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No, they are not all alike. They arise from different parts of the breast, have different names and behave differently, even if they outwardly appear the same.
The first determination for naming is whether the breast cancer is "in situ" or "invasive". In situ cancers remain within the boundaries of the kind of cells that formed them. In situ means "in place", staying where it belongs and not spreading. For this reason in situ cancers are sometimes called precancerous, meaning they may develop into invasive cancers at some later time. About 20-40% of in situ cancers will do this if not removed. Currently, about 12% of detected breast cancers are in situ. This percentage is increasing because breast cancers found on mammograms are often in situ. The other breast cancers are all invasive cancers. Invasive cancers have broken out of the boundaries of the group of cells they came from and are invading or growing into the nearby breast tissue.
The second part of the name tells something about that particular kind of cancer. Some breast cancers get their names from the cells of the breast that turned into cancer. If the cancer arises from the cells of the tubes or ducts that normally carry milk to the nipple, it is called "ductal" or from the ducts. Eighty persent of breast cancers are ductal. If a cancer arises from the part of the breast that produces milk, it is called a lobular cancer. "Lobular" refers to lobes, or the milk producing structures. Ten percent of breast cancers are lobular. Another cancer type is inflammatory breast cancer (3%) which causes the breast to look like it has an infection. The names of other uncommon forms describe what the pathologist sees when s/he looks at the cancer under the microscope. For example, tubular breast cancer still forms tube-like structures, medullary breast cancer has the color of the part of the brain called the medulla, mucinous cancers contain mucus-like material, and papillary cancer has finger-like projections.
Normal cells in our bodies have a predetermined life span, They grow, they give rise to new cells and they die. Our bodies continually replace dead cells with new ones. With millions of new cells being made everyday, mistakes can and do happen, causing abnormal cells. Normally cells have ways of checking and identifying problems. Defective or abnormal cells are destroyed. If something goes wrong with this detection system, the abnormal cells are permitted to grow. Cells grow by first increasing in size and then splitting into two. One cell becomes two, two become four and so forth. Normally, new cells are created at the same rate as old cells die. Cancer cells do not maintain this normal balance. They divide at a faster rate than cells die, causing the cancer to grow.
A second problem with most cancers is that, unlike normal cells, they can spread to other parts of the body or "metastasize". Normal cells do not travel to other parts of the body or the body's immune system detects and destroys them before they can grow.
Most women are shocked to find out that they have had their breast cancer for years before it was discovered. Cancer growth is measured in doubling times. One doubling time is the amount of time that it takes for the mass of cancer cells to double in size. It takes about 23 doubling times to go from one cancer cell to become a large enough mass to be seen on a mammogram, and about 30 doubling times to become large enough to be felt as a lump, about one billion cells. Doubling times may be as short as 10 days or as long as several years. Four months is an average doubling time. A cancer's doubling time is an indication of how fast it grows. The doubling time is very important in determining the time course of the cancer. For example, a cancer first starts when a woman is 40. It is a fast growing cancer with a doubling time of 2 months. It takes 46 months (2x23), or almost four years, before it is large enough to be detected by a mammogram and 60 months, or five years, before she feels it. She is diagnosed with cancer at age 44 or 45. If, on the other hand, she has a slow growing cancer with a doubling time of two years, she would be 86 before it could be found on a mammogram and 100 before she could feel it. She probably would die of other causes before she ever knew she had cancer. Carefully performed autopsy studies show undetected invasive breast cancer in over 3% of women age 40 and older. Since most breast cancers grow at an intermediate pace, usually the cancer has been present for 8-10 years before being discovered. Metastatic cancer, like the original cancer in the breast, must double in size at least 23 times before it can be found.
Send comments or questions to wolberg@surgery.wisc.edu
Up-dated 6/30/98
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