium is not yet sufficiently known at this stage and the study is still in process. However, this anti-cancer action is assumed to run over several mechanisms, some of them we will describe shortly.
A first possible antineoplastic action would consist in blocking the protein-biosynthesis (33). It is suspected that this blocking is caused by transferring selenium to factor 2, which is essential to the protein biosynthesis (the so-called elongation factor 2, EF 2). This is a protein which contains sulphhydril groups and therefore changes into a seleno- trisulfide by the reaction with selenodiglutathione, whereby the biologic inactive oxidated from of EF 2 (with S-S-linkages) is created.
As a principle, this would entail an oxidation catalysed by selenium which could explain the blocking of the protein biosynthesis (34).Another important theory comes from Doctor PASSWATER (35), with respect to the function of the free radicals (36) in the body. Free radicals are extremely aggressive molecule fragments which damage the human organism to a great extent (such as the impairment of the cellular membrane (37)), through which the cell loses its capability of absorbing nutritious substances and eliminating poisonous substances.
In order to prevent this, our body produces enzymes or protein groups which function as catalysts. One of these enzymes is glutathionperoxide which contains selenium atoms and was named selenoenzyme by ROTRUCK et al. (38)
MARTIN and SPALLHOLZ (39) followed in the footsteps of the Russian scientist BERENSHTEIN (40) and studied the influence of selenium on immune defence. They both, separately, ascertained in animal tests that Se and vitamin E could significantly increase the antibody titre. This was confirmed by many other researchers on the basis of test animals (41).
WASSENBERG (42) considers the anti-neoplastic action of selenium on different levels, namely 1) change in the metabolism of the carcinogens by reduction of inactivation, by detoxification or by both; 2) purification of molecules from their carcinogenic ballast and keeping this below the toxic level; 3) change in permeability of transport ; and 4) competitive blocking.
GRIFFIN and LANE (43) obtained a reduction of glucuronyl-transfrasis under the influence of Se, which could point to .... (see laetrile).
It appeared furthermore that selenium possesses certain anti-mutagenic characteristics (44) and is thus capable of preventing damage chromo-somes as a consequence of carcinogenic substances (45).
It is suggested that selenium activates DNS-reparation-enzymes or directs the mechanism of cell division in such a way that mistakes in cell reproduction are avoided (46).________________________________________________________________________________
Foot-notes
(1) BERZELIUS, J.J., Abhandl. Fys. Kemi Mineralogi, 6, 42, 1818.
(2) N.N, Selenium. Medical and Biologic Effects of Environmental Pollutants, National Academy Sciences, Washington D.C., 28-35, 1976.
(3) SCHRAUZER, G.N., Selen, Neuere Entwicklingen aus der Biologie, Biochemie und Medizin, E. Fischer Verlag, Heidelberg, 1983, 15.
IRGOLIC, K.G., KADSCHADKER, M.V., Organic Chemistry of Selenium, in ZINGARO, R.A., COOPER, W.C. (ed.), Selenium, Van Nostrand Reinhold Co., New York, 1974, 408.
HOUBEN-WEYL, S., Methoden der Org. Chemie, in VON EUGEN (ed.), Bd. IX: Schwevel-, Selen- und Tellurverbindungen, G. Thieme Verl., Stuttgart, 1955, 917.
KLAYMAN, D.L., GÜNTHER, W.H., Organic Selenium Compounds, their chemistry and biology, Wiley Interscience, New York, 1973.(4) JEAN, Y., ROCHEFORT, J.G., LANCOT, C., ROBERTs, K.D., CHAPDELAINE, A., BLEAU, G., in SPALLHOLZ, J.E., MARTIN, J.L., GANTHER, H.E., (ed.), Avi Publ. Co. Inc., Westport, Conn., 1981, 422.
(5) GOSIO, B., Z. Hygiene 51, 1905, 65.
(6) WASSERMANN, A von, KEYSSER, F., WASSERMANN, M., Dtsch Mediz. Wschr., 2389, 1911.
(7) WALKER, C.H., KLEIN, F., Am. Med. J., 628, 1915.
(8) DELBERT, P., Assoc. Franc. pour l'Etude du Cancer, 5, 121, 1912. zie ook hfdst. over Magnesiumtherapie.
(9) NELSON, A.A., FITZHUG, O.G., CALVEY, H.O., Cancer Res., 3, 230, 1943.
(10) WATSON-WILLIAMS, E., The Brit. J. of Surgery, 8, 50, 1920.
(11) TODD, A.T., Brit. Med. J., 1935, 172.
(12) REVICI, E., Research in Physiopoathology as Basis of Guided Chemtherapy, Amer. Foundation for Cancer Research, D. Van Nostrand Company, New York, 1961.
(13) WEISBERGER, A.S., SUHRLAND, L.G., Blood, 11, 19, 1956.
(14) WEISBERGER, A.S., SUHRLAND, L.G., Blood, 11, 11, 1956.
(15) SHAMBERGER, R.J., RUDOLPH, G., Experimentia, 22, 116, 1966.
(16) SHAMBERGER, R.J., FROST, D.V., Canad. Med. Assoc. J., 100, 682, 1969.
(17) ABDULLAEV, G.B., GASANOV, G.G., RAGIMOV, R.N., TEPLYAKOVA, G.V., MEKHITIEV, M.A., DZAFAROV, A.I., Dokl. Akad. Nauk. Azerb. SSR, 29, 18, 1973.
(18) GREEDER, G.A., MILNER, J.A., Science (Washington), 209, 825, 1980.
(19) MILNER, J.A., HSU, C.Y., Cancer Res., 41, 1652, 1981.
(20) IP, C., SINHA, D., Cancer Res., 41, 31, 1981.
Carcinogenesis, 2, 435, 1981.(21) SCHRAUZER, G.N., ISHMAEL, D., Ann. Clin. Lab. Sci. 4, 441, 1974
SCHRAUZER, G.N., WHITE, D.A., SCHNEIDER, C.J., Bionorg. Chem., 6 265, 1976
idid. 8, 387, 1978.
SCHRAUZER, G.N., McGUINESS, J.E., KÜHN, K., Carcinogenesis, 1, 199, 1980.(22) ROSENFELD, I., BEATH, O.A., Selenium. Academic Press, New York, 1964.
(23) SUTTON, B., BUTLER, D., American Ferriers J., 1980, 44.
(24) ROBINSON, W.O., J. Ass. Off. Agr. Chemists, 16, 423, 1933.
(25) DUDLEY, H.C., Amer. J. Hyg., 23, 169, 1936.
(26) N.N., Selenium, Medical and Biological Effects on Environmental Polutions, Natl. Res. Coucil, Natl. Acad. of Sciences, 1976.
(27) BOSTEDT, H., SCHRAMEL, P., Zbl. Vet. Med., 28, 529, 1981.
CONRAD, H.R., MOXON, A.L., Ohio Report, 65 (1), Jan-Feb., 1980.
SHARMAN, G.A.M., BLAXTER, K.L., WILSON, R.S., The Veterinary Record, 26, 536, 1959.(28) BOSTEDT, H., Der praktische Tierarzt, 61, 45, 1980.
(29) FROST, D.V., LISH, P.M., Ann. Rev. of Pharmacol., 18, 259, 1975.
MANKTELOW, B.W., New Zealand Vet. J., 11, 52, 1963.
MUTH, O.H., OLDFIELD, J.E., SCHUBERT, J.R., REMMERT, L.F.,Am. J. Vet. Res., 20, 231, 1959.
SHRIFT, A., Fed. Proc., 20, 695, 1961.
WOLF, E., KOLLONITSCH, V., KLINE, C.H.,
J. Agricult. and Food Chem., 11, 355, 1963.
(30) AMIN, S., COLLIPP, P.J., CHEN, S.Y., Nutrition and Metabolism, 24 331, 1980.
CALVIN, H.L., COOPER, G.W., WALLACE, E., Gamete Res., 4, 139, 1981.
HARTLEY, W.J., GRANT, A.B., Fed. Proc., Fed. Amer. Soc. Exp. Biol., 20, 679, 1961.
McCONNELL, K.P., BURTON, R.M., in SPALLHOLZ, J.E., MARTIN, J.L., GANTHER, H.E., (ed.), Selenium in Biology and Medicine, Avi Publishing Co., Inc., Westport/Connecticut, 132, 1981.
PATTERSON, E.L., MISTREY, R., STOKSTAD, E.L.R., Proc. Soc. Exp. Biol. Med., 96, 617, 1957.
WU, S., OLDFIELD, J.E., WHANGER, P.D., WESWIG, P.H.,Biol. Reprod., 8, 625, 1973.(31) Norwich telt 11% en Upper Sheringham 15% van ouder dan 75 jaar, tegen een landgemiddelde van amper 5% van de bevolking.
(32) z. ....... (Reckeweg-HEEL)
(33) SCHRAUZER, G.N., Selen. Neuere Entwicklngen aus der Biologie, Biochemie und Medizin, Dr. E. Fischer Verlag, Heidelberg, 1983, 72.
VERNIE, L.N., BONT, W.S., EMMELOT, P., Biochemistry, 13, 337, 1974.
VERNIE, L.N., BONT, W.S., GINJAAR, H.B., EMMELOT, P., Biochim. Biophys. Acta, 414, 283, 1975.
VERNIE, L.N., GINJAAR, H.B., WILDERS, I.T., BONT, W.S., Biochem. Biophys. Acta, 518, 507, 1978..
VERNIE, L.N., COLLARD, J.G., EKER, A.P.M., DE WILDT, A., WILDERS, I.T., Biochem. J., 180, 213, 1979.(34) SCHRAUZER, G.N., ibid.
(35) auteur van .... z. ook verder blz ....
(36) z. ook blz ....
(37) MILLS, G.C., J. Biol. Chem., 229, 189, 1957.
(38) SCHRAUZER, G.N., ibid. 41 e.v.
ROTRUCK, J.T., POPE, A.E., GANTHER, H.E., SWANSON, A.B., HAFERMAN, D.G., HOEKSTRA, W.G., Science (Washington), 179, 588, 1973.(39) MARTIN, J.L., SPALLHOLZ, J.S., Proc. Symp. Selenium-Tellurium in the environment, University of Notre Dame, Notre Dame/Indiana, 1976, 204.
(40) BERENSHTEIN, T.F., Zdravookhr. Beloruss., 18 (10), 34, 1972.
(41) NORMAN, B.B., JOHNSON, W., Anim. Nutr. Heatlth, 31, 6, 1976.
ALEKSANDROWICZ, J., WASEWSKA-CZYZEWSKA, M., BODZON, A., DOLEZAL, M., DUBIS, K., KLEWSKA, D., Rocz. Nauk. Zootech., 4, 113, 1977.
DESOWITZ, R.S., BARNNELL, J.W., Infect. Immun., 27, 87, 1980.
BAUER, K.H., Das Krebsproblem, 2. Auflage, Springer Verlag, Berlin/Göttingen/Heidelberg, 1963, 817.
SCHRAUZER, G.N., Adv. Nutr. Res. in DRAPER, H.H. (ed.), 1979, 219.(42) WATTENBERG, L.W., Inhibitors of chemical carcinogenesis, Adv. Cancer Res., 26, 197, 1978.
(43) GRIFFIN, A.C., LANE, H.W., Selenium Chemoprevention of Cancer in Animals and Possible Human Implications, in SPALLHOLZ, J.E.,...
MARTIN, J.L., GANTHER, H.E. (ed.), Selenium in Biology and Medicine, Avi Publishing Company, Inc., Westport, Connecticut, 1981, 160.(44) JANSSON, B., JACOBS, M.M., GRIFFIN, C.A., Advances in Exp. Medicine and Biology, Vol. 91, in SCHRAUZER, G.N., (ed.) Vol. 91, 305, 1978.
(45) SHAMBERGER, R.J., BAUGHMAN, F.F., KALCHERT, S.L., WILLIS, C.E., HOFFMAN, G.C., Proc. Natl. Acad. Sci., USA, 70, 1461, 1973.
(46) SCHRAUZER, G.N., ibid. 72.
Dr. Henri ROSENBERG, LL.D., Ph.D., N.D.
Doctor of Naturopathy
Permanent Member of the British
Guild of Drugless Practitioners.
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