|
Record 1 from database: MEDLINE
 Return
To Top
- Title
- Associations of smoking, alcohol and physical activity
with risk factors for coronary heart disease and diabetes
in the first follow-up cohort of the Heart Disease and
Diabetes Risk Indicators in a Screened Cohort study
(HDDRISC-1).
- Author
- Godsland IF; Leyva F; Walton C; Worthington M; Stevenson
JC
- Address
- Wynn Department of Metabolic Medicine, Imperial College
School of Medicine, London, UK.
- Source
- J Intern Med, 1998 Jul, 244:1, 33-41
- Abstract
- OBJECTIVES: To investigate the associations between risk
factors for cardiovascular disease and cigarette smoking,
alcohol intake, and physical activity in a group of
predominantly healthy men. DESIGN: Cohort study with
baseline characterisation, clinical follow-up, and
identification of predictors of coronary artery disease
and diabetes. SETTING: University hospital metabolic day
ward. SUBJECTS: Participants in a company health programme
(n=742). MAIN OUTCOME MEASURES: Routine haematology and
biochemistry, cholesterol, triglycerides, high density
lipoprotein (HDL) cholesterol (on a subset of 522
subjects), and glucose and insulin levels during a 3 h
oral glucose tolerance test (OGTT). RESULTS: Independent
associations with previous cigarette smoking included high
uric acid and low HDL cholesterol, and with current
cigarette smoking, high haemoglobin and white cell count
and low OGTT insulin. Increasing alcohol intake was
associated with increasing blood pressure, uric acid, HDL
cholesterol and fasting glucose. The moderate range of
exercise intensity in this cohort was associated with
decreasing systolic blood pressure, fasting insulin and
OGTT glucose and insulin. Factor analysis distinguished
principal factors comprising features of the metabolic
syndrome with low physical activity, and high white cell
count, high haemoglobin concentration and low HDL
cholesterol with increasing previous and current cigarette
smoking and alcohol intake. CONCLUSIONS: Some
characteristics of the metabolic syndrome were seen with
previous but not current smoking habit. Regular alcohol
consumption was associated with mainly unfavourable
metabolic characteristics, although there was an
independent beneficial association with HDL cholesterol.
The improved metabolic syndrome profile seen with
increasing exercise is consistent with even moderate
degrees of physical activity having beneficial effects on
metabolism.
- Language of Publication
- English
- Unique Identifier
- 98361487
Return
To Top
- MeSH Heading (Major)
- Alcohol Drinking|*AE; Coronary Disease|*ET; Diabetes
Mellitus|*ET; Exercise|*; Smoking|*AE
- MeSH Heading
- Adult; Aged; Blood Glucose; Blood Pressure; Factor
Analysis, Statistical; Follow-Up Studies; Health Behavior;
Human; Linear Models; Lipoproteins, HDL Cholesterol|BL;
Male; Middle Age; Predictive Value of Tests; Prospective
Studies; Risk Factors; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0954-6820
- Country of Publication
- ENGLAND
Record 2 from database: MEDLINE
Return
To Top
- Title
- Interactions between diabetes and family history of
coronary heart disease and other risk factors for coronary
heart disease among adults with diabetes in Utah.
- Author
- Schumacher MC; Hunt SC; Williams RR
- Address
- Department of Internal Medicine, University of Utah
School of Medicine, Salt Lake City 84108.
- Source
- Epidemiology, 1990 Jul, 1:4, 298-304
- Abstract
- We used a unique data base containing medical family
history information from representative Utah families to
investigate interactions between diabetes and family
history of coronary heart disease and other risk factors
for coronary heart disease. We compared nonrelated
individuals reported to have had diabetes mellitus
diagnosed over the age of 19 (948) with 2150 nondiabetic
individuals. Among both men and women, diabetes and family
history of early coronary heart disease magnified the risk
for coronary heart disease, so that in diabetic
individuals with a positive family history of coronary
heart disease, about 74% of the coronary heart disease
could be attributed to interaction. Relative to
nondiabetics without a family history of early coronary
heart disease, nondiabetics with family history had a
relative risk of 4.5 (2.3-8.7), diabetics without a family
history had a relative risk of 2.8 (1.6-4.9), and
diabetics with a family history had a relative risk of
21.3 (9.1-50.0). Smoking also interacted with diabetes;
among smoking diabetics, 47% of early heart disease may be
attributable to interaction between smoking and diabetes.
Smoking entailed the highest risk for diabetic women.
Hypertension and diabetes appeared to act additively, with
little interaction. Among women, family history of
diabetes was a risk factor for coronary heart disease with
a relative risk of 2.5 (1.0-6.4), whereas for men the
relative risk was estimated to be 0.4 (0.2-1.1).
- Language of Publication
- English
- Unique Identifier
- 91191033
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*ET/GE; Diabetes Mellitus|*CO/GE
- MeSH Heading
- Adult; Age Factors; Comparative Study; Female; Human;
Hypertension|CO; Male; Middle Age; Risk Factors; Sex
Factors; Smoking|AE; Support, Non-U.S. Gov't; Support,
U.S. Gov't, P.H.S.; Utah
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1044-3983
- Country of Publication
- UNITED STATES
Record 3 from database: MEDLINE
Return
To Top
- Title
- Family history of coronary heart disease is a stronger
predictor of coronary heart disease morbidity and
mortality than family history of non-insulin dependent
diabetes mellitus.
- Author
- Kekäläinen P; Sarlund H; Pyörälä K; Laakso M
- Address
- Department of Medicine, Kuopio University Hospital,
Finland.
- Source
- Atherosclerosis, 1996 Jun, 123:1-2, 203-13
- Abstract
- The aim of this study was to compare the effect of
family history of non-insulin dependent diabetes mellitus
(NIDDM) and coronary heart disease (CHD) as risk factors
for CHD morbidity and mortality. Altogether, 394 siblings
of NIDDM probands and non-diabetic probands, with and
without CHD, were followed for 8 years with respect to CHD
events in a prospective population-based study. The
baseline study was conducted from 1983 to 1985. Age- and
sex-adjusted cumulative occurrence of CHD events was
higher in the siblings of the probands with CHD and with
NIDDM (13.1%; P = 0.037) and in the siblings of the
probands with CHD and without NIDDM (15.4%; P = 0.054),
compared with the siblings of the probands without NIDDM
and without CHD (4.8%). The incidence of fatal CHD events
tended to be higher in a group with a family history of
NIDDM and CHD, but the trend was not statistically
significant. In univariate logistic regression analyses, a
family history of CHD was positively associated with
cumulative occurrence of CHD events (odds ratio 2.53, P =
0.009), whereas a family history of NIDDM had no
significant association (odds ratio 1.39, P = 0.312).
After adjustment for age, sex, family history of NIDDM and
major cardiovascular risk factors, the association between
family history of CHD and cumulative occurrence of CHD
events remained significant (odds ratio 2.25, P = 0.048).
In conclusion, the present study indicates that a family
history of CHD is a stronger predictor of future CHD
events than a family history of NIDDM.
- Language of Publication
- English
- Unique Identifier
- 96377002
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*EP/GE; Diabetes Mellitus,
Non-Insulin-Dependent|*EP/GE
- MeSH Heading
- Aged; Body Mass Index; Cholesterol|BL; Female;
Finland|EP; Follow-Up Studies; Glucose Tolerance Test;
Human; Lipoproteins|BL; Logistic Models; Male; Middle Age;
Nuclear Family; Prospective Studies; Risk Factors;
Support, Non-U.S. Gov't; Survival Rate; Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0021-9150
- Country of Publication
- IRELAND
Record 4 from database: MEDLINE
Return
To Top
- Title
- The Rochester Coronary Heart Disease Project: effect of
cigarette smoking, hypertension, diabetes, and steroidal
estrogen use on coronary heart disease among 40- to
59-year-old women, 1960 through 1982 [see comments]
- Author
- Beard CM; Kottke TE; Annegers JF; Ballard DJ
- Address
- Section of Clinical Epidemiology, Mayo Clinic,
Rochester, MN 55905.
- Source
- Mayo Clin Proc, 1989 Dec, 64:12, 1471-80
- Abstract
- A population-based case-control study of coronary heart
disease (CHD) risk in young women attributable to
cigarette smoking, hypertension, diabetes, and steroidal
estrogen use was conducted among residents of Rochester,
Minnesota. All newly diagnosed cases of CHD (sudden
unexpected death [SUD], N = 18; myocardial infarction
[MI], N = 90; and angina, N = 133) among female Rochester
residents 40 to 59 years of age during the years 1960
through 1982 were identified, and two community control
subjects were matched for age and duration of community
medical record. The overall adjusted odds ratio (OR) for
the association between steroidal estrogen use and
definite CHD (MI and SUD) was 0.6 (95% confidence interval
[CI] = 0.2 to 1.3). Smoking (OR = 5.1; 95% CI = 2.3 to
11.6), hypertension (OR = 4.8; 95% CI = 2.3 to 10.2), and
diabetes (OR = 8.4; 95% CI = 1.6 to 44.5) were strong risk
factors for CHD events. If considered causal, cigarette
smoking accounted for 64% of all MIs and SUDs in the
community, hypertension accounted for 45%, and diabetes
accounted for 13%. Although steroidal estrogen exposure
reduced CHD among these women by 14%, giving steroidal
estrogens to all women in this age group might reduce the
population rates of MI by as much as 45%.
- Language of Publication
- English
- Unique Identifier
- 90097220
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|BL/EP/*ET/MO/PC; Diabetes Mellitus|*CO;
Estrogen Replacement Therapy|*; Estrogens, Conjugated|*TU;
Hypertension|*CO/PC; Smoking|*AE/BL/PC
- MeSH Heading
- Adult; Analysis of Variance; Bias (Epidemiology);
Cholesterol|BL; Comparative Study; Confounding Factors
(Epidemiology); Evaluation Studies; Female; Human;
Menopause; Middle Age; Minnesota; Retrospective Studies;
Risk Factors; Support, U.S. Gov't, P.H.S.; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0025-6196
- Country of Publication
- UNITED STATES
Record 5 from database: MEDLINE
Return
To Top
- Title
- The association of body fat distribution with
hypertension, hypertensive heart disease, coronary heart
disease, diabetes and cardiovascular risk factors in men
and women aged 18-79 years.
- Author
- Gillum RF
- Address
-
- Source
- J Chronic Dis, 1987, 40:5, 421-8
- Abstract
- To confirm the reported association of body fat
distribution with cardiovascular disease, diabetes, blood
pressure and serum cholesterol, data from the 1960-62
Health Examination Survey were analyzed. In this sample
drawn from the noninstitutionalized population of the
United States aged 18-79, mean values of two indices of
upper versus lower body fat distribution increased
steadily with age. Men had higher values than women, and
black women had higher values than white women. Higher
values of the indices were significantly associated with
higher blood pressure, post-load serum glucose and greater
prevalence of definite hypertension and definite
hypertensive heart disease independent of multiple
confounders. Associations with higher serum cholesterol
and definite coronary heart disease prevalence were
independent of overall ponderosity but not of age and
multiple other confounders. Greater abdominal relative to
lower body fat deposits were independently associated with
increased cardiovascular risk in men and women, blacks and
whites.
- Language of Publication
- English
- Unique Identifier
- 87166547
Return
To Top
- MeSH Heading (Major)
- Adipose Tissue|*AH; Anthropometry|*; Cardiovascular
Diseases|*EP; Coronary Disease|*EP; Diabetes Mellitus|*EP;
Heart Diseases|*EP; Hypertension|*EP
- MeSH Heading
- Adolescence; Adult; Age Factors; Aged; Blood Pressure;
Cholesterol|BL; Comparative Study; Cross-Sectional
Studies; Female; Health Surveys; Human; Male; Middle Age;
Negroid Race; Risk; Sex Factors; United States
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0021-9681
- Country of Publication
- ENGLAND
Record 6 from database: MEDLINE
Return
To Top
- Title
- Heart rate variability in patients with diabetes
mellitus, ischemic heart disease, and congestive heart
failure.
- Author
- Takase B; Kurita A; Noritake M; Uehata A; Maruyama T;
Nagayoshi H; Nishioka T; Mizuno K; Nakamura H
- Address
- First Department of Internal Medicine, National Defense
Medical College, Saitama, Japan.
- Source
- J Electrocardiol, 1992 Apr, 25:2, 79-88
- Abstract
- The prognosis of patients with heart disease and
prediction of sudden cardiac death can be assessed through
heart rate variability, an indirect measure of abnormal
autonomic control. The authors have evaluated the heart
rate variability by 24-hour ambulatory
electrocardiographic monitoring in 25 diabetic patients,
19 ischemic heart disease patients, 18 congestive heart
failure patients, and 10 normal subjects. Thirteen
diabetic patients had autonomic neuropathy and 12 patients
did not. Heart rate variability index (mean SD) in
patients with diabetes mellitus, ischemic heart disease,
and congestive heart failure was significantly lower (34.5
+/- 12.6 ms, 43.7 +/- 15.4 ms, and 34.6 +/- 15.8 ms vs
65.6 +/- 16.7 ms, p less than 0.05) than that of normal
subjects. Mean SD was significantly lower in patients with
autonomic neuropathy as compared to patients without
autonomic neuropathy (26.4 +/- 6.5 ms vs 44.2 +/- 11.0 ms,
p less than 0.05) mean SD as compared to survivors: 49 +/-
7 ms in patients with mild ischemic heart disease, 48 +/-
15 ms in patients with severe ischemic heart disease, and
23 +/- 7 ms in patients who died. Similarly, the mean SD
in 4 congestive heart failure patients who died was lower
significantly (p less than 0.05) than in those who
survived (19.0 +/- 5.6 ms vs 40.0 +/- 14.5 ms). Among
congestive heart failure patients, clinical improvement by
therapy was associated with a significant increase in mean
SD. When the mean SD of 30 ms was used as the cutoff point
for detection of autonomic dysfunction or patient death,
specificity exceeded 90% and sensitivity was 75%.(ABSTRACT
TRUNCATED AT 250 WORDS)
- Language of Publication
- English
- Unique Identifier
- 92395400
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|EP/*PP; Diabetes Mellitus, Non-Insulin-Dependent|EP/*PP;
Heart Failure, Congestive|EP/*PP; Heart Rate|*PH
- MeSH Heading
- Adult; Aged; Analysis of Variance; Circadian Rhythm|PH;
Comparative Study; Coronary Angiography; Diabetic
Neuropathies|EP/PP; Echocardiography; Electrocardiography,
Ambulatory|IS/MT/SN; Female; Human; Male; Middle Age
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-0736
- Country of Publication
- UNITED STATES
Record 7 from database: MEDLINE
Return
To Top
- Title
- Decreased heart rate variability in patients with
diabetes mellitus and ischemic heart disease.
- Author
- Fujimoto Y; Fukuki M; Hoshio A; Sasaki N; Hamada T;
Tanaka Y; Yoshida A; Shigemasa C; Mashiba H
- Address
- First Department of Internal Medicine, Tottori
University Hospital, Yonago, Japan.
- Source
- Jpn Circ J, 1996 Dec, 60:12, 925-32
- Abstract
- We investigated the characteristics of decreased heart
rate variability (HRV) in diabetic patients with ischemic
heart disease (IHD). Twenty-one healthy control subjects,
17 diabetic patients without IHD, and 33 diabetic patients
with IHD were studied. The diabetic patients with IHD were
subdivided into 2 groups according to the severity of
their IHD: severe or mild. HRV was evaluated in all
subjects using the spectral variables of the
all-frequency, low-frequency, high-frequency (AF, LF, HF)
components and the LF/HF ratio were determined from Holter
recordings. The AF and LF components in patients with
diabetes only or diabetes and severe IHD were
significantly lower than in control group, but the HF
component was significantly lower only in the group of
patients with diabetes and severe IHD. The LF/HF ratio did
not differ significantly among the 4 groups, but was the
lowest in diabetic patients without IHD. Patients with
diabetes and mild IHD showed a slight decrease in HRV, but
this was not significant. With regard to the circadian
rhythm of HRV, the AF and LF components in patients with
diabetes-only or diabetes and severe IHD were
significantly decreased and showed the same pattern
throughout the day. However, the HF component was
decreased during more time zones in patients with diabetes
and severe IHD, whereas the LF/HF ratio was lower during
more time zones in the diabetes-only group. All spectral
variables showed a tendency to be inversely related to the
duration of diabetes in all diabetic patients. In
particular, the LF/HF ratio showed a significant negative
correlation. The HRV of diabetic patients was
characterized by a decreased LF/HF ratio. It was concluded
that, although HRV in diabetic patients with severe IHD
was reduced mainly as a result of diabetic neuropathy,
this was also partly due to a decline in parasympathetic
tone as a result of myocardial injury.
- Language of Publication
- English
- Unique Identifier
- 97149888
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|CO/*PP; Heart Rate|*PH; Myocardial
Ischemia|CO/*PP
- MeSH Heading
- Aged; Circadian Rhythm|PH; Electrocardiography,
Ambulatory; Female; Human; Male; Middle Age; Prognosis;
Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0047-1828
- Country of Publication
- JAPAN
Record 8 from database: MEDLINE
Return
To Top
- Title
- Determinants for coronary heart disease in
non-insulin-dependent diabetes mellitus: lessons from the
diabetes intervention study.
- Author
- Hanefeld M; Schmechel H; Julius U; Schwanebeck U
- Address
- Department of Clinical Metabolic Research, Medical
Faculty, Technical University Dresden, Germany.
- Source
- Diabetes Res Clin Pract, 1996 Feb, 30 Suppl:, 67-70
- Abstract
- In NIDDM a clustering of established coronary risk
factors, e.g. the metabolic syndrome is responsible for
excessive incidence of myocardial infarction. The harmful
effects of these risk factors are aggravated by poor
glucose control. Hyperinsulinaemia is associated with a
higher level of risk factors for coronary heart disease.
Individuals with subsequent myocardial infarction exhibit
higher levels of serum insulin at entry. However, insulin
in multivariate analysis was no independent risk factor.
Perfect control of blood glucose, triglycerides and blood
pressure was associated with a lower incidence of coronary
heart disease. By extrapolation an integrated approach to
correct the anomalies of the metabolic syndrome seems to
be necessary to prevent macroangiopathy and improve life
expectancy.
- Language of Publication
- English
- Unique Identifier
- 96252128
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*; Diabetes Mellitus,
Non-Insulin-Dependent|*PP
- MeSH Heading
- Clinical Trials; Human; Insulin|BL; Multicenter Studies;
Myocardial Infarction; Risk Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0168-8227
- Country of Publication
- IRELAND
Record 9 from database: MEDLINE
Return
To Top
- Title
- Diabetes and coronary heart disease in American Indians:
The Strong Heart Study.
- Author
- Howard BV; Lee ET; Fabsitz RR; Robbins DC; Yeh JL; Cowan
LD; Welty TK
- Address
- Medlantic Research Institute, Washington, DC 20010, USA.
- Source
- Diabetes, 1996 Jul, 45 Suppl 3:, S6-13
- Abstract
- Coronary heart disease (CHD) is the leading cause of
death among American Indians. However, information on the
prevalence of CHD and its association with known risk
factors is limited. The purpose of the Strong Heart Study
is to quantify CHD and its risk factors among three
geographically diverse groups of American Indians. The
population consists of 4,549 adults between 45 and 74
years of age in 13 Indian communities in Arizona,
Oklahoma, and South and North Dakota. The phase I
examination (1989-1991) revealed very high prevalence
rates of diabetes that ranged from 33 to 72% in men and
women in the three centers. Prevalence rates of definite
myocardial infarction (MI) and definite CHD were higher in
men than in women in all three centers (P < 0.0001) and
in those with diabetes (P = 0.002 and P = 0.0003 in women
and men respectively). Diabetes was associated with a
relatively greater increase in prevalence of MI
(prevalence rate = 3.8 vs. 1.9) and CHD (prevalence rate =
4.6 vs. 1.8) in women than in men. Logistic regression
analysis indicated that the prevalence of CHD among
American Indians was significantly related to age,
diabetes, hypertension, albuminuria, percentage of body
fat, smoking, high concentrations of plasma insulin, and
low concentrations of HDL cholesterol. Lower prevalence
rates of CHD were found in Arizona despite higher rates of
diabetes, obesity, hypertension, and albuminuria; these
lower rates may be in part related to lower smoking
frequency and lower concentrations of total and LDL
cholesterol. These findings from the baseline Strong Heart
Study examination emphasize the relative importance of
diabetes and its associated variables as risk factors for
CHD among American Indian populations.
- Language of Publication
- English
- Unique Identifier
- 96289825
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*EP; Diabetes Mellitus|*EP
- MeSH Heading
- Adult; Aged; Female; Fibrinogen|AN; Human; Indians,
North American; Lipoproteins|BL; Male; Middle Age;
Obesity|CO; Odds Ratio; Regression Analysis; Risk Factors;
Smoking; Socioeconomic Factors; Tobacco
- Publication Type
- JOURNAL ARTICLE; MULTICENTER STUDY
- ISSN
- 0012-1797
- Country of Publication
- UNITED STATES
Record 10 from database: MEDLINE
Return
To Top
Back 10 records
- Title
- Diabetes and the heart: coronary heart disease.
- Author
- Jarrett J
- Address
-
- Source
- Clin Endocrinol Metab, 1977 Jul, 6:2, 389-402
- Abstract
- 1. Diabetics have a greater risk of experiencing and of
dying from a CHD event than age matched non-diabetics. 2.
The excess risk is particularly notable in insulin
dependent female diabetics who seem to lose the usual
'protection' accorded to women. 3. The cause or causes of
the excess risk are not known. There are a variety of
'risk factors' observed in diabetics which, in sum, may
contribute. 4. At least in insulin-dependent diabetics
some cardiac morbidity and mortality may also be due, not
to coronary heart disease, but to a cardiomyopathy
secondary to intramural obstructive vascular disease
and/or disordered myocardial metabolism. 5. No therapy has
yet been convincingly proved to reduce (or to increase)
the risk of cardiac morbidity or mortality. Nevertheless,
in treating diabetics there is an a priori case for using
diets designed to lower plasma lipid levels as well as the
blood sugar, for early treatment of hypertension and for
discouraging cigarette smoking.
- Language of Publication
- English
- Unique Identifier
- 77244722
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*/BL/CO/EP/MO; Diabetic Angiopathies|*/BL/CO/EP/MO
- MeSH Heading
- Adolescence; Adult; Age Factors; Cholesterol|BL; Female;
Human; Hypertension|CO/EP; Male; Middle Age; Obesity|CO;
Risk; Sex Factors; Smoking; Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE; REVIEW
- ISSN
- 0300-595X
- Country of Publication
- ENGLAND
Record 11 from database: MEDLINE
Return
To Top
- Title
- Prevalence of coronary heart disease in subjects with
normal and impaired glucose tolerance and
non-insulin-dependent diabetes mellitus in a biethnic
Colorado population. The San Luis Valley Diabetes Study.
- Author
- Rewers M; Shetterly SM; Baxter J; Marshall JA; Hamman RF
- Address
- Department of Preventive Medicine and Biometrics,
University of Colorado School of Medicine, Denver.
- Source
- Am J Epidemiol, 1992 Jun, 135:12, 1321-30
- Abstract
- The prevalence of coronary heart disease was studied in
1984-1988 in 1,092 individuals with normal glucose
tolerance, 173 individuals with impaired glucose
tolerance, and 429 individuals with non-insulin-dependent
diabetes mellitus, who were age 25-74 years and were from
a biethnic community in the San Luis Valley, Colorado.
Glucose tolerance was classified using the World Health
Organization criteria, and coronary heart disease
prevalence was assessed using the Rose Questionnaire and a
resting electrocardiogram. Compared with normal glucose
tolerance, coronary heart disease was significantly more
prevalent in diabetic non-Hispanic white women (odds ratio
(OR) for all end points combined = 3.2, 95% confidence
interval (Cl) 1.8-5.5) and men (OR = 1.9, 95% Cl 1.1-3.3)
and in diabetic Hispanic women (OR = 1.7, 95% Cl 1.1-2.5),
but not men (OR = 1.0, 95% Cl 0.6-1.7). Among diabetic
men, the prevalence of possible myocardial infarction was
lower in Hispanics than in non-Hispanic whites (OR = 0.4,
95% Cl 0.2-0.7). Similar patterns of coronary heart
disease were observed in individuals with impaired glucose
tolerance. The paradoxically low prevalence of coronary
heart disease in Hispanics with non-insulin-dependent
diabetes mellitus, especially men, may be due to unknown
protective factors, increased case fatality, or competing
mortality in this group.
- Language of Publication
- English
- Unique Identifier
- 92377784
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|CO/*EH; Diabetes Mellitus,
Non-Insulin-Dependent|*CO; Glucose Tolerance Test|*;
Hispanic Americans|*; Whites|*
- MeSH Heading
- Adult; Aged; Colorado|EP; Comparative Study;
Cross-Sectional Studies; Female; Human; Male; Middle Age;
Prevalence; Risk Factors; Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9262
- Country of Publication
- UNITED STATES
Record 12 from database: MEDLINE
Return
To Top
- Title
- The level of autoantibodies against oxidized LDL is not
associated with the presence of coronary heart disease or
diabetic kidney disease in patients with
non-insulin-dependent diabetes mellitus.
- Author
- Leinonen JS; Rantalaiho V; Laippala P; Wirta O;
Pasternack A; Alho H; Jaakkola O; Ylä Herttuala S;
Koivula T; Lehtimäki T
- Address
- Medical School, University of Tampere, and Department of
Clinical Chemistry, Tampere University Hospital, Finland.
bljale@uta.fi
- Source
- Free Radic Res, 1998 Aug, 29:2, 137-41
- Abstract
- Oxidation of low-density lipoprotein (LDL) may be an
important factor in the development of diabetic
macrovascular and renal complications. The level of
autoantibodies against oxidized LDL (oxLDL-Ab) can be used
as an index of LDL oxidation in vivo. The purpose of this
study was to investigate the association between the level
of oxLDL-Ab and the presence of coronary heart disease and
renal dysfunction in patients with non-insulin-dependent
diabetes mellitus (NIDDM). We determined the plasma levels
of oxLDL-Ab in 46 NIDDM patients and 48 well matched
nondiabetic control subjects. NIDDM patients had a
moderately higher level of oxLDL-Ab than control subjects
(0.083 +/- 0.051 vs. 0.062 +/- 0.045, p = 0.04). However,
there was no difference in the level of oxLDL-Ab between
subjects with and without coronary heart disease, and the
level of oxLDL-Ab was not associated with indices of
glomerular filtration rate or urinary albumin excretion.
- Language of Publication
- English
- Unique Identifier
- 99005176
Return
To Top
- MeSH Heading (Major)
- Autoantibodies|*BL; Coronary Disease|*IM; Diabetes
Mellitus, Non-Insulin-Dependent|*IM; Diabetic
Nephropathies|*IM; Lipoproteins, LDL|*IM
- MeSH Heading
- Aged; Diabetic Angiopathies|IM; Female; Human; Male;
Middle Age; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1071-5762
- Country of Publication
- SWITZERLAND
Record 13 from database: MEDLINE
Return
To Top
- Title
- Management of patients with diabetes after heart attack:
a population-based study of 1982 patients from a heart
disease register.
- Author
- Lim LL; Tesfay GM; Heller RF
- Address
- Centre for Clinical Epidemiology and Biostatistics,
University of Newcastle, NSW.
- Source
- Aust N Z J Med, 1998 Jun, 28:3, 334-42
- Abstract
- BACKGROUND: Previous studies examining the management of
patients with diabetes after acute myocardial infarction
(AMI) have been based on clinical studies under
experimental conditions. We used data from a
population-based heart disease register to document
differences in the management after AMI between patients
with and without diabetes. HYPOTHESIS: There were no
differences in the prescription rates of aspirin, beta
blockers, streptokinase, ACE inhibitors and calcium
channel blockers between patients with and without
diabetes admitted to hospital with AMI. METHODS: A
retrospective study of 268 patients with, and 1714
patients without, diabetes discharged from hospital with
'definite' AMI between August 1988 and March 1994.
RESULTS: The prescription rates of all five drug classes
increased between 1988 and 1994 both for patients with and
without diabetes. Patients with diabetes were
significantly less likely to have been prescribed aspirin
(76% vs 85%), beta blockers (41% vs 53%) and streptokinase
(25% vs 43%) but more likely to have been prescribed ACE
inhibitors (47% vs 29%) and calcium channel blockers (50%
vs 40%). The differences in prescription rates were
statistically significant after controlling for age, sex,
history of ischaemic heart disease, smoking status,
educational level and disease severity. CONCLUSION:
Patients with diabetes were less likely to have been
prescribed three of the five drug classes where evidence
points to a beneficial effect after AMI. Further work is
needed to identify the reasons for the disparity between
management of patients with and without diabetes, and to
develop effective strategies to increase the
implementation of best practice guidelines in the
management of patients with diabetes after AMI.
- Language of Publication
- English
- Unique Identifier
- 98338534
Return
To Top
- MeSH Heading (Major)
- Cardiovascular Agents|*AD; Diabetes Mellitus|*DT;
Diabetic Angiopathies|*DT; Myocardial Infarction|*DT;
Registries|*
- MeSH Heading
- Adrenergic beta-Antagonists|AD; Adult; Aged; Angiotensin-Converting
Enzyme Inhibitors|AD; Aspirin|AD; Australia; Calcium
Channel Blockers|AD; Drug Utilization; Evidence-Based
Medicine; Female; Human; Male; Middle Age; Prescriptions,
Drug; Streptokinase|AD; Support, Non-U.S. Gov't; Treatment
Outcome
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0004-8291
- Country of Publication
- AUSTRALIA
Record 14 from database: MEDLINE
Return
To Top
- Title
- Coronary heart disease and diabetic retinopathy in newly
diagnosed diabetes in Da Qing, China: the Da Qing IGT and
Diabetes Study.
- Author
- Hu YH; Pan XR; Liu PA; Li GW; Howard BV; Bennett PH
- Address
- Da Qing First Hospital, China.
- Source
- Acta Diabetol, 1991, 28:2, 169-73
- Abstract
- In 1986, 110,660 of 281,589 residents aged 25-74 years
in Da Qing, Hei Long Jiang Province of China, were
surveyed. Based on the results of a 75-g oral glucose
tolerance test, 630 subjects were found to have previously
undiagnosed diabetes according to 1985 WHO criteria. Among
them, 600 diabetics aged 35-74 years (288 men, 312 women)
and 410 non-diabetics of similar age with normal glucose
tolerance (207 men, 203 women) were examined to determine
the prevalence of retinopathy and coronary heart disease (CHD)
and to evaluate associated characteristics. Retinal
examinations of 423 newly diagnosed diabetics showed that
15.4% had several microaneurysms and/or small intraretinal
haemorrhage, 5.5% soft exudates, 7.1% hard exudates, and
2.3% proliferative retinopathy. Among 220 non-diabetics,
13.6% had one or two microaneurysms and/or small
intraretinal haemorrhage, and only 1.4% had a few soft
exudates; half of the non-diabetics with retinopathy had
hypertension. CHD, according to Minnesota coding (1.1-1.3,
5.1-5.3 and 7.1) of resting electrocardiograms, was ten
times more frequent in the diabetics (3.59%) than in the
controls (0.32%), after adjusting for age and sex.
Multiple regression analysis showed that plasma glucose
concentration was a risk factor for retinopathy after
adjusting for age, sex, body mass index (BMI), smoking and
blood pressure. Two-hour plasma glucose concentration
(after adjusting for age, sex, BMI, smoking and blood
pressure) and blood pressure (after adjusting for age, sex
BMI, smoking and 1-h or 2-h plasma glucose level) were
associated with CHD among the diabetics and non-diabetics
and among the diabetics alone. Thus, both micro- and
macrovascular complications occur frequently in previously
undiagnosed Chinese diabetics and the frequency of CHD is
markedly increased compared to the low frequency among
Chinese non-diabetics.
- Language of Publication
- English
- Unique Identifier
- 92135868
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|CO/*EP/PC; Diabetes Mellitus|CO/*EP/PC;
Diabetic Angiopathies|*EP; Diabetic Retinopathy|CO/*EP
- MeSH Heading
- Adult; Aged; Blood Pressure; China|EP;
Electroencephalography; Female; Glucose Tolerance Test;
Human; Hyperlipidemia|CO/EP; Male; Mass Screening; Middle
Age; Obesity in Diabetes|EP; Prevalence; Support, Non-U.S.
Gov't; Urban Population
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0940-5429
- Country of Publication
- GERMANY
Record 15 from database: MEDLINE
Return
To Top
- Title
- Increased left atrial size relative to left ventricular
size in young women with insulin-dependent diabetes; a
pre-clinical sign of the specific heart disease of
diabetes?
- Author
- Airaksinen KE; Ikäheimo MJ; Linnaluoto MK; Huikuri HV;
Takkunen JT
- Address
- Department of Medicine, Oulu University Central
Hospital, Finland.
- Source
- Diabetes Res, 1987 Sep, 6:1, 37-41
- Abstract
- Echocardiography was performed on 71 young (mean age 26
years) insulin-dependent diabetic women without clinical
evidence of heart disease and on 36 healthy women of the
same age. 39 diabetic women had microvascular
complications and 9 of them also had abnormalities in
autonomic function tests. The diabetic women had smaller
left ventricular (LV) end-diastolic diameters (44 vs. 47
mm, p less than 0.001) than the controls, although the
left atrial sizes did not differ between the groups. They
also had higher heart rates (80 vs. 70 bpm, p less than
0.001) and shortening fractions (35 vs. 33%, p less than
0.01), smaller stroke volumes (66 vs. 76 ml, p less than
0.01) and thicker interventricular septae (9 vs. 8 mm, p
less than 0.01) than the controls. The diminution of LV
size was most prominent in patients with severe
microvascular complications. These data suggest that the
myocardial contractility of young insulin-dependent
diabetic women is not depressed, but rather exaggerated.
The observed diminution of LV size in combination with
normal left atrial diameter may reflect increased LV wall
stiffness, a possible pre-clinical manifestation of the
specific heart disease of diabetes.
- Language of Publication
- English
- Unique Identifier
- 88081302
Return
To Top
- MeSH Heading (Major)
- Cardiomyopathy, Hypertrophic|*PA; Diabetes Mellitus,
Insulin-Dependent|*PA; Heart Atrium|*PA; Heart
Ventricle|*PA
- MeSH Heading
- Adolescence; Adult; Coronary Disease|PA; Diabetic
Angiopathies|PA; Echocardiography; Female; Heart Septum|PA;
Hemodynamics; Human; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0265-5985
- Country of Publication
- SCOTLAND
Record 16 from database: MEDLINE
Return
To Top
- Title
- Hemorheological characteristics of blood in various
disease: diabetes mellitus, hypertension, acute infection,
ischaemic heart disease & attempted suicide.
- Author
- Singh M; Muthukrishnan V
- Address
-
- Source
- Biorheology, 1982, 19:1/2, 245-52
- Abstract
- The hemorheological characteristics of the blood
samples, obtained by venepuncture from various groups of
patients, are determined. Shear stress-shear rate
relationship were determined by capillary viscometer at
various shear rates ranging from 1 sec-1 to 30 sec-1.
Erythrocyte sedimentation rate (ESR) was determined by
Westergren method. The results indicate that at constant
hematocrit, the slope of the line representing shear
stress-shear rate relationship, and ESR of blood samples
change, depending on the clinical conditions of the
individuals. For various values of the hematocrits, the
variation of the above mentioned parameters along with
fibrinogen level & blood viscosity, in various
diseases are given.
- Language of Publication
- English
- Unique Identifier
- 82232412
Return
To Top
- MeSH Heading (Major)
- Blood Circulation|*; Coronary Disease|*PP; Diabetes
Mellitus|*PP; Hypertension|*PP; Infection|*PP; Suicide,
Attempted|*
- MeSH Heading
- Blood Sedimentation; Blood Viscosity; Comparative Study;
Erythrocytes|PH; Fibrinogen|AN; Hematocrit; Human;
Rheology; Stress, Mechanical
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0006-355X
- Country of Publication
- ENGLAND
Record 17 from database: MEDLINE
Return
To Top
- Title
- Mortality from diabetes mellitus, ischemic heart
disease, and cerebrovascular disease among blacks in a
higher income area.
- Author
- Polednak AP
- Address
- Department of Preventive Medicine, School of Medicine,
State University of New York, Stony Brook 11794.
- Source
- Public Health Rep, 1990 Jul, 105:4, 393-9
- Abstract
- According to the 1980 census, blacks in Suffolk County
on Long Island, NY, had a median family income of almost
$20,000 versus $12,618 for blacks in the entire United
States, or only 20 percent lower than that for whites in
the county. Black-white ratios of age-specific death rates
for 1979-83 in Suffolk County were elevated for all causes
for men and women in age groups from 35-44 to 55-64 years
(but not for those 75 years or older), for ischemic heart
disease for women (but not men) for age groups from 35-44
to 55-64 years, for diabetes mellitus for most ages
(especially for females), and for cerebrovascular disease
for both men and women for all age groups from 35-44 to
65-74 years. The age-specific proportional mortality
ratios (PMRs) for ischemic heart disease within
educational level (less than 12 years and 12 or more years
of school) were lower for black than for white men but
more similar for black and white women. For diabetes, the
PMRs were higher for black versus white women within both
educational levels. PMRs for cerebrovascular disease were
higher for black than white men within the group of
decedents with less than 12 years of education. The
findings are discussed with reference to racial
differences in the prevalence of poverty as well as
possible differences in risk factors (for example,
obesity) or medical care independent of poverty.
- Language of Publication
- English
- Unique Identifier
- 90341480
Return
To Top
- MeSH Heading (Major)
- Blacks|*SN; Cerebrovascular Disorders|*MO; Coronary
Disease|*MO; Diabetes Mellitus|*MO; Income|*
- MeSH Heading
- Adult; Aged; Comparative Study; Female; Human; Male;
Middle Age; New York; Risk Factors; Whites|SN
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0033-3549
- Country of Publication
- UNITED STATES
Record 18 from database: MEDLINE
Return
To Top
- Title
- Congestive heart failure in women: focus on heart
failure due to coronary artery disease and diabetes.
- Author
- Kimmelstiel C; Goldberg RJ
- Address
- Division of Cardiology, University of Massachusetts
Medical School, Worcester.
- Source
- Cardiology, 1990, 77 Suppl 2:, 71-9
- Abstract
- Congestive heart failure (CHF) is an important clinical
syndrome. Evidence from several observational studies
suggests sex-related differences in the incidence and
prognosis of CHF, particularly in the setting of coronary
artery disease. Women appear to be more prone than men to
develop heart failure late after myocardial infarction as
well as in the peri-infarction period. Additionally,
diabetes mellitus appears to promote heart failure to a
greater extent in women than in men.
- Language of Publication
- English
- Unique Identifier
- 90329642
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*CO; Diabetes Mellitus|*CO; Heart
Failure, Congestive|DT/*EP/ET/MO
- MeSH Heading
- Female; Human; Incidence; Male; Sex Factors; Survival
Rate
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0008-6312
- Country of Publication
- SWITZERLAND
Record 19 from database: MEDLINE
Return
To Top
- Title
- Dyslipidemia, morbidity, and mortality in
non-insulin-dependent diabetes mellitus. Lipoproteins and
coronary heart disease in non-insulin-dependent diabetes
mellitus.
- Author
- Laakso M
- Address
- Department of Medicine, University of Kuopio, Finland.
- Source
- J Diabetes Complications, 1997 Mar, 11:2, 137-41
- Abstract
- Lipid and lipoprotein abnormalities in
non-insulin-dependent diabetes mellitus (NIDDM) include
particularly elevated levels of total and very-low-density
lipoprotein (VLDL) triglycerides and reduced levels of
high-density lipoprotein (HDL) cholesterol. Total and
low-density lipoprotein (LDL) cholesterol levels are
usually normal if glycemic control is adequate. The
worsening of glycemic control deteriorates lipid and
lipoprotein abnormalities and particularly total and LDL
cholesterol levels are often elevated in patients with
poor glycemic control. According to prospective
population-based studies total cholesterol is a powerful
risk factor for coronary heart disease (CHD) in NIDDM
patients as in nondiabetic subjects. In contrast, high
total triglycerides and low HDL cholesterol may be even
stronger risk factors for CHD in NIDDM patients than in
nondiabetic individuals, but more prospective studies are
needed to substantiate this view. Compositional changes in
LDL and VLDL particles may further increase the risk for
CHD but epidemiologic data are missing to support this
notion. Preliminary data from the Scandinavian Simvastatin
Survival Study including 202 diabetic patients seem to
indicate that diabetic patients benefit from simvastatin
treatment equally to nondiabetic subjects.
- Language of Publication
- English
- Unique Identifier
- 97256069
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*BL/ET; Diabetes Mellitus, Non-Insulin-Dependent|CO/*MO;
Diabetic Angiopathies|BL/ET/*MO; Hyperlipidemia|DT/ET/*MO;
Lipoproteins|*BL
- MeSH Heading
- Antilipemic Agents|TU; Clinical Trials; Human; Risk
Factors
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 1056-8727
- Country of Publication
- UNITED STATES
Record 20 from database: MEDLINE
Return
To Top
Back 10 records
- Title
- Fibrinogen in relation to personal history of prevalent
hypertension, diabetes, stroke, intermittent claudication,
coronary heart disease, and family history: the Scottish
Heart Health Study.
- Author
- Lee AJ; Lowe GD; Woodward M; Tunstall Pedoe H
- Address
- Cardiovascular Epidemiology Unit, Ninewells Hospital and
Medical School, Dundee.
- Source
- Br Heart J, 1993 Apr, 69:4, 338-42
- Abstract
- OBJECTIVE--To determine the relations of plasma
fibrinogen to family history of premature heart disease,
personal history of hypertension, diabetes, stroke,
coronary heart disease, and to presence of intermittent
claudication. DESIGN--Random population survey across 22
local government districts in Scotland.
PARTICIPANTS--10,359 men and women aged 40 to 59 years.
Plasma fibrinogen was measured in 8824. MAIN OUTCOME
MEASURE--Plasma fibrinogen concentration. RESULTS--Persons
with a family history of heart disease or a personal
history of high blood pressure, diabetes, stroke, or
presence of intermittent claudication all had higher
plasma fibrinogen concentrations than those without. When
compared with participants without cardiovascular or
related disease (men: 2.27 (SE = 0.01) g/l, n = 3367;
women 2.34 (0.01) g/l, n = 3096), predefined cases of
either myocardial infarction (men: 2.51 (0.02) g/l, n =
248; women: 2.63 (0.04) g/l, n = 72) or angina (men: 2.45
(0.02) g/l, n = 394; women: 2.50 (0.02) g/l, n = 398) had
significantly higher plasma fibrinogen concentrations (p
< 0.001). After adjustment for 10 other coronary risk
factors, there was a noticeable linear trend in the odds
ratios for myocardial infarction across all quartiles
(quarters) of plasma fibrinogen concentrations in both
sexes. Similarly, the risk of angina increased linearly
with increasing fibrinogen concentrations, although the
test for a linear trend was NS among women.
CONCLUSIONS--This large population study confirms that
plasma fibrinogen is not only a risk factor for coronary
heart disease and stroke, but it is also raised with
family history of premature heart disease and with
personal history of hypertension, diabetes, and presence
of intermittent claudication.
- Language of Publication
- English
- Unique Identifier
- 93257253
Return
To Top
- MeSH Heading (Major)
- Cerebrovascular Disorders|*BL; Coronary Disease|*BL;
Diabetes Mellitus|*BL; Fibrinogen|*AN; Hypertension|*BL
- MeSH Heading
- Adult; Angina Pectoris|BL; Cross-Sectional Studies;
Family; Female; Heart Diseases|BL/GE; Human; Intermittent
Claudication|BL; Male; Middle Age; Myocardial
Infarction|BL; Risk Factors; Sex Factors; Support,
Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0007-0769
- Country of Publication
- ENGLAND
Record 21 from database: MEDLINE
Return
To Top
- Title
- Affective, substance use, and anxiety disorders in
persons with arthritis, diabetes, heart disease, high
blood pressure, or chronic lung conditions.
- Author
- Wells KB; Golding JM; Burnam MA
- Address
- University of California, Los Angeles.
- Source
- Gen Hosp Psychiatry, 1989 Sep, 11:5, 320-7
- Abstract
- The authors estimated the sex- and age-adjusted
prevalence of affective, substance use, and anxiety
disorders in persons in a general population sample who
identified themselves as having arthritis, diabetes, heart
disease, high blood pressure, chronic lung disease, or no
chronic medical conditions. Persons who reported ever
having arthritis, heart disease, chronic lung disease, or
high blood pressure had a significantly increased adjusted
prevalence of each of the three groups of lifetime
psychiatric disorders, relative to a no-chronic conditions
comparison group (each p less than 0.05). Persons who ever
had diabetes had an increased adjusted prevalence of
lifetime affective and anxiety but not substance use
disorder. Persons with current (i.e., active) arthritis,
heart disease, or high blood pressure had a significantly
increased adjusted prevalence of recent (6-month) anxiety
disorder, whereas those with current chronic lung disease
had an increased adjusted prevalence of recent affective
and substance use but not anxiety disorder.
- Language of Publication
- English
- Unique Identifier
- 90006715
Return
To Top
- MeSH Heading (Major)
- Anxiety Disorders|*PX; Chronic Disease|*PX; Mood
Disorders|*PX; Sick Role|*; Substance-Related Disorders|*PX
- MeSH Heading
- Adult; Arthritis, Rheumatoid|PX; Cross-Sectional
Studies; Depressive Disorder|PX; Diabetes Mellitus|PX;
Female; Heart Diseases|PX; Human; Hypertension|PX; Los
Angeles; Lung Diseases, Obstructive|PX; Male; Risk
Factors; Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0163-8343
- Country of Publication
- UNITED STATES
Record 22 from database: MEDLINE
Return
To Top
- Title
- In-hospital complications among survivors of admission
for congestive heart failure, chronic obstructive
pulmonary disease, or diabetes mellitus.
- Author
- Geraci JM; Ashton CM; Kuykendall DH; Johnson ML; Wu L
- Address
- Houston Center for Quality of Care and Utilization
Studies, Houston Veterans Affairs Medical Center, Baylor
College of Medicine 77030, USA.
- Source
- J Gen Intern Med, 1995 Jun, 10:6, 307-14
- Abstract
- OBJECTIVE: To determine the frequency of hospital
complications among survivors of inpatient treatment for
congestive heart failure (CHF), chronic obstructive
pulmonary disease (COPD), or diabetes mellitus (DM).
DESIGN: Retrospective cohort study. SETTING: Nine Veterans
Affairs hospitals in the southern United States. PATIENTS:
1,837 men veterans discharged alive following
hospitalization for CHF, COPD, or DM between January 1987
and December 1989. This patient population represents a
subset of cases gathered to study the process of care in
the hospital and subsequent early readmission; thus,
veterans who died in the hospital were not included.
MEASUREMENTS: Medical record review to record the
occurrence of any of 30 in-hospital complications such as
cardiac arrest, nosocomial infections, or delirium
(overall agreement between two reviewers = 84%, kappa =
0.37). RESULTS: Complications occurred in 15.7% of the CHF
cases, 13.1% of the COPD cases, and 14.8% of the DM cases.
Hypoglycemic reactions were the most frequent individual
adverse events in the CHF and DM cases (3.6% and 11.4% of
the cases, respectively), and theophylline toxicity was
most frequent among the COPD cases (4.9%). Patient age,
the presence of comorbid diseases, and the Acute
Physiology Score (APS) of APACHE II were associated with
complication occurrence. For each disease, the patients
who had a complication had significantly longer mean
hospital stays than did the patients who did not have
complications (14.6 to 14.9 days vs 7.2 to 8.2 days, p
< 0.01). CONCLUSIONS: Complications are frequent among
patients discharged alive with CHF, COPD, or DM. The
patients who experienced complications were more ill on
admission and had longer hospital stays.
- Language of Publication
- English
- Unique Identifier
- 96006726
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|*CO; Heart Failure, Congestive|*CO;
Hospitalization|*; Lung Diseases, Obstructive|*CO
- MeSH Heading
- Adult; Aged; Aged, 80 and over; APACHE; Cohort Studies;
Comorbidity; Comparative Study; Hospitals, Veterans|ST;
Human; Male; Middle Age; Outcome and Process Assessment
(Health Care); Retrospective Studies; Support, Non-U.S.
Gov't; Support, U.S. Gov't, Non-P.H.S.; United States
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0884-8734
- Country of Publication
- UNITED STATES
Record 23 from database: MEDLINE
Return
To Top
- Title
- The frequency of known diabetes, hypertension and
ischaemic heart disease in affluent and poor urban
populations of Karachi, Pakistan.
- Author
- Hameed K; Kadir M; Gibson T; Sultana S; Fatima Z; Syed A
- Address
- Department of Medicine, Aga Khan University Hospital,
Karachi, Pakistan.
- Source
- Diabet Med, 1995 Jun, 12:6, 500-3
- Abstract
- The high frequency of diabetes mellitus and coronary
artery disease among people of South Asian extraction
living in the West is well established. The prevalence of
these disorders in Southern Asia is less certain. No
previous attempt has been made to estimate their
occurrence in Pakistan. In order to compare the prevalence
of known diabetes mellitus, hypertension and ischaemic
heart disease between affluent and poor urban communities
in Pakistan, a survey of consecutive households was
undertaken in a relatively prosperous and a poor area in
Karachi. Information was obtained on 4232 adults evenly
distributed between the two areas. Body weight and height
were measured in 199 healthy subjects at the two sites.
The prevalence of known diabetes in the affluent
population was 4.5%, significantly higher than 1.8% in the
poor area (p < 0.001). A maximal prevalence of 25% was
seen in the affluent community aged 55-64. Diabetes was
more common in females in both populations. The overall
prevalence of hypertension was similar in the two areas
although significantly more frequent in the middle aged
and affluent. A history of ischaemic heart disease
occurred in 1.9% of the affluent and 0.6% of the poor (p =
0.003). Healthy subjects were heavier and more obese in
the richer community. Thus the susceptibility of South
Asian populations to diabetes and ischaemic heart disease
is also apparent in an affluent segment of Pakistani
society. The phenomenon is not attributable simply to
urbanization. Obesity is probably an important
contributory factor. The economic implications for
developing South Asian countries are serious.
- Language of Publication
- English
- Unique Identifier
- 95376926
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|*EP; Hypertension|*EP; Myocardial
Ischemia|*EP; Urban Health|*
- MeSH Heading
- Adolescence; Adult; Age Distribution; Aged; Female;
Human; Male; Middle Age; Pakistan|EP; Poverty; Prevalence;
Risk Factors; Social Class; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0742-3071
- Country of Publication
- ENGLAND
Record 24 from database: MEDLINE
Return
To Top
- Title
- Essential fatty acid metabolism in patients with
essential hypertension, diabetes mellitus and coronary
heart disease.
- Author
- Das UN
- Address
- Department of Medicine, Nizam's Institute of Medical
Sciences, Punjagutta, Hyderabad, India.
- Source
- Prostaglandins Leukot Essent Fatty Acids, 1995 Jun,
52:6, 387-91
- Abstract
- Mortality and morbidity from coronary heart disease (CHD),
diabetes mellitus (DM) and essential hypertension (HTN)
are higher in people of South Asian descent than in other
groups. There is evidence to believe that essential fatty
acids (EFAs) and their metabolites may have a role in the
pathobiology of CHD, DM and HTN. Fatty acid analysis of
the plasma phospholipid fraction revealed that in CHD the
levels of gamma-linolenic acid (GLA), arachidonic acid
(AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA) are low, in patients with HTN linoleic acid (LA) and
AA are low, and in patients with non-insulin dependent
diabetes mellitus (NIDDM) and diabetic nephropathy the
levels of dihomo-gamma-linolenic acid (DGLA), AA, alpha-linolenic
acid (ALA) and DHA are low, all compared to normal
controls. These results are interesting since DGLA, AA and
EPA form precursors to prostaglandin E1, (PGE1),
prostacyclin (PGI2), and PGI3, which are potent platelet
anti-aggregators and vasodilators and can prevent
thrombosis and atherosclerosis. Further, the levels of
lipid peroxides were found to be high in patients with CHD,
HTN, NIDDM and diabetic nephropathy. These results suggest
that increased formation of lipid peroxides and an
alteration in the metabolism of EFAs are closely
associated with CHD, HTN and NIDDM in Indians.(ABSTRACT
TRUNCATED AT 250 WORDS)
- Language of Publication
- English
- Unique Identifier
- 95372442
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*ME; Diabetes Mellitus|*ME; Fatty
Acids, Essential|BL/*ME; Hypertension|*ME
- MeSH Heading
- Adult; Diabetes Mellitus, Non-Insulin-Dependent|ME;
Diabetic Nephropathies|ME; Diet; Fatty Acids,
Unsaturated|BL; Female; Human; India; Lipid Peroxides|BL;
Male; Malondialdehyde|BL; Middle Age; Phospholipids|BL;
Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0952-3278
- Country of Publication
- SCOTLAND
Record 25 from database: MEDLINE
Return
To Top
- Title
- Coronary heart disease risk factors in black and white
patients with non-insulin-dependent diabetes mellitus.
- Author
- Summerson JH; Bell RA; Konen JC
- Address
- Department of Family and Community Medicine, Bowman Gray
School of Medicine, Wake Forest University, Winston-Salem
NC 27157, USA.
- Source
- Ethn Health, 1996 Mar, 1:1, 9-20
- Abstract
- OBJECTIVE: To determine possible racial differences in
risk factors for coronary heart disease (CHD) in black and
white patients with noninsulin-dependent diabetes mellitus
(NIDDM). METHODS: Study of risk factors for coronary heart
disease among 308 subjects who met the WHO criteria for
NIDDM. RESULTS: Both black and white patients were found
to have a high prevalence of hypertension, obesity, low
high density lipoprotein (HDL) cholesterol, low
leisure-time physical activity levels, and an atherogenic
dietary profile. Black males were more likely to have
hypertension, reported a greater intake of dietary
cholesterol, and had lower triglycerides, higher HDL
cholesterol levels, a lower CHOL/HDL ratio, and a lower
waist to hip ratio (WHR) than white males. Black females
had higher mean arterial and diastolic blood pressures,
had lower triglycerides, higher HDL cholesterol, a lower
CHOL/HDL ratio, a higher subscapular/triceps ratio and
lower reported leisure-time energy expenditure compared to
white females. There were no racial differences found for
obesity level. CONCLUSION: Our results indicate that
racial differences in CHD risk factors exist among black
and white patients with NIDDM. The complex genetic,
sociocultural and environmental interactions involving CHD
risk factors that contribute to the development of CHD may
eventually provide clues to the etiology of the disease.
- Language of Publication
- English
- Unique Identifier
- 98051726
Return
To Top
- MeSH Heading (Major)
- Caucasoid Race|*; Coronary Disease|*EH/ET/PC; Diabetes
Mellitus, Non-Insulin-Dependent|*EH/ET/PC; Negroid Race|*
- MeSH Heading
- Aged; Comparative Study; Cross-Cultural Comparison;
Female; Health Behavior; Human; Life Style; Male; Middle
Age; Risk Factors; United States
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1355-7858
- Country of Publication
- ENGLAND
Record 26 from database: MEDLINE
Return
To Top
- Title
- Deoxyribonucleic acid polymorphism of the apoprotein AI-CIII-AIV
gene cluster and coronary heart disease in
non-insulin-dependent diabetes.
- Author
- Trembath RC; Thomas DJ; Hendra TJ; Yudkin JS; Galton DJ
- Address
-
- Source
- Br Med J (Clin Res Ed), 1987 Jun, 294:6587, 1577-8
- Abstract
- The prevalence of an uncommon allelic variant (S2) of
the apoprotein AI-CIII-AIV gene cluster was determined in
non-insulin-dependent diabetics with or without evidence
of coronary heart disease and in controls. Frequencies of
the S2 allele were 14% for diabetics with coronary heart
disease compared with 2% for non-diabetics with no
clinical evidence of occlusive vascular disease. No
subject with the S2 allele was detected among a further
group of matched diabetics without clinical features of
macrovascular disease. The results suggest that a genetic
component contributes to the susceptibility to coronary
heart disease in non-insulin-dependent diabetics. Whether
the observed deoxyribonucleic acid variant is aetiological
for atherosclerosis or in linkage disequilibrium with
other atherogenic loci on chromosome 11 remains to be
clarified.
- Language of Publication
- English
- Unique Identifier
- 87300499
Return
To Top
- MeSH Heading (Major)
- Apolipoproteins C|*GE; Coronary Disease|*GE; Diabetes
Mellitus, Non-Insulin-Dependent|*GE; DNA|*GE
- MeSH Heading
- Alleles; Autoradiography; Female; Gene Frequency;
Genetic Markers; Human; Male; Multigene Family;
Polymorphism (Genetics); Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0267-0623
- Country of Publication
- ENGLAND
Record 27 from database: MEDLINE
Return
To Top
- Title
- Hypertension and serum Mg in the patients with diabetes
and coronary heart disease.
- Author
- Nagase N
- Address
- Internal Medicine, National Sanatorium Higashi Tokushima
Hospital, Itano-cho, Itano-gun, Japan.
- Source
- Hypertens Res, 1996 Jun, 19 Suppl 1:, S65-8
- Abstract
- Interrelations between hypertension (HT), ischemic heart
disease (IHD) and diabetes mellitus (DM) were investigated
in the diabetic subjects without IHD (DM group) or with
IHD (DM + IHD group) and subjects with IHD (IHD group)
which were not complicated with DM. 1. The incidence of
hypertension of DM group, DM+IHD group and IHD group is
40, 54, 38% respectively. 2. The incidence of
hyperlipidemia of DM group, DM + IHD group and IHD group
is 55, 71, 56% respectively. 3. Serum Mg levels of DM (1.9
+/- 0.37 mg/dl), DM + IHD (1.8 +/- 0.23) and IHD (1.9 +/-
0.33) were significantly lower than that of normal control
(2.3 +/- 0.32). 4. Serum Mg level of poorly controlled
diabetic patients is lower than that of well controlled
diabetic patients. These results suggested that Magnesium
deficient state is one of the cause of insulin resistancy.
- Language of Publication
- English
- Unique Identifier
- 97382785
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|BL/CO/*PP; Diabetes Mellitus|BL/CO/*PP;
Diabetes Mellitus, Experimental|BL/*PP; Hypertension|CO/*PP;
Magnesium|*BL
- MeSH Heading
- Adult; Aged; Animal; Blood Glucose; Blood Pressure;
Female; Human; Insulin Resistance; Male; Mice; Middle Age
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0916-9636
- Country of Publication
- JAPAN
Record 28 from database: MEDLINE
Return
To Top
- Title
- Lipid and lipoprotein abnormalities associated with
coronary heart disease in patients with insulin-dependent
diabetes mellitus.
- Author
- Laakso M; Pyörälä K; Sarlund H; Voutilainen E
- Address
-
- Source
- Arteriosclerosis, 1986 Nov, 6:6, 679-84
- Abstract
- We measured serum lipid and lipoprotein levels in 63
insulin-dependent diabetic (IDD) patients (32 men, 31
women) and in 63 nondiabetic control subjects (32 men, 31
women) without coronary heart disease (CHD) and in 19 IDD
patients (11 men, 8 women) and in 18 nondiabetic subjects
(8 men, 10 women) with CHD. All diabetic patients had
postglucagon C-peptide levels of less than 0.60 mmol/liter
and none had signs of renal failure. Male IDD patients
with CHD had higher levels of total cholesterol, low
density lipoprotein (LDL) cholesterol, total triglycerides,
very low density lipoprotein (VLDL) triglycerides and
lower level of high density lipoprotein (HDL) cholesterol
than male IDD patients without CHD. In female IDD
patients, similar lipid and lipoprotein abnormalities were
observed between the groups of diabetics with and without
CHD except for total cholesterol, which was the same in
both groups. A comparison between IDD patients without CHD
and nondiabetic control subjects without CHD showed no
difference in lipid and lipoprotein levels in males;
female IDD patients without CHD showed even higher levels
of HDL and HDL2 cholesterol and lower levels of VLDL
triglycerides than nondiabetic controls. Our results
indicate that in IDD patients without nephropathy and CHD,
the lipid and lipoprotein levels do not differ from
nondiabetic controls, but in IDD patients with CHD the
lipid and lipoprotein pattern is similar to that known to
be characteristic for nondiabetic patients with CHD.
- Language of Publication
- English
- Unique Identifier
- 87048317
Return
To Top
- MeSH Heading (Major)
- Cholesterol|*BL; Coronary Disease|*BL; Diabetes
Mellitus, Insulin-Dependent|*BL/DT; Triglycerides|*BL
- MeSH Heading
- Adrenergic beta-Antagonists|TU; Diuretics|TU; Female;
Human; Hypertension|BL/DT; Lipoproteins, HDL
Cholesterol|BL; Lipoproteins, LDL Cholesterol|BL;
Lipoproteins, VLDL|BL; Male; Middle Age; Sex Factors;
Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0276-5047
- Country of Publication
- UNITED STATES
Record 29 from database: MEDLINE
Return
To Top
- Title
- Risk factors for cardiovascular disease in individuals
with diabetes. The Strong Heart Study.
- Author
- Howard BV
- Address
- Medlantic Research Institute, Washington, DC 20010, USA.
- Source
- Acta Diabetol, 1996 Sep, 33:3, 180-4
- Abstract
- Coronary heart disease (CHD) is the leading cause of
death among individuals with diabetes. However,
information on CHD and its association with known risk
factors in populations with high rates of diabetes is
limited. The purpose of the Strong Heart Study is to
quantify CHD and its risk factors among three
geographically diverse groups of American Indians who have
a high prevalence of diabetes. The study group consisted
of 4549 adults between 45 and 74 years of age in 13 Indian
communities in Arizona, Oklahoma, and South and North
Dakota. Rates of diabetes ranged from 33% to 72% in men
and women in the three centers. The prevalence rates of
definite myocardial infarction (MI) and definite CHD were
higher in men than in women in all three centers (P <
0.0001) and higher in those with diabetes (P = 0.002 and P
= 0.0003 in women and men, respectively). Diabetes was
associated with a relatively greater increase in
prevalence of MI (PR = 3.8 vs 1.9) and CHD (PR = 4.6 vs
1.8) in women than in men. Logistic regression analysis
indicated that prevalent CHD was significantly related to
age, diabetes, hypertension, albuminuria, percent body
fat, smoking, high concentrations of plasma insulin, and
low concentrations of high-density lipoprotein
(HDL)-cholesterol. These findings from the baseline Strong
Heart Study examination emphasize the relative importance
of diabetes-associated variables as risk factors for CHD
among populations with high rates of diabetes.
- Language of Publication
- English
- Unique Identifier
- 97060876
Return
To Top
- MeSH Heading (Major)
- Cardiovascular Diseases|*EP; Coronary Disease|*EP;
Diabetes Mellitus|*PP; Diabetic Angiopathies|*EP
- MeSH Heading
- Adult; Age Factors; Aged; Arizona; Comparative Study;
Female; Human; Hypertension|EP; Indians, North American;
Lipoproteins|BL; Male; Middle Age; North Dakota;
Obesity|EP; Oklahoma; Prevalence; Regression Analysis;
Risk Factors; Sex Factors; Smoking|EP; South Dakota;
United States|EP
- Publication Type
- JOURNAL ARTICLE; MULTICENTER STUDY
- ISSN
- 0940-5429
- Country of Publication
- GERMANY
Record 30 from database: MEDLINE
Return
To Top
Back 10 records
- Title
- Does treatment of noninsulin-dependent diabetes mellitus
reduce the risk of coronary heart disease?
- Author
- Giugliano D
- Address
- Department of Geniatrics and Metabolic Diseases, Second
University of Naples, Italy.
- Source
- Curr Opin Lipidol, 1996 Aug, 7:4, 227-33
- Abstract
- Diabetes is an independent risk factor for the
development of coronary heart disease and has a tremendous
impact on mortality. In patients with noninsulin-dependent
diabetes mellitus, coronary heart disease is the leading
cause of death. Both hyperinsulinemia and hyperglycemia
have been suggested as risk factors for accelerated
atherogenesis in diabetes. Whichever mechanism is
implicated, a beneficial effect of therapy in preventing
cardiovascular disease is a major requirement. Until now,
it is not clear whether stringent control of blood glucose
levels reduces the risk of development of coronary heart
disease in patients with noninsulin-dependent diabetes
mellitus. This review emphasizes the relative roles of
insulin and glucose on coronary heart disease development
in noninsulin-dependent diabetes mellitus. The different
therapeutic options of pharmacological treatment in
hyperglycemia in noninsulin-dependent diabetes mellitus
are discussed, as well as their impact on coronary heart
disease risk.
- Language of Publication
- English
- Unique Identifier
- 97037870
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*ET/PC; Diabetes Mellitus, Non-Insulin-Dependent|CO/*DT;
Hypoglycemic Agents|AE/PD/*TU
- MeSH Heading
- Glucose|ME; Human; Hyperglycemia|CO; Hyperinsulinemia|CO;
Insulin|AE/ME/PD/TU; Male; Metformin|AE/PD/TU; Risk
Factors; Sulfonylurea Compounds|AE/PD/TU; Treatment
Outcome
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0957-9672
- Country of Publication
- UNITED STATES
Record 31 from database: MEDLINE
Return
To Top
- Title
- Will correction of dyslipoproteinaemia reduce coronary
heart disease risk in patients with non-insulin-dependent
diabetes? Need for trial evidence.
- Author
- Pyörälä K; Steiner G
- Address
- Department of Medicine, University of Kuopio, Finland.
- Source
- Ann Med, 1996 Aug, 28:4, 357-62
- Abstract
- The incidence of atherosclerotic vascular disease is
greatly increased in patients with non-insulin-dependent
diabetes (NIDDM). The most frequent lipoprotein
abnormalities in this type of diabetes are an increase in
triglyceride-rich lipoproteins and a decrease in
high-density lipoproteins. Hypertriglyceridaemia appears
to be a stronger coronary heart disease risk factor in
patients with NIDDM than in nondiabetic subjects. Plasma
total and low-density lipoprotein cholesterol levels in
NIDDM patients and nondiabetic subjects do not differ.
Hypercholesterolaemia is, however, as powerful a predictor
of coronary heart disease risk in diabetic patients as in
nondiabetic subjects. In spite of this knowledge, there is
to date no solid evidence to indicate whether correction
of dyslipoproteinaemia in order to reduce coronary heart
disease risk in patients with NIDDM is more, equally, or
less beneficial than it is in nondiabetic subjects. The
only available data come from post-hoc subgroup analyses
of the Helsinki Heart Study and the Scandinavian
Simvastatin Survival Study (4S). Other trials including
patients with diabetes are in progress. Only one
intervention trial (currently in its treatment phase), the
Diabetes Atherosclerosis Intervention Study (DAIS), is
specifically designed to examine the lipid hypothesis in
patients with NIDDM.
- Language of Publication
- English
- Unique Identifier
- 97016054
Return
To Top
- MeSH Heading (Major)
- Antilipemic Agents|*TU; Coronary
Arteriosclerosis|*CO/EP; Diabetes Mellitus,
Non-Insulin-Dependent|*CO; Hyperlipidemia|CO/*DT;
Lipoproteins|*BL/ME
- MeSH Heading
- Clinical Trials; Human; Incidence; Risk Factors;
Survival Rate
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0785-3890
- Country of Publication
- ENGLAND
Record 32 from database: MEDLINE
Return
To Top
- Title
- Lipids and lipoproteins as risk factors for coronary
heart disease in non-insulin-dependent diabetes mellitus.
- Author
- Laakso M
- Address
- Department of Medicine, University of Kuopio, Finland.
- Source
- Ann Med, 1996 Aug, 28:4, 341-5
- Abstract
- Dyslipidaemia is frequent in non-insulin-dependent
diabetes mellitus (NIDDM). Lipid and lipoprotein
abnormalities include particularly elevated levels of
total and very-low-density lipoprotein (VLDL)
triglycerides and reduced levels of high-density
lipoprotein (HDL) cholesterol. The worsening of glycaemic
control further deteriorates lipid and lipoprotein
abnormalities and furthermore, total and low-density
lipoprotein (LDL) cholesterol levels are often elevated in
poor glycaemic control. Epidemiological data show that
total cholesterol is as powerful risk factor for coronary
heart disease (CHD) in NIDDM patients as in nondiabetic
subjects. High total triglycerides and low HDL cholesterol
may be even stronger risk factors for CHD in NIDDM
patients than in nondiabetic individuals, but more
prospective studies are needed to substantiate this view.
Compositional changes in LDL and VLDL particles may
further increase the risk of CHD but epidemiological data
are missing to support this notion.
- Language of Publication
- English
- Unique Identifier
- 97016052
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*/CO/EP/PP; Diabetes Mellitus,
Non-Insulin-Dependent|*CO; Hyperlipidemia|*/CO/EP/PP
- MeSH Heading
- Clinical Trials; Human; Incidence; Lipids|ME;
Lipoproteins|ME; Prognosis; Risk Factors
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0785-3890
- Country of Publication
- ENGLAND
Record 33 from database: MEDLINE
Return
To Top
- Title
- Diabetes, mortality and coronary heart disease in the
prospective Dubbo study of Australian elderly.
- Author
- Simons LA; McCallum J; Friedlander Y; Simons J
- Address
- University of New South Wales Lipid Research Department,
St Vincent's Hospital, Sydney.
- Source
- Aust N Z J Med, 1996 Feb, 26:1, 66-74
- Abstract
- BACKGROUND: A prospective study of Australian elderly
living in Dubbo has shown that diabetes is a significant
predictor of all-causes mortality and coronary heart
disease (CHD). AIM: To examine and contrast clinical and
socio-demographic predictors of these outcomes in those
with and without diabetes. METHODS: The data are derived
from a community-based sample of subjects 60 years and
older followed over 62 months since 1988. Of 1155 men and
1472 women, 9.2% and 6.9% respectively manifested diabetes
at baseline, based on history or fasting hyperglycaemia.
RESULTS: In the presence of diabetes, all-causes mortality
was increased twofold in both sexes, CHD incidence was
increased twofold in men and threefold in women, stroke
incidence was increased twofold in women but little
changed in men. Proportional hazards models were derived
separately for persons with and without diabetes and risk
factors differentially predictive in diabetes were sought.
Significant predictors of death in diabetes were old age
and current smoking. Those factors differentially
predictive were 'being married' (Relative Risk [RR] 1.60
with diabetes and 0.69 without diabetes) and higher body
mass index (BMI) (RR 1.03 with diabetes and 0.79 without
diabetes). Significant predictors of CHD in diabetes were
old age, prior CHD, severe hypertension, low HDL
cholesterol and self-rated health. Those factors
differentially predictive were higher body mass index (RR
1.14 vs 0.83) and physical disability (RR 0.69 vs 1.55).
Differential predictions with regard to BMI may relate in
part to excess CHD and mortality at low BMI in
non-diabetic subjects. CONCLUSION: The vascular disease
burden of diabetes in the elderly has been confirmed,
especially in women. A number of conventional risk factors
are contributing to this burden and may be amenable to
treatment.
- Language of Publication
- English
- Unique Identifier
- 96371698
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|BL/EP/*MO; Diabetes Mellitus|BL/*CO/MO
- MeSH Heading
- Aged; Aged, 80 and over; Female; Human; Incidence; Male;
New South Wales|EP; Proportional Hazards Models; Risk
Factors; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0004-8291
- Country of Publication
- AUSTRALIA
Record 34 from database: MEDLINE
Return
To Top
- Title
- Effects of cigarette smoking, diabetes, high
cholesterol, and hypertension on all-cause mortality and
cardiovascular disease mortality in Mexican Americans. The
San Antonio Heart Study.
- Author
- Wei M; Mitchell BD; Haffner SM; Stern MP
- Address
- Department of Medicine, University of Texas Health
Science Center at San Antonio 78284, USA.
- Source
- Am J Epidemiol, 1996 Dec, 144:11, 1058-65
- Abstract
- Despite high levels of cardiovascular risk factors,
Mexican Americans paradoxically have a lower prevalence of
cardiovascular disease. A possible explanation is that
conventional cardiovascular risk factors have a lesser
impact on this ethnic group. In the present study, a 7- to
8-year follow-up of the San Antonio Heart Study cohort was
used to estimate total and cardiovascular disease
mortality and their association with baseline risk
factors. A total of 2,629 Mexican Americans form the basis
of this study, and 1,136 non-Hispanic whites from the same
cohort served as the comparison group. The age- and
sex-adjusted rates for total death and cardiovascular
disease death were somewhat higher in Mexican Americans
than non-Hispanic whites (rate ratio for total mortality =
1.4, 95% confidence interval 1.0-2.0; and rate ratio for
cardiovascular mortality = 1.3, 95% confidence interval
0.7-2.4). After adjustment for sex, age, and socioeconomic
status in multivariate analyses, current smoking,
diabetes, high cholesterol, and hypertension were
positively associated with all-cause mortality and
cardiovascular disease mortality in Mexican Americans.
Overall, these risk factors accounted for 45% of all-cause
mortality and 55% of cardiovascular disease mortality in
this ethnic group. In comparison, the risk factors
accounted for 46% of all-cause mortality and 46% of
cardiovascular disease mortality in non-Hispanic whites.
The authors conclude that cigarette smoking, diabetes,
high cholesterol, and hypertension are important
predictors of both all-cause and cardiovascular disease
deaths in Mexican Americans. There was no evidence for a
diminished effect of these risk factors in Mexican
Americans.
- Language of Publication
- English
- Unique Identifier
- 97097896
Return
To Top
- MeSH Heading (Major)
- Cardiovascular Diseases|EH/ET/*MO; Diabetes
Mellitus|*CO/EH; Hypercholesterolemia|*CO/EH;
Hypertension|*CO/EH; Mexican Americans|*SN; Smoking|*AE/EH
- MeSH Heading
- Adult; Cause of Death; Cohort Studies; Comparative
Study; Female; Human; Male; Middle Age; Risk; Risk
Factors; Support, U.S. Gov't, P.H.S.; Whites|SN
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9262
- Country of Publication
- UNITED STATES
Record 35 from database: MEDLINE
Return
To Top
- Title
- Relationship between insulin resistance and coronary
heart disease in diabetes mellitus and the general
population: a critical appraisal.
- Author
- Elliott TG; Viberti G
- Address
- Department of Endocrinology & Internal Medicine,
University of British Columbia, Vancouver, Canada.
- Source
- Baillieres Clin Endocrinol Metab, 1993 Oct, 7:4,
1079-103
- Abstract
- The hypothesis that a causal relationship exists between
insulin resistance and atherogenesis was first proposed
over 23 years ago, and has given rise to a vast
literature. Biological plausibility has been lent to the
hypothesis by studies in which insulin has produced some
effects in cell and tissue culture, and in vivo in
arterial tissue, consistent with our understanding of the
pathogenesis of atherosclerosis. Clinical studies
demonstrating a complex interrelationship between insulin
resistance-hyperinsulinaemia and established risk factors
for CHD--hypertension, hypertriglyceridaemia, low HDL
cholesterol levels and abdominal obesity--are reviewed. A
review of the studies examining an independent association
between hyperinsulinaemia and coronary heart disease is
presented. Cross-sectional studies in both the general
population and diabetes support the relationship; however,
prospective studies in the general population provide
limited and inconsistent support for this hypothesis and
highlight the confounding effects of blood pressure,
dyslipidaemia and obesity on the effects of
hyperinsulinaemia. In subjects with NIDDM and impaired
glucose tolerance, prospective studies have not shown a
deleterious effect of insulin treatment per se, nor have
they consistently shown a significantly increased risk for
those with higher endogenous insulin levels. The
therapeutic implications of the evidence to date are less
complex and involve weight reduction by diet and exercise,
the lowering of elevated blood pressure with metabolically
neutral agents, the judicious use of lipid lowering drugs
and, in diabetes, the use of insulin where clinically
indicated.
- Language of Publication
- English
- Unique Identifier
- 94137214
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|EP/*ET; Diabetes Mellitus,
Non-Insulin-Dependent|*CO/DT/ME; Insulin Resistance|*PH
- MeSH Heading
- Adult; Aged; Animal; Chickens; Female; Glucose|ME;
Human; Hyperinsulinism|CO/ET; Hypertension|CO/ME;
Insulin|ME/TU; Lipid Metabolism, Inborn Errors|CO/ME;
Lipids|BL; Male; Middle Age; Obesity|CO/ME; Rats; Risk
Factors; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, ACADEMIC
- ISSN
- 0950-351X
- Country of Publication
- ENGLAND
Record 36 from database: MEDLINE
Return
To Top
- Title
- Heart disease in diabetes mellitus.
- Author
- Raman M; Nesto RW
- Address
- Cardiovascular Division, Deaconess Hospital, Harvard
Medical School, Boston, Massachusetts, USA.
- Source
- Endocrinol Metab Clin North Am, 1996 Jun, 25:2, 425-38
- Abstract
- The spectrum of heart disease in diabetic patients is
broad and complex. This article discusses the
epidemiologic associations between the two causes. It
attempts to summarize the effects of diabetes at the
cellular, vascular, and myocardial levels. The clinical
manifestations are explored, and the treatment of heart
disease as it pertains to diabetic patients is discussed.
- Language of Publication
- English
- Unique Identifier
- 96392919
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|*CO/PP; Heart Diseases|EP/*ET/PP/TH
- MeSH Heading
- Adrenergic beta-Antagonists|TU; Angioplasty,
Transluminal, Percutaneous Coronary; Atherosclerosis|ET/PP;
Coronary Artery Bypass; Heart Failure, Congestive|EP;
Human; Myocardial Infarction|EP/TH; Myocardial Ischemia|ET;
Thrombolytic Therapy
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0889-8529
- Country of Publication
- UNITED STATES
Record 37 from database: MEDLINE
Return
To Top
- Title
- Risk factors for coronary heart disease mortality among
persons with diabetes.
- Author
- DeStefano F; Ford ES; Newman J; Stevenson JM; Wetterhall
SF; Anda RF; Vinicor F
- Address
- Division of Diabetes Translation, Centers for Disease
Control, Atlanta, GA.
- Source
- Ann Epidemiol, 1993 Jan, 3:1, 27-34
- Abstract
- Although coronary heart disease is a leading cause of
morbidity and mortality among persons with diabetes, the
risk factors for coronary heart disease have not been well
established for this population. The authors performed a
case-control analysis by using data from two large
population-based surveys. Cases of persons who died of
coronary heart disease were identified from the 1986
National Mortality Followback Survey, and controls were
taken from behavioral risk factor surveys conducted in 35
states in 1988. Diabetic women younger than 55 years with
no other risk factors for coronary heart disease had a
16-fold higher risk of dying from coronary heart disease
than did women without diabetes. About one-third of
younger women who died of coronary heart disease had
diabetes. Diabetic men less than 45 years old with no
other risk factors for coronary heart disease had an
eightfold higher risk of coronary heart disease mortality.
Among older white men and women, diabetes increased the
risk of mortality from coronary heart disease about
twofold. In younger diabetics, current cigarette smoking
was associated with a 50% increase in risk, and high blood
pressure increased the risk more than threefold. In the
older age group, risk factors for coronary heart disease
mortality were similar among those with and those without
diabetes: Cigarette smoking and high blood pressure each
were associated with about a twofold increase in risk.
Diabetes is a particularly strong risk factor for
mortality from coronary heart disease in young adults.
Smoking and blood pressure control represent major
opportunities to reduce the risk of coronary heart disease
among persons with diabetes.
- Language of Publication
- English
- Unique Identifier
- 94115491
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|ET/*MO; Diabetes Mellitus|CO/*EP
- MeSH Heading
- Adult; Aged; Case-Control Studies; Female; Human;
Hypertension|CO; Male; Middle Age; Obesity|CO; Risk
Factors; Smoking|AE; United States|EP
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1047-2797
- Country of Publication
- UNITED STATES
Record 38 from database: MEDLINE
Return
To Top
- Title
- Impaired glucose tolerance, diabetes, and cardiovascular
disease risk factor profiles in the elderly. The Honolulu
Heart Program.
- Author
- Rodriguez BL; Curb JD; Burchfiel CM; Huang B; Sharp DS;
Lu GY; Fujimoto W; Yano K
- Address
- Division of Clinical Epidemiology, John A. Burns School
of Medicine, University of Hawaii at Manoa, Honolulu
96817, USA. beatnz@hhs.cba.hawaii.edu
- Source
- Diabetes Care, 1996 Jun, 19:6, 587-90
- Abstract
- OBJECTIVE: The relationship between glucose tolerance
status and other cardiovascular disease (CVD) risk factors
was evaluated in a cohort of Japanese-American men (n =
3,741) ages 71-93 years who participated in the fourth
examination of the Honolulu Heart Program in 1991-1993.
RESEARCH DESIGN AND METHODS: In this cross-sectional
study, subjects were classified by reported diabetes and
glucose tolerance status using questionnaires and the
World Health Organization (WHO) criteria, respectively.
RESULTS: The prevalence of reported diabetes was 17%.
Among the men who completed an oral glucose tolerance test
and had no history of diabetes (n = 1,900), 23% were
diagnosed as diabetic and 39% had impaired glucose
tolerance (IGT) by WHO criteria. The CVD risk factor
profiles of men with IGT and diabetes were significantly
more adverse compared with men with normal glucose
tolerance after adjustment for age. The rates of
hypertension, mean levels of BMI, waist-to-hip ratio,
triglycerides, and fasting insulin were higher in men with
IGT and diabetes compared with normal subjects. Opposite
trends were observed for HDL cholesterol. Two-hour insulin
was significantly higher among men with IGT and previously
undiagnosed diabetes. Men with known diabetes had a lower
physical activity index and higher fibrinogen levels than
normal subjects. No significant differences were observed
for current smoking and alcohol intake. Differences in
risk factor levels by glucose tolerance status remained
after adjustment for age, physical activity, BMI, and
waist-to-hip ratio. CONCLUSIONS: These findings show that
among elderly men of Japanese ancestry, impaired glucose
tolerance and undiagnosed and known diabetes are highly
prevalent, and these conditions are associated with
adverse CVD factor profiles.
- Language of Publication
- English
- Unique Identifier
- 96348811
Return
To Top
- MeSH Heading (Major)
- Cardiovascular Diseases|*EP; Diabetes Mellitus|BL/*EP/PP;
Glucose Intolerance|BL/*EP/PP
- MeSH Heading
- Age Factors; Aged; Aged, 80 and over; Alcohol Drinking;
Blood Glucose|ME; Cholesterol|BL; Cohort Studies;
Cross-Sectional Studies; Fibrinogen|AN; Glucose Tolerance
Test; Hawaii|EP; Human; Insulin|BL; Male; Prevalence;
Questionnaires; Reference Values; Risk Factors; Smoking;
Support, U.S. Gov't, P.H.S.; Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0149-5992
- Country of Publication
- UNITED STATES
Record 39 from database: MEDLINE
Return
To Top
- Title
- A cross-sectional study comparing the motivation for
smoking cessation in apparently healthy patients who smoke
to those who smoke and have ischaemic heart disease,
hypertension or diabetes.
- Author
- Wilkes S; Evans A
- Address
- Coquet Medical Group, Broomhill Health Centre, Morpeth,
Northumberland, UK.
- Source
- Fam Pract, 1999 Dec, 16:6, 608-10
- Abstract
- BACKGROUND: Smoking remains the largest preventable
cause of morbidity and mortality in the UK. OBJECTIVES: We
aim to compare the motivation to stop smoking of patients
with either ischaemic heart disease, hypertension or
diabetes (diseased smokers) with apparently healthy
smokers (controls), and comment on smoking cessation rates
at 18 months following nurse-led active intervention in
those who are motivated to stop smoking. METHODS:
Questionnaires were sent out to 220 patients in each
group. Those patients who had expressed a desire to stop
smoking were invited to attend one to one or within a
group. RESULTS: In total, 328 questionnaires were
returned. Significantly more patients in the diseased
group were ex-smokers, 29% versus 18% (P = 0.04),
expressed a desire to stop smoking, 45% versus 30% (P =
0.02), and stated that they would like to receive
individual support, 38% versus 23% (P = 0.05). Thirty-four
patients attended for professional help to stop smoking.
At 18 months follow-up, four patients remained not
smoking. CONCLUSIONS: The findings in this study suggest
that individuals who smoke and have either ischaemic heart
disease, hypertension or diabetes may be more motivated to
give up smoking and were more receptive to individual
support. However smoking cessation rates at 18 months were
disappointing.
- Language of Publication
- English
- Unique Identifier
- 20088475
Return
To Top
- MeSH Heading (Major)
- Attitude to Health|*; Diabetes Mellitus|*EP/PX;
Hypertension|*EP/PX; Myocardial Ischemia|*EP/PX;
Smoking|*EP/PC; Smoking Cessation|*PX/*SN
- MeSH Heading
- Adolescence; Adult; Aged; Case-Control Studies;
Chi-Square Distribution; Comorbidity; Comparative Study;
Cross-Sectional Studies; Female; Great Britain|EP; Health
Surveys; Human; Male; Middle Age; Motivation; Reference
Values; Risk Assessment
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0263-2136
- Country of Publication
- ENGLAND
Record 40 from database: MEDLINE
Return
To Top
Back 10 records
- Title
- Diabetes and heart disease: a new strategy for managing
lipid disorders.
- Author
- Garber AJ
- Address
- Baylor College of Medicine, Methodist Hospital, Houston.
- Source
- Geriatrics, 1993 Oct, 48:10, 34-6, 39-41
- Abstract
- Dyslipidemias represent an underdiagnosed and
undertreated clinical problem in the management of
diabetic patients. Glycemic control by itself is not
sufficient to correct elevated triglycerides and low HDL
levels, which greatly increase the risk of cardiovascular
disease. Careful monitoring and aggressive intervention
can dramatically reduce the risk that these dyslipidemias
pose in diabetic and prediabetic patients. Weight loss by
obese patients, low-fat diets, and gradually increased
aerobic exercise should be tried for 6 months. If lipid
levels are still outside the acceptable range, consider
adding lipid-lowering drug therapy. Age should be no
barrier to intervention, as coronary risk factors continue
to contribute to the incidence of events into advanced
age.
- Language of Publication
- English
- Unique Identifier
- 94010354
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus, Non-Insulin-Dependent|BL/*CO;
Hyperlipidemia|*CO/*TH
- MeSH Heading
- Aged; Coronary Arteriosclerosis|CO/PC; Human; Lipids|BL;
Risk Factors
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0016-867X
- Country of Publication
- UNITED STATES
Record 41 from database: MEDLINE
Return
To Top
- Title
- Lipids and lipoproteins predicting coronary heart
disease mortality and morbidity in patients with
non-insulin-dependent diabetes [see comments]
- Author
- Laakso M; Lehto S; Penttilä I; Pyörälä K
- Address
- Department of Medicine, Kuopio University Hospital,
Finland.
- Source
- Circulation, 1993 Oct, 88:4 Pt 1, 1421-30
- Abstract
- BACKGROUND. The aim of this study was to investigate the
association of lipoprotein fractions with the future risk
of coronary heart disease (CHD) in patients with
non-insulin-dependent diabetes (NIDDM). METHODS AND
RESULTS. At baseline, lipoprotein fractions were
determined in 313 diabetic patients with NIDDM (153 men
and 160 women), and these patients were followed up for 7
years with respect to CHD events (CHD death or all CHD
events including CHD death or nonfatal myocardial
infarction). Altogether, 56 NIDDM patients (28 men and 28
women) died from CHD and 25 had a nonfatal myocardial
infarction (17 men and 8 women) during the follow-up.
NIDDM patients having these CHD events during the
follow-up had higher levels of total and very-low-density
lipoprotein (VLDL) triglycerides and VLDL cholesterol and
lower levels of high-density lipoprotein (HDL) and HDL2
cholesterol than those without CHD events. The risk for
CHD death was fourfold and for all CHD events, twofold
higher among diabetics with low HDL cholesterol (< 0.9
mmol/L) than among diabetics with HDL cholesterol > or
= 0.9 mmol/L. High triglyceride level (> 2.3 mmol/L)
was associated with a twofold increase in the risk of CHD
events. In multiple logistic regression analyses, HDL was
inversely associated with CHD events and VLDL
triglycerides with CHD events in NIDDM patients with low
HDL cholesterol level (< or = 1.12 mmol/L).
CONCLUSIONS. Our 7-year follow-up study gives evidence
that low HDL and HDL2 cholesterol, high VLDL cholesterol,
and high total and VLDL triglycerides are powerful risk
indicators for CHD events in patients with NIDDM.
- Language of Publication
- English
- Unique Identifier
- 94007018
Return
To Top
- MeSH Heading (Major)
- Cholesterol|*BL; Coronary Disease|BL/*EP; Diabetes
Mellitus, Non-Insulin-Dependent|*BL/EP; Triglycerides|*BL
- MeSH Heading
- Female; Finland|EP; Follow-Up Studies; Human;
Lipoproteins, HDL Cholesterol|BL; Lipoproteins, VLDL|BL;
Lipoproteins, VLDL Cholesterol|BL; Male; Middle Age;
Prospective Studies; Regression Analysis; Risk Factors;
Support, Non-U.S. Gov't; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0009-7322
- Country of Publication
- UNITED STATES
Record 42 from database: MEDLINE
Return
To Top
- Title
- Reduced coronary events in simvastatin-treated patients
with coronary heart disease and diabetes or impaired
fasting glucose levels: subgroup analyses in the
Scandinavian Simvastatin Survival Study [see comments]
- Author
- Haffner SM; Alexander CM; Cook TJ; Boccuzzi SJ; Musliner
TA; Pedersen TR; Kjekshus J; Pyörälä K
- Address
- Department of Medicine, University of Texas Health
Science Center at San Antonio, 78284-7873, USA. haffner@UTHSCSA.edu
- Source
- Arch Intern Med, 1999 Dec, 159:22, 2661-7
- Abstract
- BACKGROUND: Patients with diabetes mellitus (DM) have a
marked increase in coronary heart disease (CHD) events
relative to those without DM. In a previous report from
the Scandinavian Simvastatin Survival Study using a
clinical case definition of DM (n = 202), simvastatin-treated
patients had significantly fewer CHD events compared with
placebo-treated control subjects. OBJECTIVE: To examine
the effect of simvastatin therapy on CHD in patients with
DM and impaired fasting glucose levels. METHODS: Using the
1997 American Diabetes Association diagnostic criteria, we
assessed the effect of simvastatin therapy post hoc for an
average of 5.4 years in Scandinavian Simvastatin Survival
Study patients with normal fasting glucose (n = 3237),
impaired fasting glucose (n = 678), and DM (n = 483).
RESULTS: Simvastatin-treated patients with DM had
significantly reduced numbers of major coronary events
(relative risk [RR] = 0.58; P = .001) and
revascularizations (RR = 0.52; P = .005). Total (RR =
0.79; P = .34) and coronary (RR = 0.72; P = .26) mortality
were also reduced in DM, but not significantly, due to
small sample size. In impaired fasting glucose (IFG)
subjects, simvastatin use significantly reduced the number
of major coronary events (RR = 0.62; P = .003),
revascularizations (RR = 0.57; P = .009), and total (RR =
0.57; P = .02) and coronary (RR = 0.45; P = .007)
mortality. CONCLUSION: Our results extend previous
findings in patients with DM to a larger cohort,
confirming the benefit of cholesterol lowering with
simvastatin treatment on CHD events. In addition,
significant decreases in total mortality, major coronary
events, and revascularizations were observed in
simvastatin-treated patients with impaired fasting glucose
levels. These results strongly support the concept that
cholesterol lowering with simvastatin therapy improves the
prognosis of patients with elevated fasting glucose levels
(> or =6.0 mmol/L [> or =110 mg/ dL]) or DM and
known CHD.
- Language of Publication
- English
- Unique Identifier
- 20064626
Return
To Top
- MeSH Heading (Major)
- Anticholesteremic Agents|*TU; Coronary Disease|EP/*PC;
Diabetes Mellitus, Non-Insulin-Dependent|BL/*CO/EP;
Glucose Intolerance|*; Lipoproteins, LDL Cholesterol|*BL;
Simvastatin|*TU
- MeSH Heading
- Blood Glucose|AN; Double-Blind Method; Female; Human;
Incidence; Male; Middle Age; Myocardial
Revascularization|SN; Prognosis; Scandinavia|EP; Support,
Non-U.S. Gov't; Survival Analysis; Time Factors
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0003-9926
- Country of Publication
- UNITED STATES
Record 43 from database: MEDLINE
Return
To Top
- Title
- Animal product consumption and mortality because of all
causes combined, coronary heart disease, stroke, diabetes,
and cancer in Seventh-day Adventists.
- Author
- Snowdon DA
- Address
- Division of Epidemiology, School of Public Health,
University of Minnesota, Minneapolis.
- Source
- Am J Clin Nutr, 1988 Sep, 48:3 Suppl, 739-48
- Abstract
- This report reviews, contrasts, and illustrates
previously published findings from a cohort of 27,529
California Seventh-day Adventist adults who completed
questionnaires in 1960 and were followed for mortality
between 1960 and 1980. Within this population, meat
consumption was positively associated with mortality
because of all causes of death combined (in males),
coronary heart disease (in males and females), and
diabetes (in males). Egg consumption was positively
associated with mortality because of all causes combined
(in females), coronary heart disease (in females), and
cancers of the colon (in males and females combined) and
ovary. Milk consumption was positively associated with
only prostate cancer mortality, and cheese consumption did
not have a clear relationship with any cause of death. The
consumption of meat, eggs, milk, and cheese did not have
negative associations with any of the causes of death
investigated.
- Language of Publication
- English
- Unique Identifier
- 88324230
Return
To Top
- MeSH Heading (Major)
- Cause of Death|*; Diet|*; Food Preferences|*;
Longevity|*; Religion|*
- MeSH Heading
- California; Female; Human; Life Style; Male; Support,
U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE
- ISSN
- 0002-9165
- Country of Publication
- UNITED STATES
Record 44 from database: MEDLINE
Return
To Top
- Title
- New diabetes screening criteria for midlife women
evaluated for coronary heart disease risk.
- Author
- Stetson BA; Beacham AO; Rigsby V; Lobb K; Warfield J
- Address
- Department of Psychiatry and Behavioral Sciences,
University of Louisville, Kentucky 40292, USA. bastet0l@gwise.louisville.edu
- Source
- Appl Nurs Res, 1999 Nov, 12:4, 175-8
- Abstract
- The usefulness of new, lowered diabetes diagnostic
criterion to identify undiagnosed diabetics in a high-risk
sample of women was evaluated. Participants were 228
midlife women undergoing screening for heart attack risk.
Fasting plasma glucose levels of participants who were not
diagnosed with diabetes were examined to assess the number
of women who would meet diagnostic criteria for diabetes
using old (140 mg/dL) and new 126 mg/dL) American Diabetes
Association criteria. The new criterion identified more
women than did the old criterion, particularly African
Americans. Use of the new criterion flagged nearly 50% as
many women as originally diagnosed as diabetic at the time
of screening. Early identification of diabetes may afford
earlier, preventive interventions that may reduce
morbidity and mortality. Thus, findings from this study
suggest that use of the new, lowered diabetes diagnostic
criterion may have significant public health benefits for
midlife women.
- Language of Publication
- English
- Unique Identifier
- 20056483
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|*PC; Mass Screening|*MT; Women's
Health|*
- MeSH Heading
- Blood Glucose; Cardiovascular Diseases|CO/PC; Female;
Human; Middle Age; Reference Values; Risk Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0897-1897
- Country of Publication
- UNITED STATES
Record 45 from database: MEDLINE
Return
To Top
- Title
- Comparison of coronary heart disease mortality risk
between black and white people with diabetes.
- Author
- DeStefano F; Newman J
- Address
- Division of Chronic Disease Control and Community
Intervention, Centers for Disease Control and Prevention,
Atlanta, Georgia.
- Source
- Ethn Dis, 1993 Spr, 3:2, 145-51
- Abstract
- Coronary heart disease (CHD) is the leading cause of
mortality among people with diabetes. Although diabetes is
more prevalent among blacks than among whites, little is
known about CHD risk among black people with diabetes. We
performed a case-control analysis to assess CHD mortality
risk among people with diabetes. Coronary heart disease
mortality cases were identified from the 1986 National
Mortality Followback Survey, and controls were taken from
behavioral risk factor surveys conducted in 35 states in
1988. In the young age groups (men younger than 45 years
and women younger than 55), both white and black people
with diabetes and no other CHD risk factors had about a
thirteen-fold greater risk of CHD mortality compared to
people without diabetes and with no other CHD risk
factors. In the older age groups, diabetes was associated
with a lower risk of CHD mortality among blacks (OR = 1.6)
than among whites (OR = 2.5). With the exception of
smoking in young people with diabetes, we found smoking,
high blood pressure, and body mass to carry generally
similar relative risks of CHD mortality in black people
with diabetes as in white people with diabetes. Further
study of other CHD risk factors is needed in black people
with diabetes.
- Language of Publication
- English
- Unique Identifier
- 93313528
Return
To Top
- MeSH Heading (Major)
- Caucasoid Race|*; Coronary Disease|*MO; Diabetes
Mellitus, Insulin-Dependent|*CO; Diabetes Mellitus,
Non-Insulin-Dependent|*CO; Negroid Race|*
- MeSH Heading
- Body Mass Index; Comparative Study; Female; Human;
Hypertension|CO; Male; Middle Age; Odds Ratio; Risk
Factors; Smoking
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1049-510X
- Country of Publication
- UNITED STATES
Record 46 from database: MEDLINE
Return
To Top
- Title
- Parasympathetic activity is a major modulator of the
circadian variability of heart rate in healthy subjects
and in patients with coronary artery disease or diabetes
mellitus.
- Author
- Murakawa Y; Ajiki K; Usui M; Yamashita T; Oikawa N;
Inoue H
- Address
- Second Department of Internal Medicine, Tokyo University
Hospital, Japan.
- Source
- Am Heart J, 1993 Jul, 126:1, 108-14
- Abstract
- Autonomic heart rate control was assessed by power
spectral analysis of heart rate variability in 24-hour
ambulatory electrocardiographic recordings from 23 healthy
subjects, 14 patients with coronary artery disease without
cardiac dysfunction, and 14 patients with diabetes
mellitus. The log value of the ratio of the low-frequency
component (LF = 0.04 to 0.15 Hz) to the high-frequency
component (HF = 0.15 to 0.5 Hz) and logHF were employed as
indexes of sympathetic and parasympathetic activity,
respectively. Diurnal and nocturnal logLF, logHF, and
log(LF/HF) values were calculated for heart rates of 60,
70, and 80 beats/min. Intergroup differences among these
three variables were not significant at any heart rate.
Although a heart rate-related decrease in logHF was
generally observed, the relationship between log(LF/HF)
and heart rate was not consistent. The correlation between
diurnal and nocturnal logHF values was significant at all
three heart rates (r = 0.63, 0.87, and 0.59), whereas the
diurnal log(LF/HF) was correlated with the nocturnal value
only at 70 beats/min (r = 0.77). These results suggest
that the heart rate during normal daily activities is a
reliable indicator of parasympathetic tone, if not
sympathetic tone, in healthy subjects and patients with
coronary artery disease or diabetes mellitus.
- Language of Publication
- English
- Unique Identifier
- 93311288
Return
To Top
- MeSH Heading (Major)
- Autonomic Nervous System|*PH; Circadian Rhythm|*;
Coronary Disease|*PP; Diabetes Mellitus|*PP; Heart
Rate|*PH
- MeSH Heading
- Aged; Electrocardiography|MT; Female; Human; Male;
Middle Age; Parasympathetic Nervous System|PH; Signal
Processing, Computer-Assisted
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-8703
- Country of Publication
- UNITED STATES
Record 47 from database: MEDLINE
Return
To Top
- Title
- Beta-fibrinogen gene G/A-455 polymorphism in relation to
fibrinogen concentrations and ischaemic heart disease in
Chinese patients with type II diabetes.
- Author
- Lam KS; Ma OC; Wat NM; Chan LC; Janus ED
- Address
- Department of Medicine, University of Hong Kong, Queen
Mary Hospital, Hong Kong.
- Source
- Diabetologia, 1999 Oct, 42:10, 1250-3
- Abstract
- AIMS/HYPOTHESIS: We investigated the relation between
the G/A-455 (Hae III) beta-fibrinogen gene polymorphism
and plasma fibrinogen concentration and its role in
ischaemic heart disease in 264 Chinese patients with Type
II (non-insulin-dependent) diabetes mellitus and 182
non-diabetic control subjects. METHODS: The G/A-455
polymorphism was determined in genomic DNA using
polymerase chain reaction and Hae III restriction enzyme
digestion. Fibrinogen was measured with the Claus method.
RESULTS: Fibrinogen concentrations were higher in diabetic
patients (3.3 +/- 0.5 vs 2.5 +/- 0.9 g/l in controls, p
< 0. 0001) and in women (p < 0.03 vs men). Allele
frequency of the variant A allele was 27 % in both
diabetic patients and control subjects' similar to
findings in Caucasians. In control subjects, the AA
genotype was associated with higher fibrinogen
concentrations (2.8 +/- 0.38 g/l vs 2.5 +/- 0.5 in GG or
GA, p < 0.03), contributing to 4 % of the variance in
plasma fibrinogen. The genotype effect was smaller and not
significant among non-smokers, women and diabetic
patients. Higher fibrinogen concentrations and AA genotype
frequency were found in diabetic patients with ischaemic
heart disease (p < 0.05 and p < 0.005, respectively
vs unaffected patients). In a multiple logistic regression
model, AA genotype, age and mean arterial pressure were
associated with ischaemic heart disease, with odds ratios
of 4.19 (p < 0.01), 1.05 (p < 0.0001) and 1.03 (p
< 0.03), respectively. CONCLUSION/INTERPRETATION: The
G/A-455 polymorphism is a genetic determinant of
fibrinogen concentrations and ischaemic heart disease in
this Chinese cohort. It also interacts with environmental
influences associated with smoking, the female sex and
Type II diabetes in determining plasma fibrinogen
concentrations. [Diabetologia (1999) 42: 1250-1253]
- Language of Publication
- English
- Unique Identifier
- 99456808
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus, Non-Insulin-Dependent|BL/CO/*GE;
Fibrinogen|*GE/*ME; Myocardial Ischemia|BL/CO/*GE
- MeSH Heading
- Age Factors; Alleles; Body Mass Index; China; Cohort
Studies; Female; Gene Frequency; Genetic Predisposition to
Disease; Genotype; Human; Linkage (Genetics); Logistic
Models; Male; Middle Age; Polymorphism (Genetics)|GE; Risk
Factors; Sex Factors; Smoking; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0012-186X
- Country of Publication
- GERMANY
Record 48 from database: MEDLINE
Return
To Top
- Title
- Visceral adiposity and incident coronary heart disease
in Japanese-American men. The 10-year follow-up results of
the Seattle Japanese-American Community Diabetes Study.
- Author
- Fujimoto WY; Bergstrom RW; Boyko EJ; Chen KW; Leonetti
DL; Newell Morris L; Shofer JB; Wahl PW
- Address
- Department of Medicine, University of Washington,
Seattle 98195, USA. wilfuji@u.washington.edu
- Source
- Diabetes Care, 1999 Nov, 22:11, 1808-12
- Abstract
- OBJECTIVE: To identify risk factors for incident
coronary heart disease (CHD). RESEARCH DESIGN AND METHODS:
A total of 175 Japanese-American men without CHD were
followed for up to 10 years. Baseline variables were blood
pressure, weight, BMI, fat areas by computed tomography,
skinfold thicknesses, abdominal circumference, plasma
insulin, C-peptide, cholesterol, LDL cholesterol, HDL
cholesterol, HDL2 cholesterol, and HDL3 cholesterol,
triglycerides, apoproteins A1 and B, and diagnosis of
diabetes and hypertension. CHD was diagnosed by
electrocardiogram and clinical events. Logistic regression
was used to estimate odds ratio. RESULTS: There were 50
incident cases of CHD. Using univariate logistic
regression analysis, significant risk factors were
intra-abdominal fat (P = 0.0090), fasting glucose (P =
0.0002), 2-h glucose (P = 0.0008), fasting HDL cholesterol
(P = 0.0086), fasting HDL2 cholesterol (P = 0.030),
fasting HDL3 cholesterol (P = 0.018), fasting
triglycerides (P = 0.013), systolic (P = 0.0007) and
diastolic blood pressure (P = 0.0002), and presence of
diabetes (P = 0.0023). Multiple logistic regression models
adjusted for BMI and age showed that intra-abdominal fat
accounted for the effects of HDL cholesterol or
triglycerides. In a multiple logistic regression model
that included intra-abdominal fat, all systolic blood
pressure and fasting glucose were significant.
Substituting diastolic blood pressure for systolic blood
pressure and 2-h glucose or diabetes status for fasting
glucose produced similar results. CONCLUSIONS: Visceral
adiposity, blood pressure, and plasma glucose are
important independent risk factors for incident CHD in
this population of diabetic and nondiabetic
Japanese-American men.
- Language of Publication
- English
- Unique Identifier
- 20013335
Return
To Top
- MeSH Heading (Major)
- Adipose Tissue|*PH; Coronary Disease|*PP; Mongoloid
Race|*; Viscera|*PH
- MeSH Heading
- Follow-Up Studies; Human; Japan|EH; Male; Middle Age;
Odds Ratio; Support, Non-U.S. Gov't; Support, U.S. Gov't,
P.H.S.; Washington
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; JOURNAL
ARTICLE
- ISSN
- 0149-5992
- Country of Publication
- UNITED STATES
Record 49 from database: MEDLINE
Return
To Top
- Title
- Association of elevated serum uric acid with coronary
heart disease in diabetes mellitus.
- Author
- Rathmann W; Hauner H; Dannehl K; Gries FA
- Address
- Diabetes Research Institute at the Heinrich-Heine-University,
DÂusseldorf, Germany.
- Source
- Diabete Metab, 1993, 19:1 Pt 2, 159-66
- Abstract
- The relationship between elevated serum uric acid (SUA)
and coronary heart disease (CHD) is discussed
controversially. In this cross-sectional study, we
evaluated the association between hyperuricaemia and
small- and large-vessel diseases in diabetic patients by
analyzing clinical data of 7847 diabetic patients of both
sexes (Type 1 diabetes: n = 3800, Type 2 diabetes: n =
4047). Elevated serum uric acid was defined as
concentrations > 7.0 mg/dl in men and > 6.6 mg/dl in
women. The prevalence of hyperuricaemia was dependent on
age and duration of the disease in Type 1 diabetic
patients, whereas in recently diagnosed Type 2 diabetic
patients the prevalence of elevated uric acid levels was
higher than in patients with long-standing Type 1
diabetes, without any further increase with longer
duration of the disease. An elevated uric acid level was
also associated with body weight, hypertension and
nephropathy in both types of diabetes and in both sexes.
In women, hyperuricaemia was correlated with the presence
of coronary heart disease both in Type 1 and Type 2
diabetes (p < 0.05). The exclusion of hypertension and
nephropathy in the multiple logistic regression had no
effect on these associations. However, after adjustment
for these two factors a significant correlation between
hyperuricaemia and coronary heart disease was also found
in Type 2 diabetic men. In addition, increased serum uric
acid was associated with gangrene in male Type 2 diabetic
patients (p < 0.05). These results suggest that
elevated uric acid levels are correlated with the presence
of coronary heart disease in female rather than in male
diabetic patients, independently of hypertension and
nephropathy.
- Language of Publication
- English
- Unique Identifier
- 93300264
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*CO/EP/UR; Diabetes Mellitus,
Insulin-Dependent|*PP/UR; Diabetes Mellitus,
Non-Insulin-Dependent|*PP/UR; Diabetic Angiopathies|EP/*UR;
Uric Acid|*UR
- MeSH Heading
- Adolescence; Adult; Aged; Biological Markers|UR; Body
Weight; Cross-Sectional Studies; Diabetic Nephropathies|PP/UR;
Female; Human; Male; Middle Age; Odds Ratio; Prevalence;
Sex Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0338-1684
- Country of Publication
- FRANCE
Record 50 from database: MEDLINE
Return
To Top
Back 10 records
- Title
- Diabetes, blood lipids, and the role of obesity in
coronary heart disease risk for women. The Framingham
study.
- Author
- Gordon T; Castelli WP; Hjortland MC; Kannel WB; Dawber
TR
- Address
-
- Source
- Ann Intern Med, 1977 Oct, 87:4, 393-7
- Abstract
- Diabetes and a low high-density lipoprotein cholesterol
level are associated with each other and with a higher
coronary heart disease risk in women. Moreover, both are
strongly associated with obesity. These findings are
reported from the Framington Study, in which persons aged
49 to 82 were characterized, after overnight fast, for
blood lipids by the method of Fredrickson and Levy and
then followed for the subsequent development of coronary
heart disease. Low-density lipoprotein cholesterol was
also associated with coronary heart disease risk in women,
but fasting triglycerides were not associated with risk
after allowing for the association with high-density
lipoprotein cholesterol and diabetes. A low high-density
lipoprotein cholesterol in the presence of diabetes
appeared to raise the coronary heart disease risk in women
relative to that of men.
- Language of Publication
- English
- Unique Identifier
- 78018353
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|BL/*ET/PP; Diabetes Mellitus|*CO;
Lipids|*BL; Obesity|*CO
- MeSH Heading
- Adult; Aged; Blood Pressure; Cardiomegaly|CO;
Cholesterol|BL; Electrocardiography; Female; Human;
Lipoproteins, HDL|BL; Lipoproteins, LDL|BL; Longitudinal
Studies; Male; Massachusetts; Middle Age; Risk;
Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0003-4819
- Country of Publication
- UNITED STATES
Record 51 from database: MEDLINE
Return
To Top
- Title
- Special populations in cardiovascular rehabilitation.
Peripheral arterial disease, non-insulin-dependent
diabetes mellitus, and heart failure.
- Author
- Hiatt WR; Regensteiner JG; Wolfel EE
- Address
- Section of Vascular Medicine, University of Colorado
School of Medicine, Denver.
- Source
- Cardiol Clin, 1993 May, 11:2, 309-21
- Abstract
- Exercise rehabilitation has traditionally been part of
the management of patients with coronary artery disease,
particularly in the recovery period from a myocardial
infarction or after coronary artery bypass surgery. The
benefits of exercise training and formal rehabilitation
programs are not limited to patients with coronary artery
disease, and special populations described in this article
should be considered for rehabilitation services. Patients
with PAD are frequently severely limited by claudication
pain. Exercise rehabilitation is an effective means to
improve exercise performance without the use of drugs or
operation. In patients with NIDDM, an exercise program not
only improves exercise performance (which is impaired as
compared with age-matched controls) but also improves
glucose metabolism and insulin sensitivity. Patients with
left ventricular dysfunction have a severely limited peak
exercise performance. In these patients, an exercise
program can be conducted safely in a supervised setting
and will result in a significant improvement in peak
oxygen consumption.
- Language of Publication
- English
- Unique Identifier
- 93284631
Return
To Top
- MeSH Heading (Major)
- Arterial Occlusive Diseases|*RH; Diabetes Mellitus,
Non-Insulin-Dependent|*RH; Exercise Therapy|*; Heart
Failure, Congestive|*RH
- MeSH Heading
- Exercise Test; Human; Intermittent Claudication|RH;
Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0733-8651
- Country of Publication
- UNITED STATES
Record 52 from database: MEDLINE
Return
To Top
- Title
- Is the risk of coronary heart disease lower in Hispanics
than in non-Hispanic whites? The San Luis Valley Diabetes
Study.
- Author
- Rewers M; Shetterly SM; Hoag S; Baxter J; Marshall J;
Hamman RF
- Address
- Department of Preventive Medicine and Biometrics,
University of Colorado School of Medicine, Denver 80262.
- Source
- Ethn Dis, 1993 Win, 3:1, 44-54
- Abstract
- A less favorable cardiovascular risk factor profile, but
paradoxically lower coronary heart disease mortality and
prevalence have been reported for Hispanic men compared to
non-Hispanic white men. Since mortality and prevalence
data are susceptible to bias, the patterns of coronary
heart disease incidence, as well as prevalence and
mortality, were investigated in a biethnic Hispanic and
non-Hispanic white population of the San Luis Valley in
Colorado. Little evidence was found for lower incidence,
prevalence, or mortality due to coronary heart disease
among Colorado Hispanics without diabetes. The risk of
coronary heart disease among diabetic Hispanics appeared,
however, to be approximately 50% lower than among
non-Hispanic whites, especially in men. Adjustment for
selected cardiovascular risk factors (age, gender,
diabetes, hypertension, cigarette smoking, body mass
index, and high-density lipoprotein cholesterol and
triglycerides levels) did not change this ethnic pattern.
The plausible explanations of a lower coronary heart
disease risk among diabetic Hispanics, compared to
non-Hispanic whites, include both biologic mechanisms and
artifacts due to deficiencies of mortality classification
or differential access to health care. The existing
evidence is insufficient to conclude that the risk of
coronary heart disease in the general population differs
between Hispanics and non-Hispanic whites. The ethnic
patterns of coronary heart disease incidence should be
investigated further through population-based incidence
studies.
- Language of Publication
- English
- Unique Identifier
- 93284039
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*EH/EP/MO; Hispanic Americans|*
- MeSH Heading
- Adult; Aged; Colorado|EP; Comparative Study; Diabetes
Mellitus, Non-Insulin-Dependent|CO/EH/EP; Female; Human;
Incidence; Longitudinal Studies; Male; Middle Age;
Myocardial Infarction|EH/EP; Prevalence; Risk Factors;
Support, U.S. Gov't, P.H.S.; Whites
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1049-510X
- Country of Publication
- UNITED STATES
Record 53 from database: MEDLINE
Return
To Top
- Title
- Diabetes mellitus and coronary heart disease in the
elderly.
- Author
- Vokonas PS; Kannel WB
- Address
- Department of Research, University Hospital, Boston,
Massachusetts, USA.
- Source
- Clin Geriatr Med, 1996 Feb, 12:1, 69-78
- Abstract
- Data from epidemiologic studies document the role of
clinically manifest diabetes mellitus as a powerful risk
determinant for an array of atherosclerotic cardiovascular
outcomes including coronary heart disease (CHD), stroke,
and peripheral arterial disease, particularly in the
elderly. Although dyslipidemias and hypertension are quite
prevalent in persons with diabetes mellitus and contribute
heavily to the underlying atherosclerotic process, other
factors involving alternative pathogenetic mechanisms are
necessary to explain for the dramatic acceleration of
atherogenesis observed in this condition. Myocardial
ischemia may be silent and myocardial infarction (MI) may
be either painless or atypical in presentation which
further complicates both the diagnostic and therapeutic
management of CHD in older diabetic patients. MI, in this
context, is confounded by dual prognostic disadvantages of
higher risk for MI-related complications attributable to
both advanced age and diabetes mellitus. Because available
evidence has yet to demonstrate that control of
hyperglycemia, either by oral agents or by insulin,
effectively forestalls either the development or
complications of atherosclerosis, preventive management in
older patients with diabetes requires critical attention
to correcting coexisting cardiovascular risk factors.
- Language of Publication
- English
- Unique Identifier
- 96261308
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*CO/EP/PC/PP; Diabetes
Mellitus|*CO/DT/EP/PP
- MeSH Heading
- Aged; Antihypertensive Agents|TU; Female; Human;
Hypoglycemic Agents|TU; Incidence; Male; Risk Factors;
Support, Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.;
Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0749-0690
- Country of Publication
- UNITED STATES
Record 54 from database: MEDLINE
Return
To Top
- Title
- Serum levels of advanced glycation end products are
increased in patients with type 2 diabetes and coronary
heart disease.
- Author
- Kilhovd BK; Berg TJ; Birkeland KI; Thorsby P; Hanssen KF
- Address
- Aker Diabetes Research Centre, Department of
Endocrinology, Aker University Hospital, Oslo, Norway.
b.k.kilhovd@ioks.uio.no
- Source
- Diabetes Care, 1999 Sep, 22:9, 1543-8
- Abstract
- OBJECTIVE: To investigate whether serum levels of
advanced glycation end products (AGEs) and the
glycoxidation product Nepsilon-(carboxymethyl)lysine (CML)
are increased in patients with type 2 diabetes compared
with nondiabetic control subjects and whether levels of
AGEs and/or CML differ in patients with type 2 diabetes
with or without coronary heart disease (CHD). RESEARCH
DESIGN AND METHODS: Serum levels of AGEs and CML were
measured with an immunoassay in 32 men and 21 women aged
59.3+/-6.2 years (means +/- SD) with type 2 diabetes for
7.3 + 3.1 years and in 17 men and 17 women aged 56.2+/-4.2
years without diabetes. Of the patients with diabetes, 18
had CHD. RESULTS: The serum levels of AGEs and CML were
significantly increased in patients with type 2 diabetes
compared with nondiabetic control subjects (median
[5th-95th percentile]: AGEs 7.4 [4.4-10.9] vs. 4.2
[1.6-6.4] U/ml, P < 0.0001; CML 15.6 [5.6-29.9] vs. 8.6
[4.4-25.9] U/ml, P < 0.0001). The median level of AGEs
but not CML was significantly increased in patients with
type 2 diabetes and CHD compared with patients without CHD
(8.1 [6.4-10.9] vs. 7.1 [3.5-9.8] U/ml, P = 0.03). There
were significant positive correlations between serum
levels of AGEs and CML in both patients and control
subjects. CONCLUSIONS: Levels of AGEs and CML were
significantly increased in patients with type 2 diabetes
compared with nondiabetic control subjects, and levels of
AGEs but not CML were significantly higher in patients
with type 2 diabetes and CHD than in patients without
diabetes. These results may indicate a role for non-CML
AGEs in the development of macrovascular disease in
patients with type 2 diabetes.
- Language of Publication
- English
- Unique Identifier
- 99408400
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*BL/ET; Diabetes Mellitus,
Non-Insulin-Dependent|*BL; Diabetic Angiopathies|*BL;
Glycosylation End Products, Advanced|*BL
- MeSH Heading
- Aged; Epitopes|BL; Female; Human; Lysine|AA/IM; Male;
Middle Age; Multivariate Analysis; Risk Factors; Support,
Non-U.S. Gov't
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; JOURNAL
ARTICLE
- ISSN
- 0149-5992
- Country of Publication
- UNITED STATES
Record 55 from database: MEDLINE
Return
To Top
- Title
- The prevalence of coronary heart disease in the
multi-ethnic and high diabetes prevalence population of
Mauritius.
- Author
- Tuomilehto J; Li N; Dowse G; Gareeboo H; Chitson P;
Fareed D; Min Z; Alberti KG; Zimmet P
- Address
- Department of Epidemiology, National Public Health
Institute, Helsinki, Finland.
- Source
- J Intern Med, 1993 Feb, 233:2, 187-94
- Abstract
- The prevalence of coronary heart disease (CHD) was
determined in a population survey in Mauritius where the
prevalence of non-insulin dependent diabetes and mortality
from CHD are amongst the highest in the world. Men and
women aged 35-74 years of all major ethnic groups were
included: Asian Indians (Hindus and Muslims), Creoles and
Chinese. ECG abnormalities suggesting either 'probable
CHD' or 'possible CHD' were defined using standard
criteria. The overall prevalence of probable CHD was 2.7%
in men and 0.9% in women, and that of probable or possible
CHD together 17.8% in men and 33.3% in women. The
prevalence of CHD did not vary significantly between the
four ethnic groups. In the multivariate analyses, age and
high blood pressure were the most important independent
predictors of ECG abnormalities. Neither diabetes nor
serum insulin seemed to contribute independently to the
prevalence of CHD. This survey confirmed the high ranking
of Mauritius in international mortality statistics. The
high rates of CHD seen in Asian Indians, African-origin
Creoles and Chinese in the rapidly developing country of
Mauritius may be a pointer to future problems in their
regions of origin.
- Language of Publication
- English
- Unique Identifier
- 93163758
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|CO/EH/*EP; Diabetes Mellitus,
Non-Insulin-Dependent|CO/EH/*EP
- MeSH Heading
- Adult; Aged; Analysis of Variance; Female; Human; Male;
Mauritius|EH/EP; Middle Age; Multivariate Analysis;
Prevalence; Regression Analysis; Risk Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0954-6820
- Country of Publication
- ENGLAND
Record 56 from database: MEDLINE
Return
To Top
- Title
- Plasma C3d levels and ischemic heart disease in type II
diabetes.
- Author
- Figueredo A; Ibarra JL; Bagazgoitia J; Rodriguez A;
Molino AM; Fernandez Cruz A; Patino R
- Address
- Department of Internal Medicine III, Hospital
Universitario de San Carlos, Madrid, Spain.
- Source
- Diabetes Care, 1993 Feb, 16:2, 445-9
- Abstract
- OBJECTIVE--To test the hypothesis that the complement
system may be activated in patients with type II diabetes
and CAD. RESEARCH DESIGN AND METHODS--The plasma C3d
concentration was measured in 106 type II diabetic
patients and 25 nondiabetic control subjects. The patient
group was subdivided according to AER, and the groups were
adjusted for age, sex, and known duration of diabetes. For
the assignment to a given subgroup, normoalbuminuria was
defined as AER < 15 microns/min, microalbuminuria as
AER 16-250 micrograms/min, and macroalbuminuria as AER
> 250 micrograms/min. The presence or absence of
coronary disease was assessed through clinical
examination, ECG, and coronary angiography. An RIA system
was used for measurement of urinary albumin levels, and
the plasma C3d concentrations were measured by ELISA.
RESULTS--Within each of the AER-defined subgroups, the
plasma C3d levels were significantly higher in patients
with IHD than in those without. Thus, in the
normoalbuminuric group, plasma C3d levels were 16.3 AU/ml
(95% CI 13.9-19) in patients with IHD vs. 11.6 AU/ml (95%
CI 10.5-12.7) in those without (P < 0.001). The
corresponding data for the microalbuminuric and
macroalbuminuric groups were 21.8 (95% CI 18.1-26.3) vs.
13.6 (95% CI 12.3-15.1) and 31.6 (95% CI 24.9-40) vs. 17.5
(13.6-22.6) AU/ml (P < 0.01), respectively. Patients
with IHD also had significantly higher plasma C3d levels
than normal control subjects, regardless of AER subgroup.
A multiple logistic regression analysis demonstrated an
association between the plasma C3d concentration and IHD
and AER. CONCLUSIONS--Activation of the complement system
may play a role in the development of macrovascular
disease in type II diabetes.
- Language of Publication
- English
- Unique Identifier
- 93161888
Return
To Top
- MeSH Heading (Major)
- Complement 3d|*AN; Diabetes Mellitus,
Non-Insulin-Dependent|*BL/CO/UR; Myocardial
Ischemia|*BL/CO/UR
- MeSH Heading
- Albuminuria; Cholesterol|BL; Female; Human; Male; Middle
Age; Proteinuria; Reference Values; Regression Analysis;
Risk Factors; Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0149-5992
- Country of Publication
- UNITED STATES
Record 57 from database: MEDLINE
Return
To Top
- Title
- The contribution of diabetes to early deaths from
ischemic heart disease: US gender and racial comparisons.
- Author
- Will JC; Casper M
- Address
- Division of Nutrition, National Center for Chronic
Disease Prevention and Health Promotion, Centers for
Disease Control and Prevention, Atlanta, GA 30341-3724,
USA.
- Source
- Am J Public Health, 1996 Apr, 86:4, 576-9
- Abstract
- We evaluated the contribution of diabetes mellitus to
premature ischemic heart disease mortality among US race-
and gender-specific groups in 1986. Among persons aged 45
to 64 years, we examined ischemic heart disease death
rates (corrected for underreporting of diabetes on death
certificates) by diabetes status and calculated the
population attributable risk due to diabetes for each
group. Diabetes increased the ischemic heart disease death
rate by 9 to 10 times for women but by only 2 to 3 times
for men. Racial differences in ischemic heart disease
mortality attributable to diabetes were greater for women
(Blacks = 39%; Whites = 27%) than for men (Blacks = 19%;
Whites = 14%). These discrepancies in the contribution of
diabetes to ischemic heart disease mortality warrant
further study.
- Language of Publication
- English
- Unique Identifier
- 96188741
Return
To Top
- MeSH Heading (Major)
- Caucasoid Race|*; Diabetes Mellitus|*CO/EH/*MO;
Myocardial Ischemia|EH/*ET/*MO; Negroid Race|*
- MeSH Heading
- Aged; Comparative Study; Death Certificates; Female;
Human; Male; Middle Age; Population Surveillance;
Reproducibility of Results; Risk Factors; Sex
Distribution; United States|EP
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0090-0036
- Country of Publication
- UNITED STATES
Record 58 from database: MEDLINE
Return
To Top
- Title
- Impaired glucose tolerance and its relationship to
ECG-indicated coronary heart disease and risk factors
among Chinese. Da Qing IGT and diabetes study.
- Author
- Pan XR; Hu YH; Li GW; Liu PA; Bennett PH; Howard BV
- Address
- Department of Endocrinology, China Japanese Friendship
Hospital, Beijing, China.
- Source
- Diabetes Care, 1993 Jan, 16:1, 150-6
- Abstract
- OBJECTIVE--To determine the prevalence of IGT and
diabetes and identify the occurrence of CVD and its risk
factors. RESEARCH DESIGN AND METHODS--This study was a
population-based, cross-sectional study of 110,660
residents, 25-74 yr of age of DaQing, Hei Long Jiang
Province, China. RESULTS--Using 1985 WHO criteria, 577
(5.5/1000) subjects with IGT and 630 (6.0/1000) with newly
diagnosed diabetes were identified. In addition, 190
(1.7/1000) with previously known diabetes were identified.
Hypertension, obesity, and abnormal albumin excretion were
twice as frequent in those with IGT as in 279 men and 240
women of similar age and sex distribution who had normal
OGTTs. Plasma cholesterol and TGs were higher, and HDL
cholesterol was lower in subjects with IGT than in
nondiabetic subjects. Those with IGT had a prevalence of
electrocardiographically recognized CHD 9.5-fold greater
than the normoglycemic subjects. Subjects with IGT had
higher plasma insulin concentrations, but the 1-h
insulin-glucose ratio after the 75-g glucose load was
lower. In a forward stepwise multiple logistic regression
analysis, IGT itself remained an independent factor
associated with CHD after adjustment for age, sex,
cigarette smoking, plasma cholesterol, BP, and obesity.
CONCLUSIONS--Therefore, in China, IGT may occur with
almost as high a frequency as diabetes and is accompanied
by an increased frequency of CVD and its risk factors.
Estimates from this study indicate that > 12.0% of all
ECG-indicated CHD in the Da Qing population occurs in
individuals with IGT and NIDDM. The IGT subjects
identified in this survey form the cohort for a long-term
follow-up and intervention study.
- Language of Publication
- English
- Unique Identifier
- 93137643
Return
To Top
- MeSH Heading (Major)
- Blood Glucose|*ME; Coronary Disease|DI/*EP/ET; Diabetes
Mellitus|CO/*EP/PP; Electrocardiography|*; Glucose
Tolerance Test|*; Hyperglycemia|CO/*EP/PP
- MeSH Heading
- Adult; Aged; Albuminuria; Apolipoproteins B|BL; Blood
Pressure; China|EP; Cholesterol|BL; Comparative Study;
Female; Human; Insulin|BL; Lipoproteins, HDL
Cholesterol|BL; Male; Middle Age; Reference Values;
Regression Analysis; Risk Factors; Smoking; Support,
Non-U.S. Gov't; Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0149-5992
- Country of Publication
- UNITED STATES
Record 59 from database: MEDLINE
Return
To Top
- Title
- Glycemic control and the risk for coronary heart disease
in patients with non-insulin-dependent diabetes mellitus.
The Finnish studies.
- Author
- Laakso M
- Address
- Department of Medicine, University of Kuopio, Finland.
- Source
- Ann Intern Med, 1996 Jan, 124:1 Pt 2, 127-30
- Abstract
- PURPOSE: To review population-based studies that
investigated the association and nature of association
between glycemic control and the risk for coronary heart
disease in patients with non-insulin-dependent diabetes
mellitus (NIDDM). DATA SOURCES: Study 1 included 133 newly
diagnosed patients with NIDDM from eastern Finland, who
were 45 to 64 years of age at baseline. These patients
were followed up to 10 years for cardiovascular mortality.
Study 2 included 229 newly or previously diagnosed
patients with NIDDM from eastern Finland, aged 65 to 74
years at baseline. These patients were followed up to 3.5
years for coronary heart disease mortality and all
coronary heart disease events (mortality or nonfatal
myocardial infarction). STUDY SELECTION: Prospective,
population-based studies that included indicators of
glycemic control and the evaluation of coronary heart
disease and cardiovascular risk. RESULTS: Study 1: 10-year
cardiovascular mortality was significantly and linearly
associated with glycemic control (fasting blood glucose
and glycated hemoglobin A1 levels) independently of the
mode of treatment. A high fasting blood glucose level
significantly predicted cardiovascular mortality in
multiple logistic regression analysis independently of
other risk factors. Study 2: Glycated hemoglobin A1c was
the most important single risk factor associated with
coronary heart disease death or all coronary heart disease
events. In multiple logistic regression analysis, glycated
hemoglobin A1c was significantly associated with coronary
heart disease death after adjustment for other
cardiovascular risk factors. CONCLUSIONS: Two prospective,
population-based studies from Finland give evidence for
the linear association of glycemic control with the risk
for coronary heart disease in middle-aged and elderly
patients with NIDDM.
- Language of Publication
- English
- Unique Identifier
- 96147230
Return
To Top
- MeSH Heading (Major)
- Blood Glucose|*ME; Coronary Disease|*BL/*ET; Diabetes
Mellitus, Non-Insulin-Dependent|*BL/*CO
- MeSH Heading
- Aged; Female; Finland; Hemoglobin A, Glycosylated|ME;
Human; Logistic Models; Male; Middle Age; Prospective
Studies; Risk Factors; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0003-4819
- Country of Publication
- UNITED STATES
Record 60 from database: MEDLINE
Return
To Top
Back 10 records
- Title
- Serum levels of advanced glycation end products are
increased in patients with type 2 diabetes and coronary
heart disease.
- Author
- Kilhovd BK; Berg TJ; Birkeland KI; Thorsby P; Hanssen KF
- Address
- Aker Diabetes Research Centre, Department of
Endocrinology, Aker University Hospital, Oslo, Norway.
b.k.kilhovd@ioks.uio.no
- Source
- Diabetes Care, 1999 Sep, 22:9, 1543-8
- Abstract
- OBJECTIVE: To investigate whether serum levels of
advanced glycation end products (AGEs) and the
glycoxidation product Nepsilon-(carboxymethyl)lysine (CML)
are increased in patients with type 2 diabetes compared
with nondiabetic control subjects and whether levels of
AGEs and/or CML differ in patients with type 2 diabetes
with or without coronary heart disease (CHD). RESEARCH
DESIGN AND METHODS: Serum levels of AGEs and CML were
measured with an immunoassay in 32 men and 21 women aged
59.3+/-6.2 years (means +/- SD) with type 2 diabetes for
7.3 + 3.1 years and in 17 men and 17 women aged 56.2+/-4.2
years without diabetes. Of the patients with diabetes, 18
had CHD. RESULTS: The serum levels of AGEs and CML were
significantly increased in patients with type 2 diabetes
compared with nondiabetic control subjects (median
[5th-95th percentile]: AGEs 7.4 [4.4-10.9] vs. 4.2
[1.6-6.4] U/ml, P < 0.0001; CML 15.6 [5.6-29.9] vs. 8.6
[4.4-25.9] U/ml, P < 0.0001). The median level of AGEs
but not CML was significantly increased in patients with
type 2 diabetes and CHD compared with patients without CHD
(8.1 [6.4-10.9] vs. 7.1 [3.5-9.8] U/ml, P = 0.03). There
were significant positive correlations between serum
levels of AGEs and CML in both patients and control
subjects. CONCLUSIONS: Levels of AGEs and CML were
significantly increased in patients with type 2 diabetes
compared with nondiabetic control subjects, and levels of
AGEs but not CML were significantly higher in patients
with type 2 diabetes and CHD than in patients without
diabetes. These results may indicate a role for non-CML
AGEs in the development of macrovascular disease in
patients with type 2 diabetes.
- Language of Publication
- English
- Unique Identifier
- 99408400
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*BL/ET; Diabetes Mellitus,
Non-Insulin-Dependent|*BL; Diabetic Angiopathies|*BL;
Glycosylation End Products, Advanced|*BL
- MeSH Heading
- Aged; Epitopes|BL; Female; Human; Lysine|AA/IM; Male;
Middle Age; Multivariate Analysis; Risk Factors; Support,
Non-U.S. Gov't
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; JOURNAL
ARTICLE
- ISSN
- 0149-5992
- Country of Publication
- UNITED STATES
Record 61 from database: MEDLINE
Return
To Top
- Title
- Gln-Arg192 polymorphism of paraoxonase and coronary
heart disease in type 2 diabetes [see comments]
- Author
- Ruiz J; Blanché H; James RW; Garin MC; Vaisse C;
Charpentier G; Cohen N; Morabia A; Passa P; Froguel P
- Address
- Division d'EpidÆemiologie Clinique, Geneva University
Hospital, Switzerland.
- Source
- Lancet, 1995 Sep, 346:8979, 869-72
- Abstract
- Paraoxonase is a high-density-lipoprotein-associated
enzyme capable of hydrolysing lipid peroxides. Thus it
might protect lipoproteins from oxidation. It has two
isoforms, which arise from a glutamine (A isoform) to
arginine (B isoform) interchange at position 192. The
relevance of this polymorphism to coronary heart disease
(CHD) in non-insulin-dependent diabetic patients was
investigated in case-control study. Of the 434 patients,
171 had confirmed coronary artery disease; the other 263
had no history of such disease. The B allele and AB+BB
genotypes were associated with an increased risk of
coronary heart disease. Compared with subjects homozygous
for the A allele (AA genotype), the odds ratio of CHD for
subjects homozygous for the B allele was 2.5 (95% CI
1.2-5.3) and that for those heterozygous for the B allele
was 1.6 (95% CI 1.1-2.4), suggesting a codominant effect
on cardiovascular risk. When subjected to multivariate
analysis, the B allele remained significantly associated
with CHD (odds ratio 1.94, p = 0.03). The paraoxonase gene
polymorphism is thus an independent cardiovascular risk
factor in non-insulin-dependent diabetic patients. A
possible explanation for this finding is that activity of
the paraoxonase B isotype does not protect well against
lipid oxidation, a major atherogenic pathway.
- Language of Publication
- English
- Unique Identifier
- 96016242
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|CO/*EN/GE; Diabetes Mellitus,
Non-Insulin-Dependent|*CO/*EN; Esterases|*GE/ME
- MeSH Heading
- Arginine; Case-Control Studies; Female; Genotype;
Glutamine; Human; Male; Middle Age; Polymorphism
(Genetics); Regression Analysis; Risk Factors; Support,
Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0140-6736
- Country of Publication
- ENGLAND
Record 62 from database: MEDLINE
Return
To Top
- Title
- Association of coronary heart disease with serum lipid
and apolipoprotein concentrations in long-term diabetes.
Results of the Erfurt study.
- Author
- Schauer UJ; Pissarek D; Panzram G
- Address
- Poliklinik fÂur Innere Medizin, Medizinische Akademie
Erfurt, GDR.
- Source
- Acta Diabetol Lat, 1989 Jan, 26:1, 35-42
- Abstract
- The Erfurt study is concerned with the follow-up of all
the 208 long-term diabetics out of the closed area of the
Erfurt district with an at least 20 years' diabetes
survival in 1970. In 1980 risk factors for coronary heart
disease (CHD) were assessed in 71 (85% type I diabetes)
out of 76 patients still alive. Progression of CHD within
the subsequent five years (death due to CHD in 8 cases and
progression of the ECG findings according to the Minnesota
code in 3 cases) was associated with older age, lower body
mass index, higher triglycerides, and a higher total
cholesterol/HDL cholesterol ratio in comparison with the
surviving patients without progression (n = 41). No
significant differences could be found with regard to sex
distribution, age at diabetes onset, duration of diabetes,
percentage of type I diabetes, systolic and diastolic
blood pressure, smoking behavior, prevalence of
nephropathy, glycemic control, and serum levels of total
cholesterol, LDL cholesterol, and HDL cholesterol. The
subsequent reinvestigation in 1985 also included the
determination of apolipoproteins. Since type II diabetes
was not equally distributed, only type I diabetics were
considered for the comparison of patients with ECG
findings suggestive of CHD (n = 5) with the remaining
subjects (n = 35). In addition to the above mentioned
differences, CHD in long-term type I diabetes was also
accompanied by lower HDL cholesterol, lower apolipoprotein
A-I, and a higher apolipoprotein B/apolipoprotein A-I
ratio. Substantially similar differences could be observed
when type II diabetics were not excluded (10 patients with
and 37 patients without CHD). It is concluded that the
lipoprotein pattern is important for the survival in
long-term diabetes.
- Language of Publication
- English
- Unique Identifier
- 89319496
Return
To Top
- MeSH Heading (Major)
- Apolipoproteins|*BL; Coronary Disease|*BL/CO/PP;
Diabetes Mellitus|*BL/CO/PP; Lipids|*BL
- MeSH Heading
- Apolipoproteins A|BL; Apolipoproteins B|BL; Blood
Pressure; Cholesterol|BL; Diabetic Nephropathies|BL/PP;
Female; Human; Lipoproteins, HDL Cholesterol|BL;
Lipoproteins, LDL Cholesterol|BL; Male; Middle Age;
Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0001-5563
- Country of Publication
- ITALY
Record 63 from database: MEDLINE
Return
To Top
- Title
- Cardiovascular risk factors and prevalence of coronary
heart disease in type 2 (non-insulin-dependent) diabetes.
- Author
- Vlajinac H; Ilic M; Marinkovic J
- Address
- Institute of Epidemiology, School of Medicine, Belgrade
University, Beograd, Yugoslavia.
- Source
- Eur J Epidemiol, 1992 Nov, 8:6, 783-8
- Abstract
- The relationship between cardiovascular risk factors and
the prevalence of coronary heart disease was examined in
152 Type 2 diabetic patients (65 men, 87 women) aged 35-54
years and in 105 randomly selected control subjects (46
men, 59 women). Coronary heart disease, defined by
symptoms and ECG abnormalities, was 1.2 times higher in
male and 3.4 times higher in female diabetic patients than
in the controls. In logistic regression analysis
(including diabetes, age, body mass index, triglycerides,
HDL-cholesterol, non-HDL-cholesterol and hypertension)
diabetes showed an independent, significant association to
coronary heart disease in women, whereas hypertension was
independently related to coronary heart disease in men.
- Language of Publication
- English
- Unique Identifier
- 93193769
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*EP/ET; Diabetes Mellitus,
Non-Insulin-Dependent|CO/*EP
- MeSH Heading
- Adult; Blood Glucose|AN; Comparative Study; Female;
Human; Hypertension|CO/EP; Lipids|BL; Male; Middle Age;
Prevalence; Regression Analysis; Risk Factors; Smoking|EP;
Support, Non-U.S. Gov't; Yugoslavia|EP
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED
TRIAL
- ISSN
- 0393-2990
- Country of Publication
- ITALY
Record 64 from database: MEDLINE
Return
To Top
- Title
- Risk factors for coronary heart disease in noninsulin
dependent diabetes mellitus (NIDDM).
- Author
- Thulaseedharan N; Augusti KT
- Address
- Department of Biochemistry, University of Kerala,
Trivandrum.
- Source
- Indian Heart J, 1995 Sep, 47:5, 471-6
- Abstract
- Plasma levels of fasting and post-prandial blood sugar,
serum levels of total cholesterol (TC), triglycerides
(TG), HDL cholesterol (HDLc), LDL cholesterol (LDLc) and
free fatty acids (FFA) were estimated in 213 diabetic
patients (NIDDM) with coronary heart disease (CHD-group
4), 252 CHD patients (non-diabetic CHD-group 3), 164
non-insulin dependent diabetics (NIDDM-group 2) and 173
healthy subjects (controls-group 1) who did not have any
clinical evidence of CHD, diabetes mellitus or any family
history of the above diseases. Data was analysed by ANOVA
along with the Duncan procedure and multiple logistic
regression. Lipid profile of diabetic CHD patients was
characterised by significantly higher concentration of TC,
TG, LDLc, FFA, LDLc/HDLc ratio and lower concentration of
HDLc. However, in a multivariate logistic regression
analysis using 14 known risk factors, diastolic blood
pressure (BP), body mass index (BMI), alcohol consumption
and higher FFA levels seemed to be predictors of CHD in
diabetics, overriding the influence of lipoprotein
abnormalities. The same was true for nondiabetic patients
also in whom BMI, FFA and alcohol consumption were found
to be significant predictors of CHD. Thus, even though
lipid abnormalities are more prominent in diabetics, the
coexistence of obesity and hypertension seem to be
important factors in diabetics for the development of CHD.
- Language of Publication
- English
- Unique Identifier
- 96319011
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|BL/*ET/PP; Diabetes Mellitus,
Non-Insulin-Dependent|BL/*CO/PP
- MeSH Heading
- Analysis of Variance; Female; Human; Male; Middle Age;
Retrospective Studies; Risk Factors; Support, Non-U.S.
Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0019-4832
- Country of Publication
- INDIA
Record 65 from database: MEDLINE
Return
To Top
- Title
- Apolipoprotein AI-CIII-AIV genetic polymorphisms and
coronary heart disease in type 2 diabetes mellitus.
- Author
- Rigoli L; Raimondo G; Di Benedetto A; Romano G;
Procellini A; Campo S; Corica F; Riccardi G; Squadrito G;
Cucinotta D
- Address
- Department of Internal Medicine, University of Messina,
Italy.
- Source
- Acta Diabetol, 1995 Dec, 32:4, 251-6
- Abstract
- The aim of this study was to verify whether or not the
increased prevalence of coronary heart disease (CHD)
commonly observed in patients with type 2 diabetes
mellitus is related to a genetic background involving
restriction fragment length polymorphisms (RFLPs) of
apolipoproteins. On the basis of a case-control design, 62
type 2 diabetic patients with CHD (confirmed by clinical
history and electrocardiogram) and 62 age- and sex-matched
diabetic subjects without CHD were enrolled. In each of
them RFLPs of the apolipoprotein CIII gene (S1 or S2
allele) and AI promoter region (A or G allele), together
with fasting plasma lipids and apolipoproteins levels,
were assessed. The rare S2 allele was found significantly
(P = 0.05) more frequently in patients with CHD, and its
related S1S2 genotype was associated with higher plasma
levels of total cholesterol (P = 0.01), triglycerides (P =
0.007) and apo B (P = 0.001) than the S1S1 genotype. The A
allele was more frequent (P = 0.004) in patients without
CHD and was associated with lower plasma cholesterol (P =
0.0001), low-density lipoprotein (LDL)-cholesterol (P =
0.0001) and apo B (P = 0.005). The S1/A haplotype was more
frequent (P = 0.05) in patients without CHD and was
associated with the lowest plasma lipid levels. These
results suggest that genetic factors, related to the apo
AI-CIII-AIV gene cluster, could play a role in the
development of CHD in type 2 diabetic patients, probably
through modification of their plasma lipid pattern.
- Language of Publication
- English
- Unique Identifier
- 96341861
Return
To Top
- MeSH Heading (Major)
- Apolipoprotein A-I|BL/*GE; Apolipoproteins A|BL/*GE;
Apolipoproteins C|BL/*GE; Coronary Disease|BL/CO/*GE;
Diabetes Mellitus, Non-Insulin-Dependent|BL/CO/*GE;
Polymorphism, Restriction Fragment Length|*
- MeSH Heading
- Alleles; Apolipoproteins B|BL; Base Sequence;
Case-Control Studies; Cholesterol|BL; Comparative Study;
DNA Primers; Female; Gene Frequency; Genetic Markers;
Genotype; Human; Lipoproteins, HDL Cholesterol|BL;
Lipoproteins, LDL Cholesterol|BL; Male; Middle Age;
Molecular Sequence Data; Polymerase Chain Reaction;
Reference Values; Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0940-5429
- Country of Publication
- GERMANY
Record 66 from database: MEDLINE
Return
To Top
- Title
- Hypertriglyceridaemia as a risk factor of coronary heart
disease mortality in subjects with impaired glucose
tolerance or diabetes. Results from the 11-year follow-up
of the Paris Prospective Study.
- Author
- Fontbonne A; Eschwège E; Cambien F; Richard JL;
Ducimetière P; Thibult N; Warnet JM; Claude JR; Rosselin
GE
- Address
- INSERM UnitÆe 21, Villejuif, Paris, France.
- Source
- Diabetologia, 1989 May, 32:5, 300-4
- Abstract
- The Paris Prospective Study is a long-term investigation
of the incidence of coronary heart disease in a large
population of working men. The first follow-up examination
involved 7,038 men, aged 43-54 years. Subjects with
impaired glucose tolerance or diabetes (n = 943) were
selected from the total population for a separate analysis
of coronary heart disease mortality risk factors. During a
mean follow-up of 11 years, 26 of these 943 subjects with
abnormal glucose tolerance died from coronary heart
disease. Univariate analysis showed that plasma
triglyceride level (p less than 0.006), plasma cholesterol
level (p less than 0.02), and plasma insulin level both
fasting and 2-h post-glucose load (p less than 0.02), were
significantly higher in subjects who died from coronary
heart disease compared to those who did not. In
multivariate regression analysis using the Cox model,
plasma triglyceride level was the only factor positively
and significantly associated with coronary death. The
distribution of plasma triglyceride levels was clearly
higher for the subjects who died from coronary heart
disease compared to those who did not die from this cause
or were alive at the end of the follow-up. This new
epidemiological evidence that hypertriglyceridaemia is an
important predictor of coronary heart disease mortality in
subjects with impaired glucose tolerance or diabetes
suggests a possible role of dyslipidaemia in the excessive
occurrence of atherosclerotic vascular disease in this
category of subjects.
- Language of Publication
- English
- Unique Identifier
- 89325905
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|CO/*MO/PP; Diabetes Mellitus|BL/*CO/PP;
Hypertriglyceridemia|BL/*CO/PP; Prediabetic
State|BL/*CO/PP
- MeSH Heading
- Blood Glucose|ME; Blood Pressure; Body Weight;
Cholesterol|BL; Human; Insulin|BL; Reference Values; Risk
Factors; Smoking; Support, Non-U.S. Gov't;
Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0012-186X
- Country of Publication
- GERMANY, WEST
Record 67 from database: MEDLINE
Return
To Top
- Title
- Diabetes mellitus and hypertension in the elderly:
concomitant hyperlipidemia and coronary heart disease
risk.
- Author
- Assmann G; Schulte H
- Address
- Institute for Clinical Chemistry and Laboratory
Medicine, University of MÂunster, West Germany.
- Source
- Am J Cardiol, 1989 May, 63:16, 33H-37H
- Abstract
- Age is an important factor in predicting risk of
myocardial infarction (MI). Age is currently treated as an
independent variable in assessing risk, but it is also
related to other major risk factors including
hyperlipidemia, hypertension and diabetes, all of which
increase in prevalence with age. Current evidence
indicates that a combination of 2 or more of the major
risk factors predisposes a person to a high risk of MI. In
the experience of the Prospective Cardiovascular Munster
study, patients with diabetes alone have twice the risk of
MI, but those with diabetes and hyperlipidemia have about
a 15-fold increased risk. Similarly, patients with
hypertension alone have twice the risk of MI, but those
with hypertension combined with hyperlipidemia have
approximately a 15-fold increased risk.
- Language of Publication
- English
- Unique Identifier
- 89205397
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|*CO; Hyperlipidemia|*CO;
Hypertension|*CO; Myocardial Infarction|*EP/ET
- MeSH Heading
- Adult; Age Factors; Aged; Clinical Trials; Female;
Germany, West; Human; Male; Middle Age; Prospective
Studies; Risk Factors
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE
- ISSN
- 0002-9149
- Country of Publication
- UNITED STATES
Record 68 from database: MEDLINE
Return
To Top
- Title
- Hyperinsulinemia in a normal population as a predictor
of non-insulin-dependent diabetes mellitus, hypertension,
and coronary heart disease: the Barilla factory revisited.
- Author
- Zavaroni I; Bonini L; Gasparini P; Barilli AL;
Zuccarelli A; DallAglio E; Delsignore R; Reaven GM
- Address
- Department of Internal Medicine and Biomedical Science,
Parma University, Italy.
- Source
- Metabolism, 1999 Aug, 48:8, 989-94
- Abstract
- The study was initiated to evaluate the ability of
hyperinsulinemia (as a surrogate measure of insulin
resistance) to predict the development in a previously
healthy population of three putative outcomes of this
abnormality--glucose intolerance, hypertension, and
coronary heart disease (CHD). The study involved defining
the incidence at which these changes occurred between 1981
and 1993 to 1996 in 647 individuals who were free of any
disease when initially studied. The study population
consisted of approximately 90% of the subjects evaluated
in 1981, divided into quartiles on the basis of the plasma
insulin response to a glucose challenge as determined in
1981. The results indicated that the 25% of the population
with the highest insulin response in 1981 had significant
(P < .001) increases in the incidence of impaired
glucose tolerance (IGT) or type 2 diabetes (eightfold),
hypertension (twofold), or CHD (threefold). Furthermore,
the ability of hyperinsulinemia to predict the three
clinical endpoints was independent of differences in age,
gender, or body mass index (BMI). Finally, if CHD is
considered the clinical endpoint, multiple logistic
regression analysis indicates that the values for plasma
triglyceride (TG) and mean arterial blood pressure ([MAP]
as measured in 1981) also predict the development of CHD.
These results indicate that the untoward clinical effects
of insulin resistance and/or compensatory
hyperinsulinemia, glucose intolerance, hypertension, and
CHD clearly can develop in less than 15 years.
- Language of Publication
- English
- Unique Identifier
- 99387319
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*ET/ME; Diabetes Mellitus,
Non-Insulin-Dependent|*ET/ME; Hyperinsulinemia|*CO/ME;
Hypertension|*ET/ME
- MeSH Heading
- Adult; Body Mass Index; Female; Glucose Tolerance Test;
Human; Insulin Resistance; Male; Predictive Value of
Tests; Support, Non-U.S. Gov't; Support, U.S. Gov't,
P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0026-0495
- Country of Publication
- UNITED STATES
Record 69 from database: MEDLINE
Return
To Top
- Title
- The relationship between diabetes mellitus and coronary
heart disease.
- Author
- Inoue S; Ohta M; Iizuka T; Murao S
- Address
-
- Source
- Tohoku J Exp Med, 1983 Dec, 141 Suppl:, 495-8
- Abstract
- The present study was aimed at investigating the
relationship between diabetes and coronary heart disease.
100 g oral glucose tolerance test was performed on 32
well-defined male non-obese patients with coronary heart
disease (myocardial infarction and angina pectoris, 16
patients each; average age 47.5 years) and 12 non-obese
controls (average age 46.2 years). The results were as
follows: 1) Glucose tolerance was impaired in 19 of 32
patients. 2) Insulin response to glucose in patients with
normal glucose tolerance was similar to that in controls,
while insulin response in patients with impaired glucose
tolerance showed a delayed peak. 3) The insulinogenic
index of patients with normal glucose tolerance was the
same as that of controls, while the insulinogenic index of
patients with impaired glucose tolerance was lower, and 4)
overnight fast serum cholesterol and triglycerides in
patients with normal glucose tolerance showed similar
levels to those in controls, but were elevated in patients
with impaired glucose tolerance. These results suggest
that impaired glucose tolerance observed in patients with
coronary heart disease may result in part from
"latent diabetes."
- Language of Publication
- English
- Unique Identifier
- 85091175
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*CO; Diabetes Mellitus|*CO
- MeSH Heading
- Adult; Blood Glucose|AN; Glucose Tolerance Test; Human;
Insulin|BL; Male; Middle Age
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0040-8727
- Country of Publication
- JAPAN
Record 70 from database: MEDLINE
Return
To Top
Back 10 records
- Title
- Glucosamine levels in people with ischaemic heart
disease with and without type II diabetes.
- Author
- Nowak A; Szczesniak L; Rychlewski T; Dylewicz P;
Przywarska I
- Address
- Chair of Physiology, Biochemistry and Hygiene,
University School of Physical Education, PoznaÆn, Poland.
- Source
- Pol Arch Med Wewn, 1998 Nov, 100:5, 419-25
- Abstract
- Glucosamine has a major influence on the impairment of
some metabolic mechanisms in the human body. As shown in
vitro experiments, it takes part in inducing mechanisms of
insulin resistance. Therefore, the purpose of our study
was to evaluate glucosamine levels in the serum of
patients who suffered myocardial infarction (MI) and who
either had or didn't have diagnosed type II diabetes in
relation to healthy people. The levels of glucosamine,
immunoreactive insulin, C-peptide, glucose and lipid
indexes were measured in venous blood in investigated
patients. In patients with MI without diabetes the highest
concentrations of glucosamine, insulin and C-peptide were
noted as compared to the results obtained from other
groups of patients. In patients with diabetes, on the
other hand, the highest glucose levels were noted as
compared to the results of other patients. There were no
statistically differences of lipid indexes between two
groups of patients following MI. A negative correlation
between glucosamine levels and glucose concentrations in
patients without diabetes may suggest that glucose does
not directly determine glucosamine levels. The returning
of insulin levels to normal in patients with
hyperinsulinemia (antidiabetic drugs) may play a role in
the lowering of glucosamine induced peripheral insulin
resistance.
- Language of Publication
- English
- Unique Identifier
- 99338764
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus, Non-Insulin-Dependent|BL/*CO;
Glucosamine|*BL; Myocardial Infarction|*BL/*CO
- MeSH Heading
- Adult; C-Peptide|BL; Cholesterol|BL; Human; Insulin|BL;
Insulin Resistance|PH; Male; Middle Age; Statistics,
Nonparametric; Triglycerides|BL
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; JOURNAL
ARTICLE
- ISSN
- 0032-3772
- Country of Publication
- POLAND
Record 71 from database: MEDLINE
Return
To Top
- Title
- Type 2 (non-insulin-dependent) diabetes mellitus and
coronary heart disease-chicken, egg or neither?
- Author
- Jarrett RJ
- Address
-
- Source
- Diabetologia, 1984 Feb, 26:2, 99-102
- Abstract
- review of the literature yields much evidence against a
correlation between duration of non-insulin-dependent
diabetes mellitus (Type 2 diabetes) and the degree of
coronary atherosclerosis or the risk of clinically evident
coronary heart disease (CHD). Furthermore, an increased
risk of CHD, similar to that in previously diagnosed
diabetic subjects, has been demonstrated in persons with
impaired glucose tolerance. These observations suggest
that an increased risk of CHD is not a consequence of the
development of diabetes (i.e. persistent hyperglycaemia).
It is more likely that diabetes develops in individuals
who already possess characteristics which increase the
risk of CHD in addition to the risk of developing
diabetes.
- Language of Publication
- English
- Unique Identifier
- 84183370
Return
To Top
- MeSH Heading (Major)
- Arteriosclerosis|*CO; Atherosclerosis|*CO/MO; Coronary
Disease|*CO/MO; Diabetes Mellitus,
Non-Insulin-Dependent|*CO/MO; Diabetic
Angiopathies|*CO/MO; Hyperglycemia|*CO
- MeSH Heading
- Adolescence; Adult; Aged; Female; Follow-Up Studies;
Glucose Tolerance Test; Human; Male; Middle Age;
Prediabetic State|DI; Risk; Time Factors
- Publication Type
- JOURNAL ARTICLE; REVIEW
- ISSN
- 0012-186X
- Country of Publication
- GERMANY, WEST
Record 72 from database: MEDLINE
Return
To Top
- Title
- The prevalence of hypertension, ischaemic heart disease
and diabetes in traumatic spinal cord injured patients and
amputees.
- Author
- Yekutiel M; Brooks ME; Ohry A; Yarom J; Carel R
- Address
- Rehabilitation Center, Chaim Sheba Medical Center, Tel
Aviv University, Tel Hashomer, Israel.
- Source
- Paraplegia, 1989 Feb, 27:1, 58-62
- Abstract
- The clinical impression that spinal cord injured and
traumatic lower limb amputees are more prone to develop
degenerative diseases was investigated by comparing the
prevalence of hypertension, ischaemic heart disease, and
diabetes mellitus in these two patient groups with the
prevalence of these diseases among a group of healthy
age-matched controls. Seventy seven spinal cord injured
patients and 53 amputees fulfilled the criteria for
inclusion in this study. Our results show a significant
increased incidence of hypertension and ischaemic heart
disease among those with spinal cord injuries compared
with their controls; and among the amputees, a significant
increased incidence of ischaemic heart disease and of
diabetes mellitus.
- Language of Publication
- English
- Unique Identifier
- 89160097
Return
To Top
- MeSH Heading (Major)
- Amputation, Traumatic|*CO; Coronary Disease|*EP;
Diabetes Mellitus|*EP; Hypertension|*EP; Spinal Cord
Injuries|*CO
- MeSH Heading
- Adult; Aged; Amputees; Comparative Study;
Cross-Sectional Studies; Human; Israel; Male; Middle Age;
Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0031-1758
- Country of Publication
- SCOTLAND
Record 73 from database: MEDLINE
Return
To Top
- Title
- Konjac-mannan (glucomannan) improves glycemia and other
associated risk factors for coronary heart disease in type
2 diabetes. A randomized controlled metabolic trial.
- Author
- Vuksan V; Jenkins DJ; Spadafora P; Sievenpiper JL; Owen
R; Vidgen E; Brighenti F; Josse R; Leiter LA; Bruce
Thompson C
- Address
- Department of Nutritional Sciences, St. Michael's
Hospital, Faculty of Medicine, University of Toronto,
Ontario, Canada. v.vuksan@utoronto.ca
- Source
- Diabetes Care, 1999 Jun, 22:6, 913-9
- Abstract
- OBJECTIVE: To examine whether Konjac-mannan (KJM) fiber
improves metabolic control as measured by glycemia,
lipidemia, and blood pressure in high-risk type 2 diabetic
patients. RESEARCH DESIGN AND METHODS: A total of 11
hyperlipidemic and hypertensive type 2 diabetic patients
treated conventionally by a low-fat diet and drug therapy
participated. After an 8-week baseline, all were randomly
assigned to take either KJM fiber-enriched test biscuits
(0.7 g/412 kJ [100 kcal] of glucomannan) or matched
placebo wheat bran fiber biscuits during two 3-week
treatment phases separated by a 2-week washout period. The
diet in either case was metabolically controlled and
conformed to National Cholesterol Education Program Step 2
guidelines, while medications were maintained constant.
Efficacy measures included serum fructosamine, lipid
profiles, apolipoproteins, blood pressure, body weight,
and nutritional analysis. RESULTS: Compared with placebo,
KJM significantly reduced the metabolic control primary
end points: serum fructosamine (5.7%, P = 0.007, adjusted
alpha = 0.0167), total:HDL cholesterol ratio (10%, P =
0.03, adjusted alpha = 0.05), and systolic blood pressure
(sBP) (6.9%, P = 0.02, adjusted alpha = 0.025). Secondary
end points, including body weight, total, LDL, and HDL
cholesterol, triglycerides, apolipoproteins A-1, B, and
their ratio, glucose, insulin, and diastolic blood
pressure, were not significant after adjustment by the
Bonferroni-Hochberg procedure. CONCLUSIONS: KJM fiber
added to conventional treatment may ameliorate glycemic
control, blood lipid profile, and sBP in high-risk
diabetic individuals, possibly improving the effectiveness
of conventional treatment in type 2 diabetes.
- Language of Publication
- English
- Unique Identifier
- 99300829
Return
To Top
- MeSH Heading (Major)
- Blood Glucose|*ME; Cholesterol|*BL; Coronary
Disease|EP/*PC; Diabetes Mellitus,
Non-Insulin-Dependent|BL/PP/*TH; Diabetic Diet|*; Dietary
Fiber|*TU; Fructosamine|*BL; Mannans|*TU
- MeSH Heading
- Apolipoproteins|BL; Blood Pressure; Body Weight; Female;
Human; Insulin|BL; Male; Middle Age; Obesity in
Diabetes|BL/PP/TH; Risk Factors; Support, Non-U.S. Gov't;
Triglycerides|BL
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED
TRIAL
- ISSN
- 0149-5992
- Country of Publication
- UNITED STATES
Record 74 from database: MEDLINE
Return
To Top
- Title
- Diabetes mellitus, hypertriglyceridemia, and heart
disease risk in women.
- Author
- Barrett Connor E
- Address
- Department of Community and Family Medicine, University
of California, San Diego, La Jolla.
- Source
- Int J Fertil, 1992, 37 Suppl 2:, 72-82
- Abstract
- Coronary heart disease is the most common cause of death
in men and women in developed countries. Three primary
risk factors--high serum cholesterol concentration,
hypertension, and cigarette smoking--are known to increase
the risk in both men and women more or less equally,
although the latter two risk factors are a somewhat
greater risk to men. This paper reviews two additional
risk factors whose impact may be greater in women:
diabetes and hypertriglyceridemia. Understanding how
diabetes and hypertriglyceridemia act differently in women
may explain some of the sex differences in the risk of
heart disease.
- Language of Publication
- English
- Unique Identifier
- 92372244
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|BL/CO/*EP; Heart Diseases|*EP/ET;
Hypertriglyceridemia|BL/CO/*EP
- MeSH Heading
- Adult; Aged; Female; Human; Male; Middle Age; Risk
Factors; Sex Characteristics; Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0020-725X
- Country of Publication
- UNITED STATES
Record 75 from database: MEDLINE
Return
To Top
- Title
- Alcohol intake and the risk of coronary heart disease
mortality in persons with older-onset diabetes mellitus
[see comments]
- Author
- Valmadrid CT; Klein R; Moss SE; Klein BE; Cruickshanks
KJ
- Address
- Department of Ophthalmology and Visual Sciences,
University of Wisconsin-Madison Medical School,
53705-2397, USA.
- Source
- JAMA, 1999 Jul, 282:3, 239-46
- Abstract
- CONTEXT: Despite nutrition information and guidelines
that advise against depriving diabetic patients of the
potential benefit of moderate alcohol intake against
cardiovascular events, the association between alcohol
consumption and risk of cardiovascular outcomes in
diabetic individuals has not been determined. OBJECTIVE:
To examine the relationship between alcohol intake and
coronary heart disease (CHD) mortality in persons with
older-onset diabetes. DESIGN: Population-based,
prospective cohort study conducted from 1984 through 1996,
with a follow-up of up to 12.3 years. SETTING AND
PARTICIPANTS: A total of 983 older-onset diabetic
individuals (mean [SD] age, 68.6 [11.0] years; 45.2% male;
98.5% white) were interviewed about their past-year intake
of alcoholic beverages during the 1984-1986 follow-up
examination of a population-based study of diabetic
persons in southern Wisconsin. MAIN OUTCOME MEASURE: Time
to mortality from CHD by category alcohol intake. RESULTS:
Alcohol use was inversely associated with risk of CHD
mortality in older-onset diabetic subjects. The CHD
mortality rates for never and former drinkers were 43.9
and 38.5 per 1000 person-years, respectively, while the
rates for those with alcohol intakes of less than 2, 2 to
13, and 14 or more g/d were 25.3, 20.8, and 10.0 per 1000
person-years, respectively. Compared with never drinkers
and controlling for age, sex, cigarette smoking,
glycosylated hemoglobin level, insulin use, plasma
C-peptide level, history of angina or myocardial
infarction, digoxin use, and the presence and severity of
diabetic retinopathy, former drinkers had a relative risk
(RR) of 0.69 (95% confidence interval [CI], 0.43-1.12);
for those who drank less than 2 g/d (less frequent than 1
drink a week), the RR was 0.54 (95% CI, 0.33-0.90); for 2
to 13 g/d, it was 0.44 (95% CI, 0.23-0.84); and for 14 or
more g/d (about 1 drink or more a day), it was 0.21 (95%
CI, 0.09-0.48). Further adjustments for blood pressure,
body mass index, education, physical activity, diabetes
duration, hypertension history, overt nephropathy,
peripheral neuropathy, lipid measures, or intake of
medications such as aspirin and antihypertensive agents
did not change the associations observed. CONCLUSION: Our
results suggest an overall beneficial effect of alcohol
consumption in decreasing the risk of death due to CHD in
people with older-onset diabetes.
- Language of Publication
- English
- Unique Identifier
- 99349855
Return
To Top
- MeSH Heading (Major)
- Alcohol Drinking|*; Coronary Disease|CO/*MO; Diabetes
Mellitus|CO/*MO; Diabetic Angiopathies|CO/*MO
- MeSH Heading
- Age of Onset; Aged; Cause of Death; Female; Follow-Up
Studies; Human; Male; Proportional Hazards Models;
Prospective Studies; Risk; Support, Non-U.S. Gov't;
Support, U.S. Gov't, P.H.S.; Survival Analysis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0098-7484
- Country of Publication
- UNITED STATES
Record 76 from database: MEDLINE
Return
To Top
- Title
- Diabetes and coronary heart disease risk in Mexican
Americans [published erratum appears in Ann Epidemiol 1993
Jan;3(1):117]
- Author
- Mitchell BD; Haffner SM; Hazuda HP; Patterson JK; Stern
MP
- Address
- Department of Medicine, University of Texas Health
Science Center, San Antonio 78284-7873.
- Source
- Ann Epidemiol, 1992 Jan, 2:1-2, 101-6
- Abstract
- Mexican Americans have a high prevalence of diabetes
relative to non-Hispanic whites, but paradoxically
experience a lower prevalence of myocardial infarction and
lower cardiovascular mortality (at least in men). To
determine whether Mexican Americans might be more
resistant to the atherogenic effects of diabetes than
non-Hispanic whites, we examined the associations between
diabetes and myocardial infarction and selected coronary
heart disease (CHD) risk factors in these two ethnic
groups. The study population consisted of 5149 Mexican
Americans and non-Hispanic whites who were 25 to 64 years
old and recruited from the San Antonio Heart Study, a
population-based study of cardiovascular risk factors and
diabetes conducted between 1979 and 1988. Diabetic men
were more than twice as likely to have an
electrocardiography (ECG)-documented myocardial infarction
than were nondiabetic men, while diabetic women were more
than three times as likely to have a myocardial infarction
than were nondiabetic women. In both sexes the association
between myocardial infarction and diabetes was nearly
identical between the two ethnic groups. In both ethnic
groups diabetes was also more strongly associated with
conventional CHD risk factors (e.g., triglycerides,
systolic blood pressure, and high-density-lipoprotein
cholesterol) in women than in men. Furthermore, these
associations were at least as strong, if not stronger, in
Mexican Americans as in non-Hispanic whites. Thus, these
data provide no evidence to suggest that Mexican Americans
are resistant to the lipid-altering effects of diabetes.
We conclude that the protective effect against CHD
conferred by Mexican American ethnicity may be obscured in
part by the high prevalence of diabetes in this ethnic
group.
- Language of Publication
- English
- Unique Identifier
- 94101103
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|CO/*EH/EP; Diabetes Mellitus|CO/*EH/EP;
Mexican Americans|*
- MeSH Heading
- Adult; Cohort Studies; Female; Human; Male; Mexico|EH;
Middle Age; Myocardial Infarction|EH/EP; Prevalence; Risk
Factors; Support, U.S. Gov't, P.H.S.; United States|EP
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1047-2797
- Country of Publication
- UNITED STATES
Record 77 from database: MEDLINE
Return
To Top
- Title
- Coronary heart disease in diabetes mellitus: three new
risk factors and a unifying hypothesis.
- Author
- Yudkin JS
- Address
- Department of Medicine, University College London
Medical School, Whittington Hospital, UK.
- Source
- J Intern Med, 1995 Jul, 238:1, 21-30
- Abstract
- The standard risk factors--dyslipidaemia, hypertension
and smoking--provide little help in explaining the raised
cardiovascular risk in diabetes. It can be calculated that
intervening for disturbances of these risk factors could
do little to rectify the loss of life expectancy of around
10 years for a middle-aged diabetic man. Three new risk
factors are discussed, which together may contribute to
some of the excess cardiovascular risk in diabetes.
Plasminogen activator inhibitor is an inhibitor of
fibrinolysis which is elevated in concentration in
diabetic subjects, and may increase both the incidence of
thrombotic events and the risk of reinfarction after the
initial infarct. Recent work also suggests that high
activity of this substance may impair pharmacological
fibrinolysis. Proinsulin-like molecules are elevated in
concentration in diabetic patients and correlate with
levels of a number of other risk factors. Whilst these
correlations may represent cause and effect for
plasminogen activator inhibitor, there is no evidence that
changes in levels of proinsulin-like molecules influence
levels of other risk factors. Microalbuminuria provides a
powerful indicator of cardiovascular risk in both diabetic
and non-diabetic subjects, but whilst the mechanisms for
this association are unclear, they are again unlikely to
be mediated through changes in levels of standard risk
factors. Recent observations of an association between
short stature and microalbuminuria suggest that
intrauterine or early infant nutrition may represent a
common antecedent, these having also been shown to predict
both components of the insulin resistance syndrome and
cardiovascular disease in adult life.
- Language of Publication
- English
- Unique Identifier
- 95332828
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|ET/*PP; Diabetes Mellitus|CO/*PP
- MeSH Heading
- Albuminuria|PP; Human; Plasminogen Inactivators|PH;
Proinsulin|PH; Risk Factors
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0954-6820
- Country of Publication
- ENGLAND
Record 78 from database: MEDLINE
Return
To Top
- Title
- A cross-sectional evaluation of cardiovascular risk
factors in coronary heart disease associated with type 1
(insulin-dependent) diabetes mellitus.
- Author
- Winocour PH; Durrington PN; Bhatnagar D; Mbewu AD;
Ishola M; Mackness M; Arrol S
- Address
- University of Manchester Department of Medicine, Hope
Hospital, Salford, UK.
- Source
- Diabetes Res Clin Pract, 1992 Dec, 18:3, 173-84
- Abstract
- The contribution from lipoproteins, blood pressure,
albuminuria and demographic variables to coronary heart
disease in 90 adult subjects with and 172 without Type 1
diabetes mellitus was examined in order to investigate
whether risk factors were of equivalent importance in
diabetic and non-diabetic coronary heart disease. Coronary
heart disease (CHD) was present in roughly 25% of subjects
in each group. In Type 1 diabetes those with CHD had
significantly higher levels of systolic blood pressure,
albumin excretion, serum creatinine, triglycerides, VLDL
cholesterol and C-peptide, and reductions in serum
concentrations of HDL and HDL2 cholesterol, in comparison
to those without. However, the prevalence of smokers, and
concentrations of Lp(a), ApoB and fibrinogen were
comparable. Blood pressure and HDL cholesterol were higher
in the CHD group with Type 1 diabetes in comparison to the
nondiabetic group with CHD, although LDL concentrations
and the prevalence of Lp(a) concentrations > 200 mg/l
were lower. Logistic regression analysis revealed the
strongest independent predictors of CHD in Type 1 diabetes
were serum triglycerides, systolic blood pressure, age,
serum LDL cholesterol, and the daily insulin dosage,
whereas in the non-diabetic control group HDL2
cholesterol, Lp(a), ApoA1 and ApoB, total serum
cholesterol and body mass index were additional
predictors. CHD in Type 1 diabetes appears to be most
closely associated with increasing age and levels of blood
pressure and total serum lipids. Apolipoproteins and
albuminuria did not seem to be important independent
predictors of CHD in Type 1 diabetes, whereas the former
were more clearly associated with CHD in non-diabetic
controls.
- Language of Publication
- English
- Unique Identifier
- 93170101
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|BL/*EP/PP; Diabetes Mellitus,
Insulin-Dependent|BL/CO/*PP
- MeSH Heading
- Adult; Albuminuria; Alcohol Drinking; Apolipoproteins
A|AN; Apolipoproteins B|BL; Blood Glucose|AN; Blood
Pressure; C-Peptide|BL; Creatinine|BL; Diabetic
Retinopathy|BL/PP; Fibrinogen|AN; Human;
Lipoprotein(a)|BL; Lipoproteins, HDL|BL; Lipoproteins, HDL
Cholesterol|BL; Lipoproteins, LDL|BL; Lipoproteins, VLDL
Cholesterol|BL; Middle Age; Regression Analysis; Risk
Factors; Smoking; Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0168-8227
- Country of Publication
- NETHERLANDS
Record 79 from database: MEDLINE
Return
To Top
- Title
- Educational attainment and the risk of
non-insulin-dependent diabetes or coronary heart disease
in Japanese-American men.
- Author
- Leonetti DL; Tsunehara CH; Wahl PW; Fujimoto WY
- Address
- Department of Anthropology, University of Washington,
Seattle 98195.
- Source
- Ethn Dis, 1992 Fal, 2:4, 326-36
- Abstract
- Japanese-American men have higher rates of
non-insulin-dependent diabetes mellitus and coronary heart
disease than same-aged men in Japan. Associations of
educational attainment with either non-insulin-dependent
diabetes mellitus or coronary heart disease were examined
in a sample of 229 second-generation Japanese-American men
(aged 45 to 74 years) living in King County, Washington
(1984 through 1985). Men with a terminal school education
showed higher frequencies of both disease compared to men
with any college education and to men with high school
educations. Occupation, income, diet, physical activity,
weight, insulin, lipids, and lipoproteins were examined to
determine whether they could account for the observed
associations of educational attainment with disease.
Logistic regression analysis indicates that the
association of educational attainment with risk of
coronary heart disease is explained, in part, by the
larger average body mass index, higher total and VLDL
triglyceride, and lower HDL and HDL-2 cholesterol observed
in men with technical school educations compared to the
other men. The association of educational attainment with
risk of non-insulin-dependent diabetes is not explained by
any of the factors examined. The findings suggest that
attainment of a college education ameliorates some of the
negative effects of westernization on the health of
Japanese-American men.
- Language of Publication
- English
- Unique Identifier
- 93144997
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*EH; Diabetes Mellitus,
Non-Insulin-Dependent|*EH; Educational Status|*
- MeSH Heading
- Aged; Asian Americans; Body Mass Index; Comparative
Study; Diet; Exercise; Human; Income; Lipoproteins|BL;
Male; Middle Age; Occupations; Risk Factors; Support, U.S.
Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1049-510X
- Country of Publication
- UNITED STATES
Record 80 from database: MEDLINE
Return
To Top
Back 10 records
- Title
- Protein C antigen is not an acute phase reactant and is
often high in ischemic heart disease and diabetes.
- Author
- Viganò S; Mannucci PM; DAngelo A; Gelfi C; Gensini GF;
Rostagno C; Neri Serneri GG
- Address
-
- Source
- Thromb Haemost, 1984 Dec, 52:3, 263-6
- Abstract
- Protein C, an antithrombotic protein, was measured
immunologically in 299 patients with clinical conditions
associated with a high frequency of venous or arterial
thromboembolism. The mean protein C antigen (PC:Ag) level
was high for 48 patients with ischemic heart disease and,
to a lesser extent, for 95 diabetics. In 28 patients with
thrombotic strokes, 48 patients with proximal deep-vein
thrombosis and in 80 patients with localized or metastatic
tumors, mean PC:Ag was normal. Comparison of the pattern
of changes of PC:Ag levels with those of fibrinogen,
orosomucoid and prothrombin in 21 patients during the
postoperative period and in 20 patients with active
rheumatoid arthritis ruled out the possibility that high
PC:Ag is non-specific, acute-phase reaction to
inflammation, tissue injury or neoplastic growth.
Therefore, high PC:Ag might be specifically related to the
thrombotic tendency of these patients, but the mechanism
of such a relationship remains to be clarified.
- Language of Publication
- English
- Unique Identifier
- 85168917
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*BL; Diabetes Mellitus|*BL;
Glycoproteins|*BL/IM
- MeSH Heading
- Adolescence; Adult; Aged; Antigens|AN; Comparative
Study; Female; Human; Male; Middle Age; Neoplasms|BL;
Support, Non-U.S. Gov't; Thrombosis|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0340-6245
- Country of Publication
- GERMANY, WEST
Record 81 from database: MEDLINE
Return
To Top
- Title
- Cancer, heart disease, and diabetes in workers exposed
to 2,3,7,8-tetrachlorodibenzo-p-dioxin [see comments]
- Author
- Steenland K; Piacitelli L; Deddens J; Fingerhut M; Chang
LI
- Address
- National Institute for Occupational Safety and Health,
Cincinnati, OH, USA. steenland@iarc.fr
- Source
- J Natl Cancer Inst, 1999 May, 91:9, 779-86
- Abstract
- BACKGROUND: In 1997, the International Agency for
Research on Cancer classified
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as a group 1
human carcinogen, based largely on four highly exposed
industrial cohorts that showed an excess of all cancers
combined. In this study, we extended the follow-up period
for the largest of these cohorts by 6 years and developed
a job-exposure matrix. METHODS: We did cohort mortality
analyses involving 5132 chemical workers at 12 U.S. plants
by use of life table techniques (U.S. population referent)
and Cox regression (internal referent). We conducted
exposure-response analyses for 69% of the cohort with
adequate work history data and adequate plant data on TCDD
contamination. All P values are two-sided. RESULTS: The
standardized mortality ratio (SMR) for all cancers
combined was 1.13 (95% confidence interval = 1.02-1.25).
We found statistically significant positive linear trends
in SMRs with increasing exposure for all cancers combined
and for lung cancer. The SMR for all cancers combined for
the highest exposure group was 1.60 (95% confidence
interval = 1.15-1.82). SMRs for heart disease showed a
weak increasing trend with higher exposure (P = .14).
Diabetes (any mention on the death certificate) showed a
negative exposure-response trend. Internal analyses with
Cox regression found statistically significant trends for
cancer (15-year lag time) and heart disease (no lag).
CONCLUSIONS: Our analyses suggest that high TCDD exposure
results in an excess of all cancers combined, without any
marked specificity. However, excess cancer was limited to
the highest exposed workers, with exposures that were
likely to have been 100-1000 times higher than those
experienced by the general population and similar to the
TCDD levels used in animal studies.
- Language of Publication
- English
- Unique Identifier
- 99258660
Return
To Top
- MeSH Heading (Major)
- Carcinogens|*AE; Environmental Pollutants|*AE; Heart
Diseases|*CI/*MO; Neoplasms|*CI/*MO; Occupational
Exposure|*AE; Tetrachlorodibenzodioxin|*AE
- MeSH Heading
- Diabetes Mellitus|CI/MO; Human; Life Tables; Lung
Neoplasms|CI/MO; Odds Ratio; Proportional Hazards Models;
United States|EP
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0027-8874
- Country of Publication
- UNITED STATES
Record 82 from database: MEDLINE
Return
To Top
- Title
- Heart disease risk factors, diabetes, and prostatic
cancer in an adult community.
- Author
- Thompson MM; Garland C; Barrett Connor E; Khaw KT;
Friedlander NJ; Wingard DL
- Address
- Dept. of Community and Family Medicine, U. of California
San Diego, La Jolla 92093.
- Source
- Am J Epidemiol, 1989 Mar, 129:3, 511-7
- Abstract
- The authors studied the association between heart
disease and prostatic cancer in Rancho Bernardo,
California, from August 1972 to June 1987. During a
14-year follow-up of 1,776 men aged 50-84 years, 100 cases
of prostatic cancer were identified, of which 54 were
incident. Systolic blood pressure, cigarette smoking, and
plasma cholesterol levels in cases did not differ from
those in noncases. After adjustment for age and on
multivariate analysis, incident cases of prostatic cancer
had a nonsignificantly higher frequency of reported heart
disease at baseline. History of diabetes was inversely
associated with total prostatic cancer (age-adjusted
estimated relative risk = 0.2, 90% confidence interval:
0.0-0.8; multivariate-adjusted relative risk = 0.3, 90%
confidence interval: 0.1-1.0). The association between
heart disease and prostatic cancer is compatible with
diagnostic detection bias. The inverse association between
diabetes and prostatic cancer is compatible with a
cancer-promoting role for endogenous testosterone, the
level of which is lower in diabetics, or a risk-reducing
effect of antidiabetic diet or drug therapy.
- Language of Publication
- English
- Unique Identifier
- 89132529
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|*CO; Heart Diseases|*CO/ET; Prostatic
Neoplasms|EP/*ET/MO
- MeSH Heading
- Age Factors; Aged; Aged, 80 and over; California;
Cholesterol|BL; Death Certificates; Diet; Epidemiologic
Methods; Human; Male; Middle Age; Risk Factors;
Smoking|AE; Support, Non-U.S. Gov't; Support, U.S. Gov't,
P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9262
- Country of Publication
- UNITED STATES
Record 83 from database: MEDLINE
Return
To Top
- Title
- Poor glycemic control predicts coronary heart disease
events in patients with type 1 diabetes without
nephropathy.
- Author
- Lehto S; Rönnemaa T; Pyörälä K; Laakso M
- Address
- Department of Medicine, Kuopio University Hospital,
Kuopio, Finland.
- Source
- Arterioscler Thromb Vasc Biol, 1999 Apr, 19:4, 1014-9
- Abstract
- Patients with type 1 diabetes mellitus, especially those
with nephropathy, are at increased risk for coronary heart
disease (CHD). However, information on the predictive
value of cardiovascular risk factors and the degree of
hyperglycemia with respect to CHD events in patients with
type 1 diabetes without nephropathy is still incomplete.
Therefore, we performed a prospective study on risk
factors for CHD in patients with type 1 diabetes free of
clinical nephropathy. At baseline examination,
cardiovascular risk factor levels of CHD were determined
in 177 patients with type 1 diabetes (87 men and 90
women), age 45 to 64 years at baseline and >/=30 years
at the time of diagnosis of diabetes. These patients were
followed up to 7 years with respect to CHD events.
Altogether, 20 patients with type 1 diabetes (13 men
[7.3%] and 7 women [3.9%]) died of CHD and 28 patients
with type 1 diabetes (17 men [9.6%] and 11 women [6.2%])
had a serious CHD event (death from CHD or nonfatal
myocardial infarction). In multivariate Cox regression
analysis, a previous history of myocardial infarction
(hazard ratio [HR] and its 95% confidence interval, 8.0
[3.1 to 21.0], P<0.001), high glycohemoglobin A1
(>10.4%, the highest tertile, HR 5.4 [1.4 to 20.4],
P=0.013), and the duration of diabetes (>16 years, the
highest tertile, HR 4.2 [1.3 to 12.9], P=0.013) were the
only variables associated with CHD death even after
adjustment for other cardiovascular risk factors. These
variables also predicted the incidence of all CHD events.
Our results indicate that poor metabolic control is a
strong predictor of CHD events in patients with late-onset
type 1 diabetes without nephropathy, independently of
other cardiovascular risk factors.
- Language of Publication
- English
- Unique Identifier
- 99212177
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*BL/EP; Diabetes Mellitus,
Insulin-Dependent|*BL/EP; Diabetic Nephropathies|*BL;
Hyperglycemia|*BL/EP
- MeSH Heading
- Aged; Cohort Studies; Cross-Sectional Studies; Female;
Finland|EP; Follow-Up Studies; Hemoglobin A,
Glycosylated|ME; Human; Male; Middle Age; Predictive Value
of Tests; Prevalence; Prospective Studies; Risk Factors;
Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE; MULTICENTER STUDY
- ISSN
- 1079-5642
- Country of Publication
- UNITED STATES
Record 84 from database: MEDLINE
Return
To Top
- Title
- Relation between the serum level of C-peptide and risk
factors for coronary heart disease and diabetic
microangiopathy in patients with type-2 diabetes mellitus.
- Author
- Inukai T; Matsutomo R; Tayama K; Aso Y; Takemura Y
- Address
- Department of Medicine, Koshigaya Hospital, Dokkyo
University School of Medicine, Japan.
- Source
- Exp Clin Endocrinol Diabetes, 1999, 107:1, 40-5
- Abstract
- Syndrome X is used to describe a constellation of
factors that lead to coronary heart disease (CHD):
hypertension, hyperinsulinemia, impaired glucose
tolerance, and an abnormality in lipid metabolism. We
investigated the relationship between serum levels of
C-peptide immunoreactivity (CPR) and diabetic
complications in 256 patients with type-2 diabetes
mellitus. The serum level of CPR was measured by
radioimmunoassay (RIA). Diabetic patients were divided
into 3 groups according to the serum level of CPR as
follows: low CPR (n = 19, <0.7 ng/ml), normal CPR (n =
174, 0.7 to 2.2 ng/ml) and high CPR (n = 63, >2.2
ng/ml). The body mass index (BMI) and the serum level of
triglycerides were significantly higher in the high CPR
group (P < 0.05, respectively) compared with normal CPR
group. The prevalence of hypertension was significantly
higher in the high CPR group than in the other 2 groups
(low CPR: 16%, normal CPR: 28%, high CPR: 38%). The
frequency of the number of patients receiving insulin
therapy was greater in the low CPR group than in the other
2 groups, (low CPR: 58%, normal CPR: 15%, high CPR: 11%).
The serum CPR level was significantly lower in patients
with than without proliferative retinopathy or
macroalbuminuria. Our conclusion is that the present data
suggest that an increased serum level of CPR is associated
with obesity, elevated serum triglycerides, and
hypertension in patients with type-2 diabetes mellitus. A
low CPR level leading to hyperglycemia is associated with
the progression of diabetic microangiopathies, such as
retinopathy and nephropathy.
- Language of Publication
- English
- Unique Identifier
- 99174972
Return
To Top
- MeSH Heading (Major)
- C-Peptide|*BL; Coronary Disease|*BL; Diabetes Mellitus,
Non-Insulin-Dependent|*BL/DT; Diabetic Angiopathies|*BL
- MeSH Heading
- Albuminuria|BL; Body Mass Index; Diabetic
Retinopathy|BL; Female; Human; Hypertension|BL;
Hypertriglyceridemia|BL; Insulin|TU; Male; Middle Age;
Obesity in Diabetes|BL; Risk Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0947-7349
- Country of Publication
- GERMANY
Record 85 from database: MEDLINE
Return
To Top
- Title
- Relationship of proinsulin and insulin with
noninsulin-dependent diabetes mellitus and coronary heart
disease in Japanese-American men: impact of
obesity--clinical research center study.
- Author
- Kahn SE; Leonetti DL; Prigeon RL; Boyko EJ; Bergstrom
RW; Fujimoto WY
- Address
- Division of Metabolism, Endocrinology, and Nutrition,
University of Washington, Seattle, USA.
- Source
- J Clin Endocrinol Metab, 1995 Apr, 80:4, 1399-406
- Abstract
- Obesity is associated with noninsulin-dependent diabetes
mellitus (NIDDM) and coronary heart disease (CHD), and
these interactions have usually been related to changes in
immunoreactive insulin (IRI) levels. A role of proinsulin
(PI) in this association has been suggested. We,
therefore, examined IRI, PI, and true insulin levels and
the PI/IRI ratio by glucose tolerance or CHD status in a
cross-sectional study of 170 Japanese-American men (45-74
yr old) in whom 2 measures of adiposity (body mass index
and intraabdominal fat) were made to assess potential
associations in this population with a high prevalence of
both NIDDM and CHD. Subjects were classified as having
normal glucose tolerance (n = 58), impaired glucose
tolerance (IGT; n = 55), or NIDDM (n = 57) or were
classified by CHD status (without CHD, n = 127; with CHD,
n = 43). A positive linear relationship existed between
obesity, determined either as the body mass index or
intraabdominal fat, and IRI, PI, and true insulin, but not
the PI/IRI ratio. In the NIDDM subjects, PI levels were
disproportionately greater than those in subjects with
normal glucose tolerance or IGT, so the PI/IRI ratio was
significantly greater in the NIDDM group [mean (95%
confidence interval): normal glucose tolerance, 11.8%
(range, 10.4-13.5); IGT, 12.8% (range, 10.8-15.1); NIDDM,
19.2% (range, 15.4-24.0); P = 0.0002] even when adjusted
for obesity (P = 0.0004). In subjects with CHD compared to
subjects without CHD, IRI (P = 0.0026) and true insulin
levels (P = 0.0043) were increased, but PI levels were
not. However, these differences were not present after
adjustment for obesity. In contrast, when intraabdominal
fat was adjusted for IRI or true insulin, a significant
effect of intraabdominal fat on CHD risk was maintained (P
= 0.045 and P = 0.029, respectively), suggesting that
another factor(s) associated with central obesity may be
involved in CHD risk. Thus, in Japanese-American men,
elevated PI and PI/IRI ratio are markers of B-cell
dysfunction, and these are not the result of obesity. An
elevated true insulin level is present in those with CHD,
but this appears to be the result of obesity. In contrast,
central adiposity confers an additional risk for CHD
independent of insulin.
- Language of Publication
- English
- Unique Identifier
- 95229844
Return
To Top
- MeSH Heading (Major)
- Asian Americans|*; Coronary Disease|*CO/PA; Diabetes
Mellitus, Non-Insulin-Dependent|*BL/*CO/PA; Insulin|*BL;
Obesity|*CO/PA; Proinsulin|*BL
- MeSH Heading
- Adipose Tissue|PA; Aged; Glucose Intolerance; Human;
Japan|EH; Male; Middle Age; Support, U.S. Gov't,
Non-P.H.S.; Support, U.S. Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0021-972X
- Country of Publication
- UNITED STATES
Record 86 from database: MEDLINE
Return
To Top
- Title
- Diabetes and decline in heart disease mortality in US
adults.
- Author
- Gu K; Cowie CC; Harris MI
- Address
- National Institute of Diabetes and Digestive and Kidney
Diseases, National Institutes of Health, Bethesda, MD
20892, USA.
- Source
- JAMA, 1999 Apr, 281:14, 1291-7
- Abstract
- CONTEXT: Mortality from coronary heart disease has
declined substantially in the United States during the
past 30 years. However, it is unknown whether patients
with diabetes have also experienced a decline in heart
disease mortality. OBJECTIVE: To compare adults with
diabetes with those without diabetes for time trends in
mortality from all causes, heart disease, and ischemic
heart disease. DESIGN, SETTING, AND PARTICIPANTS:
Representative cohorts of subjects with and without
diabetes were derived from the First National Health and
Nutrition Examination Survey (NHANES I) conducted between
1971 and 1975 (n = 9639) and the NHANES I Epidemiologic
Follow-up Survey conducted between 1982 and 1984 (n =
8463). The cohorts were followed up prospectively for
mortality for an average of 8 to 9 years. MAIN OUTCOME
MEASURE: Changes in mortality rates per 1000 person-years
for all causes, heart disease, and ischemic heart disease
for the 1982-1984 cohort compared with the 1971-1975
cohort. RESULTS: For the 2 periods, nondiabetic men
experienced a 36.4% decline in age-adjusted heart disease
mortality compared with a 13.1% decline for diabetic men.
Age-adjusted heart disease mortality declined 27% in
nondiabetic women but increased 23% in diabetic women.
These patterns were also found for all-cause mortality and
ischemic heart disease mortality. CONCLUSIONS: The decline
in heart disease mortality in the general US population
has been attributed to reduction in cardiovascular risk
factors and improvement in treatment of heart disease. The
smaller declines in mortality for diabetic subjects in the
present study indicate that these changes may have been
less effective for people with diabetes, particularly
women.
- Language of Publication
- English
- Unique Identifier
- 99222825
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|*CO/*EP; Heart Diseases|*CO/*MO
- MeSH Heading
- Adult; Age Distribution; Aged; Comparative Study;
Female; Health Surveys; Human; Male; Middle Age;
Mortality|TD; United States|EP
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0098-7484
- Country of Publication
- UNITED STATES
Record 87 from database: MEDLINE
Return
To Top
- Title
- Insulin resistance, diabetes, and risk markers for
ischaemic heart disease in Asian men and non-Asian in
Bradford.
- Author
- Knight TM; Smith Z; Whittles A; Sahota P; Lockton JA;
Hogg G; Bedford A; Toop M; Kernohan EE; Baker MR
- Address
- Department of Public Health, Bradford Health Authority,
West Yorkshire.
- Source
- Br Heart J, 1992 May, 67:5, 343-50
- Abstract
- OBJECTIVE--To examine the hypothesis, in a community not
studied before, that insulin resistance associated with
centralised adiposity is the mechanism underlying the
predisposition of Asian immigrant communities to both
ischaemic heart disease and diabetes mellitus.
DESIGN--Cross sectional study within one socioeconomic
stratum. SETTING--Two factories in the textile sector in
Bradford, West Yorkshire. SUBJECTS--Male manual workers of
Asian (110) and non-Asian origin (156) aged 20-65 years.
RESULTS--Diabetes was almost three times more prevalent in
the Asian group. Two hours after an oral glucose load
Asian men had double the serum insulin concentrations of
non-Asian men (p < 0.0001). Asian men also had
significantly lower concentrations of plasma total
cholesterol (p < 0.03), high density lipoprotein
cholesterol (HDL) (HDL2, p < 0.0001; HDL3, p <
0.0001), and apolipoprotein AI (p < 0.0001). Fasting
plasma triglyceride concentrations were slightly higher (p
= 0.072) in the Asian men; thus the ratio of triglyceride
cholesterol was higher (p = 0.006). The inter-relation
between serum insulin and plasma lipid concentrations
indicated metabolic differences between the ethnic groups.
Insulin concentrations were associated with cholesterol
concentrations in the Asian men only and there was a lack
of association between triglyceride, low density
lipoprotein cholesterol, and HDL cholesterol in this
group. The risk marker profile in the Asian men was
therefore quite different to that of their non-Asian
counterparts and was associated with a greater tendency to
centralised adiposity. CONCLUSION--These data support the
insulin resistance hypothesis and thus have important
implications for strategies for the prevention of heart
disease in Asian communities in the United Kingdom.
- Language of Publication
- English
- Unique Identifier
- 93001814
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|BL/*EH; Diabetes Mellitus,
Non-Insulin-Dependent|BL/*EH; Insulin Resistance|*
- MeSH Heading
- Adult; Aged; Anthropometry; Asia|EH; Blood Glucose|ME;
Blood Pressure|PH; Cross-Sectional Studies; England;
Human; Insulin|BL; Lipids|BL; Male; Middle Age; Risk
Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0007-0769
- Country of Publication
- ENGLAND
Record 88 from database: MEDLINE
Return
To Top
- Title
- Very low density lipoprotein. Qualitative abnormalities
in patients with premature coronary heart disease and in
patients with insulin dependent diabetes.
- Author
- Mancini M; Pauciullo P; Cortese C; Rubba P; Riccardi G;
Rivellese A
- Address
- Institute of Internal Medicine and Metabolic Diseases,
2nd Medical School, University of Naples, Italy.
- Source
- Horm Metab Res Suppl, 1988, 19:, 13-5
- Abstract
- VLDL composition has been investigated in two groups of
patients: one with Premature Coronary Heart Disease (PCHD)
and another one with Insulin Dependent Diabetes Mellitus.
Both groups showed abnormal VLDL composition. PCHD
patients had VLDL significantly enriched in free
cholesterol and triglycerides in comparison with a group
of controls matched with patients for sex, age, BMI, serum
cholesterol and TG. This VLDL composition indicates a
prevalence of big particles, which can be found at the
beginning of the lipolytic cascade. On the other hand VLDL
of diabetic patients were enriched in cholesterol,
especially esterified cholesterol, and apo B in comparison
with the respective control group suggesting an increase
of smaller VLDL, considered more atherogenic. In
conclusion these two studies demonstrate that VLDL
compositional abnormalities can be found in two different
groups of patients even in the absence of hyperlipidemia.
- Language of Publication
- English
- Unique Identifier
- 89172808
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*BL; Diabetes Mellitus,
Insulin-Dependent|*BL; Lipoproteins, VLDL|*BL
- MeSH Heading
- Adult; Apolipoproteins B|BL; Cholesterol|BL; Comparative
Study; Human; Lipoproteins, HDL|BL; Lipoproteins, LDL|BL;
Male; Reference Values; Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0018-5043
- Country of Publication
- GERMANY, WEST
Record 89 from database: MEDLINE
Return
To Top
- Title
- Lack of association between lipoprotein (a)
concentrations and coronary heart disease mortality in
diabetes: the Wisconsin Epidemiologic Study of Diabetic
Retinopathy.
- Author
- Haffner SM; Moss SE; Klein BE; Klein R
- Address
- Department of Medicine, University of Texas Health
Science Center, San Antonio.
- Source
- Metabolism, 1992 Feb, 41:2, 194-7
- Abstract
- Recently, considerable data have suggested that
lipoprotein (a) [Lp(a)] is a strong independent risk
factor for coronary heart disease. Since Lp(a) is
increased in both insulin-dependent diabetes mellitus
(IDDM) and non-insulin-dependent diabetes mellitus
(NIDDM), this study examined the relationship of Lp(a)
concentrations to coronary heart disease (CHD) mortality
in the 4-year follow-up of the Wisconsin Epidemiologic
Study of Diabetic Retinopathy (WESDR). Twenty-four
older-onset subjects and 11 younger-onset subjects who
died of CHD (cases) before the age of 70 were matched by
age, gender, and type of diabetes to subjects who remained
alive (controls). The distribution and mean levels of
Lp(a) in the cases and controls were very similar,
suggesting a lack of association between Lp(a)
concentrations and CHD mortality. Although the number of
subjects was small, caution should be used in
extrapolating results on Lp(a) relationships in
nondiabetic subjects to diabetic subjects.
- Language of Publication
- English
- Unique Identifier
- 92140067
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|CO/*MO/PP; Diabetes Mellitus|*CO/MO/PP;
Diabetic Retinopathy|*EP; Lipoproteins|*BL
- MeSH Heading
- Biological Markers|BL; Blood Pressure; Cholesterol|BL;
Diabetes Mellitus, Insulin-Dependent|CO/MO/PP; Diabetes
Mellitus, Non-Insulin-Dependent|CO/MO/PP; Female; Human;
Lipoproteins, HDL Cholesterol|BL; Male; Middle Age; Sex
Characteristics; Smoking; Support, U.S. Gov't, P.H.S.;
Wisconsin|EP
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0026-0495
- Country of Publication
- UNITED STATES
Record 90 from database: MEDLINE
Return
To Top
Back 10 records
- Title
- Risk factors for coronary heart disease in diabetes
mellitus.
- Author
- Jarrett RJ
- Address
- United Medical School, Guy's Hospital, London, United
Kingdom.
- Source
- Diabetes, 1992 Oct, 41 Suppl 2:, 1-3
- Abstract
- A review of the putative risk factors associated with
the development of coronary heart disease in diabetes is
presented. Emphasis is given to the effect of nephropathy
(persistent proteinuria) and hypertension on
cardiovascular mortality in IDDM. Risk factors associated
with CHD in NIDDM are also reviewed. Finally, possible
reasons to explain the increased incidence of CHD
associated with proteinuria in IDDM patients, including
lipoprotein abnormalities, increased fibrinogen levels,
increased platelet adhesiveness, and altered hemostatic
variables, are discussed.
- Language of Publication
- English
- Unique Identifier
- 92405825
Order
full text for this document
- MeSH Heading (Major)
- Coronary Disease|*ET; Diabetes Mellitus|*CO
- MeSH Heading
- Diabetes Mellitus, Insulin-Dependent|CO; Diabetes
Mellitus, Non-Insulin-Dependent|CO; Human; Risk Factors
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0012-1797
- Country of Publication
- UNITED STATES
Record 91 from database: MEDLINE
Return
To Top
- Title
- Body fat distribution and coronary heart disease
mortality in subjects with impaired glucose tolerance or
diabetes mellitus: the Paris Prospective Study, 15-year
follow-up.
- Author
- Fontbonne A; Thibult N; Eschwège E; Ducimetière P
- Address
- INSERM U21, Villejuif, France.
- Source
- Diabetologia, 1992 May, 35:5, 464-8
- Abstract
- The Paris Prospective Study is a long-term, large-scale
study of the factors predicting coronary heart disease in
healthy middle-aged men. Subjects with impaired glucose
tolerance or diabetes (not treated by insulin) at the
first follow-up examination (n = 973) were selected from
the total cohort for a separate analysis of the predictors
of death from coronary heart disease. An index of body fat
distribution, the iliac to thigh ratio, was entered into
the list of potentially predictive variables, despite the
fact that it had been measured one year before the first
follow-up examination. After 15 years of mean follow-up,
41 of the selected subjects had died from coronary heart
disease. Univariate analysis showed that these subjects
differed from the subjects who died of another cause or
who were alive at 15 years on the following variables:
iliac to thigh ratio (p less than 0.0005), plasma
triglyceride level (p less than 0.006), systolic blood
pressure (p less than 0.01), and body mass index (p less
than 0.04). In multivariate regression analysis using the
Cox model, only iliac to thigh ratio and triglyceride
plasma level achieved statistical significance as
independent predictors. This result supports the current
hypothesis that upper-body fat distribution, a
characteristic trait of subjects with diabetes of glucose
intolerance, plays an important role towards their high
cardiovascular risk. However, it is unlikely that this
role would be mediated through the lipid abnormalities
that have been described as associated with upper-body fat
deposition.
- Language of Publication
- English
- Unique Identifier
- 92394430
Return
To Top
- MeSH Heading (Major)
- Adipose Tissue|*AH; Coronary Disease|BL/CO/*MO; Diabetic
Angiopathies|CO/*MO; Hyperglycemia|*CO
- MeSH Heading
- Blood Pressure; Cholesterol|BL; Comparative Study;
Follow-Up Studies; Glucose Tolerance Test; Human; Male;
Middle Age; Multivariate Analysis; Paris; Prospective
Studies; Regression Analysis; Risk Factors; Smoking;
Support, Non-U.S. Gov't; Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0012-186X
- Country of Publication
- GERMANY
Record 92 from database: MEDLINE
Return
To Top
- Title
- Mortality from coronary heart disease in subjects with
type 2 diabetes and in nondiabetic subjects with and
without prior myocardial infarction [see comments]
- Author
- Haffner SM; Lehto S; Rönnemaa T; Pyörälä K; Laakso M
- Address
- Department of Medicine, University of Texas Health
Science Center at San Antonio, 78284-7873, USA.
- Source
- N Engl J Med, 1998 Jul, 339:4, 229-34
- Abstract
- BACKGROUND: Type 2 (non-insulin-dependent) diabetes is
associated with a marked increase in the risk of coronary
heart disease. It has been debated whether patients with
diabetes who have not had myocardial infarctions should be
treated as aggressively for cardiovascular risk factors as
patients who have had myocardial infarctions. METHODS: To
address this issue, we compared the seven-year incidence
of myocardial infarction (fatal and nonfatal) among 1373
nondiabetic subjects with the incidence among 1059
diabetic subjects, all from a Finnish population-based
study. RESULTS: The seven-year incidence rates of
myocardial infarction in nondiabetic subjects with and
without prior myocardial infarction at base line were 18.8
percent and 3.5 percent, respectively (P<0.001). The
seven-year incidence rates of myocardial infarction in
diabetic subjects with and without prior myocardial
infarction at base line were 45.0 percent and 20.2
percent, respectively (P<0.001). The hazard ratio for
death from coronary heart disease for diabetic subjects
without prior myocardial infarction as compared with
nondiabetic subjects with prior myocardial infarction was
not significantly different from 1.0 (hazard ratio, 1.4;
95 percent confidence interval, 0.7 to 2.6) after
adjustment for age and sex, suggesting similar risks of
infarction in the two groups. After further adjustment for
total cholesterol, hypertension, and smoking, this hazard
ratio remained close to 1.0 (hazard ratio, 1.2; 95 percent
confidence interval, 0.6 to 2.4). CONCLUSIONS: Our data
suggest that diabetic patients without previous myocardial
infarction have as high a risk of myocardial infarction as
nondiabetic patients with previous myocardial infarction.
These data provide a rationale for treating cardiovascular
risk factors in diabetic patients as aggressively as in
nondiabetic patients with prior myocardial infarction.
- Language of Publication
- English
- Unique Identifier
- 98328630
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|CO/*MO; Diabetes Mellitus,
Non-Insulin-Dependent|*CO; Myocardial Infarction|CO/*EP/MO
- MeSH Heading
- Case-Control Studies; Cross-Sectional Studies; Female;
Finland|EP; Follow-Up Studies; Human; Incidence; Male;
Middle Age; Proportional Hazards Models; Risk Factors;
Support, Non-U.S. Gov't; Survival Analysis
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0028-4793
- Country of Publication
- UNITED STATES
Record 93 from database: MEDLINE
Return
To Top
- Title
- The Prospective Cardiovascular Münster (PROCAM) study:
prevalence of hyperlipidemia in persons with hypertension
and/or diabetes mellitus and the relationship to coronary
heart disease.
- Author
- Assmann G; Schulte H
- Address
- Institute for Clinical Chemistry and Laboratory
Medicine, University of MÂunster, West Germany.
- Source
- Am Heart J, 1988 Dec, 116:6 Pt 2, 1713-24
- Abstract
- The ongoing Prospective Cardiovascular Münster (PROCAM)
study was initiated in 1979. The objectives of this trial
were to determine the prevalence of coronary heart disease
(CHD) risk factors in the German population, improve the
prediction and early detection of CHD, and derive
recommendations for the primary prevention of vascular
disease from the trial results. Of male PROCAM trial
participants, ages 40 to 65 years, who had been free of
myocardial infarction or stroke at the time of entry and
had been followed up for 4 years, longitudinal data
analysis shows that hypertension, diabetes mellitus, and
hyperlipidemia are independent risk factors for CHD. The
concomitant occurrence of these factors leads to a
cumulative increase in CHD risk. Hyperlipidemia is a more
significant risk factor for CHD than hypertension or
diabetes mellitus. Ongoing data from 4043 men and 1333
women, ages 50 to 65 years, show that more than 50% of all
diabetics are hypertensive. Cholesterol is slightly
increased in male hypertensives and diabetics of either
sex, whereas low-density lipoprotein cholesterol is
slightly raised in male hypertensives and female diabetics
only. The serum triglyceride concentrations are higher for
hypertensives and markedly higher for diabetics of both
sexes. High-density lipoprotein cholesterol concentrations
are decreased in hypertensives, especially in hypertensive
women, and even more so in diabetics. The European
Consensus Conference for primary prevention of CHD has
classified hyperlipidemia into five groups (A to E). For
hypertensives, the proportion of patients in group D
(cholesterol between 200 and 300 mg/dl and triglyceride
levels between 200 and 500 mg/dl) is 20.4% for men and
6.2% for women, about twice as high as those in the
control groups. The occurrence of combined (group D) or
massive hyperlipidemia (group E: cholesterol greater than
300 mg/dl and/or triglycerides greater than 500 mg/dl) is
prevalent in more than 30% of all diabetics: two to three
times more frequently than in nondiabetic patients. When
concomitant hypertension is included, this prevalence
increases to more than 40% for diabetic men. Among those
patients endangered by three risk factors, approximately
40% of all men and 60% of all women have the particularly
atherogenic combination that includes lowered high-density
lipoprotein cholesterol.
- Language of Publication
- English
- Unique Identifier
- 89074529
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|EP/*ET/PC; Diabetes Mellitus|CO/*EP;
Hyperlipidemia|CO/*EP; Hypertension|CO/*EP
- MeSH Heading
- Adult; Age Factors; Aged; Female; Human; Male; Middle
Age; Prospective Studies; Risk Factors; Support, Non-U.S.
Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-8703
- Country of Publication
- UNITED STATES
Record 94 from database: MEDLINE
Return
To Top
- Title
- Ionizing radiation and genetic risks. VI. Chronic
multifactorial diseases: a review of epidemiological and
genetical aspects of coronary heart disease, essential
hypertension and diabetes mellitus.
- Author
- Sankaranarayanan K; Chakraborty R; Boerwinkle EA
- Address
- MGC, Department of Radiation Genetics and Chemical
Mutagenesis, Sylvius Laboratories, Leiden University,
Wassenaarseweg 72, 2333 AL, Leiden,
Netherlands.sankaran@rullf2.medfac.leidenuniv.nl
- Source
- Mutat Res, 1999 Jan, 436:1, 21-57
- Abstract
- This paper provides a broad overview of the
epidemiological and genetical aspects of common
multifactorial diseases in man with focus on three
well-studied ones, namely, coronary heart disease (CHD),
essential hypertension (EHYT) and diabetes mellitus (DM).
In contrast to mendelian diseases, for which a mutant gene
either in the heterozygous or homozygous condition is
generally sufficient to cause disease, for most
multifactorial diseases, the concepts of genetic
susceptibility' and risk factors' are more appropriate.
For these diseases, genetic susceptibility is
heterogeneous. The well-studied diseases such as CHD
permit one to conceptualize the complex relationships
between genotype and phenotype for chronic multifactorial
diseases in general, namely that allelic variations in
genes, through their products interacting with
environmental factors, contribute to the quantitative
variability of biological risk factor traits and thus
ultimately to disease outcome. Two types of such allelic
variations can be distinguished, namely those in genes
whose mutant alleles have (i) small to moderate effects on
the risk factor trait, are common in the population
(polymorphic alleles) and therefore contribute
substantially to the variability of biological risk factor
traits and (ii) profound effects, are rare in the
population and therefore contribute far less to the
variability of biological risk factor traits. For all the
three diseases considered in this review, a positive
family history is a strong risk factor. CHD is one of the
major contributors to mortality in most industrialized
countries. Evidence from epidemiological studies, clinical
correlations, genetic hyperlipidaemias etc., indicate that
lipids play a key role in the pathogenesis of CHD. The
known lipid-related risk factors include: high levels of
low density lipoprotein cholesterol, low levels of high
density lipoprotein cholesterol, high apoB levels (the
major protein fraction of the low density lipoprotein
particles) and elevated levels of Lp(a) lipoprotein. Among
the risk factors which are not related to lipids are: high
levels of homocysteine, low activity of paraoxonase and
possibly also elevated plasma fibrinogen levels. In
addition to the above, hypertension, diabetes and obesity
(which themselves have genetic determinants) are important
risk factors for CHD. Among the environmental risk factors
are: high dietary fat intake, smoking, stress, lack of
exercise etc. About 60% of the variability of the plasma
cholesterol is genetic in origin. While a few genes have
been identified whose mutant alleles have large effects on
this trait (e.g., LDLR, familial defective apoB-100),
variability in cholesterol levels among individuals in
most families is influenced by allelic variation in many
genes (polymorphisms) as well as environmental exposures.
A proportion of this variation can be accounted for by two
alleles of the apoE locus that increase (ε4) and
decrease (ε2) cholesterol levels, respectively. A
polymorphism at the apoB gene (XbaI) also has similar
effects, but is probably not mediated through lipids. High
density lipoprotein cholesterol levels are genetically
influenced and are related to apoA1 and hepatic lipase
(LIPC) gene functions. Mutations in the apoA1 gene are
rare and there are data which suggest a role of allelic
variation at or linked LIPC gene in high density
lipoprotein cholesterol levels. Polymorphism at the
apoA1--C3 loci is often associated with
hypertriglyceridemia. The apo(a) gene which codes for
Lp(a) is highly polymorphic, each allele determining a
specific number of multiple tandem repeats of a unique
coding sequence known as Kringle 4. The size of the gene
correlates with the size of the Lp(a) protein. The smaller
the size of the Lp(a) protein, the higher are the Lp(a)
levels. (ABSTRACT TRUNCATED)
- Language of Publication
- English
- Unique Identifier
- 99097027
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|EP/*GE/ME/MO; Diabetes
Mellitus|CL/EP/*GE; Hypertension|CL/EP/*GE
- MeSH Heading
- Chronic Disease; Family Health; Female; Genetic
Predisposition to Disease; Human; Male; Prevalence;
Radiation, Ionizing; Risk Factors; Support, Non-U.S.
Gov't; Twin Studies
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, ACADEMIC
- ISSN
- 0027-5107
- Country of Publication
- NETHERLANDS
Record 95 from database: MEDLINE
Return
To Top
- Title
- Prevalence of impaired glucose tolerance, diabetes
mellitus and ischemic heart disease in an Italian rural
community. The Sanza Survey.
- Author
- Verrillo A; de Teresa A; Carandente Giarrusso P;
Scognamiglio A; La Rocca S; Lucibelli L
- Address
-
- Source
- Boll Soc Ital Biol Sper, 1984 Mar, 60:3, 485-91
- Abstract
- Coronary heart disease rates were estimated in three
groups of people participating in the Sanza Survey - newly
diagnosed non insulin dependent diabetics, subjects with
impaired glucose tolerance and control subjects with
normal glucose tolerance. The prevalence of
Minnesota-coded ECG abnormalities showed a significant
gradient with an approximately twofold excess in both the
newly detected diabetic and impaired glucose tolerance
cases over the subjects with normal glucose tolerance. The
doubling of ECG ischemic changes found in subjects with
impaired glucose tolerance and diabetes mellitus appeared
to operate almost equally in the absence or presence of
several other recognized risk factors for coronary
ischemic damage. It is concluded that a relatively low
degree of glucose intolerance alone may be important in
determining coronary heart disease.
- Language of Publication
- English
- Unique Identifier
- 84178792
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|CO/*EP; Diabetes Mellitus,
Non-Insulin-Dependent|CO/*EP; Glucose Tolerance Test|*
- MeSH Heading
- Adolescence; Adult; Electrocardiography; Female; Human;
Italy; Male; Middle Age; Risk
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0037-8771
- Country of Publication
- ITALY
Record 96 from database: MEDLINE
Return
To Top
- Title
- A prospective study of heart disease in diabetes
mellitus.
- Author
- Shapiro LM
- Address
-
- Source
- Q J Med, 1984 Win, 53:209, 55-68
- Abstract
- Six hundred and twenty-five patients with diabetes
mellitus were studied by standardised clinical methods,
resting and exercise electrocardiography (ECG) and
digitised echocardiography to determine the prevalence of
coronary and non-coronary heart disease. Clinical evidence
of coronary artery disease (angina and infarction) was
present in 110 (18 per cent) normotensive patients.
Hypertension (blood pressure greater than 165/95 mmHg) was
present in 172 (27 per cent) of whom 32 had cardiac
symptoms. Heart failure or left ventricular dilatation was
seen in 18 of whom 11 had either hypertension or coronary
artery disease and six asymptomatic patients had
unexplained ventricular hypertrophy. Echocardiograms in
245 of 290 asymptomatic patients with normal ECG showed
that relaxation was prolonged (p less than 0.001) and
mitral valve opening delayed (p less than 0.001) from
normal especially in those with severe microangiopathy
(proliferative retinopathy and/or heavy proteinuria). The
peak rates of cavity dimension increase and posterior wall
thinning were reduced from normal (both p less than 0.001)
and patients with severe microangiopathy had the most
marked changes. Redivision of these 245 diabetics by
abnormalities of left ventricular function showed that 147
had normal function in whom only one of 23 (random 15 per
cent sample) had a positive exercise ECG. Prolonged
relaxation or delayed mitral valve opening alone (a
nonspecific abnormality) was present in 41 and only three
of 28 had a positive exercise ECG. Thirty-one had delayed
mitral valve opening with inco-ordinate relaxation
(abnormalities very suggestive of coronary artery disease)
of whom 20 of 29 had a positive exercise ECG. Twenty-six
had delayed mitral valve opening with slow cavity
dimension increase or wall thinning (without hypertrophy)
of whom 21 of 25 had a negative exercise ECG. This is a
relatively specific abnormality similar to that found in
left ventricular hypertrophy. Coronary artery disease is
common in symptomatic and asymptomatic forms in diabetes
mellitus. Non-coronary left ventricular diseases, such as
dilation and hypertrophy, are probably no more common in
diabetics than non-diabetics. A small number of diabetics
with severe microangiopathy had abnormal relaxation and
reduced peak rate of dimension increase or wall thinning
which may represent left ventricular disease due to
microangiopathy.
- Language of Publication
- English
- Unique Identifier
- 84170877
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|*CO; Heart Diseases|*ET
- MeSH Heading
- Adolescence; Adult; Aged; Coronary Disease|ET; Diabetic
Angiopathies|CO; Echocardiography; Electrocardiography;
Female; Heart|PP; Human; Male; Middle Age; Prospective
Studies
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0033-5622
- Country of Publication
- ENGLAND
Record 97 from database: MEDLINE
Return
To Top
- Title
- Early abnormalities in coronary heart disease risk
factors in relatives of subjects with
non-insulin-dependent diabetes.
- Author
- Sarlund H; Pyörälä K; Penttilä I; Laakso M
- Address
- Department of Medicine, Kuopio University Hospital,
Finland.
- Source
- Arterioscler Thromb, 1992 Jun, 12:6, 657-63
- Abstract
- Coronary heart disease risk factor levels were studied
in 184 first-degree relatives (sisters and brothers) of
non-insulin-dependent diabetic subjects (124 relatives
with normoglycemia, 34 relatives with impaired glucose
tolerance [IGT], and 26 relatives with
non-insulin-dependent diabetes mellitus [NIDDM]) and in
215 relatives of nondiabetic subjects (194 relatives with
normoglycemia and 21 relatives with IGT). Subjects with
IGT exhibited the highest insulin responses to an oral
glucose load. Systolic blood pressure was significantly
higher; serum high density lipoprotein cholesterol level
was significantly lower; and total, low density
lipoprotein, and very low density lipoprotein triglyceride
levels were higher in the relatives with a family history
of diabetes who had IGT or NIDDM than in the normoglycemic
relatives without a family history of diabetes. These
abnormal changes were not seen in normoglycemic relatives
or relatives with IGT who had no family history of NIDDM.
Thus, in relatives of diabetics, abnormal glucose
tolerance seems to induce changes in cardiovascular heart
disease risk factor levels that are similar to those
observed in NIDDM. Therefore, a family history of diabetes
adds substantially to the risk for atherosclerosis,
particularly in subjects with IGT.
- Language of Publication
- English
- Unique Identifier
- 92273571
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|BL/ET/*GE; Diabetes Mellitus,
Non-Insulin-Dependent|BL/CO/*GE
- MeSH Heading
- Apolipoproteins|BL; Female; Glucose Tolerance Test;
Human; Insulin|BL; Lipids|BL; Lipoproteins|BL; Male;
Middle Age; Risk Factors; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1049-8834
- Country of Publication
- UNITED STATES
Record 98 from database: MEDLINE
Return
To Top
- Title
- Diabetes mellitus and coronary heart disease.
- Author
- Wilson PW
- Address
- National Heart, Lung and Blood Institute's Framingham
Heart Study, Framingham, MA 01701, USA.
peter@fram.nhlbi.nih.gov
- Source
- Am J Kidney Dis, 1998 Nov, 32:5 Suppl 3, S89-100
- Abstract
- The prevalence of diabetes mellitus rises with age in
men and women in the United States and in westernized
regions, and the risk of vascular disease is typically
increased twofold in diabetic men and threefold in
diabetic women. Population-based data concerning the
prevalence of diabetes mellitus and its impact on coronary
heart disease (CHD) are reviewed. The vascular disease
endpoints considered include death, angina pectoris,
myocardial infarction (MI), cardiac failure, cardiac
arrhythmias, and the experience of diabetics who have
undergone angioplasty and revascularization. The impact of
coronary risk factors in diabetics is considered for
glycemic control, arterial pressure, microalbuminuria, and
lipids. Recent guidelines and recommendations concerning
lipids, glucose, and blood pressure for diabetics are
discussed.
- Language of Publication
- English
- Unique Identifier
- 99036354
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|CO/*EP; Diabetes Mellitus|CO/*EP
- MeSH Heading
- Adult; Aged; Diabetic Angiopathies|EP; Diabetic
Nephropathies|EP; Female; Human; Hypertension, Renal|EP;
Male; Middle Age; Prevalence; Risk Factors
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0272-6386
- Country of Publication
- UNITED STATES
Record 99 from database: MEDLINE
Return
To Top
- Title
- Diseases of malfunction of body mechanisms. (Heart
disease, diabetes, cancer etc.) Risk by occupation, and
correlation, male and female, with vehicle travel.
- Author
- Robinson AA
- Address
-
- Source
- Med Hypotheses, 1983 Aug, 11:4, 415-29
- Abstract
- It is shown that significant changes in the blood takes
place when driving in a motor vehicle. The risk of death
in various occupations due to diseases related to body
malfunction is calculated and this demonstrates the high
risk of workers in transport. A further test of data, the
correlation of deaths from all causes, both male and
female, with male and female road accident deaths
respectively is presented and supports the above-mentioned
findings. These correlations also demonstrate surprisingly
strong relationships with many diseases and motor vehicle
travel. These diseases are normally considered to have no
known cause.
- Language of Publication
- English
- Unique Identifier
- 84039049
Return
To Top
- MeSH Heading (Major)
- Automobile Driving|*; Mortality|*; Occupations|*;
Travel|*
- MeSH Heading
- Australia; Blood Glucose|AN; Cholesterol|AN; Comparative
Study; Fatty Acids, Nonesterified|AN; Female; Human; Male;
Risk; Triglycerides|AN
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0306-9877
- Country of Publication
- ENGLAND
Record 100 from database: MEDLINE
Return
To Top
Back 10 records
- Title
- Ischemic heart disease in patients with diabetes
mellitus in Japan.
- Author
- Takeda R; Shimizu M
- Address
- Second Department of Internal Medicine, School of
Medicine, Kanazawa University, Japan.
- Source
- Diabetes Res Clin Pract, 1994 Oct, 24 Suppl:, S199-203
- Abstract
- The risk of death by ischemic heart disease (IHD) in
patients with diabetes mellitus is higher than in
non-diabetics, and the average life span of the diabetics
is shorter than in non-diabetics in Japan. There is no
direct correlation between the occurrence of IHD and
severity or glycemic control of diabetes. However, the
mortality by IHD increases in diabetic patients with
severe retinopathy and/or massive proteinuria. Regarding
the management of IHD, diabetes is not considered a
contraindication to thrombolytic therapy. The indication
and results of percutaneous transluminal coronary
angioplasty and coronary bypass surgery are the same as in
non-diabetics.
- Language of Publication
- English
- Unique Identifier
- 95163441
Return
To Top
- MeSH Heading (Major)
- Diabetes Mellitus|CO/*EP; Diabetic
Angiopathies|*EP/ET/TH; Myocardial Ischemia|*EP/ET/TH
- MeSH Heading
- Adolescence; Adult; Aged; Aged, 80 and over; Child;
Child, Preschool; Coronary Angiography; Female; Human;
Infant; Infant, Newborn; Japan|EP; Male; Middle Age;
Prevalence; Risk Factors
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0168-8227
- Country of Publication
- IRELAND
|
