100 Scientific Studies:  Diabetes And Blindness

Record 1 from database: MEDLINE
Return To Top

Title

Chiasmal infarction and sudden blindness caused by mucormycosis in AIDS and diabetes mellitus.

Author

Lee BL; Holland GN; Glasgow BJ

Address

UCLA Ocular Inflammatory Disease Center, USA.

Source

Am J Ophthalmol, 1996 Dec, 122:6, 895-6

Abstract

PURPOSE: To report rapidly progressive rhino-orbitocerebral mucormycosis in a 47-year-old woman with both diabetes mellitus and the acquired immunodeficiency syndrome (AIDS). METHOD: Case report including postmortem examination of the eyes, orbit, and brain of a patient with rhino-orbitocerebral mucormycosis, diabetes mellitus, and AIDS. RESULTS: Invasion by hyphae of the Rhizopus species produced an occlusive vasculitis and massive infarction of the optic chiasm. Fungal organisms were discovered in multiple granulomata of the optic nerve. CONCLUSION: Infarction at the optic chiasm probably caused sudden blindness in this patient.

Language of Publication

English

Unique Identifier

97115249

Return To Top

MeSH Heading (Major)

Acquired Immunodeficiency Syndrome|*CO; Blindness|*ET/PA; Cerebral Infarction|*MI/PA; Diabetes Mellitus|*CO; Eye Infections, Fungal|*ET/PA; Mucormycosis|*CO; Optic Chiasm|*BS/MI

MeSH Heading

Case Report; Female; Human; Middle Age; Optic Nerve|MI; Orbital Diseases|MI/PA; Paranasal Sinus Diseases|MI/PA; Rhizopus|IP

Publication Type

JOURNAL ARTICLE

ISSN

0002-9394

Country of Publication

UNITED STATES

Record 2 from database: MEDLINE
Return To Top

Title

Blindness caused by diabetes--Massachusetts, 1987-1994.

Address

 

Source

MMWR Morb Mortal Wkly Rep, 1996 Nov, 45:43, 937-41

Abstract

Diabetes, the leading cause of new blindness among U.S. adults aged 20-74 years, accounts for approximately 8% of cases of legal blindness and 12% of all new cases of blindness in the United States each year. One of the national health objectives for the year 2000 is to decrease by 50% the incidence of blindness caused by diabetes (objective 17.10). However, surveillance for blindness among persons with diabetes has not been conducted nationally, and national prevalence estimates of blindness caused by diabetes have been based on state data from the register of the Massachusetts Commission for the Blind (MCB). To characterize recent trends, data on legal blindness caused by diabetes among adults with diabetes in Massachusetts were examined for 1987-1994. This report summarizes the results of that analysis, which indicate that in Massachusetts, the overall incidence and prevalence of legal blindness caused by diabetes did not decrease, despite the availability of methods to prevent vision loss.

Language of Publication

English

Unique Identifier

97056095

Return To Top

MeSH Heading (Major)

Blindness|EP/*ET; Diabetes Mellitus|*CO

MeSH Heading

Adult; Aged; Female; Human; Incidence; Male; Massachusetts|EP; Middle Age; Prevalence

Publication Type

JOURNAL ARTICLE

ISSN

0149-2195

Country of Publication

UNITED STATES

Record 3 from database: MEDLINE
Return To Top

Title

New blindness in diabetes reduced by more than one-third in Stockholm County.

Author

Bäcklund LB; Algvere PV; Rosenqvist U

Address

Department of Ophthalmology, Karolinska Institutet, St Erik's Eye Hospital, Stockholm, Sweden.

Source

Diabet Med, 1997 Sep, 14:9, 732-40

Abstract

To monitor changes over time in the incidence of blindness among people with diabetes, referrals (mentioning diabetes) to all vision rehabilitation centres in Stockholm County (1995 population 1 725 756) during 1981-1995 were registered. A mass mailing to people with diabetes in 1989 urged them to have their eyes examined. Mobile fundus photography teams initiated early diagnosis of diabetic retinopathy in primary health care in 1990. Referrals with diabetes and blindness, defined (WHO, ICD 10) as best-corrected visual acuity (VA) of the better eye less than 3/60 (0.05), occurred for 172 persons (7.6% of those referred with diabetes). During 1981-1985, 93 were referred (95% confidence interval 75 to 114); 1986-1990, 51 (38 to 67); 1991-1995, 28 (19 to 41). Five-year average annual incidence rate of referrals with blindness was reduced by 47% from 1.2 to 0.63 to 0.33 per 100,000 population. Mean yearly reduction during 1981-1995 was 11% (8 to 15%), 11.5% (8 to 15%) if blindness was defined as in the UK (VA 3/60 or less), and 7% (4 to 9%) for legal blindness (VA 6/60 or less); test for trend p < 0.001 (Poisson regression analysis). This is the first report of reduction in a geographical region of a proxy measure for new blindness in diabetes by one-third or more, attaining one of the main targets of the St Vincent Declaration.

Language of Publication

English

Unique Identifier

97445337

Return To Top

MeSH Heading (Major)

Blindness|*EP/PC; Diabetes Mellitus|*CO; Diabetic Retinopathy|*EP/PC

MeSH Heading

Adult; Age Distribution; Aged; Aged, 80 and over; Comparative Study; Female; Human; Incidence; Male; Middle Age; Sex Distribution; Support, Non-U.S. Gov't; Sweden|EP; Time Factors; Vision, Low|RH; Visual Acuity

Publication Type

JOURNAL ARTICLE

ISSN

0742-3071

Country of Publication

ENGLAND

Record 4 from database: MEDLINE
Return To Top

Title

Blindness in patients with diabetes who have been screened for eye disease.

Author

Rhatigan MC; Leese GP; Ellis J; Ellingford A; Morris AD; Newton RW; Roxburgh ST

Address

Department of Ophthalmology, Ninewells Hospital and Medical School, Dundee, UK.

Source

Eye, 1999 Apr, 13 ( Pt 2):, 166-9

Abstract

PURPOSE: Detection of diabetic retinopathy by screening is a major public health concern. Fundus photography has been shown to be a useful screening tool for the detection of diabetic retinopathy. In this paper the authors assess the incidence of blind and partially sighted registration due to diabetic eye disease in patients screened by a mobile fundus photography unit and identify the factors that contributed to loss of vision in the registered group. METHODS: A retrospective review of blind and partially sighted registrations between 1990 and 1995 was performed in a diabetic population screened by a mobile fundus photography unit in a region with a population of 390,000. The incidence of blind and partially sighted registration in the screened diabetic population was calculated. In the registered group, cause of visual loss, accuracy of photograph reporting, delay in laser treatment, adequacy of laser treatment and non-attendance rates at ophthalmic clinics were assessed. RESULTS: Of the 5390 patients screened by the mobile unit over 6 years, 68 (210 per 10(5) patient-years) were registered blind or partially sighted, but in only 17 patients (53 per 10(5) patient-years) was this as a result of diabetes. The factors contributing to loss of vision were found to be failure of laser treatment, rapidly progressive disease and poor patient attendance. CONCLUSIONS: As the majority of visual impairment in patients with diabetes is not due to diabetic retinopathy, this has important implications for screening programmes and may make the St Vincent Declaration targets difficult to achieve. The rate of new blind and partially sighted registration due to diabetes in the screened population was low at 53 per 10(5) patient-years (95% confidence interval, 29-76).

Language of Publication

English

Unique Identifier

99378869

Return To Top

MeSH Heading (Major)

Blindness|DI/EP/*ET; Diabetic Retinopathy|*CO/SU; Vision Screening|*

MeSH Heading

Adult; Aged; Aged, 80 and over; Female; Fundus Oculi; Human; Incidence; Laser Coagulation; Male; Middle Age; Mobile Health Units; Patient Acceptance of Health Care; Retrospective Studies; Scotland|EP; Treatment Failure

Publication Type

JOURNAL ARTICLE

ISSN

0950-222X

Country of Publication

ENGLAND

Record 5 from database: MEDLINE
Return To Top

Title

An approach to the prevention of blindness in diabetes.

Author

Herman WH; Teutsch SM; Sepe SJ; Sinnock P; Klein R

Address

 

Source

Diabetes Care, 1983 Nov, 6:6, 608-13

Abstract

Diabetic eye disease is the leading cause of new cases of legal blindness in American adults under the age of 65 yr. Diabetic persons are at risk for visual loss due to diabetic retinopathy, glaucoma, and cataracts. Better understanding of the natural histories of these complications and recent advances in treatment have provided a rationale for developing an approach to prevent visual loss. This approach requires that diabetic patients who are at high risk for visual loss, and not under the care of ophthalmologists, be systematically screened, referred, and treated.

Language of Publication

English

Unique Identifier

84083937

Return To Top

MeSH Heading (Major)

Blindness|DI/ET/*PC; Diabetes Mellitus|*CO/ME/PP/TH

MeSH Heading

Adult; Animal; Blood Pressure; Cataract|ET/PC; Cataract Extraction; Diabetes Mellitus, Experimental|TH; Diabetic Retinopathy|PC/SU; Dogs; Female; Glaucoma|ET/PC/TH; Human; Lasers|TU; Macula Lutea|SU; Pregnancy; Risk; Vitrectomy

Publication Type

JOURNAL ARTICLE; REVIEW

ISSN

0149-5992

Country of Publication

UNITED STATES

Record 6 from database: MEDLINE
Return To Top

Title

Transitory blindness during ethanol and phenethylbiguanide induced lactic acidosis in a subject with diabetes mellitus. A case report.

Author

Sorensen PN

Address

 

Source

Acta Ophthalmol (Copenh), 1977 Apr, 55:2, 177-82

Abstract

Transitory blindness is described in a diabetic patient with typical ethanol- and phenethylbiguanide induced lactic acidosis. The blindness developed in the course of 8 hours, but the vision returned during treatment with iv bicarbonate, insulin and glucose. The condition is discussed in relation to a presumed inhibition of the oxidative metabolism in the retina.

Language of Publication

English

Unique Identifier

77178472

Return To Top

MeSH Heading (Major)

Alcoholic Intoxication|*CO; Blindness|*CI; Diabetic Ketoacidosis|BL/*CI/CO; Diabetic Retinopathy|*CI; Phenformin|*AE

MeSH Heading

Case Report; Female; Human; Lactates|BL; Middle Age

Publication Type

JOURNAL ARTICLE

ISSN

0001-639X

Country of Publication

DENMARK

Record 7 from database: MEDLINE
Return To Top

Title

Elimination of preventable blindness from diabetes by the year 2000.

Author

Plechaty G; Smith RE; Patz A

Address

 

Source

Hawaii Med J, 1992 Jul, 51:7, 186, 196

Abstract

"Diabetes 2000" will parallel a major diabetic retinopathy public information campaign recently announced by the National Eye Institute. The NEI's National Eye Health Education Program (NEHEP), which targets both diabetic retinopathy and glaucoma, is fashioned along the lines of earlier federal initiatives against smoking and high blood pressure. By continuously updating our medical knowledge and skills related to this multisystem disorder, and by forging partnerships between physicians in the effective and efficient management of diabetic patients, we have a unique and important opportunity--we can reduce preventable blindness from diabetes by the year 2000.

Language of Publication

English

Unique Identifier

92387913

Return To Top

MeSH Heading (Major)

Blindness|*PC; Diabetic Retinopathy|*PC

MeSH Heading

Forecasting; Hawaii; Human

Publication Type

JOURNAL ARTICLE

ISSN

0017-8594

Country of Publication

UNITED STATES

Record 8 from database: MEDLINE
Return To Top

Title

Association of blindness to intensification of glycemic control in insulin-dependent diabetes mellitus.

Author

Moskalets E; Galstyan G; Starostina E; Antsiferov M; Chantelau E

Address

Diabetes Care and Education Unit, National Center for Endocrinology, Moscow, Russia.

Source

J Diabetes Complications, 1994 Jan, 8:1, 45-50

Abstract

Intensive glycemic control (IGC) in previously hyperglycemic insulin-dependent diabetes mellitus (IDDM) patients is associated with a decreased long-term risk of progression of diabetic retinopathy (DR); up to 12 months after institution of IGC, however, the risk of progression of DR transiently increases. In an observational study, a cohort of 122 patients with IDDM was followed prospectively for changes in glycosylated hemoglobin (HbA1, normal < 8%) and in DR 0-12 months after institution of IGC. In six of these patients (women, mean age 24 years, duration of diabetes 14.3 years, with incipient nephropathy and retinopathy) a total of seven eyes went blind after 6-12 months of IGC, despite laser coagulation treatment. From the whole sample, a control groups of eight patients (six women) was set up, matched for age, duration of IDDM, degree of retinopathy, visual acuity, blood pressure, and microalbuminuria, with preserved vision after 12 months of IGC. In the case patients, the mean (95% confidence interval) initial HbA1 was 14.9% (13.8%-16.1%), versus 13.4% (12.4%-14.4%) in the control patients (p < 0.05). The mean HbA1 decrements after 4 months of IGC, were 3.0% (1.9%-4.1%) in the cases, and 2.1% (1.2%-3.0%) in the controls (NS); and after 12 months, the respective decrements were 4.9% (2.4%-7.4%) in the cases versus 2.0% (0.5%-3.5%) in the controls (p = 0.04). In conclusion, IGC with a decrement of > 2% per year is associated with a high risk of progression of antecedent diabetic retinopathy to blindness in IDDM patients with an extremely high initial HbA1.(ABSTRACT TRUNCATED AT 250 WORDS)

Language of Publication

English

Unique Identifier

94220761

Return To Top

MeSH Heading (Major)

Blindness|*EP; Blood Glucose|*ME; Diabetes Mellitus, Insulin-Dependent|BL/*PP/RH; Diabetic Retinopathy|*PP; Patient Education|*

MeSH Heading

Adolescence; Adult; Female; Follow-Up Studies; Human; Male; Risk Factors; Support, Non-U.S. Gov't; Time Factors

Publication Type

JOURNAL ARTICLE

ISSN

1056-8727

Country of Publication

UNITED STATES

Record 9 from database: MEDLINE
Return To Top

Title

Diabetes insipidus and blindness caused by a suprasellar tumor: Pieter Pauw's observations from the 16th century [see comments]

Author

Kivelä T; Pelkonen R; Oja M; Heiskanen O

Address

Department of Ophthalmology, Helsinki University Central Hospital, Finland. tekivela@cc.helsinki.fi

Source

JAMA, 1998 Jan, 279:1, 48-50

Abstract

Tumors in the suprasellar region may cause both visual and endocrinologic symptoms. This association, well known to modern physicians, was established during the 19th century. However, we have identified a 16th-century autopsy report, written by the Dutch professor of anatomy Pieter Pauw (1564-1617), which describes an 18-year-old girl who developed marked polyuria and subsequently became totally blind from a cystic tumor compressing the optic chiasm. Based on prevailing theories on the nature of diabetes, Pauw attributed the disease to the kidneys. Undoubtedly, however, his lucid report is the earliest known account of diabetes insipidus caused by an arachnoid cyst, the Rathke cleft cyst, or craniopharyngioma in the region of the pouch of Rathke. The description also gives insights into the role of anatomic dissections in late 16th-century northern Europe.

Language of Publication

English

Unique Identifier

98084659

Return To Top

MeSH Heading (Major)

Craniopharyngioma|CO/*HI; Diabetes Insipidus|ET/*HI

MeSH Heading

Anatomy|HI; Autopsy|HI; Blindness|ET/HI; Female; History of Medicine, 16th Cent.; Human; Netherlands; Portraits

Publication Type

BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE

ISSN

0098-7484

Country of Publication

UNITED STATES

Record 10 from database: MEDLINE
Return To Top

Title

Incidence of blindness in relation to diabetes. A population-based study.

Author

Trautner C; Icks A; Haastert B; Plum F; Berger M

Address

Department of Biometrics and Epidemiology, Diabetes Research Institute, Heinrich Heine University, DÂusseldorf, Germany. trau@dfi.uni-duesseldorf.de

Source

Diabetes Care, 1997 Jul, 20:7, 1147-53

Abstract

OBJECTIVE: A reduction of diabetes-related blindness was declared a primary objective for Europe (St. Vincent Declaration). We collected data about incidence rates of blindness in the diabetic population compared with the nondiabetic population. Up to now, such data are scarce-even worldwide. RESEARCH DESIGN AND METHODS: A complete list of newly registered blindness allowance recipients was drawn up in the district of Württemberg-Hohenzollern, Germany, between 1990 and 1993. From these data, we estimated age-specific and standardized incidence rates of blindness in the entire, the diabetic, and the nondiabetic population, as well as relative and attributable risks due to diabetes. RESULTS: There were 2,714 people meeting the inclusion criteria; 1,823 (67.2%) were female and 781 (28.8%) had diabetes. In 318 subjects, diabetes was likely to be the only cause of blindness; in 192 subjects, it was one of several contributory causes. Age of women was 73.9 +/- 19.4 years (mean +/- SD) and of men 63.3 +/- 25.5 years. Results standardized to the (West) German population are as follows: incidence rates (per 100,000 person-years): total population: 13.5; diabetic population: 60.6; nondiabetic population: 11.6; relative risk: 5.2; attributable risk among exposed: 0.81; and population attributable risk: 0.14. The relative risks decreased considerably with increasing age. When the study is repeated to monitor the St. Vincent targets, a reduction in the incidence rate of blindness in the diabetic population by 17% will be detected with 95% power. CONCLUSIONS: Great relative and attributable risks, especially in younger age-groups, indicate the need for increased attention to preventive measures for microvascular complications.

Language of Publication

English

Unique Identifier

97347089

Return To Top

MeSH Heading (Major)

Blindness|*EP/ET; Diabetes Mellitus|*CO

MeSH Heading

Adolescence; Adult; Age Factors; Aged; Aged, 80 and over; Child; Comparative Study; Female; Germany|EP; Human; Incidence; Male; Middle Age; Risk Factors; Sex Characteristics; Support, Non-U.S. Gov't

Publication Type

JOURNAL ARTICLE

ISSN

0149-5992

Country of Publication

UNITED STATES

Record 11 from database: MEDLINE
Return To Top

Title

Blindness due to diabetes: population-based age- and sex-specific incidence rates.

Author

Icks A; Trautner C; Haastert B; Berger M; Giani G

Address

Department of Biometrics and Epidemiology, Diabetes Research Institute at DÂusseldorf University, Germany.

Source

Diabet Med, 1997 Jul, 14:7, 571-5

Abstract

Reducing the incidence of diabetic retinopathy and blindness was declared one of the main objectives in St Vincent. To date, hardly any valid data are available on the age- and sex-specific incidence of diabetes-related blindness. They are necessary, however, to evaluate intervention activities. Therefore, we used a population-based registry of blindness to calculate incidence of blindness due to diabetes. In one German district (Rhineland) we obtained complete lists of cases of blindness newly registered in 1990 and 1991 and coded as blind due to diabetes (n = 589). We estimated age-specific incidence rates in the entire as well as in the diabetic population. Incidence rates of blindness due to diabetes (100,000(-1) * year(-1)), standardized to the West-German population, were 3.2 (CI 95%: 2.9;3.4) in the entire population and 60.5 (CI 95%: 45.7;75.4) in the diabetic population. Incidence rates in the diabetic population showed a peak between 20 and 40 years of age, probably due to complications of Type 1 diabetes. Incidence was higher in diabetic women than in diabetic men (p < 0.05 at ages > or =40 years). Repeating the study will detect a decrease in the incidence of blindness due to diabetes by one-third with over 99% power.

Language of Publication

English

Unique Identifier

97366565

Return To Top

MeSH Heading (Major)

Blindness|*EP/*ET; Diabetic Retinopathy|*CO

MeSH Heading

Adolescence; Adult; Age Factors; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Germany|EP; Human; Incidence; Infant; Infant, Newborn; Male; Middle Age; Reference Standards; Registries|SN/ST; Sex Factors; Support, Non-U.S. Gov't

Publication Type

JOURNAL ARTICLE

ISSN

0742-3071

Country of Publication

ENGLAND