Photo
Of Granuloma on the Cheek (Source)
Granuloma comes with the suffix, -oma, which means "a swelling" and "granule" meaning a small particle. In this case the "small particle" is tissue composed largely of capillaries and fibroblasts. A "fibroblast" is the name given to the original cells which then become differentiated into more specialized cells -- in this case the connective tissues of the body -- muscles, tendons generally tissue-building material.
Granuloma is a condition on the surface of the body -- on the skin. Typically it is an unhealing inflammation that can develop a scab, or crust, but never really heals. It will typically bleed at a time when the skin below the scab moves, breaking the seal between the scab and the skin, allowing blood to ooze out. If the area were to "heal" then the scab could break off leaving normal skin below it. If the area below the scab is NOT healing, then as the scab is broken off, or moved, the area beneath it is still the unhealed inflammation.
A doctor who examined Karl's "bump" believed that there was an 80% chance that it was a granuloma.
In the case of Karl Loren it is possible that the fly bite in Africa, some 40 years ago, caused some "foreign material" to be left in the site. (This tends to be true of spider bites, for instance.) This could have been some of the protein components of the larva that burrowed into his body from the fly. This protein material could well have been encased, years ago, and remained in a completely inactive state. Karl's efforts at self-treatment may well have broken into this casing and exposed the foreign material to the body's defense system -- the immune system.
While the immune system can handle many different types of antigens (bacteria) it may not be equipped to deal with this type of toxic residue. We have, then, a continuing number of immune system cells which die in the attempt to get rid of the toxic residue from that ancient fly episode.
Generally granuloma is never a malignant cancer -- however, the action of granuloma can be to "spread" which can cause destruction of tissue as the inflammation spreads.
A special type of INFLAMMATION characterized by accumulations of macrophages, some of which coalesce into "giant cells." Granulomatous inflammation is especially characteristic of tuberculosis, some deep fungal infections (like histoplasmosis and coccidioidomycosis), sarcoidosis (a disease of unknown cause), and reaction to foreign bodies.
Granuloma -- Cancer & Biopsy Drawing
Granuloma Faciale - Left Cheek Photo
Response of granuloma annulare to pentoxiphylline Photo
Granuloma Pyogenicum Lip Photo
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