Metastasis
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Cancer & Biopsy
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Metastasis
is the action of a cancer that has been relatively inactive in a
relatively fixed location, for some reason, usually suddenly,
starting to spread throughout the body. The most common
reason for Metastasis would be surgery which cuts into the
cancer, usually in an effort to cut it all out, where the result is that some part of the cancer was NOT cut out and now
that the protective wall around the formerly inactive, or
slow-growing cancer is disrupted, cancer cells enter into the
blood stream, are carried to other parts of the body, and then
start growing as new cancers in those locations.
- Results for your query in Medline on July 11, 2000:
- Search all fields for: metastasis And biopsy
And spread
- Published in 1966 through 1999
- Only select references with abstracts available
- Show references published in English only
Documents: 1 to 100 of 243
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NLM database Documents
Record 1 from database: MEDLINE
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- Title
- Implantation metastasis after percutaneous transthoracic needle
aspiration biopsy.
- Author
- Sinner WN; Zajicek J
- Address
-
- Source
- Acta Radiol [Diagn] (Stockh), 1976 Jul, 17:4, 473-80
- Abstract
- The risk of tumour spread at aspiration biopsy of pulmonary tumours
through the needle track has been analyzed by reviewing the case
histories of 1 264 patients with a malignant tumour demonstrated by
needle biopsy. Only in one case did metastatic tumour growth develop at
the site of the biopsy. The history of this case is presented and the
available literature on the subject discussed.
- Language of Publication
- English
- Unique Identifier
- 77018915
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- MeSH Heading (Major)
- Biopsy, Needle|*AE; Carcinoma, Squamous Cell|*/PA/RA; Lung Neoplasms|*/PA/RA;
Neoplasm Seeding|*
- MeSH Heading
- Aged; Case Report; Follow-Up Studies; Human; Lung|PA; Male; Neoplasm
Metastasis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0567-8056
- Country of Publication
- SWEDEN
Record 2 from database: MEDLINE
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- Title
- Aspiration cytology for diagnosis of head and neck masses.
- Author
- Meyers DS; Templer J; Davis WE; Balch JA
- Address
-
- Source
- Otolaryngology, 1978 Jul, 86:4 Pt 1, ORL-650-5
- Abstract
- Most American clinicans have been relectant to utilize aspiration
biopsy due to poor interpretive skills by the pathologists in the past
and a fear of tumor spread by the needle. Voluminous European series and
recent American series have proved aspiration to be safe and reliable.
In our series of 78 cases, both thin-needle aspiration and conventional
tissue biopsies were made. The diagnoses were compared and the overall
agreement rate was 90%.
- Language of Publication
- English
- Unique Identifier
- 79245956
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- MeSH Heading (Major)
- Biopsy|*MT; Biopsy, Needle|*MT; Head and Neck Neoplasms|*PA
- MeSH Heading
- Carcinoma, Squamous Cell|PA; Comparative Study; Diagnostic Errors;
Human; Neoplasm Metastasis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0161-6439
- Country of Publication
- UNITED STATES
Record 3 from database: MEDLINE
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- Title
- Diagnosis of lymphangitic carcinomatosis by transbronchial lung
biopsy.
- Author
- Torrington KG; Hooper RG
- Address
-
- Source
- South Med J, 1978 Dec, 71:12, 1487-8
- Abstract
- The records of patients who had transbronchial lung biopsy at Walter
Reed Army Medical Center between January 1974 and September 1977 were
retrospectively reviewed. Nine patients were found whose clinical and
radiographic presentations were compatible with lymphangitic
carcinomatosis. In five patients in lymphangitic spread of carcinoma was
diagnosed from transbronchial lung biopsy specimens. A single patient
had a false-negative biopsy, proven at autopsy three weeks later. The
other three patients with negative biopsies are alive and receiving
chemotherapy 12 months later (two patients) or are lost to follow-up
(one patient). Transbronchial lung biopsy is an accurate procedure for
diagnosing lymphangitic carcinomatosis. In addition, aggressive
chemotherapy should not be used in these patients without a tissue
diagnosis.
- Language of Publication
- English
- Unique Identifier
- 79076778
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- MeSH Heading (Major)
- Carcinoma|*PA; Lung|*PA; Lung Neoplasms|*PA; Lymphangitis|*PA
- MeSH Heading
- Biopsy|MT; Bronchoscopy; Fiber Optics; Human; Neoplasm Metastasis;
Retrospective Studies
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0038-4348
- Country of Publication
- UNITED STATES
Record 4 from database: MEDLINE
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- Title
- Techniques for inhibiting tumor metastases.
- Author
- Hoover HC Jr; Ketcham AS
- Address
-
- Source
- Cancer, 1975 Jan, 35:1, 5-14
- Abstract
- Of the four major biological mechanisms of cancer spread, hematogenous
dissemination is perhaps the most significant, as it usually heralds a
fatal outcome for the patient. Recent experimental approaches have shown
ways of altering the metastatic process and even totally inhibiting it
in some animal models. It appears that these models may be applicable to
certain human cancers. To prevent hematogenous metastasis formation the
process must be inhibited at any one of four levels: 1) growth of the
primary; 2) invasion of vessel walls; 3) release of viable tumor cells;
or 4) entrapment and growth in distant organs. Judicious handling of the
primary can decrease metastasis by minimizing the shedding of tumor
cells. New experimental agents prevent the release of tumor cells from
the primary by normalizing the blood vessels of the tumor. Warfarin,
heparin, and fibrinolytic agents inhibit the entrapment of circulating
tumor cells, presumably by their effect on coagulative mechanisms. A
better understanding of the benefits of combined approaches to cancer
using chemotherapy, irradiation, and immunotherapy, alone and as
adjuncts to surgery, offers new opportunity to study methods of
controlling metastatic disease.
- Language of Publication
- English
- Unique Identifier
- 75074060
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- MeSH Heading (Major)
- Neoplasm Circulating Cells|*PC; Neoplasm Metastasis|*; Neoplasms|RT/*TH
- MeSH Heading
- Animal; Antineoplastic Agents|TU; Biopsy; Cell Adhesion; Cell
Movement; Detergents|TU; Formaldehyde|AA/TU; Heparin|TU; Human;
Immunotherapy; Mice; Mice, Inbred Strains; Neoplasms, Experimental|SU/TH;
Pharmaceutic Aids; Piperazines|TU; Polyethylene Glycols|TU; Propane|AA/TU;
Rats; Rats, Inbred Strains; Warfarin|TU
- Publication Type
- JOURNAL ARTICLE; REVIEW
- ISSN
- 0008-543X
- Country of Publication
- UNITED STATES
Record 5 from database: MEDLINE
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- Title
- Liver tumors in children in the particular reference to hepatoblastoma
and hepatocellular carcinoma: American Academy of Pediatrics Surgical
Section Survey--1974.
- Author
- Exelby PR; Filler RM; Grosfeld JL
- Address
-
- Source
- J Pediatr Surg, 1975 Jun, 10:3, 329-37
- Abstract
- A review of 227 cases of hepatoblastoma, hepatic cell carcinoma in
children seen in the United States over a 10-yr period is presented.
Both tumors were seen most commonly in infancy, but the hepatocellular
carcinoma shows a second peak of incidence around puberty. Males
predominated in both diseases more so in hepatoblastoma. Presenting
symptoms in both diseases were very similar, most commonly an upper
abdominal mass or abdominal enlargement associated with anorexia and
weight loss. In the preoperative evaluation the presence of alpha-feto
protein was one of the most helpful diagnostic tests. Disturbances of
liver function were usually mild but were more marked in those children
with hepatocellular carcinoma. Preoperative x-rays were abnormal in a
large percentage of cases with the hepatic arteriogram and vena cavagram
being the most useful diagnostic x-rays for liver tumors. Liver scans
were positive for liver tumor in 95% of the children when this test was
carried out. The follow-up for these patients ranged from 2 to 10 yr.
The size of the primary tumor did not appear to correlate with survival
but bilateral location of the tumor, 33% in hepatoblastoma and 45% in
hepatocellular carcinoma, made many of these tumors inoperable.
Multicentric tumors were also found in a large number of patients, being
more common in hepatocellular carcinoma. There was a high rate of local
recurrence or local extension after operation in both diseases, and
metastatic spread was similar being most common to the lungs and
abdomen. A wide variety of surgical procedures were carried out in these
patients from biopsy only to extended hepatic lobectomy. When incomplete
excision or biopsy only was carried out no patient survived in either
group. Among the hepatoblastoma patients, 45 of 78 patients who had
complete excision are surviving. In the hepatocellular carcinoma
patients where the operability rate was much lower 12 of 33 patients are
surviving when tumor was completely excised. Complications were
frequent, the most common being excessive blood loss at operation. There
were eight operative deaths and 17 postoperative deaths in the combined
group. There was no evidence that radiation therapy or chemotherapy
controlled disease which could not be completely excised surgically. The
only direct evidence of a favorable effect of radiation and chemotherapy
were three cases of hepatoblastoma in which the tumor changed from
inoperable to operable by a combination of radiation therapy and
multiple drug chemotherapy. Both tumors are highly malignant, and 90% of
the children who died of hepatoblastoma died within 12 mo of diagnosis.
In the hepatocellular carcinoma 80% of the deaths occurred within 1 yr
of diagnosis. At this time it seems that operative excision offers the
only chance of cure in children with these tumors and cure rates of 60%
can be expected with hepatoblastoma and 33% in hepatocellular carcinoma
if the tumor can be completely excised.
- Language of Publication
- English
- Unique Identifier
- 75191344
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- MeSH Heading (Major)
- Carcinoma, Hepatocellular|*/PA/TH; Liver Neoplasms|*/PA/TH
- MeSH Heading
- alpha-Fetoproteins|AN; Adolescence; Angiography; Biopsy; Child; Child,
Preschool; Female; Human; Infant; Infant, Newborn; Liver|PA/RA/SU; Male;
Neoplasm Metastasis; Neoplasm Recurrence, Local; Postoperative
Complications; Radionuclide Imaging
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-3468
- Country of Publication
- UNITED STATES
Record 6 from database: MEDLINE
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- Title
- Staging laparotomy in the treatment of metastatic melanoma of the
lower extremities.
- Author
- Cohen MH; Schour L; Felix EL; Bernstein AD; Chretien PB; Rosenberg SA;
Ketcham AS
- Address
-
- Source
- Ann Surg, 1975 Dec, 182:6, 710-4
- Abstract
- Twenty-six consecutive patients with melanoma of the lower extremities
metastatic to the superficial inguinal lymph nodes were subjected to
laparotomy. No patient had preoperative evidence of tumor dissemination
past the superficial inguinal nodes. However three patients (12%) had
metastases to the liver or para-aortic lymph nodes documented at
laparotomy and were not subjected to iliac and obturator lymph node
dissection. One of these patients had concomitant local recurrence of
melanoma at the ankle. The other two patients had superficial inguinal
lymph nodes at least 5 cm in diameter, although two other such patients
with similar 5 cm lymph nodes did not have positive intra-abdominal
findings. The remaining 23 of the 26 patients underwent ipsilateral
iliac and obturator lymph node dissection, which proved positive in 3/23
patients (13%). Of these 23 patients undergoing iliac and obturator node
dissection, 18 had clinically positive (and microscopically positive)
superficial inguinal nodes prior to their dissection, while the
remaining 5 patients had clinically negative (but microscopically
positive) superficial inguinal nodes. The three cases of positive
dissected iliac and obturator nodes occurred among the 18 patients with
clinically positive superficial inguinal nodes (17%). Among the 5
patients with clinically negative, microscopically positive superficial
groin nodes, there was no detectable deep inguinal nodal spread (or
hepatic or para-aortic involvement).
- Language of Publication
- English
- Unique Identifier
- 76060602
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- MeSH Heading (Major)
- Leg|*; Lymph Nodes|*PA; Melanoma|*PA/SU
- MeSH Heading
- Adolescence; Adult; Aged; Biopsy; Case Report; Child; Female; Human;
Laparotomy; Liver Neoplasms|PA/SU; Lymph Node Excision; Lymphatic
Metastasis; Male; Middle Age; Neoplasm Metastasis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0003-4932
- Country of Publication
- UNITED STATES
Record 7 from database: MEDLINE
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- Title
- Dissemination of cancer: the need for stimulation of the immune
process during the immunosuppression produced by major operations.
- Author
- Cole WH
- Address
-
- Source
- South Med J, 1982 Dec, 75:12, 1479-86
- Abstract
- There are four mechanisms of the dissemination of cancer: direct
extension by tissue planes, by lymphatics, by the vascular system, and
by implantation. Implantation may be either spontaneous or iatrogenic,
and the unique cases of spontaneous implantation reported by Beahrs, in
which carcinoma of the colon had seeded a fresh hemorrhoidectomy wound,
illustrate how hardy cancer cells can be. The factors affecting the
spread of cancer appear even more important than the mechanisms
themselves. Immunologic factors (including stimulation),
immunosuppression, tumor enhancement, tumor inhibition, and contrasting
features are important. Stimulation of the immune process is becoming
important because so many chemicals or processes are immunosuppressive,
and it is now evident that all, or practically all, major operations are
immunosuppressive. Accordingly, at the time of operation for cancer the
patient should be given something to stimulate his immune system during
the three or four weeks it is being suppressed by the operation.
- Language of Publication
- English
- Unique Identifier
- 83067685
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- MeSH Heading (Major)
- Immune Tolerance|*; Immunization|*; Neoplasm Invasiveness|*/DI;
Neoplasm Metastasis|*; Neoplasms|IM/*SU
- MeSH Heading
- Antineoplastic Agents|AE; Biopsy|AE; Biopsy, Needle|AE; Colonic
Neoplasms|SU; Female; Human; Lymphatic Metastasis|PC; Neoplasm
Circulating Cells; Neoplasm Seeding
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0038-4348
- Country of Publication
- UNITED STATES
Record 8 from database: MEDLINE
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- Title
- Lung cancer diagnosis: evaluation of diagnostic techniques.
- Author
- Healy TM; Borrie J
- Address
-
- Source
- N Z Med J, 1975 May, 81:539, 423-4
- Abstract
- In 200 patients with histologically proven lung cancer, retrospective
analysis of the relative diagnostic value of sputum cytology, bronchial
washings cytology, bronchial biopsy, scalene node biopsy,
mediastinoscopy and thoracotomy was undertaken. Bronchial biopsy proved
positive in 80 percent of patients with central tumours (those lying
between the origin of a main brochus and the origins of lobar segmental
bronchi) against 35 percent of patients with peripheral tumours (those
lying distal to the origins of the lobar segmental bronchi). Sputum
cytology was positive in 27 percent of patients so investigated and
bronchial washings cytology in 14 percent--both techniques being more
effective with central tumours. Thoracotomy, as the sole method of
obtaining histological confirmation of the clinical diagnosis, accounted
for 20.5 percent of all cases, being used more often in patients with
peripheral tumours. In 15 percent the first histologically positive
result came from distal spread. The relative indications for needle
biopsy and endobronchial fibroscopy are discussed.
- Language of Publication
- English
- Unique Identifier
- 76011247
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- MeSH Heading (Major)
- Lung Neoplasms|*DI/SU
- MeSH Heading
- Biopsy; Bronchi|PA; Bronchoscopy; Comparative Study; Cytodiagnosis;
Evaluation Studies; Female; Human; Lymph Nodes|PA; Male; Mediastinoscopy;
Neoplasm Metastasis; Pleural Effusion|CY; Retrospective Studies;
Sputum|CY; Thoracic Surgery; Thorax|SU
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0028-8446
- Country of Publication
- NEW ZEALAND
Record 9 from database: MEDLINE
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- Title
- Chemosurgery for skin cancer: fixed tissue and fresh tissue
techniques.
- Author
- Mohs FE
- Address
-
- Source
- Arch Dermatol, 1976 Feb, 112:2, 211-5
- Abstract
- Complete microscopical control of the excision of cancer of the skin
is achieved by removing tissues layer by layer and examining the
undersurface of each layer by means of frozen sections. If the cancer is
extensive and complicated or if it is of a type readily spread over an
excisional surface, the tissues are fixed in situ with zinc chloride
prior to excision (chemosurgery, fixed tissue technique). If the cancer
is not too extensive or complicated, the tissues are excised in the
fresh, unfixed state (chemosurgery, fresh tissue technique). Both
techniques are highly reliable; for example, in two consecutive series
of basal cell carcinomas treated chemosurgically, the five-year rate of
cure was 99.3% for the 9,351 lesions removed by the fixed tissue
technique and 97% for the 127 lesions removed by the fresh tissue
technique.
- Language of Publication
- English
- Unique Identifier
- 76276623
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- MeSH Heading (Major)
- Carcinoma, Basal Cell|PA/*SU; Ear Neoplasms|*SU; Facial Neoplasms|*SU;
Skin Neoplasms|PA/*SU
- MeSH Heading
- Biopsy; Ear, External|SU; Eyelid Neoplasms|PA/SU; Eyelids|PA;
Histocytochemistry; Human; Neoplasm Metastasis; Neoplasm Recurrence,
Local|SU; Staining
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0003-987X
- Country of Publication
- UNITED STATES
Record 10 from database: MEDLINE
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- Title
- Scalpel excision of primary cutaneous malignant melanomas without
metastasis.
- Author
- Castrow FF 2d; Chernosky ME
- Address
-
- Source
- J Dermatol Surg Oncol, 1979 Feb, 5:2, 109-11
- Abstract
- Views and opinions about surgical treatment of primary malignant
melanomas that are without local spread or metastasis are presented. An
attempt is made to determine the limitations of office-based
dermatologists in the treatment of malignant melanomas of this stage.
Using accepted criteria for clinical recognition of malignant melanomas
early, it is suggested that surgical excisions of small malignant
melanomas that are judged to be complete obviate preliminary biopsies
and furnish surgical specimens that can be read histopathologically for
confirmation of clinical diagnosis and adequacy of excision.
- Language of Publication
- English
- Unique Identifier
- 79110131
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- MeSH Heading (Major)
- Melanoma|CL/PA/*SU; Skin Neoplasms|CL/PA/*SU
- MeSH Heading
- Biopsy; Follow-Up Studies; Human; Neoplasm Metastasis
- Publication Type
- JOURNAL ARTICLE
- Country of Publication
- UNITED STATES
Record 11 from database: MEDLINE
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- Title
- Primary liposarcoma of bone.
- Author
- Larsson SE; Lorentzon R; Boquist L
- Address
-
- Source
- Acta Orthop Scand, 1975 Dec, 46:6, 869-76
- Abstract
- A case is presented of a rare primary liposarcoma of bone localized to
the major trochanter of the left femur of a 52-year-old female. Despite
combined treatment with curettage and irradiation with a total dose of
4,500 rad the neoplasm showed rapid invasive growth with destruction of
the bone, spread to the iliac fossa and outgrowth through the operation
wound. Approximately 5 months after admission the patient succumbed due
to widespread metastases in the lungs, liver and left kidney. The
histopathology, clinical course and treatment of this rare neoplasm of
the bone are discussed.
- Language of Publication
- English
- Unique Identifier
- 76108497
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- MeSH Heading (Major)
- Femoral Neoplasms|*/PA/RA; Liposarcoma|*/PA/RA
- MeSH Heading
- Biopsy; Case Report; Female; Femur|PA; Human; Lung Neoplasms; Middle
Age; Neoplasm Metastasis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0001-6470
- Country of Publication
- DENMARK
Record 12 from database: MEDLINE
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- Title
- Well-differentiated peripheral cholangiocarcinoma with an unusual
clinical course.
- Author
- Foucar E; Kaplan LR; Gold JH; Kiang DT; Sibley RK; Bosl G
- Address
-
- Source
- Gastroenterology, 1979 Aug, 77:2, 347-53
- Abstract
- A patient with an unresectable well-differentiated bile duct tumor who
survived for 15 yr after biopsy diagnosis is presented. Histologic
examination of the tumor revealed bland features of bile duct adenoma
despite extensive spread within the liver. Over its subsequent course,
the tumor progressively replaced the liver, achieving huge size,
although there was no evidence of metastases until shortly before the
patient's death. This clinical course was very unusual for either bile
duct adenoma or cholangiocarcinoma, but would be more characteristic of
another tumor of intrahepatic bile duct origin, the biliary cystadenoma.
However, this latter diagnosis was excluded with both gross and
microscopic pathologic criteria. Evidence is presented to support
classification of this tumor as an unusual varient of peripheral
cholangiocarcinoma which requires correlation of the clinical and
pathologic findings for correst diagnosis.
- Language of Publication
- English
- Unique Identifier
- 79192471
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- MeSH Heading (Major)
- Adenoma, Bile Duct|*DI/PA/UL; Bile Duct Neoplasms|*DI/PA/UL
- MeSH Heading
- Adult; Anemia|ET; Basement Membrane|UL; Biopsy; Case Report;
Desmosomes|UL; Epithelium|UL; Female; Gallbladder|PA; Human; Laparoscopy;
Laparotomy; Liver|PA; Lung Neoplasms; Microvilli|UL; Neoplasm
Metastasis; Pain; Palpation; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0016-5085
- Country of Publication
- UNITED STATES
Record 13 from database: MEDLINE
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- Title
- Gastrointestinal carcinoma: diagnosis, staging, and follow-up.
- Author
- Nelson RS
- Address
-
- Source
- Geriatrics, 1976 Sep, 31:9, 83-5
- Abstract
- When cancer of the gastrointestinal tract is suspected, thorough
studies should be made to determine the presence, type, and severity of
the primary tumor and whether it has spread. Besides routine x-ray
studies, angiography, scanning, and sonography may furnish valuable
information. Endoscopy, which has revolutionized diagnosis of these
tumors, not only makes it possible to obtain a specimen for histologic
analysis without laparotomy but also reveals gross involvement as a
guide to surgery. Staging of the lesion helps the physician select which
patients would benefit from surgery and which instead should be treated
with palliative chemotherapy or irradiation, or both. The patient's
quality of life during treatment also must be considered. The side
effects of multiple-agent chemotherapy, for example, may take too great
a toll on the patient's ability to function. Continuous, long-term
follow-up is essential. Metastases may develop after three to five years
in particularly indolent tumors, and new primary lesions are far from
rare.
- Language of Publication
- English
- Unique Identifier
- 76258593
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- MeSH Heading (Major)
- Gastrointestinal Neoplasms|*DI/PA/SU
- MeSH Heading
- Biopsy; Follow-Up Studies; Human; Neoplasm Metastasis; Prognosis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0016-867X
- Country of Publication
- UNITED STATES
Record 14 from database: MEDLINE
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- Title
- Diagnostic imaging in cancer.
- Author
- Berman CG; Clark RA
- Address
- Department of Radiology, University of South Florida, Tampa.
- Source
- Prim Care, 1992 Dec, 19:4, 677-713
- Abstract
- Screening chest radiographs do not reduce mortality from lung
cancer. Should an incidental noncalcified pulmonary parenchymal nodule
be discovered, chest CT will demonstrate one third of such patients
to, in fact, have the multiple nodules of metastatic disease. CT is
very helpful to guide fine needle aspiration biopsy of lung lesions
and to assist in evaluation for resectability. MR can be helpful in
special circumstances, including the definition of the extent of
paravertebral, superior sulcus, and diaphragmatic lesions. Endorectal
ultrasound is not sensitive enough to function as a screening tool for
prostate cancer but is used routinely to guide biopsies. CT and MR are
rarely helpful in staging this disease. Given the highly
characteristic trait of bone metastasis in prostate cancer, a bone
scan is mandatory in all patients. Double contrast barium enema can be
used as an adjunct or alternative to sigmoidoscopy for colorectal
cancer screening, in the preoperative evaluation of patients, and in
postoperative surveillance. CT and MR can detect macroscopic
adenopathy and liver metastases; CT is generally the preferred study.
Screening mammography can have a major impact in reducing breast
cancer mortality. It is recommended that a baseline study be obtained
at age 35. Annual or biannual examinations should commence at age 40.
Any palpable lesion, whether or not it is demonstrated
mammographically, must be subjected to biopsy. Ultrasound is the most
useful initial imaging study for evaluating pelvic masses. MR will, on
occasion, identify the origin of a mass not determinable from
ultrasound scan. MR is particularly valuable to identify parametrial
spread (inoperability) of cervical cancer, and has been underused for
this purpose. Surgery remains the mainstay for the staging of ovarian
and endometrial cancer, although CT can be helpful to identify
macroscopic relapse, ascites, or liver metastases. Bone scan and liver
CT remain the standard procedures for detecting metastases in these
respective organ systems. MR can be invaluable in the imaging of
epidural metastasis and spinal cord compression in patients with
vertebral metastatic disease. Contrast-enhanced MR is more sensitive
than contrast-enhanced CT for detecting brain metastases, but the
latter remains a useful tool. Chest CT can improve the detection of
pulmonary metastases when this is of crucial importance.
- Language of Publication
- English
- Unique Identifier
- 93101764
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- MeSH Heading (Major)
- Diagnostic Imaging|*MT; Lung Neoplasms|*DI/PA/TH; Neoplasm
Metastasis|*DI/PA
- MeSH Heading
- Biopsy, Needle|MT; Breast Neoplasms|DI/PA; Colorectal Neoplasms|DI/SU;
Human; Male; Neoplasm Staging; Prostatic Neoplasms|DI/EP/MO;
Tomography, X-Ray Computed; United States
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, ACADEMIC
- ISSN
- 0095-4543
- Country of Publication
- UNITED STATES
Record 15 from database: MEDLINE
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- Title
- Extraperitoneal pelvioscopy: a new aid in staging of lower urinary
tract tumors. A preliminary report.
- Author
- Hald T; Rasmussen F
- Address
-
- Source
- J Urol, 1980 Aug, 124:2, 245-8
- Abstract
- A new technique to obtain biopsy specimens from the pelvic lymph
nodes is presented. A mediastinoscope introduced through a small
incision in the abdominal wall allows the identification of the pelvic
nodes. A series of 12 patients with prostatic or bladder carcinoma is
presented and the feasibility of the method is documented. There was
no morbidity associated with the endoscopic node biopsy. Suggestions
for modification of the instrument are made. The method is now under
further scrutiny to establish its place among other available methods
to study lymphogenous spread of pelvic malignancies.
- Language of Publication
- English
- Unique Identifier
- 80251874
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- MeSH Heading (Major)
- Bladder Neoplasms|*PA; Neoplasm Staging|IS/*MT
- MeSH Heading
- Aged; Biopsy|IS; Female; Human; Lymph Nodes|PA; Lymphatic
Metastasis|PA; Male; Middle Age
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-5347
- Country of Publication
- UNITED STATES
Record 16 from database: MEDLINE
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- Title
- Scope and value of bone marrow biopsies in metastatic cancer.
- Author
- Frisch B; Bartl R; Mahl G; Burkhardt R
- Address
-
- Source
- Invasion Metastasis, 1984, 4 Suppl 1:, 12-30
- Abstract
- The results of examination of 1,810 bone marrow biopsies of 1,725
patients with known or suspected carcinomas are presented. The
frequency of positive biopsies was 72% for unknown primaries, 42% for
mammary, 32% for prostatic, 14% for pulmonary and 19% for other
cancers; the overall rate of detection of metastases was 35%. The mode
of spread, the grade of tumour cell differentiation and the host
response to the presence of the metastases were investigated by light
and electron microscopic studies and by means of antibody reactions on
fresh-frozen sections. The results are presented and their relevance
to the fundamental understanding of the metastatic process is
outlined. Implications for clinical oncology and patient management
are discussed.
- Language of Publication
- English
- Unique Identifier
- 85181957
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- MeSH Heading (Major)
- Bone Marrow|*PA; Bone Neoplasms|IM/PA/*SC; Neoplasm Metastasis|*PA
- MeSH Heading
- Biopsy; Cell Differentiation; Human; Neoplasm Staging; Support,
Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0251-1789
- Country of Publication
- SWITZERLAND
Record 17 from database: MEDLINE
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- Title
- 165 renal carcinomas: accuracy of imaging for diagnosis and
spread--cost efficiency.
- Author
- Plainfosse MC; Delecoeullerie G; Vital JL; Paty E; Merran S
- Address
-
- Source
- Eur J Radiol, 1983 May, 3:2, 132-7
- Abstract
- Based on a study of 165 cases of renal carcinoma, we compare the
relative diagnosis efficiency of different methods: intravenous
urography (IVU), ultrasound (U.S.), arteriography and computed
tomography (C.T.). Our evidence enables us to assert the excellent
diagnostic accuracy of ultrasound and the superiority of computed
tomography for good staging of renal carcinoma. The cost efficient
methods for the evaluation of this tumour are intravenous urography
(to show and localize the renal mass), ultrasound (to assert the
echogenic structure) and computed tomography (to establish the
diagnosis of carcinoma and judge its spread).
- Language of Publication
- English
- Unique Identifier
- 83261902
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- MeSH Heading (Major)
- Kidney Neoplasms|*DI/EC/PA
- MeSH Heading
- Angiography; Biopsy, Needle; Comparative Study; Cost-Benefit
Analysis; Diagnostic Errors; Human; Neoplasm Metastasis; Neoplasm
Staging; Tomography, X-Ray; Tomography, X-Ray Computed; Ultrasonics|DU;
Urography
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0720-048X
- Country of Publication
- GERMANY, WEST
Record 18 from database: MEDLINE
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- Title
- Detection of haematologic and nonhaematologic cancer by bone biopsy.
- Author
- Burkhardt R; Frisch B; Bartl R; Kettner G; Schlag R; Hill W
- Address
-
- Source
- Cancer Detect Prev, 1981, 4:1-4, 619-27
- Abstract
- A retrospective study was carried out to test the efficacy of
routine bone marrow biopsies for the diagnosis, classification, and
prognosis of different forms of neoplastic involvement. Trephine and
needle biopsies of the iliac crest of 3,626 patients with haematologic
and 838 patients with nonhaematologic neoplasias were embedded without
prior decalcification. 43 histologic variables were evaluated in
3-millimicrons sections of each biopsy, stained by five different
techniques. The incidence of bone marrow involvement, in decreasing
order of frequency, was as follows: plasmacytoma 55% and 95% of 428
cases, malignant lymphoma 37% and 79% of 1.112 cases, metastatic
carcinoma 20% and 63% of 838 cases, and Hodgkin disease 3% and 28% of
772 cases each without and with manifest systemic dissemination. In
the group of the metastatic carcinomas, there was a striking incidence
of bone marrow involvement--82%--due to occult primary tumours. From a
comparison of these figures with those reported in the literature, it
is concluded that the large variations in positive and negative
results are due to 1) differences in the size and the preparation of
the specimens, 2) extent of the neoplastic dissemination at the time
of the biopsy, and 3) the incidence of bone marrow involvement
characteristic for a particular type of neoplasia. In addition, a
subclassification of the chronic myeloproliferative disorders is
proposed; it is based on histologic criteria whose prognostic
relevance was tested and demonstrated by statistical analysis of the
survival rates. The high incidence of detection reported in this study
in patients without other evidence of systemic spread, or even in
patients with occult neoplasias, provides a strong justification for
the use of bone marrow biopsy as a primary diagnostic tool as well as
a staging procedure, in both haematologic and nonhaematologic cancer.
- Language of Publication
- English
- Unique Identifier
- 83155514
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- MeSH Heading (Major)
- Biopsy|*; Bone Marrow|*PA; Neoplasms|*DI
- MeSH Heading
- Bone Marrow Diseases|DI; Human; Myeloproliferative Disorders|PA;
Neoplasm Metastasis; Retrospective Studies; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0361-090X
- Country of Publication
- UNITED STATES
Record 19 from database: MEDLINE
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- Title
- Clinical implications of tumor volume measurement in stage I
adenocarcinoma of the cervix.
- Author
- Kaspar HG; Dinh TV; Doherty MG; Hannigan EV; Kumar D
- Address
- Department of Pathology, University of Texas Medical Branch,
Galveston.
- Source
- Obstet Gynecol, 1993 Feb, 81:2, 296-300
- Abstract
- OBJECTIVE: To evaluate the prognostic significance of
three-dimensional determination of tumor size in stage I cervical
adenocarcinoma. METHODS: Tumor volume was measured using hematoxylin
and eosin-stained sections of cone biopsy and hysterectomy specimens
from 36 patients with stage I adenocarcinoma of the cervix. The volume
was then correlated with pelvic lymphatic spread and clinical outcome.
RESULTS: The subjects were followed for a mean (+/- SEM) of 63 +/- 8
months. No recurrence or lymphatic seeding was encountered in the 22
tumors measuring no more than 500 mm3. Two of 25 tumors (8%) having up
to 5 mm depth of stromal invasion had lymph node metastasis, one of
which was 1.5 mm, compared with four of 11 (36%) in the group with
deeper than 5 mm invasion (P < .02). The depth of stromal invasion
predicted recurrence less significantly. Among the 25 tumors with up
to 5 mm stromal invasion, two recurred, compared with three of 11 with
more than 5 mm invasion (P < .1). Two women who had tumor volumes
below 500 mm3 and depths of stromal invasion up to 8.5 mm were
disease-free at 52 and 96 months of follow-up. On the other hand,
tumors with 2.6 and 3.8 mm stromal invasion, but with volumes
exceeding 500 mm3, recurred. CONCLUSION: Tumor volume is a better
predictor of pelvic lymph node metastasis and recurrence than is the
depth of stromal invasion in stage I cervical adenocarcinoma.
- Language of Publication
- English
- Unique Identifier
- 93141184
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- MeSH Heading (Major)
- Adenocarcinoma|EP/*PA; Cervix Neoplasms|EP/*PA; Cervix Uteri|*PA
- MeSH Heading
- Biopsy; Female; Follow-Up Studies; Human; Lymphatic Metastasis;
Middle Age; Neoplasm Invasiveness; Neoplasm Recurrence, Local|EP;
Neoplasm Staging; Prognosis; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0029-7844
- Country of Publication
- UNITED STATES
Record 20 from database: MEDLINE
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- Title
- Management of gastrointestinal lymphoma.
- Author
- Rao AR; Kagan AR; Potyk D; Nussbaum H; Chan P; Hintz BL; Wollin M;
Ryoo MC
- Address
-
- Source
- Am J Clin Oncol, 1984 Jun, 7:3, 213-9
- Abstract
- A study was made of 65 patients with primary gastrointestinal (GI)
lymphoma. The occurrence was 40 (62%) in stomach, 15 (23%) in the
small intestine, and 10 (15%) in colorectum. The majority of patients
had their histology classified according to Rappaport's
classification. Diffuse histiocytic type had the worst prognosis
(median survival 13.8 months), and nodular histology had the best
prognosis. A modified staging system proposed by Blackledge et al. was
used. Patients who had their disease confined to one viscus (Stage I)
or with spread to regional lymph nodes (Stage II) had an excellent
prognosis, with a 5-year survival of 87 and 67%, respectively.
However, those who had distant nodal involvement (Stage III, e.g.,
para-aortic nodes) or spread to adjacent organs within the abdomen
(Stage IV) had worse prognosis, with 5-year survival of 40 and 13%,
respectively. In Stage I, radiotherapy alone was as effective as
surgical resection. None of the 11 patients treated by radiotherapy
alone had perforation or bleeding. The 5-year disease-free survival
was 51%.
- Language of Publication
- English
- Unique Identifier
- 84228327
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- MeSH Heading (Major)
- Gastrointestinal Neoplasms|PA/*TH; Lymphoma|PA/*TH
- MeSH Heading
- Adolescence; Adult; Age Factors; Aged; Antineoplastic Agents,
Combined|TU; Biopsy; Child; Combined Modality Therapy; Female;
Follow-Up Studies; Human; Lymphatic Metastasis; Male; Middle Age;
Neoplasm Staging; Neoplasms, Multiple Primary; Prognosis; Support,
U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0277-3732
- Country of Publication
- UNITED STATES
Record 21 from database: MEDLINE
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- Title
- Significance of supraclavicular lymph node biopsy for staging,
therapy and prognosis of testicular tumors.
- Author
- Adolphs HD; Weissbach L; Distelmaier W
- Address
-
- Source
- Eur Urol, 1980, 6:6, 339-43
- Abstract
- Supraclavicular lymph node biopsies were performed in 40 patients
with germinal testicular tumors. The radiologic visualization of both
the thoracic ducts and the supraclavicular lymph nodes was reviewed
and no relation to retroperitoneal lymph node involvement was found.
In 5 patients with retroperitoneal but without distant metastases,
supraclavicular lymph nodes revealed tumor metastases, two of which
had been clinically suspected. Depending on the staging system
applied, the tumor stage had to be changed in 1 or 3 patients,
respectively. For comparison, in 4 patients with distant metastases no
metastatic involvement of the supraclavicular nodes was demonstrable.
It is concluded that supraclavicular tumor spread is not indicative of
distant metastasis and incurability. Therefore, in these cases primary
radical surgery should not be considered contraindicated.
- Language of Publication
- English
- Unique Identifier
- 81114299
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- MeSH Heading (Major)
- Lymph Nodes|*PA; Testicular Neoplasms|*DI/RA/TH
- MeSH Heading
- Biopsy; Human; Lymphatic Metastasis; Male; Neoplasm Staging;
Prognosis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0302-2838
- Country of Publication
- SWITZERLAND
Record 22 from database: MEDLINE
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- Title
- The role of transcarinal needle aspiration in the staging of
bronchogenic carcinoma.
- Author
- Utz JP; Patel AM; Edell ES
- Address
- Division of Thoracic Diseases and Internal Medicine, Mayo Medical
Center, Rochester, Minn. 55905.
- Source
- Chest, 1993 Oct, 104:4, 1012-6
- Abstract
- Metastatic spread to subcarinal lymph nodes in patients with
bronchogenic carcinoma generally indicates unresectability.
Transcarinal needle aspiration of the main carina (TCNA) has been
used to obviate the need for more invasive procedures, particularly
thoracic surgery. Of 510 transbronchial needle aspirations performed
at our institution from 1983 to 1991, 88 (17 percent) were from the
main carina in patients with bronchogenic carcinoma. We reviewed
these 88 TCNA procedures to assess our experience with TCNA in the
staging of lung cancer. The TCNA results were positive in 32 of 88
(36 percent) patients (20 non-small-cell cancers, 12 small-cell lung
cancers). Following bronchoscopy, TCNA was the only evidence of
unresectability in all 20 patients with non-small-cell lung cancer
and was the only mode of diagnosis in 5 of 12 (42 percent) patients
with small-cell lung cancer. Thirteen patients with non-small-cell
lung cancer and positive TCNA also had positive bronchial secretion
cytologic studies. Five of these patients had further subcarinal
sampling and in all cases metastatic involvement was confirmed. TCNA
was positive in 29 of 67 (43 percent) patients with radiographic
evidence of mediastinal adenopathy. Of the remaining 38 patients
with radiographic evidence of mediastinal adenopathy and negative
TCNA results, 23 patients had further mediastinal sampling with
mediastinoscopy or thoracotomy and in all cases mediastinal spread
of cancer was established. Nineteen of 58 (33 percent) patients with
an endoscopically normal-appearing main carina had a positive TCNA,
while 13 of 30 (43 percent) patients with broadening or widening of
the main carina had positive TCNA results. There were no
complications. We conclude that TCNA is often a safe and useful
staging modality in patients with bronchogenic carcinoma.
- Language of Publication
- English
- Unique Identifier
- 94008088
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- MeSH Heading (Major)
- Carcinoma, Bronchogenic|EP/*PA/SC; Lung|*PA; Lung Neoplasms|EP/*PA
- MeSH Heading
- Biopsy, Needle|MT; Human; Lymphatic Metastasis; Neoplasm Staging;
Predictive Value of Tests; Retrospective Studies
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0012-3692
- Country of Publication
- UNITED STATES
Record 23 from database: MEDLINE
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- Title
- Surgical staging in carcinoma of the prostate: the RTOG
experience. Radiation Therapy Oncology Group.
- Author
- Pilepich MV; Asbell SO; Mulholland GS; Pajak T
- Address
-
- Source
- Prostate, 1984, 5:5, 471-6
- Abstract
- One hundred thirty-six patients with carcinoma of the prostate
entered on phase III RTOG studies (RTOG 75-06 and RTOG 77-06)
between 1976 and the end of 1980 underwent staging lymphadenectomy
prior to irradiation. The operative reports and histological
findings have been reviewed in order to determine the patterns of
intrapelvic tumor spread and to correlate the type of surgical
procedure and the extent of lymphatic dissection with the incidence
and type of postirradiation complications (primarily genital and
lower extremity lymphedema). The surgical procedures were classified
into three categories according to extent: 1) biopsy only, 2)
limited (diagnostic) dissection, and 3) complete (therapeutic)
dissection. The incidence of postirradiation lymphedema was found to
be strongly dependent upon the extent of dissection. Patients
undergoing limited (diagnostic) dissection followed by pelvic
irradiation have a 25-30% risk of developing this debilitating
complication. In patients undergoing complete (therapeutic)
dissection followed by pelvic irradiation lymphedema has been
observed in 66% of cases.
- Language of Publication
- English
- Unique Identifier
- 85014495
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- MeSH Heading (Major)
- Carcinoma|*PA/RT/SU; Prostatic Neoplasms|*PA/RT/SU
- MeSH Heading
- Biopsy; Follow-Up Studies; Human; Lymph Node Excision; Lymph
Nodes|PA; Lymphatic Metastasis; Lymphedema|EP; Male; Neoplasm
Staging; Radiotherapy Dosage; Random Allocation
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0270-4137
- Country of Publication
- UNITED STATES
Record 24 from database: MEDLINE
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- Title
- Inguinal pick in invasive penile carcinoma: can it stage node
negative patients?
- Author
- Ravi R; Shrivastava BR; Mallikarjuna VS
- Address
- Department of Genitourinary Surgery, Cancer Institute (WIA),
Madras, India.
- Source
- Arch Esp Urol, 1991 Nov, 44:9, 1123-6
- Abstract
- In node negative patients of invasive penile carcinoma,
prophylactic lymphadenectomy is associated with considerable
morbidity, while a "wait and watch" policy is associated
with up to 20% cancer related mortality in many series. In between,
selective node biopsies, including sentinel node biopsies, have been
suggested to stage these patients. However, these procedures are
unreliable and associated with high false negative rates. The
inguinal pick procedure was devised by us to stage these patients
more accurately. It is more elaborate that the previously described
selective biopsies and includes biopsy of all identifiable nodes in
the inguinal region, including the sentinel node area. In our
experience of the procedure in 52 patients with invasive penile
carcinoma, it was positive in 5 patients (9.6%). However, 7 of the
47 patients with negative result developed inguinal recurrences and
3 other patients developed distant metastases on follow up. The
5-year disease free survival of inguinal pick positive and negative
patients was 100% and 82.9%, respectively. The sensitivity of the
procedure in detecting regional spread in these patients was only
72%. Thus, the inguinal pick, though associated with no morbidity,
can be meaningful only if it is positive and a negative result does
not guarantee absence of regional metastases in node negative
patients of invasive penile carcinoma.
- Language of Publication
- English
- Unique Identifier
- 92222329
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- MeSH Heading (Major)
- Carcinoma|EP/*PA/SC; Lymph Node Excision|*/AE; Lymph Nodes|*PA;
Neoplasm Staging|*MT; Penile Neoplasms|EP/*PA/SU
- MeSH Heading
- Biopsy; Evaluation Studies; False Negative Reactions; Frozen
Sections; Human; Incidence; India|EP; Inguinal Canal; Lymphatic
Metastasis; Male; Neoplasm Recurrence, Local|EP; Sensitivity and
Specificity
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0004-0614
- Country of Publication
- SPAIN
Record 25 from database: MEDLINE
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- Title
- Evaluation of the scalene lymph nodes in primary and recurrent
cervical carcinoma.
- Author
- Burke TW; Heller PB; Hoskins WJ; Weiser EB; Nash JD; Park RC
- Address
- Department of Obstetrics and Gynecology, F. Edward Hebert School
of Medicine, Uniformed Services University of the Health Sciences,
Bethesda, Maryland 20814.
- Source
- Gynecol Oncol, 1987 Nov, 28:3, 312-7
- Abstract
- Open biopsy of the left scalene lymph nodes has been utilized to
identify distant spread of cervical carcinoma in selected groups of
patients who do not have other clinical evidence of disseminated
disease. Twenty-one patients with primary cervical carcinoma and
histologically proven para-aortic lymph node metastases and 10
patients with centrally recurrent tumors underwent scalene lymph
node biopsy at Walter Reed Army Medical Center or the Naval
Hospital, Bethesda, Maryland, between July 1, 1979 and June 30,
1985. All patients undergoing scalene node biopsy had clinically
negative physical examinations. There were no surgical
complications. All 31 biopsies were negative for metastatic tumor.
Combined with previously reported data from this institution, 3 of
28 patients (11%) with primary cervical carcinoma and involved para-aortic
nodes, and 6 of 35 patients (17%) with centrally recurrent disease
had subclinical scalene node metastases. Patients with clinically
suspicious scalene lymphadenopathy had fine needle aspiration
cytology performed to document metastatic disease. The success of
this technique has eliminated the need for open biopsy in these
patients. Scalene node biopsy provides valuable prognostic
information in patients with cervical cancer who have positive para-aortic
lymph nodes. It also obviates surgical exploration in some patients
felt to have resectable recurrent disease who actually have
subclinical distant spread.
- Language of Publication
- English
- Unique Identifier
- 88056535
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- MeSH Heading (Major)
- Adenocarcinoma|DI/PA/*SC; Biopsy|*; Carcinoma, Squamous Cell|DI/PA/*SC;
Cervix Neoplasms|*/PA; Lymphatic Metastasis|*DI/PA; Neoplasm
Recurrence, Local|*
- MeSH Heading
- Adult; Female; Human; Lymph Nodes|PA; Neoplasm Staging
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0090-8258
- Country of Publication
- UNITED STATES
Record 26 from database: MEDLINE
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- Title
- Radioimmunoguided surgery.
- Author
- Veroux G; Nicosia AS; Veroux P; Cardillo P; Veroux M; Amodeo C
- Address
- Institute of Surgical Pathology-University of Catania, Italy.
- Source
- Hepatogastroenterology, 1999 Nov, 46:30, 3099-108
- Abstract
- Although clinical staging of neoplastic diseases has long remained
the only approach to prognosis and treatment, parameters for stage
determination, such as tumor size (T) and lymph-node involvement
(N), do not always provide effective indication of optimal
treatment. Molecular medicine has also provided useful indications
as to an alternative and/or integration to clinical staging. Despite
the numerous possibilities afforded by pre-operative staging
techniques, failures in defining the real spread of neoplasias into
surrounding structures have remained a very important diagnostic
problem. The labeling of monoclonal antibodies binding with
neoplastic target cells by way of radioactive isotopes introduced
the techniques known as immunoscintigraphy and SPECT, which then
evolved into radioimmunoguided surgery. Fourty patients suffering
from colorectal cancer whose age ranged between 42-82 years were
singled out for this study. Before undergoing surgery, they were
administered pancoloscopy and macrobiopsies, AP-LL chest x-rays,
hepatobiliary ECT, echoendoscopy, abdomen and pelvis CT with
nephrostographic phase, and total body bone scintigraphy. They were
treated with 125I-B72.3 and 125I-FO23C5 (5% and 95% of patients,
respectively). Thyrosuppression was achieved by Lugol solution (15
drops x 3/die) from the 6th day before infusion and until the day of
surgical operation. Radioimmunoguided surgery (RIGS) has also been
tested on staging and second-look of ovarian tumors. Five years
after surgical operation the survival rate of Dukes A patients (15%)
was confirmed to amount to 100%, whereas for Dukes B patients (50%)
having undergone RIGS-guided exeresis on single unrecognized
metastases (2 patients) and on unrecognized n+ (5 patients) the
survival rate was found to be 85% after 5 years; 2 patients deceased
due to relapse; 1 patient deceased due to e.p.a. Finally, for Dukes
C patients; (35%) having undergone RIGS-guided exeresis on
unrecognized liver micrometastases (1 patient), on single isolated
metastases (2 patients) and in the occurrence of multicentric
lymph-node positivity (9 patients), the survival rate after 5 years
was found to amount to 64%; 5 patients deceased due to relapse. Out
of 19 patients without pre-operative evidence of ovarian tumor as
opposed to just 1 patient suspected of pelvic recurrence, after
intra-operative surgical radicalization (45%), 1 patient was
diagnosed fibrosis (suspicious lesion on CT) and 1 other patient
peritoneal MTS (negative CT) by means of RIGS. RIGS has made it
possible: to localize primary and/or metastatic lesions; to
determine tumor-free margins, loco-regional disease spread; to
differentiate suspicious foci on inspection and palpation (biotopic
sampling); to detect invisible and impalpable tumor foci (occult
sites); to verify radical exeresis; to evaluate lymphatic drainage
stations; to enable guided exeresis of liver metastases.
- Language of Publication
- English
- Unique Identifier
- 20091614
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- MeSH Heading (Major)
- Colorectal Neoplasms|MO/PA/RI/*SU; Ovarian Neoplasms|MO/PA/RI/*SU;
Radioimmunodetection|*; Tomography, Emission-Computed,
Single-Photon|*MT
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal|DU;
Antigens, Neoplasm|IM; Biopsy; Carcinoembryonic Antigen|IM;
Colonoscopy; Comparative Study; Female; Glycoproteins|IM; Human;
Iodine Radioisotopes|DU; Italy|EP; Lymphatic Metastasis|PA/RI; Male;
Middle Age; Monitoring, Intraoperative; Neoplasm Recurrence, Local;
Neoplasm Staging; Predictive Value of Tests; Survival Rate; Tumor
Markers, Biological
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0172-6390
- Country of Publication
- GREECE
Record 27 from database: MEDLINE
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- Title
- Passive movement of radioactive microspheres from bone and soft
tissue in an extremity.
- Author
- Robertson WW Jr; Janssen HF; Walker RN
- Address
-
- Source
- J Orthop Res, 1985, 3:4, 405-11
- Abstract
- Bone biopsy is the definitive method for bone tumor diagnosis.
Unfortunately, the procedure is not without risk and may
substantially increase the rate and extent of tumor cell metastasis.
This study used radioactive microspheres (15 micron diameter) to
explore the spread of cell-sized particles from the distal femur
into the lymphatic system, venous drainage, and local tissue
following a simulated biopsy in the canine model procedure. In the
initial group of test animals the microspheres rapidly moved from
the femur through the venous system to the lungs. There was no
movement from the femur into the lymphatic system within 4 days. The
lungs effectively filtered the 15 micron microspheres, thus
preventing arterial dissemination. Additional groups were used to
explore the movement of the cell-sized particles from the soft
tissue surrounding the bone. At the end of the 4 day experimental
period, microspheres were found in the iliac lymph nodes in two of
nine animals. Microspheres were not detected in the lungs of any of
these nine animals. These results suggest that tumor cell-sized
particles can move rapidly from the bone venous system to the lungs
following a bone biopsy. It appears that the lymphatic system does
not contribute to this rapid dissemination. However, the role of
lymphatics in a more chronic process remains unclear.
- Language of Publication
- English
- Unique Identifier
- 86062025
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- MeSH Heading (Major)
- Biopsy|*AE; Bone and Bones|*PA; Neoplasm Metastasis|*ET
- MeSH Heading
- Animal; Contrast Media; Dogs; Injections; Lung; Lymph Nodes;
Microspheres; Statistics; Thoracic Duct
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0736-0266
- Country of Publication
- UNITED STATES
Record 28 from database: MEDLINE
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- Title
- Pretherapeutic laparoscopic staging in advanced gastric carcinoma
[see comments]
- Author
- Feussner H; Omote K; Fink U; Walker SJ; Siewert JR
- Address
- Dept. of Surgery and Surgical Oncology, Klinikum rechts der Isar,
Technical University of Munich, Germany. feussner@nt1.chir.med.tu-muenchen.de
- Source
- Endoscopy, 1999 Jun, 31:5, 342-7
- Abstract
- BACKGROUND AND STUDY AIMS: Direct visualization of the abdominal
cavity by laparoscopy prior to multimodal treatment may be capable
of improving the diagnostic precision of gastric cancer staging. The
aim of this study was to evaluate whether diagnostic laparoscopy can
influence treatment strategies in gastric cancer staged T3 and T4 by
preoperative diagnostic tests. PATIENTS AND METHODS: Extended
diagnostic laparoscopy (EDL) was carried out in 111 patients with
advanced gastric cancer staged T3 or T4 by computed tomography (CT)
and endoluminal ultrasound (EUS). On Lauren's classification of
gastric cancer, 46% of the lesions were of the intestinal type and
54% of the nonintestinal type. EDL was carried out with the patients
under general anesthesia, and included visual inspection of the
abdomen, with surgical exploration of initially inaccessible
regions, laparoscopic ultrasound examination, peritoneal lavage, and
biopsies. The information provided by laparoscopy was classified as
1) no additional information, 2) important additional findings
independent of the tumor stage, 3) downgrading of the tumor to a
more favorable stage, and 4) upgrading of the tumor to a less
favorable stage. The results of EDL were then compared with those
obtained by sonography, CT and EUS in combination. RESULTS: EDL was
performed successfully in 107 patients. In 56 of the 111 patients
(50.5%), no additional findings were obtained. In 5.4% of cases,
additional unforeseen information was found, not connected with the
tumor but altering the management. EDL altered the preoperative
diagnosis in 51 of the 111 patients (46.0%), leading to changes in
management in 45 of them (40.5%). EUS provided additional
information in eight cases (7.2% of the whole group, or 15.7% of
those in whom the diagnosis had to be changed). Four metastases were
detected using EDL. It was possible to rule out peritoneal spread in
four patients, but it was newly detected in 26. CONCLUSIONS:
Additional information by EDL about the tumor stage in gastric
cancer led to a modification of the therapeutic strategy in 40% of
patients, in spite of earlier comprehensive diagnostic work-up using
modern imaging procedures. EDL should therefore be mandatory if
neoadjuvant treatment is planned, in order to avoid either
undertreatment or overtreatment of this type of tumor.
- Language of Publication
- English
- Unique Identifier
- 99360423
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- MeSH Heading (Major)
- Laparoscopy|*MT; Neoplasm Staging|*MT; Peritoneal
Cavity|*PA/RA/US; Preoperative Care|*MT; Stomach Neoplasms|*PA/RA/SU/US
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Biopsy; Comparative Study;
Diagnosis, Differential; Endosonography|MT; Female; Gastrectomy;
Human; Male; Middle Age; Neoplasm Metastasis|PA/RA/US;
Reproducibility of Results; Tomography, X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0013-726X
- Country of Publication
- GERMANY
Record 29 from database: MEDLINE
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- Title
- Occult tonsillar carcinoma in the unknown primary.
- Author
- McQuone SJ; Eisele DW; Lee DJ; Westra WH; Koch WM
- Address
- Department of Otolaryngology-Head and Neck Surgery, The Johns
Hopkins Medical Institutions, Baltimore, Maryland, USA.
- Source
- Laryngoscope, 1998 Nov, 108:11 Pt 1, 1605-10
- Abstract
- OBJECTIVES: Evaluate effectiveness of routine tonsillectomy in
the assessment of patients with squamous cell carcinoma of the
neck of unknown primary, and evaluate outcomes of this group
compared with patients without a primary identified initially.
STUDY DESIGN: A retrospective review of the medical records of 37
patients presenting with an unknown primary tumor over a 10-year
period. METHODS: Charts were reviewed for age and sex of patients,
methods of evaluation and diagnosis, sites of tissues obtained on
biopsy, N stage of disease, and presence of extracapsular spread.
Recurrence and survival data were collected over a mean follow-up
period of 34 months. RESULTS: All primary lesions discovered
through pathologic evaluation arose from the tonsil (9/9), and all
were detected in patients undergoing tonsillectomy in conjunction
with direct laryngoscopy. None of the patients (0/9) with occult
tonsillar carcinoma have had recurrence, in contrast to 60%
(15/25) of remaining patients. Patients with tonsillar primary
lesions demonstrated less extracapsular spread of disease (25%)
than patients without tonsillar primaries (67%), despite similar N
staging within the two groups. CONCLUSIONS: Occult tonsillar
carcinoma accounts for the unknown primary more frequently than
was previously recognized. Bilateral tonsillectomy is recommended
to increase the detection yield and to capture the rare case of
bilateral disease. A lower incidence of extracapsular spread and
reduced recurrence rates in patients with unknown primary tumors
presenting as occult tonsillar carcinoma may contribute to the
improved prognosis observed in this group.
- Language of Publication
- English
- Unique Identifier
- 99034122
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- MeSH Heading (Major)
- Carcinoma, Squamous Cell|PA/*SC/SU; Neoplasms, Unknown
Primary|PA/*SU; Tonsillar Neoplasms|PA/*SC/SU; Tonsillectomy|*
- MeSH Heading
- Adult; Aged; Biopsy; Comparative Study; Evaluation Studies;
Female; Follow-Up Studies; Head and Neck Neoplasms|PA/SC/SU;
Human; Incidence; Lymphatic Metastasis|PA; Male; Middle Age;
Neoplasm Recurrence, Local|PA; Neoplasm Staging; Prognosis;
Retrospective Studies; Survival Rate; Treatment Outcome
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0023-852X
- Country of Publication
- UNITED STATES
Record 30 from database: MEDLINE
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- Title
- The value of parasternal mediastinoscopy in staging bronchial
carcinoma.
- Author
- Barendregt WB; Deleu HW; Joosten HJ; Berg W; Janssen JP
- Address
- Department of General Surgery, Canisius Wilhelmina Hospital,
Nijmegen, Netherlands.
- Source
- Eur J Cardiothorac Surg, 1995, 9:11, 655-8
- Abstract
- Computed tomography (CT) is the non-invasive staging procedure
of choice for assessment of metastasis to mediastinal lymph nodes
in patients with bronchial carcinoma. Cervical mediastinoscopy can
provide histologic evidence of mediastinal spread to the
peritracheal, tracheobronchial and subcarinal lymph nodes.
Sub-aortic and para-aortic nodes cannot be sampled via this route.
The present study was performed to assess the staging value of the
parasternal mediastinoscopy as a separate entity. Cervical and
parasternal mediastinoscopy was performed in 37 patients with a
proven diagnosis of non-small cell carcinoma of the left upper
lobe. In 16 patients lymph node or tumor tissue could be biopsied
via the parasternal route, in 21 patients no parasternal biopsy
was taken. Of the 16 cases with biopsies, only one was positive
(6%). Histologic examination of lymph node biopsy tissue was false
negative in one other patient (6%). Of the 21 patients without
biopsies taken during parasternal mediastinoscopy, three (14%) had
proven lymphogenic spread to the subaortic and para-aortic nodes,
detected at thoracotomy. The parasternal procedure changed
treatment in only one patient (3%). Diagnostic sensitivity was
20%. It is concluded that parasternal mediastinoscopy should not
be used as a routine staging procedure in patients with left upper
lobe lung cancer.
- Language of Publication
- English
- Unique Identifier
- 96307619
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- MeSH Heading (Major)
- Carcinoma, Bronchogenic|*PA/RA/SC; Lung Neoplasms|*PA/RA;
Mediastinoscopy|*MT
- MeSH Heading
- Adenocarcinoma|PA; Biopsy; Carcinoma, Non-Small-Cell Lung|PA;
Carcinoma, Squamous Cell|PA; Female; Human; Lymphatic
Metastasis|PA; Male; Middle Age; Neoplasm Staging; Predictive
Value of Tests; Retrospective Studies; Sensitivity and
Specificity; Thoracotomy; Tomography, X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1010-7940
- Country of Publication
- NETHERLANDS
Record 31 from database: MEDLINE
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- Title
- Correlation of high lactate levels in human cervical cancer with
incidence of metastasis.
- Author
- Schwickert G; Walenta S; Sundf‡r K; Rofstad EK; Mueller
Klieser W
- Address
- Institute of Physiology & Pathophysiology, University of
Mainz, Germany.
- Source
- Cancer Res, 1995 Nov, 55:21, 4757-9
- Abstract
- Tissue concentrations of ATP, glucose, and lactate in cervical
cancer biopsies that were taken before a conventional radiation
treatment were imaged quantitatively with a bioluminescence
technique. Concomitantly, a number of clinically relevant data,
such as local tumor control, patient survival, metastatic spread,
etc., were documented. There was no correlation between staging or
grading and any of the metabolic parameters measured. Local
correlations between ATP, glucose, and lactate on a pixel-to-pixel
basis were generally positive, with respective Spearman's
correlation coefficients being lower in patients without
clinically documented metastasis compared to those with metastatic
spread. Lactate concentrations were significantly higher and
scattered over a wider range in tumors with metastatic spread in
comparison to malignancies in patients without metastasis. Thus,
high local lactate levels of > or = 20 mumole/g appear to be
associated with a high risk of metastasis, at least in the ten
human cervical tumors investigated to date.
- Language of Publication
- English
- Unique Identifier
- 96046566
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- MeSH Heading (Major)
- Cervix Neoplasms|*CH/PA/*SC; Lactates|*ME
- MeSH Heading
- Adenosine Triphosphate|ME; Biopsy; Comparative Study; Female;
Glucose|ME; Human; Luminescence; Necrosis|ME; Neoplasm Metastasis;
Neoplasm Staging; Prognosis; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-5472
- Country of Publication
- UNITED STATES
Record 32 from database: MEDLINE
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- Title
- Evaluation of T1N0M0 lung cancer with CT.
- Author
- Parker LA; Mauro MA; Delany DJ; King CW
- Address
- Department of Radiology, University of North Carolina School of
Medicine, North Carolina Memorial Hospital, Chapel Hill.
- Source
- J Comput Assist Tomogr, 1991 Nov, 15:6, 943-7
- Abstract
- Medical records and radiologic studies of 238 patients with
non-small cell lung cancer who had preoperative evaluation by
chest radiography and CT were reviewed. Thirty-six patients were
staged as T1N0M0 by chest radiograph. Of this group, 18 (50%) had
abnormalities on CT requiring additional evaluation. Confirmation
of abnormalities was by tissue sampling or clinical follow-up.
Evidence for unresectable spread of disease was obtained in 12
(33%). We conclude that routine preoperative staging of T1N0M0
lung cancer with CT has a positive impact on patient management.
- Language of Publication
- English
- Unique Identifier
- 92042951
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- MeSH Heading (Major)
- Carcinoma, Non-Small-Cell Lung|PA/*RA; Lung Neoplasms|PA/*RA;
Tomography, X-Ray Computed|*
- MeSH Heading
- Adenocarcinoma|PA/RA; Adenocarcinoma, Bronchiolo-Alveolar|PA/RA;
Adrenal Gland Neoplasms|SC; Adult; Aged; Aged, 80 and over;
Biopsy; Carcinoma, Squamous Cell|PA/RA; Female; Human; Liver
Neoplasms|SC; Lymphatic Metastasis; Male; Middle Age; Neoplasm
Staging; Preoperative Care
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0363-8715
- Country of Publication
- UNITED STATES
Record 33 from database: MEDLINE
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- Title
- Mapping and quantification of biomolecules in tumor biopsies
using bioluminescence.
- Author
- Schwickert G; Walenta S; Mueller Klieser W
- Address
- Institute of Physiology & Pathophysiology, University of
Mainz, Germany.
- Source
- Experientia, 1996 May, 52:5, 460-3
- Abstract
- Quantitative bioluminescence and single-photon imaging have been
applied for mapping concentration distributions of metabolites,
such as adenosine triphosphate (ATP), glucose and lactate, in
biopsies of cervical cancers in patients. Biopsies were taken
before a conventional radiation treatment, and a number of
clinically relevant data, such as local tumor control, patient
survival, metastatic spread and so forth, were documented. There
was no correlation between staging or grading and any of the
metabolic parameters measured. Local correlations between ATP,
glucose and lactate on a pixel-to-pixel basis were generally
positive, with respective Spearman's correlation coefficients less
in patients without clinically documented metastasis compared with
those with metastatic spread. Lactate concentrations were
significantly higher and scattered over a wider range in tumors
with metastatic spread in comparison to malignancies in patients
without metastasis. Thus, high local lactate levels of > or =
20 mumole/g appear to be associated with a high risk of
metastasis, at least in human cervical tumors.
- Language of Publication
- English
- Unique Identifier
- 96236447
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- MeSH Heading (Major)
- Energy Metabolism|*; Neoplasms|*ME/MO/PA
- MeSH Heading
- Adenosine Triphosphate|ME; Biopsy; Cervix Neoplasms|ME/PA;
Female; Glucose|ME; Human; Lactates|ME; Luminescence; Necrosis;
Neoplasm Metastasis; Neoplasm Staging; Statistics, Nonparametric;
Support, Non-U.S. Gov't; Survival Rate
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0014-4754
- Country of Publication
- SWITZERLAND
Record 34 from database: MEDLINE
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- Title
- Preoperative evaluation of tumor ploidy in endometrial
carcinoma: An accurate tool to identify patients at risk for
extrauterine disease and recurrence.
- Author
- Susini T; Rapi S; Massi D; Savino L; Amunni G; Taddei GL; Massi
G
- Address
- Obstetrics and Gynecology Department, University of Florence,
Florence, Italy.
- Source
- Cancer, 1999 Sep, 86:6, 1005-12
- Abstract
- BACKGROUND: Tumor ploidy is a strong prognostic factor in
patients with endometrial carcinoma, but generally is evaluated
only after surgery. The availability of a simple and reliable
method to determine tumor ploidy before any treatment is initiated
could be helpful in the selection of patients at high risk for
advanced primary disease and subsequent recurrence, with several
possible benefits. The objectives of the current study were: 1) to
test the accuracy of flow cytometric determination of tumor ploidy
from preoperative outpatient endometrial biopsies compared with
standard postoperative evaluation from the surgical specimen and
2) to correlate this preoperative parameter with the local
recurrence and extrauterine tumor spread. METHODS: Tumor ploidy
from both preoperative biopsy material and the macroscopic
surgical specimens was evaluated prospectively in 50 consecutive
patients with endometrial carcinoma. DNA analyses were performed
in a blind fashion. Patients were followed for a median of 26
months (range, 16-46 months). RESULTS: In 9 of 50 cases (18%) an
aneuploid tumor was found by the standard postoperative analysis.
All 9 aneuploid tumors (100%) also were identified correctly by
the preoperative test on biopsy material. Occult extrauterine
tumor spread was found in 10 patients (20%). The incidence rate of
aneuploidy among these tumors was 50% compared with 10% in
surgical International Federation of Gynecology and Obstetrics
Stage I tumors (P = 0.01). The recurrence rate was 55.5% (5 of 9
tumors) in the aneuploid group and 2.4% (1 of 41 tumors) in the
diploid group (P < 0.001). The disease free survival rates of
patients with diploid and aneuploid tumors were 97.5% and 44.4%,
respectively (P < 0.0001). CONCLUSIONS: Preoperative tumor
ploidy determination based on outpatient endometrial biopsy is as
accurate as the standard postoperative evaluation in patients with
endometrial carcinoma. Tumor aneuploidy confirms the usefulness of
this method in selecting patients at risk for occult extrauterine
tumor diffusion and recurrence. Copyright 1999 American Cancer
Society.
- Language of Publication
- English
- Unique Identifier
- 99423596
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- MeSH Heading (Major)
- Carcinoma|GE/*PA/SU; Endometrial Neoplasms|GE/*PA/SU; Ploidies|*
- MeSH Heading
- Adult; Aged; Aneuploidy; Biopsy; Comparative Study; Disease-Free
Survival; Female; Flow Cytometry; Human; Middle Age; Neoplasm
Metastasis; Neoplasm Recurrence, Local|GE; Preoperative Care;
Prognosis; Risk Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-543X
- Country of Publication
- UNITED STATES
Record 35 from database: MEDLINE
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- Title
- Accuracy of intraoperative staging of the NO neck in squamous
cell carcinoma.
- Author
- Rassekh CH; Johnson JT; Myers EN
- Address
- Department of Otolaryngology, University of Texas Medical Branch
Hospitals, Galveston 77555-0521, USA.
- Source
- Laryngoscope, 1995 Dec, 105:12 Pt 1, 1334-6
- Abstract
- Management of the neck in squamous cell carcinoma of the upper
aerodigestive tract continues to be a topic of great debate. One
major problem is that incorrect clinical staging is expected in
approximately 20% of necks. This is true of both clinical stage NO
and N+ necks, even when imaging studies are used. This prospective
study of 108 necks in 79 patients examined the role of
intraoperative palpation and inspection in improving the surgeon's
ability to predict nodal stage. Of 62 patients with NO necks
clinically on both sides, 26 were staged N+ by intraoperative node
examination. Nineteen of the 26 were histologically negative (73%
false-positive). Of the 36 patients staged intraoperatively as NO,
10 were histologically positive (28% false-negative). Of 108 necks
judged clinically to be NO, 25 (23%) had occult metastases and 11
(10%) had extracapsular spread. Forty-one of 108 clinical NO necks
were believed to have positive nodes at the time of neck
dissection. Of these 41 necks, 30 (73%) were found to be
histologically NO (false-positive). Of the 67 clinical NO necks
that were also believed to be NO intraoperatively, occult
metastases were found in 14 (21% false-negative). Therefore,
intraoperative staging did not significantly improve the
false-negative rate. Frozen-section biopsy obtained in the
operating room was reliable in 24 (92.3%) of 26 patients. Although
frozen-section biopsy was not performed in all patients, these
data suggest that upstaging the neck without frozen-section biopsy
is much less reliable. This study supports the use of
frozen-section biopsy before converting the selective dissection
to a radical or modified neck dissection in most instances.
- Language of Publication
- English
- Unique Identifier
- 96101796
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- MeSH Heading (Major)
- Carcinoma, Squamous Cell|*PA/SC/*SU; Head and Neck Neoplasms|*PA/*SU;
Intraoperative Care|*; Lymph Node Excision|*; Lymph Nodes|*PA
- MeSH Heading
- Biopsy; Decision Making; False Negative Reactions; False
Positive Reactions; Forecasting; Frozen Sections; Human; Lymphatic
Metastasis|PA; Neck; Neoplasm Staging; Palpation; Prospective
Studies; Radical Neck Dissection; Reproducibility of Results;
Sensitivity and Specificity
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0023-852X
- Country of Publication
- UNITED STATES
Record 36 from database: MEDLINE
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- Title
- Transcarinal needle aspiration biopsy in the staging of lung
cancer.
- Author
- Vansteenkiste J; Lacquet LM; Demedts M; Deneffe G; Verbeken E
- Address
- Dept of Pneumology, University Hospitals, Catholic University,
Leuven, Belgium.
- Source
- Eur Respir J, 1994 Feb, 7:2, 265-8
- Abstract
- Lung cancer without distant metastasis often requires an
invasive surgical procedure to document inoperability. In order to
determine how often puncture biopsy was a valid substitute for a
surgical procedure, we investigated the performance of endoscopic
staging by means of transcarinal needle aspiration biopsy during
rigid bronchoscopy. Eighty lung cancer patients with subcarinal
lymph nodes visible on computed tomography (CT) scan were studied.
Specimens were of histological quality (i.e. lymph node tissue) in
59 out of 80 (74%) patients, and showed malignant invasion of this
lymph node tissue in 43 cases. Specimens of cytological quality
(i.e. lymph node cells) were obtained in 13 out of 80 (16%)
patients, and showed malignancy in 7 cases. Therefore, adequate
evaluation of the subcarinal lymph nodes was possible in 72 out of
80 (90%) patients. In 50 of these 72, malignant mediastinal spread
was proven, and further invasive surgical staging could be
avoided. Subgroup analysis showed that this outcome tended to be
more likely in patients with abnormal endoscopic appearance of the
main carina, with locally extensive tumours, and with nonsquamous
histology. These results indicate that transbronchial needle
aspiration biopsy of subcarinal lymph nodes can be a valuable
alternative to more invasive surgical staging in patients selected
by CT scan.
- Language of Publication
- English
- Unique Identifier
- 94215664
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- MeSH Heading (Major)
- Carcinoma, Bronchogenic|*PA/SC; Lung|*PA; Lung Neoplasms|*PA
- MeSH Heading
- Adult; Aged; Biopsy, Needle|MT; Bronchoscopy; Female; Human;
Lymph Nodes|PA; Lymphatic Metastasis; Male; Middle Age; Neoplasm
Staging
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0903-1936
- Country of Publication
- DENMARK
Record 37 from database: MEDLINE
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- Title
- Clinical implications of tumor volume measurement in stage I
adenocarcinoma of the cervix.
- Author
- Kaspar HG; Dinh TV; Doherty MG; Hannigan EV; Kumar D
- Address
- Department of Pathology, University of Texas Medical Branch,
Galveston.
- Source
- Obstet Gynecol, 1993 Feb, 81:2, 296-300
- Abstract
- OBJECTIVE: To evaluate the prognostic significance of
three-dimensional determination of tumor size in stage I cervical
adenocarcinoma. METHODS: Tumor volume was measured using
hematoxylin and eosin-stained sections of cone biopsy and
hysterectomy specimens from 36 patients with stage I
adenocarcinoma of the cervix. The volume was then correlated with
pelvic lymphatic spread and clinical outcome. RESULTS: The
subjects were followed for a mean (+/- SEM) of 63 +/- 8 months. No
recurrence or lymphatic seeding was encountered in the 22 tumors
measuring no more than 500 mm3. Two of 25 tumors (8%) having up to
5 mm depth of stromal invasion had lymph node metastasis, one of
which was 1.5 mm, compared with four of 11 (36%) in the group with
deeper than 5 mm invasion (P < .02). The depth of stromal
invasion predicted recurrence less significantly. Among the 25
tumors with up to 5 mm stromal invasion, two recurred, compared
with three of 11 with more than 5 mm invasion (P < .1). Two
women who had tumor volumes below 500 mm3 and depths of stromal
invasion up to 8.5 mm were disease-free at 52 and 96 months of
follow-up. On the other hand, tumors with 2.6 and 3.8 mm stromal
invasion, but with volumes exceeding 500 mm3, recurred.
CONCLUSION: Tumor volume is a better predictor of pelvic lymph
node metastasis and recurrence than is the depth of stromal
invasion in stage I cervical adenocarcinoma.
- Language of Publication
- English
- Unique Identifier
- 93141184
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- MeSH Heading (Major)
- Adenocarcinoma|EP/*PA; Cervix Neoplasms|EP/*PA; Cervix Uteri|*PA
- MeSH Heading
- Biopsy; Female; Follow-Up Studies; Human; Lymphatic Metastasis;
Middle Age; Neoplasm Invasiveness; Neoplasm Recurrence, Local|EP;
Neoplasm Staging; Prognosis; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0029-7844
- Country of Publication
- UNITED STATES
Record 38 from database: MEDLINE
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- Title
- Relationship of tumor thickness in punch biopsy and subsequent
surgical specimens in stage I squamous cell carcinoma of the lower
lip.
- Author
- de Visscher JG; Schaapveld M; Grond AJ; van der Waal I
- Address
- Department of Oral and Maxillofacial Surgery, Medisch Centrum
Leeuwarden, The Netherlands.
- Source
- Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1999 Aug,
88:2, 141-4
- Abstract
- OBJECTIVE: Among the histologic features of squamous cell
carcinoma of the lower lip, maximum tumor thickness in particular
is a predictor of regional nodal metastatic spread and thus an
important parameter in treatment planning. The purpose of this
study was to investigate the relationship between maximum tumor
thickness in punch biopsies and maximum tumor thickness in
subsequent surgical specimens. STUDY DESIGN: This retrospective
study examined the relationship between maximum tumor thickness in
punch biopsies with that in subsequent surgical specimens obtained
in 72 patients with clinical stage I squamous cell carcinoma of
the lower lip. RESULTS: A correlation between maximum tumor
thickness in punch biopies and in subsequent surgical specimens
was found only for tumors with a thickness less than 3 mm.
CONCLUSIONS: Reliable predictive information could be obtained
from punch biopsies with a maximum tumor thickness less than 3 mm.
When the maximum tumor thickness exceeds 3 mm, better information
may be obtained from either a large incisional biopsy or the
surgical specimen.
- Language of Publication
- English
- Unique Identifier
- 99396559
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- MeSH Heading (Major)
- Biopsy|*MT; Carcinoma, Squamous Cell|*PA/SC/SU; Lip Neoplasms|*PA/SU
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Female; Forecasting; Human;
Lymphatic Metastasis|PA; Male; Middle Age; Neoplasm Staging;
Normal Distribution; Reproducibility of Results; Retrospective
Studies
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1079-2104
- Country of Publication
- UNITED STATES
Record 39 from database: MEDLINE
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- Title
- Expression of intercellular adhesion molecule 3 (CDw50) on
endothelial cells in cutaneous lymphomas. A comparative study
between nodal and cutaneous lymphomas.
- Author
- Dommann SN; Dommann Scherrer CC; Ziegler T; Meyer J; Trüeb RM;
Kündig T; Panizzon R; Burg G
- Address
- Department of Dermatology, University Hospital of Zurich,
Switzerland.
- Source
- Am J Dermatopathol, 1997 Aug, 19:4, 391-5
- Abstract
- Advances in the molecular definition of surface proteins
(adhesion molecules) involved in tumor metastasis may help to
explain the invasive behavior of malignant tumors, that is, the
migration of tumor cells involving reversible adhesive contacts,
their release in the circulation, and their extravasation into
distant sites. Intercellular adhesion molecule-3 (ICAM-3), the
third receptor for the lymphocyte function-associated antigen
molecule-1 (LFA-1) was recently characterized. We investigated
fresh frozen skin biopsies from 10 patients with mycosis fungoides,
four with pleomorphic T-cell lymphoma, six with Sézary syndrome,
10 with primary cutaneous B-cell lymphoma, and 10 with eczematous
lesions as controls. The biopsies were compared with lymph node
biopsies of five patients with known cutaneous T-cell lymphoma (CTCL),
10 with primary nodal B-cell lymphoma, and 11 with lymph-node
specimens showing dermatopathic lymphadenopathy as controls. The
specimens were stained with ICAM-3 antibody (Bender Medical
Science) using the alkaline phosphatase antialkaline phosphatase
method. Using cytomorphologic criteria, neoplastic lymphocytes
could be differentiated from smaller reactive cells. Staining
intensities were classified semiquantitatively as follows: 4,
strong expression in 75 to 100% of the tumor cells; 3, 50 to 75%;
2, 25 to 50%; 1, 5 to 25%; and 0 fewer than 5% of the tumor cells.
The endothelial cells in skin biopsies of seven of 30 primary
cutaneous lymphomas expressed ICAM-3. In contrast, no expression
of ICAM-3 could be demonstrated on endothelial cells in lymph
nodes infiltrated with tumor cells of CTCL. Finally, endothelial
cells of lymph nodes infiltrated with primary nodal B-cell
lymphomas showed expression of ICAM-3 in three of 10 patients. The
endothelial cells in the 11 control patients presenting with both
eczematous lesions and dermatopathic lymphadenopathy showed no
staining for ICAM-3. Every patient who expressed ICAM-3 on
endothelial cells showed systemic spread of this disease. The
findings suggest that ICAM-3 expression may be induced on
endothelial cells in late-stage cutaneous lymphomas, probably by a
cytokine-mediated mechanism.
- Language of Publication
- English
- Unique Identifier
- 97404767
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- MeSH Heading (Major)
- Cell Adhesion Molecules|AN/*GE; Endothelium|*PA; Lymph
Nodes|*PA; Lymphoma, T-Cell, Cutaneous|*PA; Skin Neoplasms|*PA
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Alkaline Phosphatase|DU; Biopsy;
Cell Movement; Comparative Study; Dyes|DU; Eczema|PA; Female; Gene
Expression Regulation, Neoplastic; Human; Lymphatic Diseases|PA;
Lymphatic Metastasis|PA; Lymphocyte Function-Associated
Antigen-1|AN/GE; Lymphocytes|PA; Lymphoma, B-Cell|PA; Lymphoma,
Lymphoblastic|PA; Male; Middle Age; Mycosis Fungoides|PA; Neoplasm
Circulating Cells|PA; Sezary Syndrome|PA; Skin|PA
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0193-1091
- Country of Publication
- UNITED STATES
Record 40 from database: MEDLINE
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- Title
- The role of transcarinal needle aspiration in the staging of
bronchogenic carcinoma.
- Author
- Utz JP; Patel AM; Edell ES
- Address
- Division of Thoracic Diseases and Internal Medicine, Mayo
Medical Center, Rochester, Minn. 55905.
- Source
- Chest, 1993 Oct, 104:4, 1012-6
- Abstract
- Metastatic spread to subcarinal lymph nodes in patients with
bronchogenic carcinoma generally indicates unresectability.
Transcarinal needle aspiration of the main carina (TCNA) has been
used to obviate the need for more invasive procedures,
particularly thoracic surgery. Of 510 transbronchial needle
aspirations performed at our institution from 1983 to 1991, 88 (17
percent) were from the main carina in patients with bronchogenic
carcinoma. We reviewed these 88 TCNA procedures to assess our
experience with TCNA in the staging of lung cancer. The TCNA
results were positive in 32 of 88 (36 percent) patients (20
non-small-cell cancers, 12 small-cell lung cancers). Following
bronchoscopy, TCNA was the only evidence of unresectability in all
20 patients with non-small-cell lung cancer and was the only mode
of diagnosis in 5 of 12 (42 percent) patients with small-cell lung
cancer. Thirteen patients with non-small-cell lung cancer and
positive TCNA also had positive bronchial secretion cytologic
studies. Five of these patients had further subcarinal sampling
and in all cases metastatic involvement was confirmed. TCNA was
positive in 29 of 67 (43 percent) patients with radiographic
evidence of mediastinal adenopathy. Of the remaining 38 patients
with radiographic evidence of mediastinal adenopathy and negative
TCNA results, 23 patients had further mediastinal sampling with
mediastinoscopy or thoracotomy and in all cases mediastinal spread
of cancer was established. Nineteen of 58 (33 percent) patients
with an endoscopically normal-appearing main carina had a positive
TCNA, while 13 of 30 (43 percent) patients with broadening or
widening of the main carina had positive TCNA results. There were
no complications. We conclude that TCNA is often a safe and useful
staging modality in patients with bronchogenic carcinoma.
- Language of Publication
- English
- Unique Identifier
- 94008088
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- MeSH Heading (Major)
- Carcinoma, Bronchogenic|EP/*PA/SC; Lung|*PA; Lung Neoplasms|EP/*PA
- MeSH Heading
- Biopsy, Needle|MT; Human; Lymphatic Metastasis; Neoplasm
Staging; Predictive Value of Tests; Retrospective Studies
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0012-3692
- Country of Publication
- UNITED STATES
Record 41 from database: MEDLINE
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- Title
- Inadvertent spread of cancer at surgery.
- Author
- Fortner JG
- Address
- Department of Surgery, Memorial Sloan-Kettering Cancer Center,
New York, NY 10021.
- Source
- J Surg Oncol, 1993 Jul, 53:3, 191-6
- Abstract
- Surgical cure requires that a given cancer be removed without
inadvertent spillage of cancer cells by technical error. Potential
mishaps include pressing a ligature, while tying, against a
protruding tumor and cutting into it; inserting a hemostat into
the tumor area to gain control of an escaped short
pancreaticoduodenal artery stump which has retracted; grasping a
lymph node with forceps which invariably fragments it spilling any
cancer cells it may contain; and injecting local anesthesia into
or adjacent to a lesion for biopsy. If the lesion is a cutaneous
melanoma or other cancer the resulting pressure may force cancer
cells into the lymphatic or bloodstream. Other misadventures
include touching that portion of a biopsy needle which has been in
the tumor and doing an intraoperative biopsy which allows blood or
tissue fluid to flow out the opening from the tumor. Sensitivity
to such dangers appears essential to avoiding spillage of cancer
cells and obtaining maximal benefit from surgery.
- Language of Publication
- English
- Unique Identifier
- 93323506
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- MeSH Heading (Major)
- Neoplasm Seeding|*; Neoplasms|*SU
- MeSH Heading
- Biopsy, Needle|AE; Hemostasis, Surgical; Hemostatic Techniques;
Human; Intraoperative Care|MT; Lymph Node Excision|MT; Lymphatic
Metastasis; Palpation|AE; Surgical Instruments; Suture Techniques
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-4790
- Country of Publication
- UNITED STATES
Record 42 from database: MEDLINE
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- Title
- Mobilization of tumour cells during biopsy in an infant with
Ewing sarcoma.
- Author
- Zoubek A; Kovar H; Kronberger M; Amann G; Windhager R; Gruber B;
Gadner H
- Address
- St. Anna Children's Hospital, Children's Cancer Research
Institute, Kinderspitalgasse 6, Vienna, Austria.
- Source
- Eur J Pediatr, 1996 May, 155:5, 373-6
- Abstract
- Ewing sarcoma and the closely related peripheral primitive
neuroectodermal tumour, recently referred to as Ewing tumour (ET),
are characterised by unique gene rearrangements on chromosome 22.
The breakpoints have been cloned and shown to fuse the Ewing
sarcoma gene to one of two closely related ETS proto-oncogens,
FLI-1 or ERG, which reside on chromosomes 11 and 21, respectively.
The rearrangement results in the expression of specific hybrid
transcripts which can be detected with high sensitivity by the
reverse transcriptase polymerase chain reaction technique (RT-PCR)
in primary tumours, blood and bone marrow. We report on a
7-month-old boy with a pelvic Ewing sarcoma in whom circulating
tumour cells were identified in the peripheral blood during open
tumour biopsy by RT-PCR. However, before and 6 days after surgery
no tumour cells could be detected in the peripheral blood.
CONCLUSION: The application of RT-PCR to monitor shedding of
tumour cells during surgical intervention will help to evaluate if
open biopsy potentially contributes to metastatic tumour cell
spread.
- Language of Publication
- English
- Unique Identifier
- 96302958
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- MeSH Heading (Major)
- Bone Neoplasms|*BL/GE/PA/SU; Neoplasm Circulating Cells|*;
Sarcoma, Ewing's|*BL/GE/PA/SU
- MeSH Heading
- Base Sequence; Biopsy; Case Report; Human; Infant; Male;
Molecular Sequence Data; Neoplasm Metastasis; Polymerase Chain
Reaction; Support, Non-U.S. Gov't; Transcription, Genetic
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0340-6199
- Country of Publication
- GERMANY
Record 43 from database: MEDLINE
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- Title
- Occult papillary carcinoma of the thyroid with pulmonary
lymphangitic spread diagnosed by lung biopsy.
- Author
- Fend F; Gruber U; Fritzsche H; Rothmund J; Breitfellner G; Mikuz
G
- Address
- Institut fÂur Pathologische Anatomie, UniversitÂat Innsbruck.
- Source
- Klin Wochenschr, 1989 Jul, 67:13, 687-90
- Abstract
- Distant metastases from occult papillary carcinoma of the
thyroid, which is defined as a tumor less than 15 mm in diameter,
are extremely rare. A 21-year-old patient with miliary
micronodular densities in both lungs is described, in whom
pulmonary lymphangitic spread of occult papillary thyroid
carcinoma was diagnosed by transthoracic lung biopsy.
- Language of Publication
- English
- Unique Identifier
- 89329502
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- MeSH Heading (Major)
- Carcinoma, Papillary|PA/*SC; Lung Neoplasms|PA/*SC; Lymph
Nodes|*PA; Thyroid Neoplasms|*PA
- MeSH Heading
- Adult; Biopsy; Case Report; Female; Human; Lung|PA; Lymphatic
Metastasis; Neoplasm Circulating Cells
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0023-2173
- Country of Publication
- GERMANY, WEST
Record 44 from database: MEDLINE
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- Title
- Selection of patients for curative or palliative resection of
esophageal cancer based on preoperative endoscopic ultrasonography.
- Author
- Peters JH; Hoeft SF; Heimbucher J; Bremner RM; DeMeester TR;
Bremner CG; Clark GW; Kiyabu M; Parisky Y
- Address
- Department of Surgery, University of Southern California School
of Medicine, Los Angeles.
- Source
- Arch Surg, 1994 May, 129:5, 534-9
- Abstract
- OBJECTIVE: To assess the accuracy of pretreatment staging and
the potential of using endosonographic findings to select patients
for curative or palliative resection by comparing the preoperative
endosonographic and computed tomographic (CT) findings with the
histology of the surgical specimen. METHODS: Forty-two patients
referred to our clinic with esophageal carcinoma underwent
preoperative upper endoscopy with biopsy, endosonography, thoracic
CT, and abdominal CT. Based on endoscopic ultrasonographic
findings, patients with early-stage disease underwent en-bloc
esophagogastrectomy, whereas those with advanced disease had a
palliative transhiatal esophagectomy. Exceptions included patients
with poor physiologic reserve who were treated by the transhiatal
route. RESULTS: In eight patients, we were unable to pass the
ultrasonographic endoscope. Seven of these eight had transmural
tumors with nodal involvement on histologic study. Tumor length,
based on endosonographic measurements, was correctly predicted in
34 patients (85%). Extent of wall penetration was accurately
predicted in 26 (76%) of the 34, and regional lymph node status
was accurately predicted in 28 (82%) of the 34. Of the patients
with sonographic wall penetration, 80% had histologic evidence of
one or more positive nodes. Using the WNM staging system,
endoscopic ultrasonography correctly staged the cancer in 68% of
the patients. Three patients were treated with an inappropriate
procedure. CONCLUSION: Endosonography is a reliable method for the
preoperative staging and selection of patients for curative or
palliative resection. Endosonographic wall penetration appears to
be a critical factor in determining tumor spread.
- Language of Publication
- English
- Unique Identifier
- 94241880
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- MeSH Heading (Major)
- Esophageal Neoplasms|PA/RA/*SU/*US; Palliative Care|*
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Biopsy; Comparative Study;
Esophagectomy; Esophagoscopy; Esophagus|PA; Female; Human;
Lymphatic Metastasis; Male; Middle Age; Neoplasm Invasiveness;
Neoplasm Staging; Predictive Value of Tests; Preoperative Care|MT;
Reproducibility of Results; Tomography, X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0004-0010
- Country of Publication
- UNITED STATES
Record 45 from database: MEDLINE
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- Title
- Metastatic tumours of the parotid gland.
- Author
- Malata CM; Camilleri IG; McLean NR; Piggott TA; Soames JV
- Address
- West of Scotland Plastic and Oral Surgery Unit, Canniesburn
Hospital, Glasgow, UK.
- Source
- Br J Oral Maxillofac Surg, 1998 Jun, 36:3, 190-5
- Abstract
- Twenty patients (12 men and 8 women, median age 69 years) with
metastatic tumours in the parotid gland who presented over a
12-year period were evaluated retrospectively. Preoperative
investigations included fine needle aspiration cytology (n = 11)
and computed tomography or magnetic resonance imaging (MRI) (n =
14). Most tumours originated from the head and neck region, the
two main types being squamous cell carcinoma (n = 10) and
malignant melanoma (n = 7). All 20 presented with a parotid mass
and 11/20 (55%) had associated lymphadenopathy. Eleven patients
(55%) underwent superficial, five total, and four radical,
parotidectomy. Neck dissection was required in 16 patients (80%),
and all 11 patients with clinically palpable lymph nodes had
evidence of tumour in the neck dissection specimens. Half of all
patients (n = 10) received adjuvant postoperative radiotherapy.
Three-quarters of the patients (n = 15) were alive after a mean
follow-up of 31 months and only one developed a marginal
recurrence. The cumulative 5-year survival rate was 51%, and there
was no significant difference (P = 0.48) in the 3-year survival
rates of patients who had radical compared with those who had
modified neck dissections. Patients who had superficial
parotidectomy had a longer overall survival compared with those
who had total or radical parotidectomy (P = 0.04) perhaps
reflecting the advanced nature of tumours that required total or
radical excision of the gland. We conclude that superficial
parotidectomy is usually an adequate treatment for secondary
parotid tumours (when disease is clinically limited to the
superficial lobe), and we suggest that patients in whom metastatic
disease of the parotid gland is suspected do not require neck
dissection if they have no palpable lymph nodes and MRI shows no
evidence of spread. There seems to be no survival advantage in
radical over modified neck dissection.
- Language of Publication
- English
- Unique Identifier
- 98342024
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- MeSH Heading (Major)
- Parotid Neoplasms|DI/*SC/TH
- MeSH Heading
- Adolescence; Adult; Aged; Aged, 80 and over; Biopsy, Needle;
Carcinoma, Squamous Cell|PA/SC; Comparative Study; Disease-Free
Survival; Female; Follow-Up Studies; Head and Neck Neoplasms|PA;
Human; Lymph Node Excision; Lymphatic Metastasis|PA; Magnetic
Resonance Imaging; Male; Melanoma|PA/SC; Middle Age; Neoplasm
Staging; Parotid Gland|SU; Radical Neck Dissection; Radiotherapy,
Adjuvant; Retrospective Studies; Survival Rate; Tomography, X-Ray
Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0266-4356
- Country of Publication
- SCOTLAND
Record 46 from database: MEDLINE
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- Title
- Penile cancer. Aspiration biopsy cytology for staging.
- Author
- Scappini P; Piscioli F; Pusiol T; Hofstetter A; Rothenberger K;
Luciani L
- Address
-
- Source
- Cancer, 1986 Oct, 58:7, 1526-33
- Abstract
- Appropriate management and prognosis of patients with penile
carcinoma depends on an accurate knowledge of the regional node
status. The usefulness of clinical and radiologic examinations in
detecting the nodal spread of the disease is limited by the high
rates of false-positive and false-negative results. On the other
hand, routine or prophylactic lymphadenectomy is associated with
30% to 50% of the major morbidity and 3% of the mortality rate, so
that caution is advisable for its use in patients with
disease-free nodes. Even bilateral sentinel lymph node biopsy, as
proposed by Cabanas, does not warrant an adequate selection of
patients candidates to surgical treatment. The role of aspiration
biopsy cytology in the management of penile carcinoma was
evaluated in a study of 29 cases from the authors' institutions.
Aspiration under fluoroscopic or computed tomographic guidance was
performed using a 22-23-gauge Chiba needle. The accuracy of
aspiration biopsy cytology in identifying the true stage of the
disease was 100%. On histologic control, only one node contained
malignant cells that were not detected by aspiration biopsy
cytology, but this finding did not alter the stage of the patient.
Positive cytology is conclusive of Stage III disease and, in this
case, a curative lymphadenectomy may be attempted. Negative
aspirations do not warrant the absence of metastatic nodal
involvement as can be seen in two patients in this series. In such
cases, however, a policy of "wait and watch" may be
adopted, with repeated aspiration biopsies or surgical biopsy of
the sentinel node area.
- Language of Publication
- English
- Unique Identifier
- 86298118
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- MeSH Heading (Major)
- Biopsy, Needle|*; Carcinoma, Squamous Cell|MO/*PA/RA; Penile
Neoplasms|MO/*PA/RA
- MeSH Heading
- Adult; Aged; Diagnostic Errors; Human; Lymphatic Metastasis;
Male; Melanoma|MO/PA/RA; Middle Age; Neoplasm Staging; Prognosis;
Tomography, X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-543X
- Country of Publication
- UNITED STATES
Record 47 from database: MEDLINE
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- Title
- Widespread lymph node metastases in a patient with microinvasive
cervical carcinoma.
- Author
- Collins HS; Burke TW; Woodward JE; Spurlock JW; Heller PB
- Address
- Gynecologic Oncology Service, Walter Reed Army Medical Center,
Washington, D.C. 20307-5001.
- Source
- Gynecol Oncol, 1989 Aug, 34:2, 219-21
- Abstract
- Lymph node metastasis is uncommon in patients with microinvasive
squamous cell carcinoma of the cervix and is particularly unusual
in tumors with early stromal invasion. We describe a patient with
maximum stromal invasion of 0.8 mm who had extensive pelvic and
para-aortic nodal metastases discovered at laparotomy. Despite
combined modality therapy, she died with progressive disease. New
clinical staging definitions for Stage IA cervical carcinoma
incorporate measurement of both depth of invasion and lateral
tumor spread and have resolved many of the descriptive
controversies surrounding this entity. Our case illustrates that
any degree of stromal invasion carries some risk of nodal
metastasis. The management of patients with microinvasive
carcinoma should be individualized. An abdominal approach should
be considered for patients being treated by extrafascial
hysterectomy to allow assessment of the regional lymph nodes.
Whether more aggressive therapy will influence the outcome for the
rare patient with lymph node metastasis is unknown.
- Language of Publication
- English
- Unique Identifier
- 89326315
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- MeSH Heading (Major)
- Cervix Neoplasms|*PA
- MeSH Heading
- Adult; Basement Membrane|PA; Biopsy; Case Report; Female; Human;
Lymph Nodes|PA; Lymphatic Metastasis; Neoplasm Invasiveness
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0090-8258
- Country of Publication
- UNITED STATES
Record 48 from database: MEDLINE
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- Title
- Detection of occult lymph node metastases in esophageal cancer
by minimally invasive staging combined with molecular diagnostic
techniques.
- Author
- Kassis ES; Nguyen N; Shriver SP; Siegfried JM; Schauer PR;
Luketich JD
- Address
- Department of Surgery, University of Pittsburgh Medical Center,
PA 15213, USA.
- Source
- JSLS, 1998 Oct, 2:4, 331-6
- Abstract
- BACKGROUND AND OBJECTIVES: Lymph node metastases are the most
important prognostic factor in patients with esophageal cancer.
Histologic examination misses micrometastases in up to 20% of
lymph nodes evaluated. In addition, non-invasive imaging
modalities are not sensitive enough to detect small lymph nodes
metastases. The objective of this study was to investigate the use
of reverse transcriptase-polymerase chain reaction (RT-PCR) of
messenger RNA (mRNA) for carcinoembryonic antigen (CEA) to
increase the detection of micrometastases in lymph nodes from
patients with esophageal cancer. METHODS: RT-PCR of CEA mRNA was
performed in lymph nodes from patients with malignant and benign
esophageal disease. Each specimen was examined histopathologically
and by RT-PCR and the results were compared. RESULTS: Metastases
were present in 29 of 60 (48%) lymph nodes sample by minimally
invasive staging from 13 patients with esophageal cancer when
examined histopathologically. RT-PCR identified nodal metastases
in 46 of these 60 (77%) samples. RT-PCR detected CEA mRNA in all
29 histologically positive samples and in 17 histologically
negative lymph nodes. All lymph nodes from patients with benign
disease (n = 15) were negative both histopathologically and by
RT-PCR. The stage of two patients was reclassified based on the
RT-PCR results, which identified lymph node spread undetected
histopathologically. Both of these patients developed recurrent
disease after resection of the primary tumor. CONCLUSIONS: RT-PCR
is more sensitive than histologic examination in the detection of
lymph node metastases in esophageal cancer and can lead to
diagnosis of a more advanced stage in some patients. The
combination of minimally invasive surgical techniques in
combination with new molecular diagnostic techniques may improve
our ability to stage cancer patients.
- Language of Publication
- English
- Unique Identifier
- 99154222
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- MeSH Heading (Major)
- Adenocarcinoma|*PA/*SC/SU; Carcinoembryonic Antigen|*AN;
Esophageal Neoplasms|*PA/SU; RNA, Messenger|*AN; RNA,
Neoplasm|*AN; Tumor Markers, Biological|*AN
- MeSH Heading
- Base Sequence; Biopsy, Needle; Comparative Study; Female; Human;
Lymph Nodes|PA; Lymphatic Metastasis; Male; Molecular Sequence
Data; Neoplasm Staging; Polymerase Chain Reaction; Reference
Values; Sensitivity and Specificity; Surgical Procedures,
Minimally Invasive
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE
- Country of Publication
- UNITED STATES
Record 49 from database: MEDLINE
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- Title
- Small B cell NHL and their leukemic counterpart: differences in
subtyping and assessment of leukemic spread.
- Author
- Criel A; Pittaluga S; Verhoef G; Wlodarska I; Meeus P; Mecucci
C; Van Orshoven A; Van den Berghe H; Boogaerts M; De Wolf Peeters
C
- Address
- Department of Hematology, KU, Leuven, Belgium.
- Source
- Leukemia, 1996 May, 10:5, 848-53
- Abstract
- Three subtypes of small lymphocytic lymphoma were studied,
namely B cell chronic lymphocytic leukemia (B-CLL), mantle cell
lymphoma (MCL) and follicle center lymphoma (FCL). Agreement
between tissue diagnosis, based on the proposal for a revised
European-American classification of lymphoid neoplasms from the
International Lymphoma Study Group, and the cytomorphological
diagnosis on peripheral blood and/or bone marrow smears, using the
proposals for the classification of chronic (mature) B and T
lymphoid leukemias of the French-American-British Cooperative
Group, was studied. Full agreement was found in 90% of the CLL and
82% of the FCL cases. In MCL cases, agreement was 65% including
all cases classified as intermediate/mantle zone lymphoma
according to FAB criteria. The incidence of bone marrow
involvement detection in trephines compared to smears was equal in
CLL (both 100%) and slightly higher in MCL (56 vs 48.5%); in FCL,
however, trephine biopsies provided more reliable material (71 vs
35%).
- Language of Publication
- English
- Unique Identifier
- 96216625
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- MeSH Heading (Major)
- Leukemia, B-Cell, Chronic|BL/*CL/PA; Lymphoma, Small-Cell|BL/*CL/PA
- MeSH Heading
- Biopsy; Cell Division; Comparative Study; Human; Lymph Nodes|PA;
Lymphoma, Follicular|CL/PA; Neoplasm Invasiveness; Neoplasm
Metastasis; Spleen|PA; Terminology
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0887-6924
- Country of Publication
- ENGLAND
Record 50 from database: MEDLINE
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- Title
- Subtypes of renal cell carcinoma. Different onset and sites of
metastatic disease.
- Author
- Renshaw AA; Richie JP
- Address
-
- Source
- Am J Clin Pathol, 1999 Apr, 111:4, 539-43
- Abstract
- Different subtypes of renal cell carcinoma have different
genetic features and prognoses. Whether the patterns of metastatic
spread of different subtypes of renal cell carcinoma are different
is unknown. To assess this, we reviewed the time course and sites
of all pathologically confirmed metastatic disease in patients who
underwent resection of the primary tumor at Brigham and Women's
Hospital, Boston, MA, between 1973 and 1997. In 82 patients, 119
metastatic lesions were identified. Compared with clear cell
tumors, papillary tumors were more likely to be Fuhrman grade 3 or
4, to have metastases present at the time of resection, and to
involve lymph nodes but not lung. Metastases associated with
chromophobe tumors developed in 3 patients, all of whom had
Fuhrman grade 2 tumors, and were found only in the liver. We
conclude that different subtypes of renal cell carcinoma develop
pathologically confirmed metastases at different times and sites.
The value of Fuhrman grading may depend on the subtype of renal
cell carcinoma.
- Language of Publication
- English
- Unique Identifier
- 99207500
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- MeSH Heading (Major)
- Carcinoma, Renal Cell|*CL/PA/SC; Kidney Neoplasms|*CL/PA;
Neoplasm Metastasis|*
- MeSH Heading
- Aged; Biopsy; Female; Human; Liver Neoplasms|SC; Lung
Neoplasms|SC; Lymphatic Metastasis; Male; Middle Age; Prognosis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9173
- Country of Publication
- UNITED STATES
Record 51 from database: MEDLINE
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- Title
- Aspiration cytology in the staging of urologic cancer.
- Author
- Piscioli F; Scappini P; Luciani L
- Address
-
- Source
- Cancer, 1985 Sep, 56:5, 1173-80
- Abstract
- Knowledge of the status of the pelvic lymph nodes is vital for
accurate staging and adequate treatment of patients with urologic
cancer. Noninvasive techniques for assessing the lymphatic spread
of urologic neoplasms have proved to be of limited value. Bipedal
lymphangiography and percutaneous fine needle aspiration cytology
under fluoroscopic guidance were performed for staging purposes in
71 patients with clinically localized bladder, prostatic and
penile cancer from 257 nodal chains. The overall diagnostic
accuracy was 93% and the correct aspiration of 186 lymph nodes was
surgically confirmed. There were 11 (6%) false-negative biopsy
results and no false-positive diagnoses. Aspiration cytology is a
safe, well tolerated, accurate, and rapid method of determining
the presence of metastatic disease in lymphangiographically
visualized pelvic nodes. In the management of prostatic carcinoma,
positive cytologic results are diagnostic of nodal metastatic
involvement and spare the patients unnecessary surgical staging.
Negative cytologic findings may be considered diagnostic of
localized disease in the patients with well differentiated
prostatic carcinoma (2-4 Gleason's sum). Since most surgeons are
reluctant to perform a staging lymphadenectomy in the management
of invasive bladder carcinoma, aspiration cytology can provide
accurate staging, thus permitting an appropriate treatment plan.
In patients with carcinoma of the penis, a positive aspirate
permits an early and even curative lymphadenectomy in cases with
clinically negative but pathologically positive nodes.
- Language of Publication
- English
- Unique Identifier
- 85254334
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- MeSH Heading (Major)
- Biopsy, Needle|*; Lymph Nodes|*PA; Urologic Neoplasms|*PA/RA
- MeSH Heading
- Bladder Neoplasms|PA/RA; Cytodiagnosis; Diagnostic Errors;
Human; Lymphatic Metastasis; Lymphography; Male; Neoplasm
Staging|MT; Pelvis; Penile Neoplasms|PA/RA; Prostatic Neoplasms|PA/RA;
Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-543X
- Country of Publication
- UNITED STATES
Record 52 from database: MEDLINE
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- Title
- Role of thoracoscopic lymph node staging for lung and esophageal
cancer.
- Author
- Krasna MJ
- Address
- Division of Thoracic and Cardiovascular Surgery, University of
Maryland, School of Medicine, Baltimore, USA.
- Source
- Oncology (Huntingt), 1996 Jun, 10:6, 793-802; discussion 804,
813-4
- Abstract
- Staging is extremely important in determining the proper
treatment of patients with thoracic malignancies. Staging groups
can be used to predict outcome after cancer treatment and allocate
patients to appropriate treatment regimens. Thoracoscopy is an
excellent means of staging intrathoracic malignancies. It is a
good tool for biopsy of mediastinal lymph nodes and evaluation of
the pleural cavity. Routine thoracoscopic and laparoscopic lymph
node staging have been used in patients with esophageal carcinoma
with excellent results. For patients with lung cancer,
thoracoscopy augments other noninvasive and minimally invasive
staging procedures. It is used as a complement to standard
cervical mediastinoscopy in assessing mediastinal and hilar lymph
nodes. It can thus help avoid an unnecessary thoracotomy for
attempted resection in a patient who is found to have gross spread
of locoregional disease.
- Language of Publication
- English
- Unique Identifier
- 96421098
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- MeSH Heading (Major)
- Esophageal Neoplasms|*PA; Lung Neoplasms|*PA; Lymph Nodes|*PA;
Neoplasm Staging|*; Thoracoscopy|*MT
- MeSH Heading
- Biopsy; Human; Laparoscopy|MT; Lymphatic Metastasis;
Mediastinum|PA; Prognosis
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0890-9091
- Country of Publication
- UNITED STATES
Record 53 from database: MEDLINE
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- Title
- Minimally invasive staging for esophageal cancer.
- Author
- Krasna MJ
- Address
- Division of Thoracic and Cardiovascular Surgery, University of
Maryland School of Medicine, Baltimore, USA.
- Source
- Chest, 1997 Oct, 112:4 Suppl, 191S-194S
- Abstract
- Thoracoscopy is an excellent means for staging esophageal
cancer. Staging of esophageal carcinoma facilitates
prognostication and allocation of patients to appropriate
treatment regimens. Thoracoscopy is also useful in biopsies of
direct mediastinal invasion. Routine thoracoscopic and
laparoscopic lymph node staging has been used in patients with
esophageal carcinoma with excellent results. Thoracoscopy can
allocate patients for neoadjuvant therapy and help avoid an
unnecessary thoracotomy in patients found to have gross spread of
locoregional disease.
- Language of Publication
- English
- Unique Identifier
- 97477223
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- MeSH Heading (Major)
- Adenocarcinoma|*PA/TH; Carcinoma, Squamous Cell|*PA/TH;
Esophageal Neoplasms|*PA/TH; Neoplasm Staging|*MT; Thoracoscopy|*
- MeSH Heading
- Biopsy; Combined Modality Therapy; Human; Laparoscopy; Lymph
Nodes|PA; Lymphatic Metastasis; Retrospective Studies
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0012-3692
- Country of Publication
- UNITED STATES
Record 54 from database: MEDLINE
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- Title
- Malignant epithelioid hemangioendothelioma of the liver in young
women. Relationship to oral contraceptive use.
- Author
- Dean PJ; Haggitt RC; OHara CJ
- Address
-
- Source
- Am J Surg Pathol, 1985 Oct, 9:10, 695-704
- Abstract
- Epithelioid hemangioendothelioma (EH) is a vascular neoplasm
that occurs predominantly in soft tissue and is not infrequently
misdiagnosed as an epithelial neoplasm or angiosarcoma. Only a few
cases of hepatic EH have been described, and a relationship to
oral contraceptive (OC) use in patients with the hepatic lesions
has not generally been recognized. We present a series of five
patients with malignant epithelioid hemangioendothelioma of the
liver. Confirmation of the endothelial origin of these tumors was
provided by positive immunoperoxidase staining for
Factor-VIII-related antigen in the four cases studied by that
technique, and by the demonstration of Weibel-Palade bodies in two
tumors examined by electron microscopy. All five patients were
young women (mean age 33 years) and all five gave a history of OC
use of 4-7 years' duration. The clinical course varied from
indolent but progressive to rapid death. One patient who underwent
resection of the primary tumor has survived 3 years without
evidence of disease, and one patient with metastatic disease who
was treated with radiation and chemotherapy has survived for 8
years with disease. Three patients with extrahepatic spread have
died of the tumor. Early diagnosis of this distinctive tumor might
offer the hope of salvage by resection or liver transplantation.
- Language of Publication
- English
- Unique Identifier
- 86048321
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- MeSH Heading (Major)
- Contraceptives, Oral, Hormonal|*AE; Hemangioendothelioma|*CI/ME/PA;
Liver Diseases|*CI/ME/PA
- MeSH Heading
- Adult; Biopsy; Female; Histocytochemistry; Human; Immunoenzyme
Techniques; Liver|ME/PA; Lymph Nodes|ME/PA; Lymphatic Metastasis;
Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0147-5185
- Country of Publication
- UNITED STATES
Record 55 from database: MEDLINE
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- Title
- Sentinel node dissection in the treatment of melanoma. Report of
three cases and review of the literature.
- Author
- Cottingham T; Larson J; Delaney JP; Zachary C
- Address
- Department of Dermatology, University of Minnesota, Minneapolis
55455-0392, USA.
- Source
- Dermatol Surg, 1997 Feb, 23:2, 113-8; discussion 118-9
- Abstract
- BACKGROUND: Elective lymph node dissection for treatment of
cutaneous malignant melanoma is controversial. Sentinel node
dissection involves removing the primary lymph node in a nodal
basin that drains a particular cutaneous lesion. Theoretically,
this node would collect regional metastases first. Therefore, if
this node is negative, the chances are low that the melanoma would
have spread either systemically or to other nodes within this
basin. Removing one node would decrease the morbidity associated
with radical lymph node dissection. However, the actual risk of
widespread metastases in sentinel node-negative patients is yet to
be determined, pending results of large, multicenter studies
currently under investigation. OBJECTIVE: To present three cases
of intermediate thickness cutaneous melanoma treated with
selective lymph node dissection and to review the techniques of
selective lymphadenectomy and lymphoscintigraphy. METHODS: In a
nonrandomized prospective evaluation, patients with intermediate
depth melanomas or in transit metastases without signs of systemic
disease were given the opportunity for further investigation by
sentinel node dissection to determine if additional lymph node
dissection or adjunctive therapies would be advantageous. RESULTS:
All three patients had negative sentinel node examinations. Two
are without visceral or nodal metastases 1 year after the
procedure. The third had in-transit metastases from the outset,
had in-transit metastases on sentinel node/lymphatic examination,
and now has systemic cutaneous metastases. Complications of
sentinel node dissection were limited to transient postoperative
lymphedema of the extremities and transient seroma formation. No
postoperative wound infections or permanent nerve damage were
noted. CONCLUSIONS: Our preliminary findings in this limited
series suggests that sentinel node dissection appears to be a
procedure of low morbidity and relatively high predictive value.
- Language of Publication
- English
- Unique Identifier
- 97261331
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- MeSH Heading (Major)
- Lymph Node Excision|*; Melanoma|RI/*SC/*SU; Skin Neoplasms|RI/*SU
- MeSH Heading
- Aged; Aged, 80 and over; Biopsy; Case Report; Female; Human;
Lymph Nodes|PA/RI; Lymphatic Metastasis; Male; Middle Age;
Neoplasm Staging; Prospective Studies
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
- ISSN
- 1076-0512
- Country of Publication
- UNITED STATES
Record 56 from database: MEDLINE
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- Title
- Determining the extent of the cancer and clinical planning for
cure.
- Author
- Karnofsky DA
- Address
-
- Source
- Cancer, 1968 Oct, 22:4, 730-4
- Abstract
- The patient with presumed localized cancer should be carefully
surveyed both for evidence of spread of the disease, and in order
to obtain baseline data which may be relevant to interpret any
later clinical changes. The procedures used--a careful medical
history, complete physical examination, laboratory tests, biopsy
and cytology preparations, radiographic procedures and radioactive
isotope scans of selected organ system--are listed. The
recommended procedures in the individual patient are related to
the primary site and apparent local extent of the cancer, a
knowledge of the natural history of the particular cancer, and the
practicalities of the situation. Proper study will direct an
attempt at optimal curative therapy or spare the patient with
metastatic disease unrewarding and possibly disabling therapeutic
efforts.
- Language of Publication
- English
- Unique Identifier
- 85151532
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- MeSH Heading (Major)
- Neoplasms|DI/*TH
- MeSH Heading
- Human; Neoplasm Metastasis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-543X
- Country of Publication
- UNITED STATES
Record 57 from database: MEDLINE
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- Title
- An analysis of 38 malignant fibrous histiocytomas in the
extremities.
- Author
- Ekfors TO; Rantakokko V
- Address
-
- Source
- Acta Pathol Microbiol Scand [A], 1978 Jan, 86:1, 25-35
- Abstract
- All the malignant soft tissue tumours in the extremities and
limb girdles reported to the Finnish Cancer Registry between
1960-1969 were reviewed. From a total of 246 sarcomas, 38 were
diagnosed as malignant fibrous histiocytoma. There was an equal
number of male and female patients with the median age of 67
years. The thigh was the most frequent site, and the majority of
the tumours originated in the deep soft tissues. The predominant
treatment was excision followed by radiation therapy. In 17
patients there were one or more recurrences and in 21 patients
there was a metastatic spread ascertained by biopsy, autopsy or
clinical or radiographic evidence. There were 11 survivors with a
minimum of 5 years' follow-up; seven patients died of an
intercurrent disease and the remaining 20 patients were considered
victims of their tumour. The findings that seemed to favour a poor
prognosis were higher age and female sex of the patient as well as
deep location, large size, necrotic areas, and high mitotic
activity of the tumour.
- Language of Publication
- English
- Unique Identifier
- 78141577
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- MeSH Heading (Major)
- Dermatofibroma|*/MO/PA/TH; Soft Tissue Neoplasms|*/MO/PA/TH
- MeSH Heading
- Adult; Age Factors; Aged; Arm; Female; Finland; Human; Leg;
Male; Middle Age; Neoplasm Metastasis; Neoplasm Recurrence, Local;
Prognosis; Sex Factors; Thigh
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0365-4184
- Country of Publication
- DENMARK
Record 58 from database: MEDLINE
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- Title
- Serum immunoglobulins in breast cancer.
- Author
- Alsabti EA
- Address
-
- Source
- J Surg Oncol, 1979, 11:2, 129-33
- Abstract
- Eighty-one women admitted for breast tumor biopsy have been
followed sequentially for 12 months. Thirty-one women had clinical
stage I and II breast cancer and 50 had benign breast disease. All
these women had serum immunoglobulin IgA, IgG, IgM and IgE levels
measured by immunodiffusion and radioimmunoassay preoperatively,
two weeks postoperatively, then three months, six months, nine
months and twelve months postoperatively. Significant differences
were found in IgA and IgG levels preoperatively in the cancer
group while no differences were found in IgM or IgE levels at any
time. There was positive correlation between the extent of
metastatic breast cancer and IgA level. There was negative
correlation between the extent of metastatic breast cancer and IgM
levels. These findings raise the value of measuring the levels of
immunoglobulins in patients with breast cancer as a guide to
subclinical spread of the disease. The results may also support
the hypothesis of the role of early immune defect in
immunoglobulin metabolism in the pathogenesis of breast cancer.
- Language of Publication
- English
- Unique Identifier
- 79176719
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- MeSH Heading (Major)
- Breast Neoplasms|*IM/SU; Immunoglobulins|*AN
- MeSH Heading
- Aged; Breast Diseases|IM; Female; Human; IgA|AN; IgE|AN; IgG|AN;
IgM|AN; Middle Age; Neoplasm Metastasis; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-4790
- Country of Publication
- UNITED STATES
Record 59 from database: MEDLINE
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- Title
- Parameningeal rhabdomyosarcoma.
- Author
- Chan RC; Sutow WW; Lindberg RD
- Address
-
- Source
- Radiology, 1979 Apr, 131:1, 211-4
- Abstract
- The records of 27 patients with rhabdomyosarcoma involving the
parameningeal area (nasopharynx, paranasal sinus, and middle ear)
treated from 1961 to 1976 were reviewed. Due to the location of
the primary tumor, radiation and chemotherapy were used but
surgery was limited to simple biopsy. In the literature, spread of
tumor from these primary sites to the meninges has been as high as
26-35%. In this series, meningeal disease developed in only 2 of
the 27 patients (7%).
- Language of Publication
- English
- Unique Identifier
- 79137815
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- MeSH Heading (Major)
- Ear Neoplasms|*RA/TH; Ear, Middle|*/RA; Nasopharyngeal Neoplasms|*RA/TH;
Paranasal Sinus Neoplasms|*RA/TH; Rhabdomyosarcoma|*RA/TH
- MeSH Heading
- Adolescence; Human; Infant; Meningeal Neoplasms|RA; Neoplasm
Metastasis; Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0033-8419
- Country of Publication
- UNITED STATES
Record 60 from database: MEDLINE
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- Title
- Zosteriform inflammatory metastatic carcinoma.
- Author
- Hodge SJ; Mackel S; Owen LG
- Address
-
- Source
- Int J Dermatol, 1979 Mar, 18:2, 142-5
- Abstract
- A 57-year-old man presented with chest wall lesions and swelling
of his left arm. The rapid onset of vesicular lesions in a
dermatomal distribution resulted in an initial diagnosis of herpes
zoster. Cutaneous biopsy revealed adenocarcinoma and further
evaluation revealed a primary source of pulmonary adenocarcinoma.
Lymphatic spread of tumor cells is the most likely source of the
zosteriform skin lesions, but other possibilities are discussed.
- Language of Publication
- English
- Unique Identifier
- 79129699
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- MeSH Heading (Major)
- Adenocarcinoma|*PA; Lung Neoplasms|*PA; Skin|*PA; Skin Neoplasms|*PA
- MeSH Heading
- Case Report; Diagnosis, Differential; Herpes Zoster|PA; Human;
Male; Middle Age; Neoplasm Metastasis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0011-9059
- Country of Publication
- UNITED STATES
Record 61 from database: MEDLINE
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- Title
- Prospective staging evaluation of patients with cutaneous T-cell
lymphomas. Demonstration of a high frequency of extracutaneous
dissemination.
- Author
- Bunn PA Jr; Huberman MS; Whang Peng J; Schechter GP; Guccion JG;
Matthews MJ; Gazdar AF; Dunnick NR; Fischmann AB; Ihde DC; Cohen
MH; Fossieck B; Minna JD
- Address
-
- Source
- Ann Intern Med, 1980 Aug, 93:2, 223-30
- Abstract
- A prospective pretreatment staging evaluation was done on 49
consecutive patients with mycosis fungoides or the Sézary
syndrome to study patterns of disease spread and prognostic
factors. Routine staging procedures included complete blood count,
blood chemistries, chest roentgenogram, lymphangiogram,
radionuclide scans, bone marrow aspiration and biopsy, liver
biopsy, and lymph node biopsy. Special evaluations included
cytogenetic analysis, electron microscopy, and T-cell cytology.
Extracutaneous lymphoma was documented by light microscopy in 51%
of patients and by the three special procedures in 88%.
Extracutaneous lymphoma was most frequent in blood and lymph
nodes; 18% of patients had visceral involvement. Patients with
generalized erythroderma had a higher frequency of extracutaneous
disease than did patients with cutaneous plaques and tumors by
both light microscopy and special studies. Survival was directly
related to the type of skin involvement and the presence or
absence of extracutaneous disease. Systemic dissemination of
cutaneous T-cell lymphoma is frequent, generally asymptomatic, and
develops early via the circulation. These findings may explain why
cutaneous therapies are associated with a high frequency of
relapse.
- Language of Publication
- English
- Unique Identifier
- 80263798
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- MeSH Heading (Major)
- Lymphoma|MO/*PA/SC; Neoplasm Circulating Cells|*; Skin
Neoplasms|MO/*PA; T-Lymphocytes|*
- MeSH Heading
- Adult; Aged; Female; Human; Intestinal Neoplasms|SC; Lymphatic
Metastasis; Male; Middle Age; Mycosis Fungoides|PA; Neoplasm
Staging; Prospective Studies; Sezary Syndrome|PA
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0003-4819
- Country of Publication
- UNITED STATES
Record 62 from database: MEDLINE
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- Title
- Malignant mesothelioma of the pleura: review of 123 patients.
- Author
- Brenner J; Sordillo PP; Magill GB; Golbey RB
- Address
-
- Source
- Cancer, 1982 Jun, 49:11, 2431-5
- Abstract
- One-hundred-twenty-three cases of malignant pleural mesothelioma
were reviewed. Exposure to asbestos or to other industrial dusts
or chemicals was an important etiologic factor with 24% of
patients relating such a history. A history of prior irradiation
or previous lung disease was also occasionally noted. Diagnosis
was most often made by exploratory thoracotomy, with pleural
biopsy or cytology rarely helpful. Except for nine patients, tumor
was confined to the chest at the time of diagnosis, but in 33 of
the remaining 114 patients, spread to the abdomen or distant
metastasis was seen during the course of disease. Surgery and
radiotherapy were ineffective in preventing local recurrence.
There were only three major responses to chemotherapy in 111
trials. Median survival was 12 months, and only seven patients
(5.6%) lived more than five years. Patients with epithelial
mesothelioma and Stage I disease had the most favorable prognosis.
- Language of Publication
- English
- Unique Identifier
- 82184108
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- MeSH Heading (Major)
- Mesothelioma|*DI/PA/SU; Pleural Neoplasms|*DI/PA/SU
- MeSH Heading
- Adolescence; Female; Human; Lymphatic Metastasis; Male; Middle
Age; Neoplasm Metastasis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-543X
- Country of Publication
- UNITED STATES
Record 63 from database: MEDLINE
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- Title
- Squamous cell carcinoma of the penis. III. Treatment of regional
lymph nodes.
- Author
- Horenblas S; van Tinteren H; Delemarre JF; Moonen LM; Lustig V;
van Waardenburg EW
- Address
- Department of Urology, Netherlands Cancer Institute, Antoni van
Leeuwenhoekhuis, Amsterdam.
- Source
- J Urol, 1993 Mar, 149:3, 492-7
- Abstract
- We analyzed the management of regional lymph nodes in 110
patients with squamous cell carcinoma of the penis treated at the
Netherlands Cancer Institute between 1956 and 1989 with curative
intent. Of 66 patients who presented with unsuspected nodes 57
were placed on a surveillance program, while lymph node dissection
was performed in 5 (with adjuvant external radiation therapy in 1)
and 4 were treated with external radiation therapy only. The
management of 40 patients with clinically suspected nodes included
surveillance in 5, lymph node dissection in 27 (with adjuvant
radiotherapy in 11), biopsy in 4 and external radiation therapy in
4. Postoperative radiotherapy had been given if more than 2 nodes
were involved or when extracapsular growth was observed. Overall,
25 patients had a regional recurrence, 5 of whom could be cured
subsequently. All regional recurrences developed within 2 years
after primary treatment. Analysis showed 100% survival in
histologically proved node negative patients (stage pN0). The
success of lymph node dissection was related to the extent of the
metastatic spread and to the number of involved nodes. Patients
with 1 positive node and unilateral inguinal involvement showed a
statistically significant survival advantage compared to patients
with more extensive spread. Considering the indications for node
dissection we found a clear relationship among T category, grade
and the probability of lymph node invasion. Patients with stage T1
tumors and stage T2, grades 1 and 2 tumors presented significantly
less often with lymphatic invasion than those with other
categories of disease and were less likely to have a regional
recurrence after treatment of the primary tumor only. In these
categories we recommend surveillance of the regional lymph nodes
in patients who present with unsuspected nodes. However, patients
with stage T2 grade 3, stage T3 and operable stage T4 tumors
should undergo an immediate inguinal node dissection because of
the high probability of clinically occult lymph node invasion (in
our material more than 50%). With respect to the extent of the
node dissection, we found that the likelihood of spread to the
contralateral and/or pelvic regions was related to the number of
invaded nodes in the inguinal region. We recommend contralateral
node dissection and unilateral pelvic node dissection when 2 or
more positive nodes are found in the dissected groin specimen.
Primary pelvic node dissection should be performed in patients who
present initially with cytologically or biopsy proved positive
inguinal nodes.(ABSTRACT TRUNCATED AT 400 WORDS)
- Language of Publication
- English
- Unique Identifier
- 93172416
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- MeSH Heading (Major)
- Carcinoma, Squamous Cell|MO/PA/*SC/*TH; Penile Neoplasms|MO/PA/*TH
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Clinical Protocols; Combined
Modality Therapy; Follow-Up Studies; Human; Lymph Node Excision;
Lymphatic Metastasis; Male; Middle Age; Neoplasm Recurrence,
Local|EP; Neoplasm Staging; Remission Induction; Survival Rate
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-5347
- Country of Publication
- UNITED STATES
Record 64 from database: MEDLINE
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- Title
- Staging of cancer of the breast as a guide to therapy.
- Author
- Beahrs OH
- Address
-
- Source
- Cancer, 1984 Feb, 53:3 Suppl, 592-4
- Abstract
- Staging of a cancer of the breast reflects the anatomic extent
of the tumor either at the time of diagnosis prior to treatment
based on clinical, diagnostic, and biopsy information or at the
time of postsurgical resection when all pathologic information
obtained or studied of the resected specimen is used. In the
future, chemical or biological markers may add another dimension
to staging. There have been several schemes suggested for staging
breast cancer, but the current recommendation of the American
Joint Committee on Cancer (AJCC) jointly with the TNM Committee of
the International Union against Cancer (UICC) should be
universally used. More complete definitions of staging of the
primary tumor (T), nodes (N), and distant spread (M), are
discussed in this report. It is stressed that, obviously, the
smaller a cancer and the earlier it is diagnosed has a greater
influence on therapy.
- Language of Publication
- English
- Unique Identifier
- 84106261
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- MeSH Heading (Major)
- Breast Neoplasms|*PA
- MeSH Heading
- Breast|PA; Human; Lymph Nodes|PA; Lymphatic Metastasis|PA;
Neoplasm Staging
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-543X
- Country of Publication
- UNITED STATES
Record 65 from database: MEDLINE
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- Title
- Merkel cell carcinoma of the eyelid and periocular tissues.
- Author
- Rubsamen PE; Tanenbaum M; Grove AS; Gould E
- Address
- Department of Ophthalmology, Bascom Palmer Eye Institute, Miami,
Florida 33101.
- Source
- Am J Ophthalmol, 1992 Jun, 113:6, 674-80
- Abstract
- Five patients had eyelid and periocular Merkel cell carcinoma.
The tumor was located on the left lower eyelid in two patients,
the left upper eyelid in one patient, the right upper eyelid in
one patient, and was metastatic to the right outer canthus in one
patient. The mean duration of symptoms was approximately four
months. The diagnosis of Merkel cell carcinoma was not suspected
clinically in any of the four primary eyelid cases, but was only
established on histopathologic examination of biopsy specimens.
Light microscopy disclosed carcinoma with small primitive cells in
all five tumor biopsy specimens. Immunohistochemical studies
showed neuron-specific enolase and keratin and transmission
electron microscopy demonstrated neurosecretory granules typical
for Merkel cell carcinoma. All five patients in this study were
treated with wide surgical excision of the eyelid tumors with
intraoperative frozen-section monitoring of the margins of
resection. The left lower eyelid Merkel cell carcinoma spread to
the preauricular lymph node in one patient. This patient
subsequently died of metastatic Merkel cell carcinoma. One patient
with metastatic right outer canthus Merkel cell carcinoma received
radiotherapy (6,550 cGy). Eyelid Merkel cell carcinoma has the
potential for recurrence and metastatic spread. We recommend
lifetime follow-up for patients treated for eyelid Merkel cell
carcinoma.
- Language of Publication
- English
- Unique Identifier
- 92286335
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- MeSH Heading (Major)
- Carcinoma, Merkel Cell|*PA/RT/SU; Eyelid Neoplasms|*PA/RT/SU;
Facial Neoplasms|*PA/RT/SU
- MeSH Heading
- Aged; Aged, 80 and over; Case Report; Female; Human; Lymph
Nodes|PA; Lymphatic Metastasis|PA; Male; Middle Age; Neoplasm
Recurrence, Local
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9394
- Country of Publication
- UNITED STATES
Record 66 from database: MEDLINE
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- Title
- Computed tomography in carcinoma of the rectum.
- Author
- Zaunbauer W; Haertel M; Fuchs WA
- Address
-
- Source
- Gastrointest Radiol, 1981 Jan, 6:1, 79-84
- Abstract
- A total of 11 cases of untreated carcinoma of the rectosigmoid
colon and 56 cases of recurrent rectosigmoid carcinoma have been
investigated by computed tomography. A tumor size of more than 2
cm in diameter is easily demonstrated within the rectosigmoid
wall. Invasion of the pararectal fatty planes and the neighboring
structures and organs is conclusively diagnosed when obliteration
of the demarcating fat planes is demonstrated. Enlargement of the
regional lymph nodes of more than 15 mm diameter indicates
malignant metastatic spread. Local malignant recurrence following
complete resection of the rectum is recognized when the tumor size
has reached 2 cm or more. Fine-needle aspiration biopsy may be
necessary to conclusively identify malignant tissue within the
postoperative cavity.
- Language of Publication
- English
- Unique Identifier
- 81261785
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- MeSH Heading (Major)
- Rectal Neoplasms|*RA; Tomography, X-Ray Computed|*
- MeSH Heading
- Adult; Aged; Female; Human; Lymphatic Metastasis; Male; Middle
Age; Neoplasm Recurrence, Local|RA; Neoplasm Staging|MT
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0364-2356
- Country of Publication
- UNITED STATES
Record 67 from database: MEDLINE
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- Title
- Sebaceous carcinoma of meibomian gland origin. The diagnostic
importance of pagetoid spread of neoplastic cells.
- Author
- Russell WG; Page DL; Hough AJ; Rogers LW
- Address
-
- Source
- Am J Clin Pathol, 1980 Apr, 73:4, 504-11
- Abstract
- The clinical and pathologic features of four sebaceous
carcinomas primary located in the eyelids were studied in detail.
The neoplasms occurred in four patients of ages 62 to 76 years,
were often misdiagnosed at initial excision, and recurred in all
four cases. Three of the four cases required orbital exenteration,
and preauricular lymph node metastases developed in two. The
tumors were characterized by variable histologic growth patterns
and evidence of sebaceous differentiation. Pagetoid spread of the
neoplastic cells in the overlying epithelium was found in all four
cases. Recognition of the pagetoid growth pattern in biopsy
material was essential in correctly diagnosing two of the four
cases. It is one of the important features enabling sebaceous
carcinoma to be distinguished from basal cell carcinomas showing
sebaceous differentiation.
- Language of Publication
- English
- Unique Identifier
- 80172509
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- MeSH Heading (Major)
- Carcinoma|*PA/SU; Eyelid Neoplasms|*PA/SU; Eyelids|*PA;
Meibomian Glands|*PA; Sebaceous Gland Neoplasms|*PA/SU
- MeSH Heading
- Aged; Case Report; Diagnostic Errors; Epithelium|PA; Female;
Human; Lymphatic Metastasis; Male; Middle Age; Neoplasm
Recurrence, Local|PA; Orbit|SU; Support, U.S. Gov't, Non-P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9173
- Country of Publication
- UNITED STATES
Record 68 from database: MEDLINE
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- Title
- Prognostic significance of morphology of tumor and
retroperitoneal lymph nodes in epithelial carcinoma of the ovary.
I. Correlation with lymph node metastasis.
- Author
- Chen SS; Lee L
- Address
-
- Source
- Gynecol Oncol, 1984 May, 18:1, 87-93
- Abstract
- The prognostic indices based on a morphologic study of tumor and
retroperitoneal lymph nodes in 63 patients with epithelial
carcinoma of the ovary are reported. The purpose of the study was
to identify those variables most frequently related to nodal
involvement. The cases in the series consisted of 11 Stage I, 10
Stage II, 34 Stage III, and 8 Stage IV. Histologic distribution
was 60.4% serous type, 11.1% mucinous, 6.3% endometrioid, 6.3%
clear cell, and 15.9% unclassified. All patients had maximal
surgery and selective biopsy of para-aortic and pelvic lymph
nodes. The results showed statistically significant variables
associated with nodal metastasis in both primary tumor and
regional lymph nodes. The indices in primary tumor were grade of
tumor, vascular invasion, lymphocytic infiltration, and stromal
fibrosis; those in lymph node were type of lymph node reaction,
sinus histiocytosis, and fibroblastic proliferation. The nodes
with lymphocyte depletion were associated with nodal spread in
81.3% of cases. It is concluded that morphologic study of tumor
and lymph node could identify prognostic factors predicting
regional nodal metastasis in ovarian carcinoma.
- Language of Publication
- English
- Unique Identifier
- 84183805
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- MeSH Heading (Major)
- Lymph Nodes|IM/*PA; Ovarian Neoplasms|BS/*PA/SU; Retroperitoneal
Neoplasms|*SC
- MeSH Heading
- Female; Human; Lymphatic Metastasis; Lymphocyte Depletion;
Neoplasm Staging; Prognosis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0090-8258
- Country of Publication
- UNITED STATES
Record 69 from database: MEDLINE
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- Title
- Post-thoracotomy diagnostic and staging conversion rates of
clinically staged I lung cancer.
- Author
- Valente M; Pastorino U; Piva L; Guzzon A; Ravasi G
- Address
-
- Source
- Tumori, 1981 May, 67:3, 239-43
- Abstract
- The accuracy of stage I lung cancer assessment achieved by
traditional clinico-diagnostic staging was retrospectively
evaluated in 164 consecutive patients who underwent thoracotomy.
The diagnostic conversion rate was 6.7% (1 carcinoid and 10
innocent pulmonary lesions) and occurred only in the subset of
patients lacking preoperative pathologic confirmation (15%). The
conversion rate to unresectable tumor extent was 8% (11/153), and
local spread was the main cause of unresectability (5.5%). The
staging conversion rate was 29% (43/153): the conversion rate for
nodal evaluation was double that of primary tumor evaluation (24%
versus 12%), but conversion to anatomically unresectable nodal
diffusion occurred in only one patient (0.6%). The ability of the
surgeon to convert the wrong diagnosis was scanty without
extemporary biopsy, and 7 patients with innocent lesions underwent
standard resection for primary cancer. Surgical staging was a
precise as pathological staging in primary tumor evaluation, but
was faulty in nodal evaluation (15% error in sN- and sN1-2
assessment). It is concluded that following stage I lung cancer
assessment by traditional means, supplementary examinations are
requested for a better sensitivity of pathological confirmation
and a better refinement of local spread. Better nodal evaluation
has less value until a biologic limit to surgery for anatomically
resectable nodal diffusion is universally accepted.
- Language of Publication
- English
- Unique Identifier
- 82018500
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- MeSH Heading (Major)
- Lung Neoplasms|DI/*PA
- MeSH Heading
- Adult; Aged; Diagnostic Techniques, Surgical; Female; Human;
Lymphatic Metastasis; Male; Middle Age; Neoplasm Staging;
Retrospective Studies
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0300-8916
- Country of Publication
- ITALY
Record 70 from database: MEDLINE
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- Title
- Preoperative prediction of nodal state in gastric cancer by
nuclear DNA content.
- Author
- Hashizume T; Nakajima T; Nagamachi Y
- Address
- First Department of Surgery, Gumma University School of
Medicine, Japan.
- Source
- Eur J Surg, 1991 Apr, 157:4, 267-9
- Abstract
- To see if there was an association between the number of lymph
node metastases and the macroscopic findings of the tumour (such
as size, location, and gross appearance), the nuclear DNA content
was cytophotometrically analysed in biopsy specimens taken at
preoperative endoscopy from 84 cases of gastric cancer. The DNA
ploidy patterns were classified into type D, type A1, and type A2,
according to the stem lines and the degree of scatter of the
cells. Lymph nodes were positive in 2 of 20 (10%) in type D and 10
of 30 (33%) in type A1; these were both significantly lower than
that in type A2 (24 of 34, 71%). Knowing the degree of nodes
metastases or the microscopic lymphatic spread before the
operation is almost impossible at present; the nuclear DNA content
is closely associated with metastatic content of the nodes, so the
cytophotometric determination of the DNA ploidy patterns from
biopsy specimens may be useful in predicting the nodal state.
- Language of Publication
- English
- Unique Identifier
- 91308501
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- MeSH Heading (Major)
- DNA, Neoplasm|*AN; Lymphatic Metastasis|*DI; Stomach Neoplasms|*PA/SU
- MeSH Heading
- Aged; Female; Human; Male; Middle Age; Ploidies
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1102-4151
- Country of Publication
- SWEDEN
Record 71 from database: MEDLINE
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- Title
- Infratentorial glioblastoma: the role of neuraxis irradiation.
- Author
- Kopelson G; Linggood R
- Address
-
- Source
- Int J Radiat Oncol Biol Phys, 1982 Jun, 8:6, 999-1003
- Abstract
- The patterns of clinical-and autopsy-documented tumor spread
were evaluated for 15 patients with biopsy-proven infratentorial
(8 cerebellar, 2 brainstem, 5 intramedullary spinal cord)
glioblastoma. No patient developed clinical nor autopsy evidence
of subarachnoid dissemination, even though no patient had received
craniospinal axis irradiation. Fully 14 of the 21 previously
reported patients with subarachnoid dissemination from
infratentorial glioblastoma had this diagnosis made only at
autopsy. The overall poor prognosis at present (8% 3-year survival
from the present series and recent literature) along with the
demonstrated pattern of local-regional aggressiveness as the major
form of initial spread and post-irradiation recurrence, suggests
that routine craniospinal axis irradiation may not be indicated
for most patients with infratentorial glioblastoma.
- Language of Publication
- English
- Unique Identifier
- 82265210
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- MeSH Heading (Major)
- Astrocytoma|*RT; Brain Neoplasms|*RT; Cerebellar Neoplasms|*RT;
Glioma|*RT; Spinal Cord Neoplasms|*RT
- MeSH Heading
- Adolescence; Adult; Aged; Brain Stem; Child; Female; Follow-Up
Studies; Human; Male; Middle Age; Neoplasm Metastasis; Prognosis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0360-3016
- Country of Publication
- UNITED STATES
Record 72 from database: MEDLINE
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- Title
- Adenocarcinoma of the gastric cardia. The choice of gastrectomy.
- Author
- Papachristou DN; Fortner JG
- Address
-
- Source
- Ann Surg, 1980 Jul, 192:1, 58-64
- Abstract
- A retrospective study of 101 patients with adenocarcinoma of the
gastric cardia treated with proximal subtotal, extended proximal
subtotal, total, and extended total gastrectomy demonstrated the
following: 1) There were no five year survivors among patients
with TNM stage III and IV disease. 2) Surgical treatment was
curative only in the presence of stage I and II disease, where
extended total gastrectomy resulted in a significantly higher
survival rate than proximal subtotal gastrectomy (p less than
0.03). 3) Proximal subtotal gastrectomy resulted in a high
incidence of local recurrence, particularly when it was applied in
patients with stage I and II neoplasms. 4) There were no
significant differences in operative mortality between the four
procedures. Since the choice of operative procedure makes a
difference only in patients with TNM stage I and II disease,
intraoperative classification should be considered in the
management of adenocarcinoma of the cardia. Classification should
be based on lymph node biopsy unless the neoplasm has spread
beyond the confines of gastrectomy.
- Language of Publication
- English
- Unique Identifier
- 80264331
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- MeSH Heading (Major)
- Adenocarcinoma|MO/PA/*SU; Cardia|*; Gastrectomy|*MT; Stomach
Neoplasms|MO/PA/*SU
- MeSH Heading
- Adult; Aged; Comparative Study; Esophageal Neoplasms|SC/SU;
Esophagogastric Junction|SU; Female; Follow-Up Studies; Human;
Lymphatic Metastasis; Male; Middle Age; Neoplasm Staging;
Retrospective Studies; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0003-4932
- Country of Publication
- UNITED STATES
Record 73 from database: MEDLINE
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- Title
- Bone marrow evaluation in small cell lung cancer.
- Author
- Muss HB; Jackson DV Jr; Richards F 2d; White DR; Cooper MR;
Stuart JJ; Spurr CL; Lawhon K; Watson NE; Shore A
- Address
-
- Source
- Am J Clin Oncol, 1984 Feb, 7:1, 59-63
- Abstract
- The records of 87 patients with small cell lung cancer were
reviewed. Patients were clinically staged with bone marrow
aspirate and biopsy as well as radionuclide scans of bone, liver,
and brain. Extrathoracic spread was noted in 54% (47/87) and
limited disease in 46% (40/87). The bone marrow evaluation was
positive in 13/62 patients (21%) and seven of these thirteen
patients had normal bone scans (54%). Of these seven patients,
five had no other evidence of distant metastases and their
survival was 7-10 months, considerably shorter than patients found
to have limited disease. Bone marrow examination appears to
complement radionuclide scanning in the initial staging of
patients with small cell carcinoma of the lung and provides
important prognostic information.
- Language of Publication
- English
- Unique Identifier
- 84125193
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- MeSH Heading (Major)
- Bone Marrow Examination|*; Carcinoma, Small Cell|MO/*TH; Lung
Neoplasms|MO/*TH
- MeSH Heading
- Bone and Bones|RI; Bone Neoplasms|SC; Brain|RI; Combined
Modality Therapy; Evaluation Studies; Human; Liver|RI; Lymphatic
Metastasis; Neoplasm Staging; Prognosis; Retrospective Studies;
Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0277-3732
- Country of Publication
- UNITED STATES
Record 74 from database: MEDLINE
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- Title
- Current imaging strategies for colorectal cancer.
- Author
- Collier BD; Foley WD
- Address
- Department of Nuclear Medicine, Medical College of Wisconsin,
Milwaukee 53226.
- Source
- J Nucl Med, 1993 Mar, 34:3 Suppl, 537-40
- Abstract
- Endoscopy and barium enema examinations are used to identify
the primary site of disease in patients with clinical suspicion
of colorectal cancer. Once colorectal cancer has been confirmed
by imaging studies and biopsy, preoperative evaluation is
directed toward accurate disease staging. Most currently
available imaging techniques are inaccurate for detecting
transmural extension, perienteric spread of tumors and distant
lymph node involvement. Although both computed tomography (CT)
and magnetic resonance imaging (MRI) have an unacceptably low
sensitivity for accurate staging, CT is clearly superior to MRI
for detecting extrahepatic metastases. Transrectal
ultrasonography, however, is a promising new method for
detecting perirectal spread of disease. The diagnostic efficacy
of MRI and intravenous dynamic hepatic CT for detecting liver
metastases is approximately equal. CT during arterial
portography is recommended before resection of solitary liver
metastases. Chest radiography is also part of the routine
preoperative evaluation. Bone scans are rarely performed in
patients without the skeletal pain suggestive of bone
metastases. During the years following surgery for colorectal
cancer, many patients undergo special imaging studies to
identify local tumor recurrence, secondary tumor growth
elsewhere within the large bowel and both regional and distant
spread of disease. Thus, for the patient with a sharply
increasing carcinoembryonic antigen level, CT of the abdomen and
liver is the current recommendation. Immunoscintigraphy is a new
imaging modality that addresses some of the limitations of
current diagnostic procedures for colorectal cancer. This
procedure gives whole body information on disease extent,
especially in the extrahepatic abdomen and pelvis, and can
therefore contribute to patient management decisions.
- Language of Publication
- English
- Unique Identifier
- 93179987
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- MeSH Heading (Major)
- Colorectal Neoplasms|*DI/PA
- MeSH Heading
- Human; Liver Neoplasms|SC; Lymphatic Metastasis; Magnetic
Resonance Imaging; Neoplasm Recurrence, Local; Tomography, X-Ray
Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0161-5505
- Country of Publication
- UNITED STATES
Record 75 from database: MEDLINE
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- Title
- Thoracic metastases from carcinoma of the nasopharynx: high
frequency of hilar and mediastinal lymphadenopathy.
- Author
- Daly BD; Leung SF; Cheung H; Metreweli C
- Address
- Department of Diagnostic Radiology and Organ Imaging, Chinese
University of Hong Kong, Prince of Wales Hospital, Shatin.
- Source
- AJR Am J Roentgenol, 1993 Feb, 160:2, 241-4
- Abstract
- OBJECTIVE. Nasopharyngeal carcinoma is a malignant tumor
commonly encountered in Chinese patients living in or
originating from Hong Kong or southern China. This article
describes the previously unreported radiologic appearances of
thoracic metastases from nasopharyngeal carcinoma. MATERIALS AND
METHODS. The radiographic (33 patients) and CT (eight patients)
appearances of thoracic metastases from nasopharyngeal carcinoma
were studied retrospectively. All 33 patients had biopsy-proved
primary nasopharyngeal carcinoma, and seven patients had
biopsy-proved thoracic metastases. Radiologic and clinical
evidence of metastases was unequivocal in 26 others, 16 of whom
had synchronous spread to cervical lymph nodes, bone, or liver.
RESULTS. Twenty-one patients (64%) had evidence of thoracic
lymphadenopathy, most frequently hilar (n = 18, 55%), on chest
radiographs or CT scans. Seventeen patients (52%) had evidence
of multiple parenchymal pulmonary metastases. Enlargement of
lymph nodes without multiple pulmonary deposits was seen in 12
patients (36%), seven of whom had radiologic signs of bronchial
obstruction, hemoptysis, or a single pulmonary lesion simulating
a synchronous bronchial neoplasm. Pleural effusions or deposits
(n = 6), lymphangitis carcinomatosa (n = 5), and rib metastases
(n = 4) also were seen. CONCLUSION. Metastases from
nasopharyngeal carcinoma may be detected in a wide range of
thoracic sites. This disease appears to be as likely to
disseminate to the mediastinal or hilar lymph nodes as to the
pulmonary parenchyma, and it can simulate a primary bronchial
tumor or lymphoma.
- Language of Publication
- English
- Unique Identifier
- 93142635
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- MeSH Heading (Major)
- Carcinoma, Squamous Cell|RA/*SC; Lymph Nodes|*RA;
Nasopharyngeal Neoplasms|*PA; Thoracic Neoplasms|RA/*SC
- MeSH Heading
- Adult; Female; Human; Lung Neoplasms|RA/SC; Lymphatic
Metastasis|RA; Male; Mediastinal Neoplasms|RA/SC; Middle Age;
Retrospective Studies; Tomography, X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0361-803X
- Country of Publication
- UNITED STATES
Record 76 from database: MEDLINE
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- Title
- Effect of Matrigel and laminin peptide YIGSR on tumor growth
and metastasis [see comments]
- Author
- Yamamura K; Kibbey MC; Jun SH; Kleinman HK
- Address
- Laboratory of Developmental Biology, National Institute of
Dental Research, NIH, Bethesda, MD 20892.
- Source
- Semin Cancer Biol, 1993 Aug, 4:4, 259-65
- Abstract
- Basement membrane has a variety of effects on tumor cells and
promotes malignant behavior. Tumor cell growth is enhanced both
in vitro and in vivo in mice in the presence of basement
membrane. This has led to the ability to grow various tumors
including human biopsy specimens in nude mice. Furthermore, low
cell numbers can be used when coinjected with Matrigel, a
basement membrane extract. The basement membrane glycoprotein
laminin is important in promoting invasive behavior and the
level of a 32/67 kDa laminin receptor has been shown to
correlate with malignancy. A sequence of five amino acids,
tyrosine-isoleucine-glycine-serine-arginine (YIGSR) has been
shown to recognize this receptor and to reduce experimental
metastases (tail vein injection resulting in colonization of the
lung) and subcutaneous tumor growth. This peptide is active in
both models either when coinjected or when daily intraperitoneal
injections are given after tumor growth has initiated. YIGSR
does not effect cell arrest but does inhibit angiogenesis which
is necessary for tumor growth. YIGSR also appears to have an
additional antitumor effect via its interaction with a specific
receptor. YIGSR-adherent cells established after 30 successive
selections on YIGSR-coated dishes in vitro formed more lung
colonies after intravenous injection and larger tumors after
subcutaneous injection than the parent B16F10 melanoma cells.
The YIGSR-non-adherent cells formed fewer lung colonies and
smaller subcutaneous tumors. These data demonstrate the
importance of laminin-tumor cell interactions in malignancies
and suggest that a short sequence from laminin has multiple
effects in reducing tumor growth and spread.(ABSTRACT TRUNCATED
AT 250 WORDS)
- Language of Publication
- English
- Unique Identifier
- 94003091
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- MeSH Heading (Major)
- Collagen|CH/*PH; Laminin|CH/*PH; Neoplasms, Experimental|*PA;
Oligopeptides|CH/*PH; Proteoglycans|CH/*PH
- MeSH Heading
- Amino Acid Sequence; Animal; Basement Membrane|PH; Cell
Division|DE; Drug Combinations; Human; Mice; Molecular Sequence
Data; Neoplasm Metastasis; Receptors, Laminin|PH; Tumor Cells,
Cultured
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 1044-579X
- Country of Publication
- UNITED STATES
Record 77 from database: MEDLINE
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- Title
- Thoracoscopic lymph node staging for esophageal cancer.
- Author
- Krasna MJ; McLaughlin JS
- Address
- Division of Thoracic and Cardiovascular Surgery, University of
Maryland School of Medicine, Baltimore 21201.
- Source
- Ann Thorac Surg, 1993 Sep, 56:3, 671-4
- Abstract
- Thoracoscopy allows evaluation of the mediastinum and
assessment of the local spread of malignancy. Adjuvant therapy
trials have shown some increased survival for esophageal cancer
although morbidity is high. Preoperative staging may allow
appropriate allocation of adjuvant therapy. Patients with
esophageal cancer underwent computed tomographic scan, magnetic
resonance imaging, and endoesophageal ultrasonography.
Thoracoscopic staging was performed through the left chest with
biopsy of American Thoracic Society level 5 and 6 and 8 and 9
lymph nodes. Resection at a separate sitting with complete
intraoperative lymph node sampling was done. Fourteen patients
underwent thoracoscopic lymph node staging. One procedure could
not be completed because of adhesions. Of the 13 patients
undergoing successful staging, all had correct thoracic lymph
node staging confirmed at surgical exploration. Two patients
with adenocarcinoma of the distal third/gastroesophageal
junction were found at laparotomy to have positive celiac lymph
nodes. Two patients who had lymph nodes positive at computed
tomographic scan and magnetic resonance imaging were found to
have negative lymph nodes at thoracoscopy and subsequent
resection. Two patients were found to have pulmonary metastasis
at thoracoscopy. Lymph node stage in esophageal carcinoma is an
important prognostic indicator. Thoracoscopic lymph node staging
provides accurate pre-resection staging information.
- Language of Publication
- English
- Unique Identifier
- 93393316
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- MeSH Heading (Major)
- Adenocarcinoma|PA/*SC; Carcinoma, Squamous Cell|PA/*SC;
Esophageal Neoplasms|*PA; Thoracoscopy|*
- MeSH Heading
- Comparative Study; Diagnostic Imaging; Female; Human;
Lymphatic Metastasis; Male; Neoplasm Staging
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE
- ISSN
- 0003-4975
- Country of Publication
- UNITED STATES
Record 78 from database: MEDLINE
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- Title
- Variations in the ganglioside profile of uveal melanoma
correlate with cytologic heterogeneity.
- Author
- Kanda S; Cochran AJ; Lee WR; Morton DL; Irie RF
- Address
- Department of Surgery, Jonsson Comprehensive Cancer Center,
UCLA School of Medicine 90024.
- Source
- Int J Cancer, 1992 Nov, 52:5, 682-7
- Abstract
- Gangliosides may play an important role in the proliferation
and spread of human malignant melanoma. Because the frequency of
metastases in uveal and cutaneous melanoma differs, it is
possible that they may express different gangliosides. We
analyzed the ganglioside profiles of primary uveal melanoma in
14 cases and of cutaneous melanoma metastasis in 19 cases. In
cutaneous melanoma, GM3 ranged from 4.2% to 74.6% and GD3 from
22.1% to 91.8% of total lipid-bound sialic acid. GM2 (found in
13 of 19 cases, ranging from 0.5% to 11.7%), GD2 (11/19,
0.5%-22.0%) and 9-O-acetyl-GD3 (13/19, 0.5%-12.6%) were also
frequently observed. By contrast, in 11 cases of uveal melanoma,
GM3 was > 90%, GD3 was < 10%, GM2 was < 1.1%; neither
GD2 nor 9-O-acetyl-GD3 were detected. The ganglioside profiles
of these uveal melanomas were virtually identical to those of
normal melanocytes obtained from foreskins. Histological
examination of these 11 biopsies showed a monomorphous cell
composition, but neither infiltration of lymphocytes or
melanophages nor cell necrosis was observed. In 3 other cases,
GD3 was increased to 19.5%-46.0%. Histological examination of
these 3 biopsy specimens showed at least 2 populations of tumor
cells that were separable based on morphological grounds, and
mononuclear inflammatory cells interspersed among the tumor
cells. An increase in GD3 appears to be related to tumor
polyclonality and infiltration of the tumor by lymphocytes and
macrophages. These results suggest that ganglioside expression
of uveal melanoma is associated with host immune responses to
the tumor. Furthermore, the low metastatic capacity of uveal
melanoma, in contrast to the high metastatic rate of cutaneous
melanoma, may be a result of its differentiated ganglioside
expression, which is strikingly similar to that of normal
melanocytes.
- Language of Publication
- English
- Unique Identifier
- 93052851
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- MeSH Heading (Major)
- Gangliosides|*CH; Melanoma|*CH/PA; Uveal Neoplasms|*CH/PA
- MeSH Heading
- Human; Neoplasm Metastasis; Skin Neoplasms|CH; Support, U.S.
Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0020-7136
- Country of Publication
- UNITED STATES
Record 79 from database: MEDLINE
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- Title
- Complementation of intracavitary and intravenous
administration of a monoclonal antibody (B72.3) in patients with
carcinoma [published erratum appears in Cancer Res 1987 Nov
15;47(22):6161]
- Author
- Colcher D; Esteban J; Carrasquillo JA; Sugarbaker P; Reynolds
JC; Bryant G; Larson SM; Schlom J
- Address
-
- Source
- Cancer Res, 1987 Aug, 47:15, 4218-24
- Abstract
- Monoclonal antibody (MAb) B72.3 has been shown to have
selective reactivity for a wide range of carcinomas (colorectal,
ovarian, breast, lung, gastric, and endometrial) versus normal
adult tissues. 131I-Labeled B72.3 IgG has recently been shown to
selectively bind carcinoma lesions when administered i.v. in
patients with metastatic colorectal cancer. We report here the
first direct comparison of i.p. administered [131I]B72.3 IgG to
specifically localize metastatic carcinoma. Three of 10 patients
studied were negative for tumor detection by both CAT scan and
X-ray but were positive for tumor localization via gamma
scanning i.p. administered 131I-labeled MAb B72.3 IgG. Direct
analyses of biopsy specimens of carcinoma and normal tissues
demonstrated ratios of greater than 70:1 (based on percentage of
injected dose/mg) for tumor MAb localization versus normal
tissues. Specificity of [131I]B72.3 tumor targeting was
demonstrated by the concomitant administration of an equal dose
of an 125I-labeled isotype identical (IgG1) control MAb.
Simultaneous i.p. administration of [131I]B72.3, and i.v.
administration of [125I]B72.3 in individual patients
demonstrated: peritoneal implants are targeted more efficiently
via i.p. MAb administration, and hematogenously spread and lymph
node metastases as well as local recurrences are targeted more
efficiently by i.v. administered MAb. No antibody toxicity was
observed in any patients. Pharmacokinetics of MAb clearance
demonstrated that only 10 to 30% of the i.p. administered MAb
was found in plasma. These studies thus demonstrate the efficacy
of intracavitary MAb administration as well as the advantage of
the concomitant use of intracavitary and i.v. administered MAbs
for tumor targeting and for potential MAb guided therapy of
metastatic carcinoma.
- Language of Publication
- English
- Unique Identifier
- 87273209
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- MeSH Heading (Major)
- Antibodies, Monoclonal|AD/*DU/ME; Antibodies, Neoplasm|AD/*DU/ME;
Colonic Neoplasms|IM/*PA; Neoplasm Metastasis|IM/*RI; Rectal
Neoplasms|IM/*PA
- MeSH Heading
- Adolescence; Adult; Antibody Specificity; Human; Injections,
Intraperitoneal; Injections, Intravenous; Iodine
Radioisotopes|AD/DU; Metabolic Clearance Rate; Middle Age
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-5472
- Country of Publication
- UNITED STATES
Record 80 from database: MEDLINE
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- Title
- Progress in the recognition and treatment of soft tissue
sarcomas.
- Author
- Eilber FR; Huth JF; Mirra J; Rosen G
- Address
- Department of Surgery/Oncology, University of California, Los
Angeles 90024.
- Source
- Cancer, 1990 Feb, 65:3 Suppl, 660-6
- Abstract
- Over the past 10 years there has been significant progress
made in the recognition and treatment of soft tissue sarcomas.
With the advent of CAT scans and MRI, preoperative delineation
of soft tissue tumors has become readily available. The
diagnostic use of these modalities in patients presenting with
an ill-defined asymptomatic mass has been extremely helpful in
terms of screening patients to decide whether or not a biopsy is
indicated. These techniques have also provided a much clearer
delineation of the anatomic extent of the primary tumor, which
has been of great assistance both in radiation therapy treatment
calculations as well as in preoperative surgical planning. The
recognition that tumor grade is the dominant prognostic variable
has resulted in the more common use of a grading system, and a
more uniform reporting and stratification of end results. Recent
studies with immunohistochemical staining have proven of value
in determining the histogenesis of many tumors that in the past
were difficult to classify accurately. Most recently the use of
flow cytometry suggests that this will also be a valuable
adjunct in determining tumor grade and thereby prognosis. The
most recent investigations of molecular biologic evaluation of
genetic DNA and RNA sequences, as well as of oncogenes are
extremely interesting from a diagnostic standpoint and in
demonstrating the potential of molecular biologic evaluation for
understanding the origin of these tumors. Multimodality therapy
with surgery, radiation, chemotherapy, or all three has resulted
in a marked improvement in local tumor control for patients with
soft tissue sarcomas. The combination of modalities has allowed
smaller surgical excisions of the tumor and thereby preservation
of the extremity and much of its function. There are currently
several different methods of multimodality therapy used
including neoadjuvant therapy and postoperative therapy, both of
which have been proven efficacious. Chemotherapy is now playing
an increased role in clinical investigation and treatment. The
availability of Adriamycin, DTIC, cisplatin, and most recently
ifosfamide has added several chemotherapeutic agents for use by
the clinician. Combination chemotherapy and radiation is of
value in the neoadjuvant setting, and several studies are now
underway to determine whether postoperative adjuvant
chemotherapy is of similar value in reducing systemic spread of
disease. Finally, surgical resection of pulmonary metastases has
been proven of value in 20% to 25% of patients who subsequently
develop metastatic disease. As a result of these advances in
several different treatment disciplines, the overall survival
rate and quality of life of patients with soft tissue sarcoma
have improved markedly over the past 10 years.(ABSTRACT
TRUNCATED AT 400 WORDS)
- Language of Publication
- English
- Unique Identifier
- 90149988
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- MeSH Heading (Major)
- Sarcoma|*/DI/PA/TH; Soft Tissue Neoplasms|*/DI/PA/TH
- MeSH Heading
- Antineoplastic Agents, Combined|TU; Brachytherapy; Clinical
Trials; Combined Modality Therapy; Human; Immunohistochemistry;
Magnetic Resonance Imaging; Neoplasm Metastasis; Tomography,
X-Ray Computed
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE
- ISSN
- 0008-543X
- Country of Publication
- UNITED STATES
Record 81 from database: MEDLINE
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- Title
- Squamous cell carcinoma of the penis. III. Treatment of
regional lymph nodes.
- Author
- Horenblas S; van Tinteren H; Delemarre JF; Moonen LM; Lustig
V; van Waardenburg EW
- Address
- Department of Urology, Netherlands Cancer Institute, Antoni
van Leeuwenhoekhuis, Amsterdam.
- Source
- J Urol, 1993 Mar, 149:3, 492-7
- Abstract
- We analyzed the management of regional lymph nodes in 110
patients with squamous cell carcinoma of the penis treated at
the Netherlands Cancer Institute between 1956 and 1989 with
curative intent. Of 66 patients who presented with unsuspected
nodes 57 were placed on a surveillance program, while lymph node
dissection was performed in 5 (with adjuvant external radiation
therapy in 1) and 4 were treated with external radiation therapy
only. The management of 40 patients with clinically suspected
nodes included surveillance in 5, lymph node dissection in 27
(with adjuvant radiotherapy in 11), biopsy in 4 and external
radiation therapy in 4. Postoperative radiotherapy had been
given if more than 2 nodes were involved or when extracapsular
growth was observed. Overall, 25 patients had a regional
recurrence, 5 of whom could be cured subsequently. All regional
recurrences developed within 2 years after primary treatment.
Analysis showed 100% survival in histologically proved node
negative patients (stage pN0). The success of lymph node
dissection was related to the extent of the metastatic spread
and to the number of involved nodes. Patients with 1 positive
node and unilateral inguinal involvement showed a statistically
significant survival advantage compared to patients with more
extensive spread. Considering the indications for node
dissection we found a clear relationship among T category, grade
and the probability of lymph node invasion. Patients with stage
T1 tumors and stage T2, grades 1 and 2 tumors presented
significantly less often with lymphatic invasion than those with
other categories of disease and were less likely to have a
regional recurrence after treatment of the primary tumor only.
In these categories we recommend surveillance of the regional
lymph nodes in patients who present with unsuspected nodes.
However, patients with stage T2 grade 3, stage T3 and operable
stage T4 tumors should undergo an immediate inguinal node
dissection because of the high probability of clinically occult
lymph node invasion (in our material more than 50%). With
respect to the extent of the node dissection, we found that the
likelihood of spread to the contralateral and/or pelvic regions
was related to the number of invaded nodes in the inguinal
region. We recommend contralateral node dissection and
unilateral pelvic node dissection when 2 or more positive nodes
are found in the dissected groin specimen. Primary pelvic node
dissection should be performed in patients who present initially
with cytologically or biopsy proved positive inguinal
nodes.(ABSTRACT TRUNCATED AT 400 WORDS)
- Language of Publication
- English
- Unique Identifier
- 93172416
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- MeSH Heading (Major)
- Carcinoma, Squamous Cell|MO/PA/*SC/*TH; Penile Neoplasms|MO/PA/*TH
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Clinical Protocols; Combined
Modality Therapy; Follow-Up Studies; Human; Lymph Node Excision;
Lymphatic Metastasis; Male; Middle Age; Neoplasm Recurrence,
Local|EP; Neoplasm Staging; Remission Induction; Survival Rate
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-5347
- Country of Publication
- UNITED STATES
Record 82 from database: MEDLINE
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- Title
- Lymphoscintigraphy with sentinel lymph node biopsy in
cutaneous Merkel cell carcinoma.
- Author
- Sian KU; Wagner JD; Sood R; Park HM; Havlik R; Coleman JJ
- Address
- Department of Surgery, Indiana University Medical Center,
Indianapolis, USA.
- Source
- Ann Plast Surg, 1999 Jun, 42:6, 679-82
- Abstract
- Merkel cell carcinoma (MCC) is a rare cutaneous malignancy
characterized by an aggressive clinical behavior with high
rates of locoregional and systemic recurrence. Regional
disease and distant metastases are associated with poor
prognosis. Despite a predisposition of MCC to spread via the
lymphatics, prophylactic lymph node dissection in the absence
of clinically apparent lymph node involvement is
controversial. The value of lymphoscintigraphy in cutaneous
melanoma is established in lesions with ambiguous lymphatic
drainage patterns. When used with sentinel lymph node biopsy (SLNB),
it can identify subjects with occult regional node metastasis.
The authors present 2 patients with MCC who underwent regional
node staging with lymphoscintigraphy-directed SLNB. Both
patients had sentinel nodes that were positive for metastatic
disease. In patients with MCC, minimally invasive regional
node staging SLNB may be useful in limiting the sequelae of
routine lymphadenectomies. Whether early identification and
treatment of patients with occult regional node disease can
influence survival in MCC is not known.
- Language of Publication
- English
- Unique Identifier
- 99310181
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- MeSH Heading (Major)
- Carcinoma, Merkel Cell|PA/*RI/SU; Lymph Nodes|PA/*RI; Skin
Neoplasms|PA/*RI/SU
- MeSH Heading
- Aged; Case Report; Female; Human; Lymph Node Excision;
Lymphatic Metastasis|RI; Neoplasm Staging;
Radiopharmaceuticals|DU; Technetium Tc 99m Sulfur Colloid|DU
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0148-7043
- Country of Publication
- UNITED STATES
Record 83 from database: MEDLINE
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- Title
- Comparison of c-erbB-2 oncoprotein expression in tissue and
serum of patients with stomach cancer.
- Author
- Chariyalertsak S; Sugano K; Ohkura H; Mori Y
- Address
- Division of Clinical Laboratory, National Cancer Center
Hospital, Thailand.
- Source
- Tumour Biol, 1994, 15:5, 294-303
- Abstract
- Resected specimens of 288 primary stomach cancers (175 early
cases and 113 advanced cases) and recurrent tumors or biopsy
specimens of 21 recurrent or inoperable metastatic stomach
cancers were examined immunohistochemically for expression of
c-erbB-2 oncogene product. c-erbB-2 protein-positive staining
was detected in 6.9, 15.9 and 28.6% of early, advanced and
recurrent or inoperable metastatic stomach cancers,
respectively, the difference being significant (p < 0.005).
Four patients with advanced cancer showed positive staining in
metastatic lymph nodes but not in the primary tumors. The
results of tissue immunostaining were compared with c-erbB-2
protein levels in sera of the patients measured by an
enzyme-linked immunosorbent assay. The levels of this oncogene
product were consistently low in the sera of most of the
patients with primary stomach cancers, regardless of whether
or not c-erbB-2 protein was expressed in the tumor. However,
in the recurrent or inoperable metastatic stomach cancers, 5
of 6 patients with c-erbB-2 protein-positive tumors showed
elevated levels of c-erbB-2 protein in the serum. After
following up c-erbB-2 protein levels in the sera of 3 patients
during the period of chemotherapy against recurrent or
inoperable metastatic disease, we found that the levels
increased only in the late stage. These results suggest that,
in stomach cancer, c-erbB-2 protein is likely to be excreted
into the serum at a relatively late stage, reflecting systemic
spread of the disease.
- Language of Publication
- English
- Unique Identifier
- 95084089
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- MeSH Heading (Major)
- Adenocarcinoma|*ME/PA; Carcinoma, Signet Ring Cell|*ME/PA;
Proto-Oncogene Proteins c-erbB-2|*BI/BL; Stomach Neoplasms|BL/DT/*ME/PA;
Tumor Markers, Biological|*AN/BL
- MeSH Heading
- Antineoplastic Agents, Combined|TU; Cell Membrane|PA;
Comparative Study; Enzyme-Linked Immunosorbent Assay; Human;
Immunohistochemistry; Lymphatic Metastasis; Neoplasm
Metastasis; Neoplasm Staging; Recurrence; Support, Non-U.S.
Gov't
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
- ISSN
- 1010-4283
- Country of Publication
- SWITZERLAND
Record 84 from database: MEDLINE
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- Title
- Growth characteristics and metastatic properties of human
breast cancer xenografts in immunodeficient mice.
- Author
- Visonneau S; Cesano A; Torosian MH; Miller EJ; Santoli D
- Address
- The Wistar Institute of Anatomy and Biology, Philadelphia,
Pennsylvania 19104, USA.
- Source
- Am J Pathol, 1998 May, 152:5, 1299-311
- Abstract
- We evaluated the growth and metastatic potential of two
human breast cancer cell lines and 16 patient-derived biopsy
specimens, representing the most common histological types of
breast carcinomas, upon subcutaneous implantation into severe
combined immunodeficient (SCID) mice. The method of
engraftment we used, based on implantation of intact tissue
specimens and complete immunosuppression of the host, provided
an easier system to grow human breast carcinoma specimens in
mouse models and resulted in a 50% success rate of tumor take.
No correlation was found between growth in SCID mice and
pathological diagnosis, grading, or estrogen/progesterone
receptor expression by the tumor biopsy specimen. Serial
passage of the tumor fragments in SCID mice resulted in
increased metastasis rates and more rapid emergence of a
palpable tumor mass. A tumor from a patient with infiltrating
ductal carcinoma, which grew aggressively and metastasized in
100% of the female SCID mice, was also successfully engrafted
in 100% of nonobese diabetic (NOD)/SCID female mice, but
systemic spread was minimal. Fragments of the same tumor grew
in only 33% of male SCID mice with very limited metastases. A
strong correlation (r = 0.997) was observed between tumor
burden and the presence of soluble (serum) interleukin-2
receptor, a marker associated with a subset of human breast
tumors. All together, these data indicate the usefulness of
SCID/human breast tumor xenografts for measuring tumor
progression and evaluating novel therapeutic approaches to
breast cancer.
- Language of Publication
- English
- Unique Identifier
- 98248312
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- MeSH Heading (Major)
- Breast Neoplasms|BL/GE/*PA; Carcinoma, Infiltrating Duct|BL/GE/*PA;
Carcinoma, Lobular|BL/GE/*PA; Severe Combined
Immunodeficiency|*PA
- MeSH Heading
- Adenocarcinoma|PA; Aged; Animal; Etoposide|AD; Female;
Human; Injections, Intravenous; Injections, Subcutaneous;
Lymphatic Metastasis|PA; Male; Mice; Mice, Inbred NOD; Mice,
SCID; Middle Age; Neoplasm Transplantation; Polymerase Chain
Reaction; Support, Non-U.S. Gov't; Transplantation,
Heterologous; Tumor Cells, Cultured|PA/TR; Tumor Markers,
Biological|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9440
- Country of Publication
- UNITED STATES
Record 85 from database: MEDLINE
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- Title
- Laparoscopic lymph node assessment in pretherapeutic staging
of gastric and esophageal cancer.
- Author
- Rau B; Hünerbein M; Reingruber B; Hohenberger P; Schlag PM
- Address
- Virchow Klinikum, Medical Faculty of the Humboldt
University, Robert-RÂossle Cancer Hospital, Max DelbrÂuck
Center of Molecular Medicine, Berlin, Germany.
- Source
- Recent Results Cancer Res, 1996, 142:, 209-15
- Abstract
- In gastric cancer lymph node metastases at the
hepatoduodenal ligament and in esophageal cancer, metastases
at the celiac axis are classified as distant metastases (M1
LYMPH) and implying a poor prognosis. In pretherapeutic
staging, imaging procedures such as computed tomography of the
abdomen or transcutaneous ultrasonic examination are of
limited value in the assessment of enlarged or metastatic
lymph nodes. Conversely, laparoscopic staging with subsequent
biopsy of suspicious lymph nodes provides essential diagnostic
information. After exclusion of distant metastases (liver,
lung, bone) in 73 patients with esophageal-(n = 21) and
gastric cancer (n = 52), staging laparoscopy, including
laparoscopic ultrasound, were performed during an
18-month-period (July/ 93-December/94). After laparoscopic
exclusion of peritoneal seedings, the hepatoduodenal ligament
was examined and enlarged lymph nodes were biopsied. In a
total of 73 patients, laparoscopy revealed previously
undiagnosed liver metastases in 14 and peritoneal carcinosis
in 19 patients. Additionally, in eight (esophageal cancer; n =
3, gastric cancer; n = 5) of the remaining 40 patients, lymph
nodes in the M1-position were regarded suspicious and biopsied.
In six of these, malignant spread was observed. Thus, in a
further six of 40 patients, surgically incurable situations
could be detected. In esophageal and gastric cancer, staging
laparoscopy, including laparoscopic ultrasound and biopsy, is
a sensitive technique to assess local tumor spread and distant
metastases. The detection of M1- lymph node metastases is
facilitated by the use of laparoscopic ultrasound. Tumor
spread, which limits surgical curability, can be properly
assessed and exploratory laparotomy avoided.
- Language of Publication
- English
- Unique Identifier
- 97048507
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- MeSH Heading (Major)
- Esophageal Neoplasms|*PA/TH; Stomach Neoplasms|*PA/TH
- MeSH Heading
- Human; Laparoscopy; Lymphatic Metastasis; Neoplasm Staging
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0080-0015
- Country of Publication
- GERMANY
Record 86 from database: MEDLINE
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- Title
- Staging laparotomy for endometrial carcinoma: assessment of
retroperitoneal lymph nodes.
- Author
- Chuang L; Burke TW; Tornos C; Marino BD; Mitchell MF;
Tortolero Luna G; Levenback C; Morris M; Gershenson DM
- Address
- Department of Gynecologic Oncology, University of Texas M.
D. Anderson Cancer Center, Houston 77030, USA.
- Source
- Gynecol Oncol, 1995 Aug, 58:2, 189-93
- Abstract
- The surgical staging scheme for uterine corpus cancer
adopted in 1988 by the International Federation of Gynecology
and Obstetrics assigns patients with tumor spread to
retroperitoneal lymph nodes to stage IIIC. However, a
recommended approach to the detection of lymph node metastasis
is not delineated. As part of an ongoing project to assess the
value of surgical staging procedures, we reviewed the
techniques of lymph node evaluation in 295 at-risk patients.
Cases included clinical stage I patients whose preoperative
biopsies demonstrated grade 2 or 3 adenocarcinoma or papillary
serous, clear cell, or mixed carcinoma. We arbitrarily divided
the retroperitoneal space into 10 lymphatic zones: left and
right para-aortic, common iliac, external iliac, hypogastric,
and obturator. Eighty-two percent of patients had some type of
node sampling that involved a mean of three zones.
Thirty-three of 244 sampled cases (13.5%) had nodal
metastases: 20 had gross involvement and 13 had microscopic.
We stratified patients into three groups: (1) those who had no
node sampling (n = 51), (2) those with some nodes biopsied (n
= 193), and (3) those whose node sampling included a minimum
of one para-aortic plus at least one right and left pelvic
specimen (n = 51). Retroperitoneal recurrences thought to
originate from lymph node sites were identified for the
"node-negative" patients in each group: Group 1,
4/51 (8%); Group 2, 9/173 (5%); and Group 3, 0/38 (0%).
Lymphatic site failures were seen in 8 of 33 (24%) patients
with biopsy-proven metastases. We found that failure to
systematically sample pelvic and para-aortic nodes results in
a small, but real, risk of undetected extrauterine metastasis.
A selective approach to sampling that includes biopsy from
both para-aortic and bilateral pelvic lymphatic zones appears
to provide an accurate estimate of true node negativity.
Further evaluation of this approach is warranted.
- Language of Publication
- English
- Unique Identifier
- 95347655
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- MeSH Heading (Major)
- Endometrial Neoplasms|*PA/*SU; Lymph Nodes|*PA
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Fallopian Tubes|SU; Female;
Follow-Up Studies; Human; Hysterectomy; Lymphatic Metastasis;
Middle Age; Neoplasm Staging|MT; Ovariectomy; Retroperitoneal
Space
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0090-8258
- Country of Publication
- UNITED STATES
Record 87 from database: MEDLINE
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- Title
- Mortality in prostatic carcinoma.
- Author
- Kuban DA; el Mahdi AM; Schellhammer PF
- Address
- Department of Radiation Oncology and Biophysics, Eastern
Virginia Medical School, Norfolk.
- Source
- Urology, 1989 Jan, 33:1, 1-5
- Abstract
- One hundred forty-seven patients definitively irradiated for
biopsy-proved adenocarcinoma of the prostate from December,
1975, to March, 1979, have either died after a median survival
of forty-five months or have been followed up for a minimum of
seven years. Seventy-six patients (52%) are currently alive,
62 of them with no evidence of disease. Seventy-one patients
(48%) have died, 28 without disease. In addition, 12 patients
died with prostatic carcinoma but of other causes. In
assessing the characteristics of those patients who remain
disease-free following treatment, a significant difference in
disease control was seen based on tumor stage, histologic
differentiation, pelvic lymph node status, and whether or not
tumor was present microscopically at rebiopsy. Of those
deceased patients with recurrent prostate cancer, more than
one-half had distant metastasis only. In all, 61 percent of
patients had no further evidence of prostatic carcinoma after
definitive irradiation, 20 percent had distant metastasis
alone, and only 18 percent had locally recurrent disease along
with distant disease spread.
- Language of Publication
- English
- Unique Identifier
- 89101361
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- MeSH Heading (Major)
- Prostatic Neoplasms|*MO/PA/RT
- MeSH Heading
- Aged; Aged, 80 and over; Cause of Death; Follow-Up Studies;
Human; Lymph Nodes|PA; Male; Middle Age; Neoplasm Metastasis;
Neoplasm Recurrence, Local; Neoplasm Staging; Pelvis; Support,
Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0090-4295
- Country of Publication
- UNITED STATES
Record 88 from database: MEDLINE
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- Title
- Propensity of retroperitoneal lymph node metastasis in
patients with stage I sarcoma of the uterus.
- Author
- Chen SS
- Address
- Department of Obstetrics and Gynecology, Long Island Jewish
Medical Center, New Hyde Park, New York 11042.
- Source
- Gynecol Oncol, 1989 Feb, 32:2, 215-7
- Abstract
- Information in the literature about the incidence of nodal
spread and its clinical implication in stage I sarcoma of the
uterus is limited. The purpose of this study is to provide
additional information derived from surgical staging of 20
patients who were treated by primary surgery to include total
abdominal hysterectomy, bilateral salpingo-oophorectomy, and
selective biopsy of paraaortic and pelvic nodes. Nine out of
20 patients (45%) of this small series had lymph node
metastases either to both pelvic and paraaortic nodes (6) or
pelvic nodes alone (3). This high rate of nodal involvement
was associated with deep myometrial invasion, uteri sounding
larger than 8 cm, patients older than 65 years, and
leiomyosarcoma. In 12 of 20 patients, clinical staging was an
underestimate. In a follow-up from 2 to 12 years, all 9
patients with positive nodes succumbed to their diseases. This
result indicates that incidence of nodal spread in stage I
sarcoma of the uterus is a frequent occurrence and is related
to ultimate survival. Furthermore, it suggests that lymphatic
permeation might precede hematogenous spread in early sarcoma
of the uterus.
- Language of Publication
- English
- Unique Identifier
- 89092136
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- MeSH Heading (Major)
- Sarcoma|MO/*PA; Uterine Neoplasms|MO/*PA
- MeSH Heading
- Aged; Aged, 80 and over; Female; Human; Lymphatic
Metastasis; Middle Age; Neoplasm Staging; Retroperitoneal
Space
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0090-8258
- Country of Publication
- UNITED STATES
Record 89 from database: MEDLINE
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- Title
- Preoperative diagnostics in pancreatic carcinoma: would less
be better?
- Author
- Böttger T; Engelman R; Seifert JK; Löw R; Junginger T
- Address
- Klinik und Poliklinik fÂur Allgemein- und
Abdominalchirurgie, Johannes-Gutenberg-UniversitÂat Mainz,
Germany.
- Source
- Langenbecks Arch Surg, 1998 Aug, 383:3-4, 243-8
- Abstract
- OBJECTIVE: The objective of this study was to investigate
the value of preoperative diagnostics in patients with
pancreatic carcinoma in terms of tumor diagnosis and
evaluation of resectability. PATIENTS/METHODS: From 1
September 1985 to 31 December 1997, 408 patients shown by
histology to have a ductal (n=330) or periampullary carcinoma
(n=78) were treated at our hospital. RESULTS: In determining
the presence of tumor, ultrasonography and computed tomography
(CT) had a sensitivity of 88.3% and 94.0%, respectively;
combined, they had a sensitivity of 96.2%. Endoscopic
retrograde cholangiopancreatography (ERCP) had a sensitivity
of 96.2%. Preoperative aspiration biopsy cytology had a
sensitivity of 71.4%. No correlation was found in the patients
undergoing surgery between the preoperative level of serum CA
19-9 and the presence of distant metastases. Tumor
infiltration of the portal vein was shown with a sensitivity
of 33.3%, 24.3%, and 76.5% and a specificity of 93.9%, 98.9%,
and 65.6% by ultrasonography, CT, and angiography,
respectively. Ultrasonography and CT detected liver metastases
or peritoneal carcinomatosis with a sensitivity of 35.9% each
and a specificity of 91.9% and 91.7%, respectively.
CONCLUSION: This study shows that, in 96% of patients with
pancreatic carcinoma, ultrasonography and CT are adequate for
diagnosis and for the evaluation of resectability. ERCP is not
the method of choice in the diagnosis of pancreatic carcinoma
due to its invasiveness and to the fact that it fails to
demonstrate the pathological anatomical location of the tumor;
it should only be used if a tumor is suspected despite
negative results on ultrasonography and CT or as an additional
diagnostic method to differentiate between chronic
pancreatitis and carcinoma. On account of the low sensitivity
of percutaneous aspiration biopsy cytology, this method is not
necessary preoperatively and may even lead to the spread of
tumor cells. In 7% of patients, routine laparoscopy would
additionally show liver metastases or peritoneal
carcinomatosis not demonstrated using the imaging techniques.
- Language of Publication
- English
- Unique Identifier
- 98447345
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- MeSH Heading (Major)
- Carcinoma|*DI/SU/US; Carcinoma, Infiltrating Duct|*DI/SU/US;
Pancreatic Neoplasms|*DI/SU/US
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Cholangiopancreatography,
Endoscopic Retrograde; CA-19-9 Antigen|AN; Female; Human;
Male; Middle Age; Neoplasm Invasiveness; Neoplasm Metastasis;
Sensitivity and Specificity; Tomography, X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1435-2443
- Country of Publication
- GERMANY
Record 90 from database: MEDLINE
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- Title
- A case of malignant pleural mesothelioma with metastasis to
the orbit.
- Author
- Kubota K; Furuse K; Kawahara M; Ogawara M; Ryu S; Yamamoto S
- Address
- Department of Internal Medicine, National Kinki Central
Hospital for Chest Diseases, Sakai, Osaka.
- Source
- Jpn J Clin Oncol, 1996 Dec, 26:6, 469-71
- Abstract
- A 58-year-old woman with malignant mesothelioma metastatic
to the orbit is reported. Malignant pleural mesothelioma was
diagnosed by pleural biopsy. Marked reduction of pleural
effusion was obtained with intrapleural interleukin-2 therapy.
Systemic chemotherapy failed to elicit a response after the
first recurrence of the tumor. Multiple systemic metastasis,
including metastasis to the orbit, developed and the patient
died one year and 4 months after the initial diagnosis.
Although malignant mesothelioma is known to spread
hematogenously, sometimes producing brain metastasis, there
have been few reports of orbital metastasis, and in fact the
present report may be the first clinically documented account
of its kind.
- Language of Publication
- English
- Unique Identifier
- 97154636
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- MeSH Heading (Major)
- Mesothelioma|*SC/TH; Neoplasm Circulating Cells|*; Orbital
Neoplasms|*SC; Pleural Neoplasms|*PA/TH
- MeSH Heading
- Case Report; Female; Heart Neoplasms|SC; Human;
Interleukin-2|TU; Lung Neoplasms|SC; Lymphatic Metastasis;
Middle Age; Pleural Effusion, Malignant|ET/TH; Support,
Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0368-2811
- Country of Publication
- JAPAN
Record 91 from database: MEDLINE
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- Title
- Spread of ovarian cancer after laparoscopic surgery: report
of eight cases.
- Author
- Leminen A; Lehtovirta P
- Address
- Department of Obstetrics and Gynecology, Helsinki University
Central Hospital, HYKS, 00029, Finland.
- Source
- Gynecol Oncol, 1999 Dec, 75:3, 387-90
- Abstract
- OBJECTIVE: The aim of this study was to describe early
occurrences of metastases after laparoscopy of ovarian masses
later found to be malignant. METHODS: The hospital charts of
eight women having undergone laparoscopic surgery for ovarian
mass were reviewed and analyzed. RESULTS: The mean age of the
patients was 40 years (range 25 to 66). Size of the tumor
ranged from 2 to 15 cm. In four patients the ovarian mass was
suspected to be malignant in the laparoscopy. Diagnostic
procedure (biopsy of the tumor) was performed in two and
salpingo-oophorectomy in six patients. Staging laparotomy was
performed within the mean of 17 days (range 7-29). In four
patients (50%) the cancer had spread from a localized to an
advanced stage during the delay. Ascites was present in the
laparoscopy in two of the four patients with port site or
abdominal wall metastases. CONCLUSIONS: Laparoscopic surgery
of ovarian mass later found to be malignant can cause
considerable and early spread of the cancer. Copyright 1999
Academic Press.
- Language of Publication
- English
- Unique Identifier
- 20069529
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- MeSH Heading (Major)
- Laparoscopy|*AE; Ovarian Neoplasms|PA/*SU
- MeSH Heading
- Adult; Aged; Female; Human; Middle Age; Neoplasm Metastasis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0090-8258
- Country of Publication
- UNITED STATES
Record 92 from database: MEDLINE
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- Title
- Routine CT scan in cystectomy patients: does it change
management? [published erratum appears in Urology 1996
May;47(5):785]
- Author
- Herr HW
- Address
- Urology Service, Department of Surgery Memorial Sloan,
Kettering Cancer Center, New York, USA.
- Source
- Urology, 1996 Mar, 47:3, 324-5
- Abstract
- OBJECTIVES: To evaluate the practical use of routine
computed tomography (CT) scan in changing management of
patients with muscle-invasive bladder cancer who are
candidates for cystectomy. METHODS: One hundred five patients
(52 with tumors confined to the bladder and 53 with
extravesical spread) were evaluated for cystectomy. The
presence of nodal metastasis at surgery or biopsy was
correlated with preoperative CT findings. RESULTS: The CT scan
was abnormal (nodes > 1.5 cm in size) in 32% and normal
(nodes < 1.5 cm) in 68% of 28 patients with positive nodes.
Of 52 cases with T2 tumors, CT scan was abnormal in 6, 14% (1
of 7) with positive and 11% (5 of 45) with negative nodes,
whereas of 53 with T3-4 tumors, 15 had abnormal scans, 38% (8
of 21) with positive and 22% (7 of 32) with negative nodes. CT
scan changed management (a biopsy deferred surgery) in 2 (2%)
of the 105 cases. CONCLUSIONS: A routine CT scan was not
helpful in management of operable T2 tumors but might change
therapy in selected patients with T3-4 tumors who are
considered for cystectomy.
- Language of Publication
- English
- Unique Identifier
- 96217855
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- MeSH Heading (Major)
- Bladder Neoplasms|PA/*RA/*SU; Cystectomy|*; Tomography,
X-Ray Computed|*
- MeSH Heading
- Bladder|PA; Human; Lymph Nodes|PA/RA; Lymphatic Metastasis;
Muscle Neoplasms|PA; Neoplasm Invasiveness
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0090-4295
- Country of Publication
- UNITED STATES
Record 93 from database: MEDLINE
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- Title
- Absence of epidermal growth factor receptor expression in
squamous cell carcinoma of the uterine cervix is an indicator
of limited tumor disease.
- Author
- Biesterfeld S; Schuh S; Muys L; Rath W; Mittermayer C;
Schröder W
- Address
- Institute of Pathology, University of Aachen, D-52057 Aachen,
Germany.
- Source
- Oncol Rep, 1999 Jan, 6:1, 205-9
- Abstract
- The expression of growth factors is considered as an
important diagnostic and prognostic feature in tumor
pathology. We investigated the value of the
immunohistochemical EGF-receptor expression (EGF-R) in 30
squamous cell carcinomas of the uterine cervix, treated by
radical hysterectomy and lymphadenectomy according to the
Wertheim-Meigs-Okabayashi technique. Immunohistochemical
reactions were performed on 4 microm sections from
paraffin-embedded tissue, using an indirect peroxidase method.
The staining results were evaluated semiquantitatively as
negative (n=9; 30%) or as slightly, moderately or severely
positive (n=21; 70%). The EGF-R-negative tumors were found in
less advanced tumor stages. None had invaded into the
parametrium (100%), eight were staged as T1 (89%), seven as N0
(78%), and seven showed no evidence for lymphangiosis
carcinomatosa (78%). The respective values for the EGF-R-positive
tumors ranged from 52% to 67%. However, only the difference in
parametral invasion (EGF-R-negative: 0%, EGF-R-positive: 38%)
was statistically significant (p=0.0306), probably due to the
small number of cases. The EGF-R-expression was not correlated
to histomorphological tumor grading. The results of this study
indicate an inverse correlation between EGF-R expression and
tumor spread. Assuming that this trend could be confirmed by a
larger group of patients, immunostaining for EGF-R in a tumor
biopsy could be useful to adapt surgical strategies and
adjuvant therapy in the individual patient. Moreover, the EGF-R
is an interesting target for immunotherapeutic approaches in
squamous cell cervical carcinoma.
- Language of Publication
- English
- Unique Identifier
- 99085140
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- MeSH Heading (Major)
- Carcinoma, Squamous Cell|*CH/PA; Cervix Neoplasms|*CH/PA;
Neoplasm Proteins|*AN; Receptor, Epidermal Growth Factor|*AN;
Tumor Markers, Biological|*AN
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Comparative Study;
Evaluation Studies; Female; Human; Immunoenzyme Techniques;
Lymphatic Metastasis; Middle Age; Neoplasm Invasiveness;
Neoplasm Staging; Pregnancy
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1021-335X
- Country of Publication
- GREECE
Record 94 from database: MEDLINE
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- Title
- Prognostic value of p53 protein accumulation in cancer cell
nuclei in adenocarcinoma of the uterine cervix.
- Author
- Tsuda H; Jiko K; Tsugane S; Yajima M; Yamada T; Tanemura K;
Tsunematsu R; Ohmi K; Sonoda T; Hirohashi S
- Address
- Pathology Division, National Cancer Center Research
Institute and Hospital, Tokyo.
- Source
- Jpn J Cancer Res, 1995 Nov, 86:11, 1049-53
- Abstract
- Adenocarcinoma of the uterine cervix (CxAd) is one of the
most distressing malignancies of the female reproductive
system because of its tendency to spread aggressively and to
be resistant to radiation and systemic therapies. To clarify
the prognostic significance of p53 alteration in CxAd, we
immunohistochemically examined the incidence of p53 nuclear
accumulation, which is considered to be mostly parallel with
p53 gene mutation, and its association with
clinicopathological parameters in 26 patients with CxAd. The
overall incidence of p53 nuclear accumulation was 46% (12 of
26), being higher in groups with clinically advanced disease,
higher degrees of cellular atypia, and deeper myometrial
invasion, but significantly lower in patients with integration
of human papillomavirus (HPV) type 16 or 18 DNA. Nuclear p53
immunoreactivity as well as lymph node status, depth of
invasion and the absence of HPV-DNA integration were
significant indicators of a poor prognosis. Examination of p53
nuclear accumulation could be applied to biopsy material, and
would be of practical assistance in predicting the prognosis
of CxAd both preoperatively and postoperatively.
- Language of Publication
- English
- Unique Identifier
- 96159041
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- MeSH Heading (Major)
- Adenocarcinoma|*CH/MO/PA/VI; Cell Nucleus|*CH; Cervix
Neoplasms|*CH/MO/PA/VI; Neoplasm Proteins|*AN; Protein
p53|*AN; Tumor Markers, Biological|*AN
- MeSH Heading
- Comorbidity; DNA Probes, HPV; DNA, Neoplasm|AN; DNA,
Viral|AN; Female; Genes, p53; Human; Neoplasm Metastasis;
Neoplasm Staging; Papillomavirus, Human|IP; Papovaviridae
Infections|EP; Polymerase Chain Reaction; Polymorphism,
Single-Stranded Conformational; Prognosis; Support, Non-U.S.
Gov't; Survival Rate; Tumor Virus Infections|EP
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0910-5050
- Country of Publication
- JAPAN
Record 95 from database: MEDLINE
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- Title
- Circulating albumin messenger RNA in hepatocellular
carcinoma: results of a multicenter prospective study.
- Author
- Barbu V; Bonnand AM; Hillaire S; Coste T; Chazouilleres O;
Gugenheim J; Boucher E; Poupon R; Poupon RE
- Address
- Laboratoire de Biologie MolÆeculaire, HÈopital
Saint-Antoine, and INSERM Unit 402 Paris, France.
- Source
- Hepatology, 1997 Nov, 26:5, 1171-5
- Abstract
- The presence of circulating tumor cells might be an
indicator of hematogenous spread of tumor cells leading to
extrahepatic metastasis. Messenger RNA (mRNA) expression of
human albumin, as a liver specific cell marker, has been
proposed for this purpose in hepatocellular carcinoma. We
conducted a multicenter prospective study in 101 patients with
biopsy-proven hepatocellular carcinoma followed-up every 3
months for 1 year or until death. At entry into the study,
albumin mRNA was detected in the blood by reverse
transcription-polymerase chain reaction (RT-PCR). At entry
into the study, 45% of the patients had a positive albumin
mRNA test, 53% a single tumor, 16% a portal or venous hepatic
thrombosis, and 16% had proven metastasis. After 1 year, there
was no significant difference in survival of patients with
positive or negative albumin mRNA at entry (P = .16, log-rank
test). When patients with metastasis at entry were excluded,
again survival did not differ between the two groups (P =
.20). Independent prognostic factors of survival were radical
therapeutic procedures, metastasis, number of tumors,
Child-Pugh score, and thrombosis, but not the albumin mRNA
test. Taking the presence of metastasis as a reference, the
specificity of the test was 56%, its sensitivity 50%, and its
negative predictive value 85%. The present study shows that
circulating albumin mRNA detected by means of RT-PCR fails to
provide significant information in the diagnosis and prognosis
of hepatocellular carcinoma. Further studies are needed to
determine whether the use of specific tumor markers could have
clinical relevance in this setting.
- Language of Publication
- English
- Unique Identifier
- 98026681
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- MeSH Heading (Major)
- Carcinoma, Hepatocellular|*ME; Liver Neoplasms|*ME; RNA,
Messenger|*ME; Serum Albumin|*GE
- MeSH Heading
- Adult; Aged; Aged, 80 and over; Female; Human; Male; Middle
Age; Neoplasm Metastasis; Polymerase Chain Reaction;
Prognosis; Prospective Studies; Sensitivity and Specificity;
Support, Non-U.S. Gov't; Survival Analysis; Transcription,
Genetic
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
- ISSN
- 0270-9139
- Country of Publication
- UNITED STATES
Record 96 from database: MEDLINE
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- Title
- Current imaging strategies for colorectal cancer.
- Author
- Collier BD; Foley WD
- Address
- Department of Nuclear Medicine, Medical College of
Wisconsin, Milwaukee 53226.
- Source
- J Nucl Med, 1993 Mar, 34:3 Suppl, 537-40
- Abstract
- Endoscopy and barium enema examinations are used to identify
the primary site of disease in patients with clinical
suspicion of colorectal cancer. Once colorectal cancer has
been confirmed by imaging studies and biopsy, preoperative
evaluation is directed toward accurate disease staging. Most
currently available imaging techniques are inaccurate for
detecting transmural extension, perienteric spread of tumors
and distant lymph node involvement. Although both computed
tomography (CT) and magnetic resonance imaging (MRI) have an
unacceptably low sensitivity for accurate staging, CT is
clearly superior to MRI for detecting extrahepatic metastases.
Transrectal ultrasonography, however, is a promising new
method for detecting perirectal spread of disease. The
diagnostic efficacy of MRI and intravenous dynamic hepatic CT
for detecting liver metastases is approximately equal. CT
during arterial portography is recommended before resection of
solitary liver metastases. Chest radiography is also part of
the routine preoperative evaluation. Bone scans are rarely
performed in patients without the skeletal pain suggestive of
bone metastases. During the years following surgery for
colorectal cancer, many patients undergo special imaging
studies to identify local tumor recurrence, secondary tumor
growth elsewhere within the large bowel and both regional and
distant spread of disease. Thus, for the patient with a
sharply increasing carcinoembryonic antigen level, CT of the
abdomen and liver is the current recommendation.
Immunoscintigraphy is a new imaging modality that addresses
some of the limitations of current diagnostic procedures for
colorectal cancer. This procedure gives whole body information
on disease extent, especially in the extrahepatic abdomen and
pelvis, and can therefore contribute to patient management
decisions.
- Language of Publication
- English
- Unique Identifier
- 93179987
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- MeSH Heading (Major)
- Colorectal Neoplasms|*DI/PA
- MeSH Heading
- Human; Liver Neoplasms|SC; Lymphatic Metastasis; Magnetic
Resonance Imaging; Neoplasm Recurrence, Local; Tomography,
X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0161-5505
- Country of Publication
- UNITED STATES
Record 97 from database: MEDLINE
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- Title
- Thoracic metastases from carcinoma of the nasopharynx: high
frequency of hilar and mediastinal lymphadenopathy.
- Author
- Daly BD; Leung SF; Cheung H; Metreweli C
- Address
- Department of Diagnostic Radiology and Organ Imaging,
Chinese University of Hong Kong, Prince of Wales Hospital,
Shatin.
- Source
- AJR Am J Roentgenol, 1993 Feb, 160:2, 241-4
- Abstract
- OBJECTIVE. Nasopharyngeal carcinoma is a malignant tumor
commonly encountered in Chinese patients living in or
originating from Hong Kong or southern China. This article
describes the previously unreported radiologic appearances of
thoracic metastases from nasopharyngeal carcinoma. MATERIALS
AND METHODS. The radiographic (33 patients) and CT (eight
patients) appearances of thoracic metastases from
nasopharyngeal carcinoma were studied retrospectively. All 33
patients had biopsy-proved primary nasopharyngeal carcinoma,
and seven patients had biopsy-proved thoracic metastases.
Radiologic and clinical evidence of metastases was unequivocal
in 26 others, 16 of whom had synchronous spread to cervical
lymph nodes, bone, or liver. RESULTS. Twenty-one patients
(64%) had evidence of thoracic lymphadenopathy, most
frequently hilar (n = 18, 55%), on chest radiographs or CT
scans. Seventeen patients (52%) had evidence of multiple
parenchymal pulmonary metastases. Enlargement of lymph nodes
without multiple pulmonary deposits was seen in 12 patients
(36%), seven of whom had radiologic signs of bronchial
obstruction, hemoptysis, or a single pulmonary lesion
simulating a synchronous bronchial neoplasm. Pleural effusions
or deposits (n = 6), lymphangitis carcinomatosa (n = 5), and
rib metastases (n = 4) also were seen. CONCLUSION. Metastases
from nasopharyngeal carcinoma may be detected in a wide range
of thoracic sites. This disease appears to be as likely to
disseminate to the mediastinal or hilar lymph nodes as to the
pulmonary parenchyma, and it can simulate a primary bronchial
tumor or lymphoma.
- Language of Publication
- English
- Unique Identifier
- 93142635
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- MeSH Heading (Major)
- Carcinoma, Squamous Cell|RA/*SC; Lymph Nodes|*RA;
Nasopharyngeal Neoplasms|*PA; Thoracic Neoplasms|RA/*SC
- MeSH Heading
- Adult; Female; Human; Lung Neoplasms|RA/SC; Lymphatic
Metastasis|RA; Male; Mediastinal Neoplasms|RA/SC; Middle Age;
Retrospective Studies; Tomography, X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0361-803X
- Country of Publication
- UNITED STATES
Record 98 from database: MEDLINE
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- Title
- Surgery in the management of mediastinal carcinoid.
- Author
- Best LA; Westbrook BM; Trastek VF; Payne WS; Pairolero PC
- Address
- Mayo Clinic, Rochester, Minnesota, USA.
- Source
- J Cardiovasc Surg (Torino), 1994 Dec, 35:6 Suppl 1, 133-5
- Abstract
- Primary carcinoid tumors of the mediastinum were described
for the first time in 1972 as thymic carcinoids. Our
experience with 16 patients who underwent diagnostic and
surgical procedures at the Mayo Clinic is presented. All of
these patients had mediastinal carcinoid. The surgical
procedures included node biopsy, anterior mediastinotomy
(Chamberlain), median sternotomy and posterior lateral
thoracotomy. Complete resection was possible in 9 (56.3%)
patients, 3 (18.7%) had partial removal (debulking), and 4
(25%) had diagnostic biopsies only. The operative morbidity
was 25%. There were no postoperative deaths. In resectable
patients, the average disease free interval was 45.7 months.
Five year and ten year survival was 47% and 22%, respectively.
Local or distant metastatic spread developed in all patients
(100%). Mediastinal carcinoids are a separate entity from
other thymic and mediastinal neoplasms. (We suggest that)
Surgical excision may be possible earlier in the disease and
radiation and chemotherapy are of doubtful value.
- Language of Publication
- English
- Unique Identifier
- 95294077
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- MeSH Heading (Major)
- Carcinoid Tumor|MO/SC/*SU; Mediastinal Neoplasms|MO/*SU
- MeSH Heading
- Adult; Aged; Comparative Study; Disease-Free Survival;
Female; Follow-Up Studies; Human; Male; Middle Age; Neoplasm
Metastasis; Neoplasm Recurrence, Local|SU; Postoperative
Complications; Radical Neck Dissection; Reoperation; Survival
Analysis; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0021-9509
- Country of Publication
- ITALY
Record 99 from database: MEDLINE
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- Title
- Technetium-99m-MIBI in primary and recurrent head and neck
tumors: contribution of bone SPECT image fusion.
- Author
- Leitha T; Glaser C; Pruckmayer M; Rasse M; Millesi W; Lang
S; Nasel C; Backfrieder W; Kainberger F
- Address
- University Clinic of Nuclear Medicine, Department of
Biomedical Engineering and Physics, Vienna, Austria.
- Source
- J Nucl Med, 1998 Jul, 39:7, 1166-71
- Abstract
- We prospectively investigated 200 patients with the clinical
suspicion for head and neck tumors. The final diagnoses were
94 primary and 56 (37 confirmed, 19 excluded) recurrent
squamous cell carcinomas (SCCs), 3 primary and 7 (4 confirmed,
3 excluded) recurrent adenoid cystic carcinomas (ACCs), 6
non-Hodgkin's lymphomas, 10 distant metastases, 6 other
malignancies, 10 inflammatory and 8 other nonmalignant
conditions. METHODS: Bone (600 MBq
99mTc-3,3-diphosphono-1,2-propane dicarboxylic acid
tetrasodium salt) and hexakis-2-methoxyisobutyl isonitrile (MIBI)
(600 MBq 99mTc-MIBI) SPECT were both performed under identical
conditions (triple-head gamma camera; ultra-high-resolution,
parallel-hole collimators; three-dimensional postfiltering)
and judged independently and after superimposition. The
results were compared to the results of biopsy, surgery and
CT. RESULTS: The overall sensitivity/specificity of MIBI was
90%/78% for tumor detection and 90%/95% for the identification
of malignant lymph node involvement (CT: 79%/66%, respectively
90%/79%). In the subgroup of recurrent SCC and ACC the
sensitivity/specificity for tumor detection was 95%/71% for
MIBI versus 78%/68% for CT. The isolated assessment of bone
SPECT had a sensitivity/specificity of 100%/17% for osseous
tumor spread. Image fusion of MIBI and bone SPECT
differentiated between regio-local bone involvement and
inflammatory changes and increased the specificity of bone
SPECT to 100% in primary staging. Tumor size, stage, histology
and pretreatment had no statistically significant effect on
tracer uptake or diagnostic utility of scintigraphy.
CONCLUSION: We propose the combined 99mTc-MIBI and bone
ultra-high resolution SPECT as a highly useful imaging
approach in the primary and secondary staging in patients with
suspected malignancies in the head and neck region. The high
specificity for malignancies in the head and neck region may
be used in the differential diagnosis between head and neck
malignancies and inflammatory disease in patients with the
accidental finding of enlarged lymph nodes and no clinical
signs of a primary tumor. Image fusion with bone scanning is
mandatory for the topographical orientation and increases the
specificity of bone scanning to differentiate between
inflammatory or malignant causes of increased bone metabolism.
- Language of Publication
- English
- Unique Identifier
- 98332051
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- MeSH Heading (Major)
- Bone Neoplasms|PA/*RI; Head and Neck Neoplasms|PA/*RI;
Neoplasm Recurrence, Local|*RI; Radiopharmaceuticals|*DU;
Technetium Tc 99m Sestamibi|*DU; Tomography,
Emission-Computed, Single-Photon|*
- MeSH Heading
- Carcinoma, Adenoid Cystic|PA/RI; Carcinoma, Squamous Cell|PA/RI;
Comparative Study; Diphosphonates|DU; Female; Human; Image
Processing, Computer-Assisted; Lymphatic Metastasis; Male;
Middle Age; Neoplasm Staging; Organotechnetium Compounds|DU;
Prospective Studies; Sensitivity and Specificity; Tomography,
X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0161-5505
- Country of Publication
- UNITED STATES
Record 100 from database: MEDLINE
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- Title
- Spinal ependymomas--the value of postoperative radiotherapy
for residual disease control.
- Author
- Sgouros S; Malluci CL; Jackowski A
- Address
- Department of Neurosurgery, Birmingham Neurosciences Centre,
Queen Elizabeth Hospital, UK.
- Source
- Br J Neurosurg, 1996 Dec, 10:6, 559-66
- Abstract
- Spinal ependymomas are rare intramedullary tumours, usually
with a benign biological nature. They have, however, a known
potential for recurrence and metastatic spread through the CSF
pathways. Traditionally, radiotherapy has been employed as an
adjuvant to surgery. Recently, however, this view has been
increasingly questioned. Thirty-eight adult patients operated
in the West Midlands between 1956 and 1994 were reviewed. Mean
age at presentation was 37.8 years. Of all tumours 45% (17)
were situated in the conus/cauda equina region, 26% (10) in
the thoracic and 29% (11) in the cervical region. All patients
underwent surgery as primary treatment. Postoperative
mortality was 2.6% (one patient). Complete macroscopic
excision of their tumours was performed in 14 patients; of
these three received postoperative radiotherapy. Subtotal
excision was performed in 18 patients, seven receiving
adjuvant radiotherapy. Decompressive laminectomy and biopsy
was performed in five patients with either no radiotherapy in
one, radiotherapy in three or radiotherapy and chemotherapy in
one. The overall survival rate was 87% at 5 years and 73% at
10 years for the whole series. In patients treated after the
1970s, the cumulative 10-year survival was 95%. Patients over
the age of 40 years at diagnosis had a 10-year survival of 61%
compared to 78% of those under the age of 40. Intramedullary
tumours had a worse outcome with 68% survival at 10 years,
compared to 89% of tumours at the cauda equina. Total excision
carried 86% survival, subtotal excision 80% and biopsy only
25% at 10 years. In those patients treated by administration
of postoperative radiotherapy the 10-year survival was 48%,
compared to 96% in those in whom radiotherapy was not given
postoperatively. Analysis of the recurrence and survival rates
demonstrated that radiotherapy did not confer any significant
protection against recurrence or disease progression. Whilst
complete excision offers the maximal potential for cure, an
expectant policy with possible repeat surgery may be
appropriate when total excision is not achieved. The main
conclusion to be drawn is that a randomized controlled trial
of the value of adjuvant radiotherapy is greatly needed.
- Language of Publication
- English
- Unique Identifier
- 97165193
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- MeSH Heading (Major)
- Cauda Equina|*PA/SU; Ependymoma|PA/*RT/SU
- MeSH Heading
- Adolescence; Adult; Age Factors; Aged; Human; Laminectomy;
Magnetic Resonance Imaging; Middle Age; Neoplasm Metastasis;
Radiation Dosage; Retrospective Studies; Spinal Cord
Neoplasms|PA/RT/SU; Survival Rate
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0268-8697
- Country of Publication
- ENGLAND
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