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NLM database Documents
Record 1 from database: MEDLINE
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- Title
- Spontaneous regression of breast cancer.
- Author
- Lewison EF
- Address
-
- Source
- Natl Cancer Inst Monogr, 1976 Nov, 44:, 23-6
- Abstract
- The dramatic but rare regression of a verified case of
breast cancer in the absence of adequate, accepted, or
conventional treatment has been observed and documented by
clinicians over the course of many years. In my practice
limited to diseases of the breast, over the past 25 years I
have observed 12 patients with a unique and unusual clinical
course valid enough to be regarded as spontaneous regression
of breast cancer. These 12 patients, with clinically
confirmed breast cancer, had temporary arrest or partial
remission of their disease in the absence of complete or
adequate treatment. In most of these cases, spontaneous
regression could not be equated ultimately with permanent
cure. Three of these case histories are summarized, and
patient characteristics of pertinent clinical interest in
the remaining case histories are presented and discussed.
Despite widespread doubt and skepticism, there is ample
clinical evidence to confirm the fact that spontaneous
regression of breast cancer is a rare phenomenon but is real
and does occur.
- Language of Publication
- English
- Unique Identifier
- 77171134
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- MeSH Heading (Major)
- Breast Neoplasms|CO/HI/*PA; Neoplasm Regression,
Spontaneous|*
- MeSH Heading
- Adult; Animal; Case Report; Castration; Cattle;
Estrogens|SE; Female; Goiter|CO; History of Medicine, 19th
Cent.; History of Medicine, 20th Cent.; Human; Male;
Medicine in Art; Menopause; Menstruation; Middle Age;
Neoplasm Metastasis; Ovary|SE; Religion and Medicine; Sex
Hormones|TU
- Publication Type
- HISTORICAL ARTICLE; JOURNAL ARTICLE
- ISSN
- 0083-1921
- Country of Publication
- UNITED STATES
Record 2 from database: MEDLINE
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- Title
- Spontaneous regression of hematologic cancers.
- Author
- Wiernik PH
- Address
-
- Source
- Natl Cancer Inst Monogr, 1976 Nov, 44:, 35-8
- Abstract
- Spontaneous regression of hematologic cancer is extremely
rare. Data gleaned from the literature and from previously
unreported cases allow certain interesting general
conclusions. Spontaneous remission of acute leukemia is
associated with bacterial infection and is of short
duration, weeks to months. Spontaneous regression of
lymphoma or plasma cell dyscrasia is often of substantial
duration, months or years, and frequently is associated with
viral infections. Spontaneous regression of chronic
lymphocytic leukemia is also of significant duration and has
been associated with the occurence of a new primary
carcinoma in one-third of the cases.
- Language of Publication
- English
- Unique Identifier
- 77171137
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- MeSH Heading (Major)
- Leukemia|CO/IM/*PA; Lymphoma|CO/*PA; Neoplasm Regression,
Spontaneous|*
- MeSH Heading
- Acute Disease; Adolescence; Adult; Aged; Bacterial
Infections|CO; Child; Child, Preschool; Female; Fever|CO;
Human; Infant; Infant, Newborn; Leukemia, Lymphocytic|PA;
Male; Middle Age; Neoplasms, Multiple Primary|PA;
Paraproteinemias|CO/PA; Time Factors; Virus Diseases|CO
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0083-1921
- Country of Publication
- UNITED STATES
Record 3 from database: MEDLINE
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- Title
- Acute necrotizing ulcerative gingivitis in children with
cancer.
- Author
- Ryan ME; Hopkins K; Wilbur RB
- Address
-
- Source
- Am J Dis Child, 1983 Jun, 137:6, 592-4
- Abstract
- We reviewed the findings for 15 immunosuppressed children
with cancer who had 18 episodes of acute necrotizing
ulcerative gingivitis. Predisposing factors were then
assessed for their influence on the course of infection. The
nutritional status and oral hygiene of most patients were
poor. Eleven of the 18 episodes involved the spontaneous
exfoliation of primary or permanent teeth, and 16 of the 18
episodes were complicated by other infections. The infection
completely cleared in only two of ten patients who were not
in remission and persisted for more than 15 weeks or until
death in all of the remaining patients with active disease.
By contrast, all six episodes of infection during remission
cleared within an average of 4 1/2 weeks. Among the many
contributing factors, decreased host resistance, relapse,
and neutropenia seemed to have the most negative influence
on recovery from this severe form of gingivitis.
- Language of Publication
- English
- Unique Identifier
- 83201130
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- MeSH Heading (Major)
- Gingivitis, Necrotizing Ulcerative|*ET/TH; Neoplasms|*CO/TH
- MeSH Heading
- Adolescence; Child; Child, Preschool; Human; Infant;
Neutropenia|CO; Nutrition; Oral Hygiene; Outcome and Process
Assessment (Health Care); Retrospective Studies
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-922X
- Country of Publication
- UNITED STATES
Record 4 from database: MEDLINE
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- Title
- Alpha-feto-protein during development and in disease.
- Author
- Adinolfi A; Adinolfi M; Lessof
- Address
-
- Source
- J Med Genet, 1975 Jun, 12:2, 138-51
- Abstract
- An alpha-feto-protein (AFP) is present in many mammals, in
birds, and in sharks during development. The AFP present in
different species have similar physicochemical properties
and often have common antigenic determinants. Their study,
both in health and disease, has provided a useful model for
the understanding of other phase-specific antigens and the
activation of the genes which control their synthesis. In
the human fetus, the level of AFP falls with increasing
maturity. The more sensitive methods of detection have
disclosed that this fetal protein persists in trace amounts
throughout life and its level increases in maternal blood
during pregnancy. The principal sites of synthesis are the
fetal liver and in some mammals, the yolk sac splanchnopleur.
In humans as well as in mice and cows, it is notable that
the synthesis of AFP is increased in liver cancer cells and
that high levels of this protein are present in serum.
Elevated values of AFP have also been detected in human
subjects with undifferentiated tumours of the testis and
ovary. A fall to normal levels has been noted in cases of
complete remission after surgery and a return to high levels
in patients who develop metastases. In some patients with
hepatitis a temporary rise in the level of AFP has also been
observed. In recent years, the detection of high levels of
AFP in amniotic fluid has proved to be of great value for
the prenatal diagnosis of neural-tube defects. Abnormal
levels have also been found in the amniotic fluid or in
maternal serum in cases of spontaneous abortion. Such
measurements are now being assessed as a methodof monitoring
abnormal pregnancy.
- Language of Publication
- English
- Unique Identifier
- 75191915
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- MeSH Heading (Major)
- alpha-Fetoproteins|*/AN/ME/PH; Fetal Proteins|*
- MeSH Heading
- Amniotic Fluid|AN; Anencephaly|ME; Animal;
Antigen-Antibody Reactions; Carcinoma, Hepatocellular|ME;
Concanavalin A|PD; Cystic Fibrosis|ME; Down Syndrome|ME;
Female; Gastrointestinal Neoplasms|ME; Gestational Age;
Hepatitis|ME; Human; Immunologic Techniques; Infant,
Newborn; Liver|CY; Liver Neoplasms; Metabolism, Inborn
Errors|ME; Neoplasm Metastasis; Neoplasms, Experimental|ME;
Pregnancy; Spinal Dysraphism|ME; Teratoma|ME
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-2593
- Country of Publication
- ENGLAND
Record 5 from database: MEDLINE
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- Title
- Adolescents with cancer. Hypnosis for the reduction of the
acute pain and anxiety associated with medical procedures.
- Author
- Kellerman J; Zeltzer L; Ellenberg L; Dash J
- Address
-
- Source
- J Adolesc Health Care, 1983 Jun, 4:2, 85-90
- Abstract
- Eighteen adolescents with cancer were trained in hypnosis
to ameliorate the discomfort and anxiety associated with
bone marrow aspirations, lumbar punctures, and
chemotherapeutic injections. Two patients rejected hypnosis.
The remaining 16 adolescents achieved significant reductions
in multiple measures of distress after hypnosis training.
Preintervention data showed no pattern of spontaneous
remission or habituation, and, in fact, an increasing
anticipatory anxiety was observed before hypnotic treatment.
Group reductions in pain and anxiety were significant at
levels ranging from p less than 0.02 to p less than 0.002
(two-tailed t-tests). Significant reductions were also found
in Trait Anxiety. A non-significant trend toward greater
self-esteem was present. The predicted changes in the Locus
of Control and General Illness Impact were not found.
Comparisons between hypnosis rejectors and successful users
unusually showed higher levels of pretreatment anxiety in
the former. The pragmatic nature of hypnosis as part of
comprehensive medical care in oncology is noted.
- Language of Publication
- English
- Unique Identifier
- 83238023
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- MeSH Heading (Major)
- Anxiety|PX/*TH; Hypnosis|*MT; Neoplasms|*CO/PX; Pain,
Intractable|PX/*TH
- MeSH Heading
- Adolescence; Bone Marrow Examination; Female; Human;
Injections|PX; Male; Spinal Puncture|PX; Support, Non-U.S.
Gov't; Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0197-0070
- Country of Publication
- UNITED STATES
Record 6 from database: MEDLINE
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- Title
- Spontaneous improvement of Pneumocystis carinii pneumonia
in childhood acute lymphocytic leukemia.
- Author
- Ettinger LJ; Torrisi J; Wood BP; Anderson VM
- Address
-
- Source
- Med Pediatr Oncol, 1982, 10:5, 477-81
- Abstract
- Until recently, Pneumocystis carinii pneumonitis was the
most common cause of death in patients with leukemia in
remission. Prior to the advent of effective antimicrobial
agents, this disease was virtually 100% fatal in the cancer
patient undergoing immunosuppressive therapy. The
spontaneous improvement of P carinii pneumonitis in a child
with acute lymphocytic leukemia suggests a higher incidence
of P carinii pneumonitis in immunocompromised patients than
is commonly realized.
- Language of Publication
- English
- Unique Identifier
- 83062316
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- MeSH Heading (Major)
- Leukemia, Lymphocytic|*CO/DT; Pneumonia, Pneumocystis
carinii|*CO/PA
- MeSH Heading
- Biopsy; Case Report; Child; Female; Follow-Up Studies;
Human; Remission, Spontaneous; Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0098-1532
- Country of Publication
- UNITED STATES
Record 7 from database: MEDLINE
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- Title
- Spontaneous remission from acute exacerbation of chronic
adult T-cell leukemia.
- Author
- Murakawa M; Shibuya T; Teshima T; Kudo J; Okamura T;
Harada M; Nagafuchi S; Niho Y; Mukae T
- Address
- First Department of Internal Medicine, Faculty of
Medicine, Kyushu University, Fukuoka, Japan.
- Source
- Blut, 1990 Dec, 61:6, 346-9
- Abstract
- Spontaneous remission without any anti-cancer therapy in a
57-year-old woman with adult T-cell leukemia (ATL) is
reported. The patient was referred to our department because
of persistent cough and appearance of abnormal lymphocytes
in the peripheral blood, and she was diagnosed as having
chronic ATL. Eight months later, she was re-admitted because
of cystitis, watery diarrhea and worsening of respiratory
symptoms with an increase of ATL cells (WBC 31 x 10(9)/l
with 56% ATL cells). Acute exacerbation of ATL was
diagnosed. Interestingly, antibiotic therapy for the
pulmonary and urinary tract infections brought about
spontaneous reduction of the ATL cell count. Spontaneous
remission of ATL continued for one year without
chemotherapy. The role of infection as a trigger of acute
exacerbation and spontaneous remission of ATL is discussed.
- Language of Publication
- English
- Unique Identifier
- 91152270
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- MeSH Heading (Major)
- Cystitis|*CO/DT; Leukemia, T-Cell, Chronic|*CO/PA;
Respiratory Tract Infections|*CO/DT
- MeSH Heading
- Amphotericin B|TU; Ampicillin|TU; Bone Marrow|PA;
Candidiasis|CO/DT; Case Report; Diarrhea|CO; Escherichia
coli Infections|CO/DT; Female; Haemophilus influenzae;
Haemophilus Infections|CO/DT; Human; Middle Age; Remission,
Spontaneous; T-Lymphocytes|PA
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0006-5242
- Country of Publication
- GERMANY
Record 8 from database: MEDLINE
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- Title
- Complete spontaneous remission in a patient with
metastatic non-small-cell lung cancer. Case report, review
of the literature, and discussion of possible biological
pathways involved.
- Author
- Kappauf H; Gallmeier WM; Wünsch PH; Mittelmeier HO;
Birkmann J; Büschel G; Kaiser G; Kraus J
- Address
- Medical Clinic 5/Oncology and Hematology, Nuremberg City
Hospital, Germany.
- Source
- Ann Oncol, 1997 Oct, 8:10, 1031-9
- Abstract
- Spontaneous remission of cancer (SR) is defined as a
complete or partial, temporary or permanent disappearance of
all or at least some relevant parameters of a soundly
diagnosed malignant disease without any medical treatment or
with treatment that is considered inadequate to produce the
resulting regression. We report the case of a 61-year-old
man who presented with extensive metatastic disease five
months after pneumonectomy for poorly differentiated large
cell and polymorphic lung cancer. A vast metastatic tumour
mass of the abdominal wall was confirmed histolologically
and there was clinical and radiographic evidence of liver
and lung metastases. Eight months later, the patient was
operated on for a hernia, which had developed in the
inguinal biopsy scar and the surgeon confirmed complete
clinical SR of the abdominal wall metastases. Again five
months later there was no longer any radiologic evidence of
liver and lung metastases. Complete remission has persisted
more than five years. Histology of the primary and of the
abdominal metastases were reviewed by several independent
pathologists. SR is an extremly rare event in lung cancer.
This is the first documented case of clinically evident
visceral metastases of a bronchiogenic adenocarcinoma
developing after complete resection of the primary and then
showing complete SR. The epidemiology of SR is reviewed and
possible mechanisms involved in SR are discussed.
- Language of Publication
- English
- Unique Identifier
- 98063770
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- MeSH Heading (Major)
- Carcinoma, Non-Small-Cell Lung|*PA; Lung Neoplasms|*PA;
Neoplasm Regression, Spontaneous|*
- MeSH Heading
- Apoptosis|PH; Case Report; Cell Differentiation|PH;
Cytokines|PH; Hormones|PH; Human; Immunity, Cellular; Male;
Middle Age; Neovascularization, Pathologic;
Psychoneuroimmunology; Support, Non-U.S. Gov't;
Telomerase|AI; Tomography, X-Ray Computed
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
- ISSN
- 0923-7534
- Country of Publication
- NETHERLANDS
Record 9 from database: MEDLINE
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- Title
- Cytotoxic activity of human pulmonary alveolar
macrophages.
- Author
- Kan Mitchell J; Hengst JC; Kempf RA; Rothbart RK; Simons
SM; Brooker AS; Kortes VL; Mitchell MS
- Address
-
- Source
- Cancer Res, 1985 Jan, 45:1, 453-8
- Abstract
- The functions of human pulmonary alveolar macrophages (PAMs)
have been relatively little studied compared with those of
their circulating counterparts, blood monocytes. This study
examined the ability of human PAMs to kill primary human
tumor cell cultures and control normal fibroblasts in vitro.
PAMs were derived by bronchial lavage from patients with
lung cancer of various histological types and stages,
patients with acute or chronic noncancerous pulmonary
disorders, and subjects with a presumed illness who proved
to be normal. After extensive washing, the PAMs were
cocultured with [3H]proline-labeled tumor cells, principally
lung cancers and melanomas, at various effector:target
ratios for 60 hr. Cytotoxicity was measured by comparing
radioactivity associated with the remaining adherent tumor
cells cultured in the presence or absence of PAMs.
Twenty-eight of 42 preparations of PAMs from 42 individuals
were cytotoxic to one or more short-term primary tumor
cultures. All 28 specimens from patients with lung cancer or
chronic pulmonary disease were cytotoxic; all of the 14 PAM
preparations lacking cytotoxicity were from individuals with
acute pulmonary disorders or who were proved free of
pulmonary disease. PAMs were cytotoxic even at
effector:target ratios of 2.5:1 or 1.25:1. Fibroblasts were
unaffected at any ratio. Sarcoidosis patients in remission
had noncytotoxic PAMs, whereas the disease in relapse was
characterized by cytotoxic PAMs. Serial study of 2 patients
confirmed a loss of reactivity during remission. Smoking did
not correlate with the presence or absence of spontaneous
cytotoxicity and did not influence the degree of
cytotoxicity in "reactors." Partially purified
alpha-interferon enhanced the killing of cytotoxic PAMs in
10 of 21 instances but did not induce cytotoxicity in 9
tests on nonreactive PAMs. We conclude that human PAMs from
patients with lung cancer or chronic pulmonary diseases,
including active sarcoidosis, were cytotoxic to several
recently explanted tumor cell cultures. PAMs from acute
pulmonary dysfunctions and those from patients with inactive
sarcoidosis were not spontaneously cytotoxic.
- Language of Publication
- English
- Unique Identifier
- 85074244
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- MeSH Heading (Major)
- Cytotoxicity, Immunologic|*; Macrophages|*IM
- MeSH Heading
- Adenocarcinoma|IM; Carcinoma, Squamous Cell|IM; Cells,
Cultured; Comparative Study; Human; Lung|IM; Lung
Neoplasms|IM; Melanoma|IM; Monocytes|IM; Smoking; Support,
Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0008-5472
- Country of Publication
- UNITED STATES
Record 10 from database: MEDLINE
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- Title
- Spontaneous remission of paraneoplastic ocular flutter and
saccadic intrusions.
- Author
- Furman JM; Eidelman BH; Fromm GH
- Address
- Department of Otolaryngology, University of Pittsburgh,
PA.
- Source
- Neurology, 1988 Mar, 38:3, 499-501
- Abstract
- We report two women with ocular flutter and saccadic
intrusions, documented by electro-oculography, who had
complete spontaneous remission of their ocular motor
findings prior to the appearance of a primary neoplastic
process remote from the nervous system. Transient elevation
of blood HVA and VMA levels was detected in one patient who
subsequently had breast cancer. These cases indicate that
spontaneous remission of saccadic oscillations does not
necessarily imply a benign outcome. Patients with this
ocular motor abnormality should be followed closely for
signs of a remote neoplasm even if initial investigation is
negative.
- Language of Publication
- English
- Unique Identifier
- 88157156
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- MeSH Heading (Major)
- Eye Movements|*; Muscular Diseases|*PP; Oculomotor
Muscles|*; Paraneoplastic Syndromes|*PP; Saccades|*
- MeSH Heading
- Adult; Case Report; Electrooculography; Female; Human;
Middle Age; Nystagmus, Physiologic; Remission, Spontaneous
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0028-3878
- Country of Publication
- UNITED STATES
Record 11 from database: MEDLINE
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- Title
- Spontaneous remission of cancer--a thyroid hormone
dependent phenomenon?
- Author
- Hercbergs A
- Address
- Department of Radiation Oncology, Cleveland Clinic
Foundation, OH 44195, USA. hercbea@radonc.ccf.org
- Source
- Anticancer Res, 1999 Nov, 19:6A, 4839-44
- Abstract
- Spontaneous remission (SR) of neoplasia is a rare
biological event. Very few reports provide evidence for an
eliciting event or mechanism. The only case in the
literature of SR of lung cancer following myxedema coma is
suggested to have been an instance of thyroid hormone
deprivation-induced total tumor apoptosis. Review of the
collective data suggests that the thyroid hormones modulate
pleiotropic neoplasia--abetting mechanisms and that
hypothyroidism may enhance the predisposition of neoplasms
to spontaneous and therapy induced regression by lowering
thresholds for apoptosis.
- Language of Publication
- English
- Unique Identifier
- 20162705
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- MeSH Heading (Major)
- Hypothyroidism|*PP; Neoplasm Regression, Spontaneous|*;
Thyroid Hormones|*DF/PH
- MeSH Heading
- Aged; Apoptosis|PH; Case Report; Cell Cycle; Female; Human
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0250-7005
- Country of Publication
- GREECE
Record 12 from database: MEDLINE
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- Title
- Upper limb reflex sympathetic dystrophy associated with
occult malignancy.
- Author
- Ku A; Lachmann E; Tunkel R; Nagler W
- Address
- Rehabilitation Medicine, New York Hospital-Cornell Medical
Center, New York, USA.
- Source
- Arch Phys Med Rehabil, 1996 Jul, 77:7, 726-8
- Abstract
- Reflex sympathetic dystrophy, characterized by pain,
swelling, vasomotor instability, and trophic changes in an
extremity, has been infrequently described in patients with
occult malignancy. Two cases of reflex sympathetic dystrophy
associated with local tumor involvement are reported. Both
patients had a history of cancer in clinical remission.
Despite aggressive physical therapy measures, the patients'
symptoms persisted. Workup of the first patient found an
apical paravertebral mass in the lung; biopsy revealed
recurrent breast carcinoma. In the second case, workup found
an axillary mass contiguous with the lower brachial plexus.
Biopsy revealed lymphoma, a second primary malignancy. In
both cases, medical treatment of the tumor was instituted,
with consequent improvement of hand and shoulder function.
Both patients required prolonged hospitalization and
multiple procedures that might have been avoided if
malignancy had been suspected. Spontaneous development of
reflex sympathetic dystrophy in patients with a history of
cancer should alert the physician to the possibility of
occult malignancy.
- Language of Publication
- English
- Unique Identifier
- 96288480
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- MeSH Heading (Major)
- Adenocarcinoma|*CO/SC; Breast Neoplasms|*PA; Lung
Neoplasms|*CO/SC; Lymphoma, Undifferentiated|*CO; Neoplasms,
Second Primary|*CO; Reflex Sympathetic Dystrophy|*ET;
Thyroid Neoplasms|*CO
- MeSH Heading
- Adult; Aged; Biopsy; Case Report; Female; Human;
Tomography, X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0003-9993
- Country of Publication
- UNITED STATES
Record 13 from database: MEDLINE
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- Title
- A workplace intervention for increasing outdoor workers'
use of solar protection.
- Author
- Girgis A; Sanson Fisher RW; Watson A
- Address
- New South Wales Cancer Council Cancer Education Research
Project, University of Newcastle, Australia.
- Source
- Am J Public Health, 1994 Jan, 84:1, 77-81
- Abstract
- OBJECTIVES. Outdoor workers are at high risk of developing
skin cancer. Primary prevention in this group can
potentially reduce the incidence of skin cancer, and also
potentiates the spontaneous remission of existing solar
keratoses. A randomized controlled trial was conducted to
evaluate a solar protection intervention targeting outdoor
workers. METHODS. Outdoor workers were randomly allocated to
an intervention (n = 65) or control group (n = 77). The
intervention group received individual skin screening by a
dermatologist and participated in an education session. Pre-
and posttest outcome measures included solar protection
behavior (assessed using a validated diary), knowledge, and
attitudes. RESULTS. There was a significant increase (16%)
in the percentage of outdoor workers who were using a high
level of solar protection at posttest compared to pretest in
the intervention group, but there was no change in the
control group. Although both groups improved in their
knowledge score, the intervention group showed a
significantly greater improvement at posttest. No changes in
attitudes were detected. CONCLUSIONS. The findings suggest
that changes in solar protection are achievable with outdoor
workers.
- Language of Publication
- English
- Unique Identifier
- 94106688
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- MeSH Heading (Major)
- Occupational Diseases|*PC; Protective Clothing|*UT; Skin
Neoplasms|ET/*PC; Sunscreening Agents|*
- MeSH Heading
- Adult; Female; Health Behavior; Human; Intervention
Studies; Knowledge, Attitudes, Practice; Male; Middle Age;
Occupational Exposure|AE; Occupational Health; Sunlight|AE
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED
TRIAL
- ISSN
- 0090-0036
- Country of Publication
- UNITED STATES
Record 14 from database: MEDLINE
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- Title
- Evidence of apoptosis in neuroblastoma at onset and
relapse. An analysis of a large series of tumors.
- Author
- Tonini GP; Mazzocco K; di Vinci A; Geido E; de Bernardi B;
Giaretti W
- Address
- Laboratory of Oncology, G. Gaslini Children's Hospital,
Genoa, Italy.
- Source
- J Neurooncol, 1997 Jan, 31:1-2, 209-15
- Abstract
- Neuroblastoma (NB) is a tumor of pediatric age that is
associated with high mortality in metastatic stages,
although stage IVS patients undergo frequent spontaneous
regression. Since apoptosis has been proposed as a possible
cause of remission among cancer patients, we tested this
hypothesis among both localized and metastatic NB and, in
particular, NB metastatic stage IVS. We have assayed 36
localized and 117 metastatic neuroblastomas for evidence of
internucleosomal DNA degradation and confirmed DNA
fragmentation by the flow cytometric Terminal
deoxynucleotidyl Transferase method, which also allowed us
to measure DNA content and cell cycle phases. These
techniques provided evidence of apoptosis in 18 out of 153
samples (11.8%), that were equally distributed among all
stages except IVS, i.e. 11.1% in stage I (2/18), 11.1% in
stage II (2/18), 13.2% in stage III (5/38), 13.4% in stage
IV (9/67), and 0% in stage IVS (0/12). Tumor tissue samples
collected at onset and also at relapse for the same patients
showed that apoptosis may occur at relapse. In addition,
cells appear to undergo apoptosis independently from N-myc
amplification, cell cycle phase and DNA ploidy. In
conclusion, apoptosis seems to take place with about an
equal frequency for both favourable and unfavourable stages
with an exception for IVS. Since DNA fragmentation remained
undetected in stage IVS, we suggest that apoptosis is not a
mechanism of spontaneous regression for these patients. A
better basic understanding of the complex molecular
mechanisms and biochemical pathways that control apoptosis
in neuroblastoma appears to be necessary.
- Language of Publication
- English
- Unique Identifier
- 97202323
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- MeSH Heading (Major)
- Apoptosis|*; DNA Fragmentation|*; Neuroblastoma|*
- MeSH Heading
- DNA, Neoplasm|AN; Electrophoresis, Agar Gel; Flow
Cytometry; Genes, myc|PH; Human; Longitudinal Studies;
Neoplasm Staging; Recurrence; S Phase; Sensitivity and
Specificity; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0167-594X
- Country of Publication
- NETHERLANDS
Record 15 from database: MEDLINE
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- Title
- The thyroid gland as an intrinsic biologic
response-modifier in advanced neoplasia--a novel paradigm.
- Author
- Hercbergs A
- Address
- Cleveland Clinic Foundation, Ohio 44195, USA.
- Source
- In Vivo, 1996 Mar, 10:2, 245-7
- Abstract
- The thyroid gland is the major endocrine modulator of
physiological processes crucial to growth, maturation and
metabolism. There is, however, a coherent body of evidence
suggesting that the thyroid hormones modulate multiple
neoplasia-dependent mechanisms. Recently spontaneous
remission of metastatic non-small cell carcinoma of lung was
reported in a man following recovery from myxedema coma.
This rare biological event following a life-threatening
clinical syndrome suggests that thyroid hormone deficiency
directly or indirectly may significantly alter the balance
between malignant tumor viability and growth on the one hand
vs. cell death on the other. Evidence, therefore, is
presented from clinical and experimental studies suggesting
that decreased thyroid function (hypothyroidism) is
associated with both enhanced response rates and unusual
longevity. Possible mechanisms of action that may promote or
retard neoplasia and are dependent on the functional state
of the thyroid will be discussed. A novel paradigm is
proposed; the thyroid gland aside from its known
physiological activity is also the central modulator of
solid neoplasia and therefore functions as an intrinsic
biologic response-modifier of neoplasia. Induction of a
clinically tolerable hypothyroid state in patients could
become an integral part of the medical care of advanced
cancer in conjunction with standard conventional modalities.
- Language of Publication
- English
- Unique Identifier
- 96348859
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- MeSH Heading (Major)
- Neoplasms|PA/*PP/TH; Thyroid Gland|*PP
- MeSH Heading
- Animal; Cell Division; Female; Human; Hypothyroidism|PP;
Male; Remission, Spontaneous; Thyroid Hormones|BL/DF
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0258-851X
- Country of Publication
- GREECE
Record 16 from database: MEDLINE
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- Title
- Hormonal therapy in the treatment of mandibular metastasis
of breast carcinoma. Report of a case.
- Author
- Ehlinger P; Peeters LC; Servais J; Fossion E
- Address
- Department of Maxillo-Facial Surgery, Algemeen Ziekenhuis
Middelheim, Antwerp, Belgium.
- Source
- Int J Oral Maxillofac Surg, 1993 Apr, 22:2, 108-9
- Abstract
- We present the clinical history of a 39-year-old woman,
who has survived for over 10 years with metastatic breast
cancer. After combined surgery and radiotherapy of the
primary tumor and the regional lymph nodes, all bone
metastases gradually disappeared under chemotherapy and
continuing hormonal treatment. This complete remission
included a large mandibular metastasis, which had received
additional radiotherapy of 21 Gy. Spontaneous reossification
was observed in this location.
- Language of Publication
- English
- Unique Identifier
- 93308374
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- MeSH Heading (Major)
- Breast Neoplasms|DT/*PA; Carcinoma, Intraductal,
Noninfiltrating|*DT/RT/*SC; Mandibular Neoplasms|*DT/RT/*SC;
Tamoxifen|AD/*TU
- MeSH Heading
- Adult; Antineoplastic Agents, Combined|TU; Bone
Neoplasms|DT/SC; Case Report; Combined Modality Therapy;
Cyclophosphamide|AD; Doxorubicin|AD; Female; Fluorouracil|AD;
Human; Methotrexate|AD
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0901-5027
- Country of Publication
- DENMARK
Record 17 from database: MEDLINE
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- Title
- Pregnancy after high therapeutic doses of iodine-131 in
differentiated thyroid cancer: potential risks and
recommendations.
- Author
- Casara D; Rubello D; Saladini G; Piotto A; Pelizzo MR;
Girelli ME; Busnardo B
- Address
- Department of Radiotherapy and Nuclear Medicine, General
Hospital of Padua, Italy.
- Source
- Eur J Nucl Med, 1993 Mar, 20:3, 192-4
- Abstract
- Seventy female patients who had been treated with high
doses of iodine-131 for differentiated thyroid cancer (DTC)
and who had a subsequent pregnancy were evaluated. The total
131I dose ranged from 1.85 to 16.55 GBq (mean +/- SD = 4.39
+/- 25.20 GBq). Age at first therapy ranged from 15 to 36
years (mean +/- SD = 24.3 +/- 5.0 years) and the interval
from 131I therapy to pregnancy varied from 2 to 10 years
(mean +/- SD = 5.3 +/- 2.8 years). The estimated radiation
dose to the gonads ranged from 10 to 63 cGy (mean +/- SD =
24.0 +/- 13.5 cGy). All patients were treated with L-thyroxine
at doses capable of suppressing thyroid-stimulating hormone.
Seventy-three children were followed-up and seven
pregnancies are still in progress. One child was affected by
Fallot's trilogy and three had a low birth weight through
with subsequent normal growth; the others were healthy with
subsequent normal growth. No newborn with clinical or
biochemical thyroid dysfunctions was found. Two spontaneous
abortions during the second month of pregnancy were
recorded. One of two patients in question subsequently had
two healthy children. On the basis of these data, previous
administration of high 131I doses does not appear to be a
valid reason for dissuading young female DTC patients from
considering pregnancy. However, patients should be advised
to avoid pregnancy after 131I administration for a period
sufficient to ensure complete elimination of the
radionuclide and to permit confirmation of complete disease
remission, i.e. at least 1 year in our opinion.
- Language of Publication
- English
- Unique Identifier
- 93215726
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- MeSH Heading (Major)
- Iodine Radioisotopes|*TU; Prenatal Exposure Delayed
Effects|*; Thyroid Neoplasms|*RT
- MeSH Heading
- Adenocarcinoma|RT; Adult; Carcinoma, Papillary|RT; Female;
Human; Levothyroxine|TU; Ovary|RE; Pregnancy; Radiotherapy
Dosage; Risk Factors; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0340-6997
- Country of Publication
- GERMANY
Record 18 from database: MEDLINE
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- Title
- Spontaneous partial fibrotic regression of a primary renal
carcinoma: a case report.
- Author
- Lacquaniti S; Pierconti F; Servello C; Pisanti F; Destito
A
- Address
- Department of Urology, Pathology Catholic University of
Sacro Cuore, Roma, Italia. s.lacquaniti@usa.net
- Source
- Arch Ital Urol Androl, 1999 Feb, 71:1, 35-6
- Abstract
- Spontaneous regression of non metastatic renal carcinoma
is a very unusual finding in daily urologic practice.
Furthermore this is the first case of a partial primary
renal cancer remission documented by hystopathological
specimens. Current hypothesis were discussed.
- Language of Publication
- English
- Unique Identifier
- 99209102
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- MeSH Heading (Major)
- Kidney Neoplasms|*PA; Neoplasm Regression, Spontaneous|*
- MeSH Heading
- Adult; Case Report; Fibrosis; Human; Male
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1124-3562
- Country of Publication
- ITALY
Record 19 from database: MEDLINE
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- Title
- Spontaneous remission of cancer: an example of health
promotion.
- Author
- Huebscher R
- Address
-
- Source
- Nurse Pract Forum, 1992 Dec, 3:4, 228-35
- Abstract
- Spontaneous remission provides an example of health
promotion: that of the body/mind/spirit maximizing its
potential and showing, not only the disappearance or
lessening of pathology, but also the healing capabilities of
the individual. This brief overview of a grounded theory
research study summarizes nine healers' experiences with a
diagnosis of cancer and their subsequent remissions.
- Language of Publication
- English
- Unique Identifier
- 93104736
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- MeSH Heading (Major)
- Alternative Medicine|*; Health Promotion|*MT; Neoplasms|NU/*PC/PX;
Remission Induction|*
- MeSH Heading
- Adaptation, Psychological; Adult; Aged; Case Report;
Female; Human; Male; Middle Age; Nursing Methodology
Research
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1045-5485
- Country of Publication
- UNITED STATES
Record 20 from database: MEDLINE
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- Title
- Spontaneous remission of bladder neoplasm.
- Author
- Hellström PA; Malinen L; Malinen H
- Address
- Department of Surgery, Oulu University Central Hospital,
Finland.
- Source
- Eur J Surg Oncol, 1992 Oct, 18:5, 521-3
- Abstract
- A case of spontaneous remission of bladder cancer in an
85-year-old man is reported. The clinicopathological
features are presented and the literature reviewed.
- Language of Publication
- English
- Unique Identifier
- 93050270
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- MeSH Heading (Major)
- Bladder Neoplasms|*PA; Carcinoma, Transitional Cell|*PA
- MeSH Heading
- Aged; Aged, 80 and over; Case Report; Human; Male;
Remission, Spontaneous
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0748-7983
- Country of Publication
- ENGLAND
Record 21 from database: MEDLINE
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- Title
- The role of electrodiagnostic studies in the diagnosis and
management of polymyositis.
- Author
- Bromberg MB
- Address
- Department of Neurology, University of Michigan Medical
Center, Ann Arbor.
- Source
- Compr Ther, 1992 Apr, 18:4, 17-22
- Abstract
- Polymyositis is an inflammatory muscle disease
preferentially affecting proximal muscles. Diagnosis is
suggested by an EMG study showing abnormal spontaneous
activity in proximal muscles and the presence of myopathic
motor unit changes. Alternative diagnoses are eliminated by
nerve conduction and neuromuscular junction studies and the
EMG. Diagnosis is confirmed by muscle biopsy. Treatment
requires aggressive and long term immunosuppressive therapy.
Expectations for improvement in strength are good, but
complete remission or cure less predictable. Polymyositis
may be associated with other systemic disorders such as
collagen vascular diseases and cancer, and an appropriate
evaluation should include these associations.
- Language of Publication
- English
- Unique Identifier
- 92331362
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- MeSH Heading (Major)
- Electrodiagnosis|*; Myositis|*DI/DT/PP
- MeSH Heading
- Human; Immunosuppressive Agents|TU
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0098-8243
- Country of Publication
- UNITED STATES
Record 22 from database: MEDLINE
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- Title
- Spontaneous regression of hepatocellular carcinoma.
- Author
- van Halteren HK; Salemans JM; Peters H; Vreugdenhil G;
Driessen WM
- Address
- Department of Internal Medicine, St Joseph Hospital,
Veldhoven, The Netherlands.
- Source
- J Hepatol, 1997 Jul, 27:1, 211-5
- Abstract
- A 72-year-old Caucasian woman suffered from histologically-proven
advanced hepatic cancer, for which she received no
treatment. She had been a regular drinker for a long time.
Serologic markers for hepatitis B and C were negative. In
spite of her poor prognosis, she remained in good clinical
condition and at 14 months of follow up the hepatocellular
carcinoma could not be visualised any more radiologically.
At that time the serum alpha foetoprotein concentration was
normal. At present, 28 months after diagnosis, the patient
is doing well and her tumour still appears to be in complete
spontaneous remission.
- Language of Publication
- English
- Unique Identifier
- 97394380
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- MeSH Heading (Major)
- Carcinoma, Hepatocellular|*PA/RA; Liver Neoplasms|*PA/RA;
Neoplasm Regression, Spontaneous|*PA
- MeSH Heading
- Aged; Biopsy; Case Report; Female; Human; Tomography,
X-Ray Computed
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0168-8278
- Country of Publication
- DENMARK
Record 23 from database: MEDLINE
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- Title
- Hormonal therapy in the treatment of mandibular metastasis
of breast carcinoma. Report of a case.
- Author
- Ehlinger P; Peeters LC; Servais J; Fossion E
- Address
- Department of Maxillo-Facial Surgery, Algemeen Ziekenhuis
Middelheim, Antwerp, Belgium.
- Source
- Int J Oral Maxillofac Surg, 1993 Apr, 22:2, 108-9
- Abstract
- We present the clinical history of a 39-year-old woman,
who has survived for over 10 years with metastatic breast
cancer. After combined surgery and radiotherapy of the
primary tumor and the regional lymph nodes, all bone
metastases gradually disappeared under chemotherapy and
continuing hormonal treatment. This complete remission
included a large mandibular metastasis, which had received
additional radiotherapy of 21 Gy. Spontaneous reossification
was observed in this location.
- Language of Publication
- English
- Unique Identifier
- 93308374
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To Menu Position #10
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To Menu Position #20
- MeSH Heading (Major)
- Breast Neoplasms|DT/*PA; Carcinoma, Intraductal,
Noninfiltrating|*DT/RT/*SC; Mandibular Neoplasms|*DT/RT/*SC;
Tamoxifen|AD/*TU
- MeSH Heading
- Adult; Antineoplastic Agents, Combined|TU; Bone
Neoplasms|DT/SC; Case Report; Combined Modality Therapy;
Cyclophosphamide|AD; Doxorubicin|AD; Female; Fluorouracil|AD;
Human; Methotrexate|AD
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0901-5027
- Country of Publication
- DENMARK
Record 24 from database: MEDLINE
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- Title
- Pregnancy after high therapeutic doses of iodine-131 in
differentiated thyroid cancer: potential risks and
recommendations.
- Author
- Casara D; Rubello D; Saladini G; Piotto A; Pelizzo MR;
Girelli ME; Busnardo B
- Address
- Department of Radiotherapy and Nuclear Medicine, General
Hospital of Padua, Italy.
- Source
- Eur J Nucl Med, 1993 Mar, 20:3, 192-4
- Abstract
- Seventy female patients who had been treated with high
doses of iodine-131 for differentiated thyroid cancer (DTC)
and who had a subsequent pregnancy were evaluated. The total
131I dose ranged from 1.85 to 16.55 GBq (mean +/- SD = 4.39
+/- 25.20 GBq). Age at first therapy ranged from 15 to 36
years (mean +/- SD = 24.3 +/- 5.0 years) and the interval
from 131I therapy to pregnancy varied from 2 to 10 years
(mean +/- SD = 5.3 +/- 2.8 years). The estimated radiation
dose to the gonads ranged from 10 to 63 cGy (mean +/- SD =
24.0 +/- 13.5 cGy). All patients were treated with L-thyroxine
at doses capable of suppressing thyroid-stimulating hormone.
Seventy-three children were followed-up and seven
pregnancies are still in progress. One child was affected by
Fallot's trilogy and three had a low birth weight through
with subsequent normal growth; the others were healthy with
subsequent normal growth. No newborn with clinical or
biochemical thyroid dysfunctions was found. Two spontaneous
abortions during the second month of pregnancy were
recorded. One of two patients in question subsequently had
two healthy children. On the basis of these data, previous
administration of high 131I doses does not appear to be a
valid reason for dissuading young female DTC patients from
considering pregnancy. However, patients should be advised
to avoid pregnancy after 131I administration for a period
sufficient to ensure complete elimination of the
radionuclide and to permit confirmation of complete disease
remission, i.e. at least 1 year in our opinion.
- Language of Publication
- English
- Unique Identifier
- 93215726
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To Menu Position #10
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To Menu Position #20
- MeSH Heading (Major)
- Iodine Radioisotopes|*TU; Prenatal Exposure Delayed
Effects|*; Thyroid Neoplasms|*RT
- MeSH Heading
- Adenocarcinoma|RT; Adult; Carcinoma, Papillary|RT; Female;
Human; Levothyroxine|TU; Ovary|RE; Pregnancy; Radiotherapy
Dosage; Risk Factors; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0340-6997
- Country of Publication
- GERMANY
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