100 Scientific Studies:  Diabetes and Heart Disease

       

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Godsland IF, et al; Associations of smoking, alcohol and physical activity with risk factors for coronary heart disease and diabetes in the first follow-up cohort of the Heart Disease and Diabetes Risk Indicators in a Screened Cohort study (HDDRISC-1). (J Intern Med, 1998 Jul, Abstract available) [MEDLINE]

2 Schumacher MC, et al; Interactions between diabetes and family history of coronary heart disease and other risk factors for coronary heart disease among adults with diabetes in Utah. (Epidemiology, 1990 Jul, Abstract available) [MEDLINE]
3 Kekäläinen P, et al; Family history of coronary heart disease is a stronger predictor of coronary heart disease morbidity and mortality than family history of non-insulin dependent diabetes mellitus. (Atherosclerosis, 1996 Jun, Abstract available) [MEDLINE]
4 Beard CM, et al; The Rochester Coronary Heart Disease Project: effect of cigarette smoking, hypertension, diabetes, and steroidal estrogen use on coronary heart disease among 40- to 59-year-old women, 1960 through 1982 [see comments] (Mayo Clin Proc, 1989 Dec, Abstract available) [MEDLINE]
5 Gillum RF; The association of body fat distribution with hypertension, hypertensive heart disease, coronary heart disease, diabetes and cardiovascular risk factors in men and women aged 18-79 years. (J Chronic Dis, 1987, Abstract available) [MEDLINE]
6 Takase B, et al; Heart rate variability in patients with diabetes mellitus, ischemic heart disease, and congestive heart failure. (J Electrocardiol, 1992 Apr, Abstract available) [MEDLINE]
7 Fujimoto Y, et al; Decreased heart rate variability in patients with diabetes mellitus and ischemic heart disease. (Jpn Circ J, 1996 Dec, Abstract available) [MEDLINE]
8 Hanefeld M, et al; Determinants for coronary heart disease in non-insulin-dependent diabetes mellitus: lessons from the diabetes intervention study. (Diabetes Res Clin Pract, 1996 Feb, Abstract available) [MEDLINE]
9 Howard BV, et al; Diabetes and coronary heart disease in American Indians: The Strong Heart Study. (Diabetes, 1996 Jul, Abstract available) [MEDLINE]
10 Jarrett J; Diabetes and the heart: coronary heart disease. (Clin Endocrinol Metab, 1977 Jul, Abstract available) [MEDLINE]
11 Rewers M, et al; Prevalence of coronary heart disease in subjects with normal and impaired glucose tolerance and non-insulin-dependent diabetes mellitus in a biethnic Colorado population. The San Luis Valley Diabetes Study. (Am J Epidemiol, 1992 Jun, Abstract available) [MEDLINE]
12 Leinonen JS, et al; The level of autoantibodies against oxidized LDL is not associated with the presence of coronary heart disease or diabetic kidney disease in patients with non-insulin-dependent diabetes mellitus. (Free Radic Res, 1998 Aug, Abstract available) [MEDLINE]
13 Lim LL, et al; Management of patients with diabetes after heart attack: a population-based study of 1982 patients from a heart disease register. (Aust N Z J Med, 1998 Jun, Abstract available) [MEDLINE]
14 Hu YH, et al; Coronary heart disease and diabetic retinopathy in newly diagnosed diabetes in Da Qing, China: the Da Qing IGT and Diabetes Study. (Acta Diabetol, 1991, Abstract available) [MEDLINE]
15 Airaksinen KE, et al; Increased left atrial size relative to left ventricular size in young women with insulin-dependent diabetes; a pre-clinical sign of the specific heart disease of diabetes? (Diabetes Res, 1987 Sep, Abstract available) [MEDLINE]
16 Singh M, et al; Hemorheological characteristics of blood in various disease: diabetes mellitus, hypertension, acute infection, ischaemic heart disease & attempted suicide. (Biorheology, 1982, Abstract available) [MEDLINE]
17 Polednak AP; Mortality from diabetes mellitus, ischemic heart disease, and cerebrovascular disease among blacks in a higher income area. (Public Health Rep, 1990 Jul, Abstract available) [MEDLINE]
18 Kimmelstiel C, et al; Congestive heart failure in women: focus on heart failure due to coronary artery disease and diabetes. (Cardiology, 1990, Abstract available) [MEDLINE]
19 Laakso M; Dyslipidemia, morbidity, and mortality in non-insulin-dependent diabetes mellitus. Lipoproteins and coronary heart disease in non-insulin-dependent diabetes mellitus. (J Diabetes Complications, 1997 Mar, Abstract available) [MEDLINE]
20 Lee AJ, et al; Fibrinogen in relation to personal history of prevalent hypertension, diabetes, stroke, intermittent claudication, coronary heart disease, and family history: the Scottish Heart Health Study. (Br Heart J, 1993 Apr, Abstract available) [MEDLINE]
21 Wells KB, et al; Affective, substance use, and anxiety disorders in persons with arthritis, diabetes, heart disease, high blood pressure, or chronic lung conditions. (Gen Hosp Psychiatry, 1989 Sep, Abstract available) [MEDLINE]
22 Geraci JM, et al; In-hospital complications among survivors of admission for congestive heart failure, chronic obstructive pulmonary disease, or diabetes mellitus. (J Gen Intern Med, 1995 Jun, Abstract available) [MEDLINE]
23 Hameed K, et al; The frequency of known diabetes, hypertension and ischaemic heart disease in affluent and poor urban populations of Karachi, Pakistan. (Diabet Med, 1995 Jun, Abstract available) [MEDLINE]
24 Das UN; Essential fatty acid metabolism in patients with essential hypertension, diabetes mellitus and coronary heart disease. (Prostaglandins Leukot Essent Fatty Acids, 1995 Jun, Abstract available) [MEDLINE]
25 Summerson JH, et al; Coronary heart disease risk factors in black and white patients with non-insulin-dependent diabetes mellitus. (Ethn Health, 1996 Mar, Abstract available) [MEDLINE]
26 Trembath RC, et al; Deoxyribonucleic acid polymorphism of the apoprotein AI-CIII-AIV gene cluster and coronary heart disease in non-insulin-dependent diabetes. (Br Med J (Clin Res Ed), 1987 Jun, Abstract available) [MEDLINE]
27 Nagase N; Hypertension and serum Mg in the patients with diabetes and coronary heart disease. (Hypertens Res, 1996 Jun, Abstract available) [MEDLINE]
28 Laakso M, et al; Lipid and lipoprotein abnormalities associated with coronary heart disease in patients with insulin-dependent diabetes mellitus. (Arteriosclerosis, 1986 Nov, Abstract available) [MEDLINE]
29 Howard BV; Risk factors for cardiovascular disease in individuals with diabetes. The Strong Heart Study. (Acta Diabetol, 1996 Sep, Abstract available) [MEDLINE]
30 Giugliano D; Does treatment of noninsulin-dependent diabetes mellitus reduce the risk of coronary heart disease? (Curr Opin Lipidol, 1996 Aug, Abstract available) [MEDLINE]
31 Pyörälä K, et al; Will correction of dyslipoproteinaemia reduce coronary heart disease risk in patients with non-insulin-dependent diabetes? Need for trial evidence. (Ann Med, 1996 Aug, Abstract available) [MEDLINE]
32 Laakso M; Lipids and lipoproteins as risk factors for coronary heart disease in non-insulin-dependent diabetes mellitus. (Ann Med, 1996 Aug, Abstract available) [MEDLINE]
33 Simons LA, et al; Diabetes, mortality and coronary heart disease in the prospective Dubbo study of Australian elderly. (Aust N Z J Med, 1996 Feb, Abstract available) [MEDLINE]
34 Wei M, et al; Effects of cigarette smoking, diabetes, high cholesterol, and hypertension on all-cause mortality and cardiovascular disease mortality in Mexican Americans. The San Antonio Heart Study. (Am J Epidemiol, 1996 Dec, Abstract available) [MEDLINE]
35 Elliott TG, et al; Relationship between insulin resistance and coronary heart disease in diabetes mellitus and the general population: a critical appraisal. (Baillieres Clin Endocrinol Metab, 1993 Oct, Abstract available) [MEDLINE]
36 Raman M, et al; Heart disease in diabetes mellitus. (Endocrinol Metab Clin North Am, 1996 Jun, Abstract available) [MEDLINE]
37 DeStefano F, et al; Risk factors for coronary heart disease mortality among persons with diabetes. (Ann Epidemiol, 1993 Jan, Abstract available) [MEDLINE]
38 Rodriguez BL, et al; Impaired glucose tolerance, diabetes, and cardiovascular disease risk factor profiles in the elderly. The Honolulu Heart Program. (Diabetes Care, 1996 Jun, Abstract available) [MEDLINE]
39 Wilkes S, et al; A cross-sectional study comparing the motivation for smoking cessation in apparently healthy patients who smoke to those who smoke and have ischaemic heart disease, hypertension or diabetes. (Fam Pract, 1999 Dec, Abstract available) [MEDLINE]
40 Garber AJ; Diabetes and heart disease: a new strategy for managing lipid disorders. (Geriatrics, 1993 Oct, Abstract available) [MEDLINE]
41 Laakso M, et al; Lipids and lipoproteins predicting coronary heart disease mortality and morbidity in patients with non-insulin-dependent diabetes [see comments] (Circulation, 1993 Oct, Abstract available) [MEDLINE]
42 Haffner SM, et al; Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels: subgroup analyses in the Scandinavian Simvastatin Survival Study [see comments] (Arch Intern Med, 1999 Dec, Abstract available) [MEDLINE]
43 Snowdon DA; Animal product consumption and mortality because of all causes combined, coronary heart disease, stroke, diabetes, and cancer in Seventh-day Adventists. (Am J Clin Nutr, 1988 Sep, Abstract available) [MEDLINE]
44 Stetson BA, et al; New diabetes screening criteria for midlife women evaluated for coronary heart disease risk. (Appl Nurs Res, 1999 Nov, Abstract available) [MEDLINE]
45 DeStefano F, et al; Comparison of coronary heart disease mortality risk between black and white people with diabetes. (Ethn Dis, 1993 Spr, Abstract available) [MEDLINE]
46 Murakawa Y, et al; Parasympathetic activity is a major modulator of the circadian variability of heart rate in healthy subjects and in patients with coronary artery disease or diabetes mellitus. (Am Heart J, 1993 Jul, Abstract available) [MEDLINE]
47 Lam KS, et al; Beta-fibrinogen gene G/A-455 polymorphism in relation to fibrinogen concentrations and ischaemic heart disease in Chinese patients with type II diabetes. (Diabetologia, 1999 Oct, Abstract available) [MEDLINE]
48 Fujimoto WY, et al; Visceral adiposity and incident coronary heart disease in Japanese-American men. The 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study. (Diabetes Care, 1999 Nov, Abstract available) [MEDLINE]
49 Rathmann W, et al; Association of elevated serum uric acid with coronary heart disease in diabetes mellitus. (Diabete Metab, 1993, Abstract available) [MEDLINE]
50 Gordon T, et al; Diabetes, blood lipids, and the role of obesity in coronary heart disease risk for women. The Framingham study. (Ann Intern Med, 1977 Oct, Abstract available) [MEDLINE]
51 Hiatt WR, et al; Special populations in cardiovascular rehabilitation. Peripheral arterial disease, non-insulin-dependent diabetes mellitus, and heart failure. (Cardiol Clin, 1993 May, Abstract available) [MEDLINE]
52 Rewers M, et al; Is the risk of coronary heart disease lower in Hispanics than in non-Hispanic whites? The San Luis Valley Diabetes Study. (Ethn Dis, 1993 Win, Abstract available) [MEDLINE]
53 Vokonas PS, et al; Diabetes mellitus and coronary heart disease in the elderly. (Clin Geriatr Med, 1996 Feb, Abstract available) [MEDLINE]
54 Kilhovd BK, et al; Serum levels of advanced glycation end products are increased in patients with type 2 diabetes and coronary heart disease. (Diabetes Care, 1999 Sep, Abstract available) [MEDLINE]
55 Tuomilehto J, et al; The prevalence of coronary heart disease in the multi-ethnic and high diabetes prevalence population of Mauritius. (J Intern Med, 1993 Feb, Abstract available) [MEDLINE]
56 Figueredo A, et al; Plasma C3d levels and ischemic heart disease in type II diabetes. (Diabetes Care, 1993 Feb, Abstract available) [MEDLINE]
57 Will JC, et al; The contribution of diabetes to early deaths from ischemic heart disease: US gender and racial comparisons. (Am J Public Health, 1996 Apr, Abstract available) [MEDLINE]
58 Pan XR, et al; Impaired glucose tolerance and its relationship to ECG-indicated coronary heart disease and risk factors among Chinese. Da Qing IGT and diabetes study. (Diabetes Care, 1993 Jan, Abstract available) [MEDLINE]
59 Laakso M; Glycemic control and the risk for coronary heart disease in patients with non-insulin-dependent diabetes mellitus. The Finnish studies. (Ann Intern Med, 1996 Jan, Abstract available) [MEDLINE]
60 Kilhovd BK, et al; Serum levels of advanced glycation end products are increased in patients with type 2 diabetes and coronary heart disease. (Diabetes Care, 1999 Sep, Abstract available) [MEDLINE]
61 Ruiz J, et al; Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes [see comments] (Lancet, 1995 Sep, Abstract available) [MEDLINE]
62 Schauer UJ, et al; Association of coronary heart disease with serum lipid and apolipoprotein concentrations in long-term diabetes. Results of the Erfurt study. (Acta Diabetol Lat, 1989 Jan, Abstract available) [MEDLINE]
63 Vlajinac H, et al; Cardiovascular risk factors and prevalence of coronary heart disease in type 2 (non-insulin-dependent) diabetes. (Eur J Epidemiol, 1992 Nov, Abstract available) [MEDLINE]
64 Thulaseedharan N, et al; Risk factors for coronary heart disease in noninsulin dependent diabetes mellitus (NIDDM). (Indian Heart J, 1995 Sep, Abstract available) [MEDLINE]
65 Rigoli L, et al; Apolipoprotein AI-CIII-AIV genetic polymorphisms and coronary heart disease in type 2 diabetes mellitus. (Acta Diabetol, 1995 Dec, Abstract available) [MEDLINE]
66 Fontbonne A, et al; Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes. Results from the 11-year follow-up of the Paris Prospective Study. (Diabetologia, 1989 May, Abstract available) [MEDLINE]
67 Assmann G, et al; Diabetes mellitus and hypertension in the elderly: concomitant hyperlipidemia and coronary heart disease risk. (Am J Cardiol, 1989 May, Abstract available) [MEDLINE]
68 Zavaroni I, et al; Hyperinsulinemia in a normal population as a predictor of non-insulin-dependent diabetes mellitus, hypertension, and coronary heart disease: the Barilla factory revisited. (Metabolism, 1999 Aug, Abstract available) [MEDLINE]
69 Inoue S, et al; The relationship between diabetes mellitus and coronary heart disease. (Tohoku J Exp Med, 1983 Dec, Abstract available) [MEDLINE]
70 Nowak A, et al; Glucosamine levels in people with ischaemic heart disease with and without type II diabetes. (Pol Arch Med Wewn, 1998 Nov, Abstract available) [MEDLINE]
71 Jarrett RJ; Type 2 (non-insulin-dependent) diabetes mellitus and coronary heart disease-chicken, egg or neither? (Diabetologia, 1984 Feb, Abstract available) [MEDLINE]
72 Yekutiel M, et al; The prevalence of hypertension, ischaemic heart disease and diabetes in traumatic spinal cord injured patients and amputees. (Paraplegia, 1989 Feb, Abstract available) [MEDLINE]
73 Vuksan V, et al; Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial. (Diabetes Care, 1999 Jun, Abstract available) [MEDLINE]
74 Barrett Connor E; Diabetes mellitus, hypertriglyceridemia, and heart disease risk in women. (Int J Fertil, 1992, Abstract available) [MEDLINE]
75 Valmadrid CT, et al; Alcohol intake and the risk of coronary heart disease mortality in persons with older-onset diabetes mellitus [see comments] (JAMA, 1999 Jul, Abstract available) [MEDLINE]
76 Mitchell BD, et al; Diabetes and coronary heart disease risk in Mexican Americans [published erratum appears in Ann Epidemiol 1993 Jan;3(1):117] (Ann Epidemiol, 1992 Jan, Abstract available) [MEDLINE]
77 Yudkin JS; Coronary heart disease in diabetes mellitus: three new risk factors and a unifying hypothesis. (J Intern Med, 1995 Jul, Abstract available) [MEDLINE]
78 Winocour PH, et al; A cross-sectional evaluation of cardiovascular risk factors in coronary heart disease associated with type 1 (insulin-dependent) diabetes mellitus. (Diabetes Res Clin Pract, 1992 Dec, Abstract available) [MEDLINE]
79 Leonetti DL, et al; Educational attainment and the risk of non-insulin-dependent diabetes or coronary heart disease in Japanese-American men. (Ethn Dis, 1992 Fal, Abstract available) [MEDLINE]
80 Viganò S, et al; Protein C antigen is not an acute phase reactant and is often high in ischemic heart disease and diabetes. (Thromb Haemost, 1984 Dec, Abstract available) [MEDLINE]
81 Steenland K, et al; Cancer, heart disease, and diabetes in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin [see comments] (J Natl Cancer Inst, 1999 May, Abstract available) [MEDLINE]
82 Thompson MM, et al; Heart disease risk factors, diabetes, and prostatic cancer in an adult community. (Am J Epidemiol, 1989 Mar, Abstract available) [MEDLINE]
83 Lehto S, et al; Poor glycemic control predicts coronary heart disease events in patients with type 1 diabetes without nephropathy. (Arterioscler Thromb Vasc Biol, 1999 Apr, Abstract available) [MEDLINE]
84 Inukai T, et al; Relation between the serum level of C-peptide and risk factors for coronary heart disease and diabetic microangiopathy in patients with type-2 diabetes mellitus. (Exp Clin Endocrinol Diabetes, 1999, Abstract available) [MEDLINE]
85 Kahn SE, et al; Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity--clinical research center study. (J Clin Endocrinol Metab, 1995 Apr, Abstract available) [MEDLINE]
86 Gu K, et al; Diabetes and decline in heart disease mortality in US adults. (JAMA, 1999 Apr, Abstract available) [MEDLINE]
87 Knight TM, et al; Insulin resistance, diabetes, and risk markers for ischaemic heart disease in Asian men and non-Asian in Bradford. (Br Heart J, 1992 May, Abstract available) [MEDLINE]
88 Mancini M, et al; Very low density lipoprotein. Qualitative abnormalities in patients with premature coronary heart disease and in patients with insulin dependent diabetes. (Horm Metab Res Suppl, 1988, Abstract available) [MEDLINE]
89 Haffner SM, et al; Lack of association between lipoprotein (a) concentrations and coronary heart disease mortality in diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy. (Metabolism, 1992 Feb, Abstract available) [MEDLINE]
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Jarrett RJ; Risk factors for coronary heart disease in diabetes mellitus. (Diabetes, 1992 Oct, Abstract available) [MEDLINE]

91 Fontbonne A, et al; Body fat distribution and coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes mellitus: the Paris Prospective Study, 15-year follow-up. (Diabetologia, 1992 May, Abstract available) [MEDLINE]
92 Haffner SM, et al; Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction [see comments] (N Engl J Med, 1998 Jul, Abstract available) [MEDLINE]
93 Assmann G, et al; The Prospective Cardiovascular Münster (PROCAM) study: prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease. (Am Heart J, 1988 Dec, Abstract available) [MEDLINE]
94 Sankaranarayanan K, et al; Ionizing radiation and genetic risks. VI. Chronic multifactorial diseases: a review of epidemiological and genetical aspects of coronary heart disease, essential hypertension and diabetes mellitus. (Mutat Res, 1999 Jan, Abstract available) [MEDLINE]
95 Verrillo A, et al; Prevalence of impaired glucose tolerance, diabetes mellitus and ischemic heart disease in an Italian rural community. The Sanza Survey. (Boll Soc Ital Biol Sper, 1984 Mar, Abstract available) [MEDLINE]
96 Shapiro LM; A prospective study of heart disease in diabetes mellitus. (Q J Med, 1984 Win, Abstract available) [MEDLINE]
97 Sarlund H, et al; Early abnormalities in coronary heart disease risk factors in relatives of subjects with non-insulin-dependent diabetes. (Arterioscler Thromb, 1992 Jun, Abstract available) [MEDLINE]
98 Wilson PW; Diabetes mellitus and coronary heart disease. (Am J Kidney Dis, 1998 Nov, Abstract available) [MEDLINE]
99 Robinson AA; Diseases of malfunction of body mechanisms. (Heart disease, diabetes, cancer etc.) Risk by occupation, and correlation, male and female, with vehicle travel. (Med Hypotheses, 1983 Aug, Abstract available) [MEDLINE]
100 Takeda R, et al; Ischemic heart disease in patients with diabetes mellitus in Japan. (Diabetes Res Clin Pract, 1994 Oct, Abstract available) [MEDLINE]


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Record 1 from database: MEDLINE
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Title
Associations of smoking, alcohol and physical activity with risk factors for coronary heart disease and diabetes in the first follow-up cohort of the Heart Disease and Diabetes Risk Indicators in a Screened Cohort study (HDDRISC-1).
Author
Godsland IF; Leyva F; Walton C; Worthington M; Stevenson JC
Address
Wynn Department of Metabolic Medicine, Imperial College School of Medicine, London, UK.
Source
J Intern Med, 1998 Jul, 244:1, 33-41
Abstract
OBJECTIVES: To investigate the associations between risk factors for cardiovascular disease and cigarette smoking, alcohol intake, and physical activity in a group of predominantly healthy men. DESIGN: Cohort study with baseline characterisation, clinical follow-up, and identification of predictors of coronary artery disease and diabetes. SETTING: University hospital metabolic day ward. SUBJECTS: Participants in a company health programme (n=742). MAIN OUTCOME MEASURES: Routine haematology and biochemistry, cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol (on a subset of 522 subjects), and glucose and insulin levels during a 3 h oral glucose tolerance test (OGTT). RESULTS: Independent associations with previous cigarette smoking included high uric acid and low HDL cholesterol, and with current cigarette smoking, high haemoglobin and white cell count and low OGTT insulin. Increasing alcohol intake was associated with increasing blood pressure, uric acid, HDL cholesterol and fasting glucose. The moderate range of exercise intensity in this cohort was associated with decreasing systolic blood pressure, fasting insulin and OGTT glucose and insulin. Factor analysis distinguished principal factors comprising features of the metabolic syndrome with low physical activity, and high white cell count, high haemoglobin concentration and low HDL cholesterol with increasing previous and current cigarette smoking and alcohol intake. CONCLUSIONS: Some characteristics of the metabolic syndrome were seen with previous but not current smoking habit. Regular alcohol consumption was associated with mainly unfavourable metabolic characteristics, although there was an independent beneficial association with HDL cholesterol. The improved metabolic syndrome profile seen with increasing exercise is consistent with even moderate degrees of physical activity having beneficial effects on metabolism.
Language of Publication
English
Unique Identifier
98361487

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MeSH Heading (Major)
Alcohol Drinking|*AE; Coronary Disease|*ET; Diabetes Mellitus|*ET; Exercise|*; Smoking|*AE
MeSH Heading
Adult; Aged; Blood Glucose; Blood Pressure; Factor Analysis, Statistical; Follow-Up Studies; Health Behavior; Human; Linear Models; Lipoproteins, HDL Cholesterol|BL; Male; Middle Age; Predictive Value of Tests; Prospective Studies; Risk Factors; Support, Non-U.S. Gov't

Publication Type
JOURNAL ARTICLE
ISSN
0954-6820
Country of Publication
ENGLAND

Record 2 from database: MEDLINE
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Title
Interactions between diabetes and family history of coronary heart disease and other risk factors for coronary heart disease among adults with diabetes in Utah.
Author
Schumacher MC; Hunt SC; Williams RR
Address
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84108.
Source
Epidemiology, 1990 Jul, 1:4, 298-304
Abstract
We used a unique data base containing medical family history information from representative Utah families to investigate interactions between diabetes and family history of coronary heart disease and other risk factors for coronary heart disease. We compared nonrelated individuals reported to have had diabetes mellitus diagnosed over the age of 19 (948) with 2150 nondiabetic individuals. Among both men and women, diabetes and family history of early coronary heart disease magnified the risk for coronary heart disease, so that in diabetic individuals with a positive family history of coronary heart disease, about 74% of the coronary heart disease could be attributed to interaction. Relative to nondiabetics without a family history of early coronary heart disease, nondiabetics with family history had a relative risk of 4.5 (2.3-8.7), diabetics without a family history had a relative risk of 2.8 (1.6-4.9), and diabetics with a family history had a relative risk of 21.3 (9.1-50.0). Smoking also interacted with diabetes; among smoking diabetics, 47% of early heart disease may be attributable to interaction between smoking and diabetes. Smoking entailed the highest risk for diabetic women. Hypertension and diabetes appeared to act additively, with little interaction. Among women, family history of diabetes was a risk factor for coronary heart disease with a relative risk of 2.5 (1.0-6.4), whereas for men the relative risk was estimated to be 0.4 (0.2-1.1).
Language of Publication
English
Unique Identifier
91191033

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MeSH Heading (Major)
Coronary Disease|*ET/GE; Diabetes Mellitus|*CO/GE
MeSH Heading
Adult; Age Factors; Comparative Study; Female; Human; Hypertension|CO; Male; Middle Age; Risk Factors; Sex Factors; Smoking|AE; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Utah

Publication Type
JOURNAL ARTICLE
ISSN
1044-3983
Country of Publication
UNITED STATES

Record 3 from database: MEDLINE
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Title
Family history of coronary heart disease is a stronger predictor of coronary heart disease morbidity and mortality than family history of non-insulin dependent diabetes mellitus.
Author
Kekäläinen P; Sarlund H; Pyörälä K; Laakso M
Address
Department of Medicine, Kuopio University Hospital, Finland.
Source
Atherosclerosis, 1996 Jun, 123:1-2, 203-13
Abstract
The aim of this study was to compare the effect of family history of non-insulin dependent diabetes mellitus (NIDDM) and coronary heart disease (CHD) as risk factors for CHD morbidity and mortality. Altogether, 394 siblings of NIDDM probands and non-diabetic probands, with and without CHD, were followed for 8 years with respect to CHD events in a prospective population-based study. The baseline study was conducted from 1983 to 1985. Age- and sex-adjusted cumulative occurrence of CHD events was higher in the siblings of the probands with CHD and with NIDDM (13.1%; P = 0.037) and in the siblings of the probands with CHD and without NIDDM (15.4%; P = 0.054), compared with the siblings of the probands without NIDDM and without CHD (4.8%). The incidence of fatal CHD events tended to be higher in a group with a family history of NIDDM and CHD, but the trend was not statistically significant. In univariate logistic regression analyses, a family history of CHD was positively associated with cumulative occurrence of CHD events (odds ratio 2.53, P = 0.009), whereas a family history of NIDDM had no significant association (odds ratio 1.39, P = 0.312). After adjustment for age, sex, family history of NIDDM and major cardiovascular risk factors, the association between family history of CHD and cumulative occurrence of CHD events remained significant (odds ratio 2.25, P = 0.048). In conclusion, the present study indicates that a family history of CHD is a stronger predictor of future CHD events than a family history of NIDDM.
Language of Publication
English
Unique Identifier
96377002

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MeSH Heading (Major)
Coronary Disease|*EP/GE; Diabetes Mellitus, Non-Insulin-Dependent|*EP/GE
MeSH Heading
Aged; Body Mass Index; Cholesterol|BL; Female; Finland|EP; Follow-Up Studies; Glucose Tolerance Test; Human; Lipoproteins|BL; Logistic Models; Male; Middle Age; Nuclear Family; Prospective Studies; Risk Factors; Support, Non-U.S. Gov't; Survival Rate; Triglycerides|BL

Publication Type
JOURNAL ARTICLE
ISSN
0021-9150
Country of Publication
IRELAND

Record 4 from database: MEDLINE
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Title
The Rochester Coronary Heart Disease Project: effect of cigarette smoking, hypertension, diabetes, and steroidal estrogen use on coronary heart disease among 40- to 59-year-old women, 1960 through 1982 [see comments]
Author
Beard CM; Kottke TE; Annegers JF; Ballard DJ
Address
Section of Clinical Epidemiology, Mayo Clinic, Rochester, MN 55905.
Source
Mayo Clin Proc, 1989 Dec, 64:12, 1471-80
Abstract
A population-based case-control study of coronary heart disease (CHD) risk in young women attributable to cigarette smoking, hypertension, diabetes, and steroidal estrogen use was conducted among residents of Rochester, Minnesota. All newly diagnosed cases of CHD (sudden unexpected death [SUD], N = 18; myocardial infarction [MI], N = 90; and angina, N = 133) among female Rochester residents 40 to 59 years of age during the years 1960 through 1982 were identified, and two community control subjects were matched for age and duration of community medical record. The overall adjusted odds ratio (OR) for the association between steroidal estrogen use and definite CHD (MI and SUD) was 0.6 (95% confidence interval [CI] = 0.2 to 1.3). Smoking (OR = 5.1; 95% CI = 2.3 to 11.6), hypertension (OR = 4.8; 95% CI = 2.3 to 10.2), and diabetes (OR = 8.4; 95% CI = 1.6 to 44.5) were strong risk factors for CHD events. If considered causal, cigarette smoking accounted for 64% of all MIs and SUDs in the community, hypertension accounted for 45%, and diabetes accounted for 13%. Although steroidal estrogen exposure reduced CHD among these women by 14%, giving steroidal estrogens to all women in this age group might reduce the population rates of MI by as much as 45%.
Language of Publication
English
Unique Identifier
90097220

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MeSH Heading (Major)
Coronary Disease|BL/EP/*ET/MO/PC; Diabetes Mellitus|*CO; Estrogen Replacement Therapy|*; Estrogens, Conjugated|*TU; Hypertension|*CO/PC; Smoking|*AE/BL/PC
MeSH Heading
Adult; Analysis of Variance; Bias (Epidemiology); Cholesterol|BL; Comparative Study; Confounding Factors (Epidemiology); Evaluation Studies; Female; Human; Menopause; Middle Age; Minnesota; Retrospective Studies; Risk Factors; Support, U.S. Gov't, P.H.S.; Time Factors

Publication Type
JOURNAL ARTICLE
ISSN
0025-6196
Country of Publication
UNITED STATES

Record 5 from database: MEDLINE
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Title
The association of body fat distribution with hypertension, hypertensive heart disease, coronary heart disease, diabetes and cardiovascular risk factors in men and women aged 18-79 years.
Author
Gillum RF
Address
 
Source
J Chronic Dis, 1987, 40:5, 421-8
Abstract
To confirm the reported association of body fat distribution with cardiovascular disease, diabetes, blood pressure and serum cholesterol, data from the 1960-62 Health Examination Survey were analyzed. In this sample drawn from the noninstitutionalized population of the United States aged 18-79, mean values of two indices of upper versus lower body fat distribution increased steadily with age. Men had higher values than women, and black women had higher values than white women. Higher values of the indices were significantly associated with higher blood pressure, post-load serum glucose and greater prevalence of definite hypertension and definite hypertensive heart disease independent of multiple confounders. Associations with higher serum cholesterol and definite coronary heart disease prevalence were independent of overall ponderosity but not of age and multiple other confounders. Greater abdominal relative to lower body fat deposits were independently associated with increased cardiovascular risk in men and women, blacks and whites.
Language of Publication
English
Unique Identifier
87166547

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MeSH Heading (Major)
Adipose Tissue|*AH; Anthropometry|*; Cardiovascular Diseases|*EP; Coronary Disease|*EP; Diabetes Mellitus|*EP; Heart Diseases|*EP; Hypertension|*EP
MeSH Heading
Adolescence; Adult; Age Factors; Aged; Blood Pressure; Cholesterol|BL; Comparative Study; Cross-Sectional Studies; Female; Health Surveys; Human; Male; Middle Age; Negroid Race; Risk; Sex Factors; United States

Publication Type
JOURNAL ARTICLE
ISSN
0021-9681
Country of Publication
ENGLAND

Record 6 from database: MEDLINE
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Title
Heart rate variability in patients with diabetes mellitus, ischemic heart disease, and congestive heart failure.
Author
Takase B; Kurita A; Noritake M; Uehata A; Maruyama T; Nagayoshi H; Nishioka T; Mizuno K; Nakamura H
Address
First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Source
J Electrocardiol, 1992 Apr, 25:2, 79-88
Abstract
The prognosis of patients with heart disease and prediction of sudden cardiac death can be assessed through heart rate variability, an indirect measure of abnormal autonomic control. The authors have evaluated the heart rate variability by 24-hour ambulatory electrocardiographic monitoring in 25 diabetic patients, 19 ischemic heart disease patients, 18 congestive heart failure patients, and 10 normal subjects. Thirteen diabetic patients had autonomic neuropathy and 12 patients did not. Heart rate variability index (mean SD) in patients with diabetes mellitus, ischemic heart disease, and congestive heart failure was significantly lower (34.5 +/- 12.6 ms, 43.7 +/- 15.4 ms, and 34.6 +/- 15.8 ms vs 65.6 +/- 16.7 ms, p less than 0.05) than that of normal subjects. Mean SD was significantly lower in patients with autonomic neuropathy as compared to patients without autonomic neuropathy (26.4 +/- 6.5 ms vs 44.2 +/- 11.0 ms, p less than 0.05) mean SD as compared to survivors: 49 +/- 7 ms in patients with mild ischemic heart disease, 48 +/- 15 ms in patients with severe ischemic heart disease, and 23 +/- 7 ms in patients who died. Similarly, the mean SD in 4 congestive heart failure patients who died was lower significantly (p less than 0.05) than in those who survived (19.0 +/- 5.6 ms vs 40.0 +/- 14.5 ms). Among congestive heart failure patients, clinical improvement by therapy was associated with a significant increase in mean SD. When the mean SD of 30 ms was used as the cutoff point for detection of autonomic dysfunction or patient death, specificity exceeded 90% and sensitivity was 75%.(ABSTRACT TRUNCATED AT 250 WORDS)
Language of Publication
English
Unique Identifier
92395400

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MeSH Heading (Major)
Coronary Disease|EP/*PP; Diabetes Mellitus, Non-Insulin-Dependent|EP/*PP; Heart Failure, Congestive|EP/*PP; Heart Rate|*PH
MeSH Heading
Adult; Aged; Analysis of Variance; Circadian Rhythm|PH; Comparative Study; Coronary Angiography; Diabetic Neuropathies|EP/PP; Echocardiography; Electrocardiography, Ambulatory|IS/MT/SN; Female; Human; Male; Middle Age

Publication Type
JOURNAL ARTICLE
ISSN
0022-0736
Country of Publication
UNITED STATES

Record 7 from database: MEDLINE
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Title
Decreased heart rate variability in patients with diabetes mellitus and ischemic heart disease.
Author
Fujimoto Y; Fukuki M; Hoshio A; Sasaki N; Hamada T; Tanaka Y; Yoshida A; Shigemasa C; Mashiba H
Address
First Department of Internal Medicine, Tottori University Hospital, Yonago, Japan.
Source
Jpn Circ J, 1996 Dec, 60:12, 925-32
Abstract
We investigated the characteristics of decreased heart rate variability (HRV) in diabetic patients with ischemic heart disease (IHD). Twenty-one healthy control subjects, 17 diabetic patients without IHD, and 33 diabetic patients with IHD were studied. The diabetic patients with IHD were subdivided into 2 groups according to the severity of their IHD: severe or mild. HRV was evaluated in all subjects using the spectral variables of the all-frequency, low-frequency, high-frequency (AF, LF, HF) components and the LF/HF ratio were determined from Holter recordings. The AF and LF components in patients with diabetes only or diabetes and severe IHD were significantly lower than in control group, but the HF component was significantly lower only in the group of patients with diabetes and severe IHD. The LF/HF ratio did not differ significantly among the 4 groups, but was the lowest in diabetic patients without IHD. Patients with diabetes and mild IHD showed a slight decrease in HRV, but this was not significant. With regard to the circadian rhythm of HRV, the AF and LF components in patients with diabetes-only or diabetes and severe IHD were significantly decreased and showed the same pattern throughout the day. However, the HF component was decreased during more time zones in patients with diabetes and severe IHD, whereas the LF/HF ratio was lower during more time zones in the diabetes-only group. All spectral variables showed a tendency to be inversely related to the duration of diabetes in all diabetic patients. In particular, the LF/HF ratio showed a significant negative correlation. The HRV of diabetic patients was characterized by a decreased LF/HF ratio. It was concluded that, although HRV in diabetic patients with severe IHD was reduced mainly as a result of diabetic neuropathy, this was also partly due to a decline in parasympathetic tone as a result of myocardial injury.
Language of Publication
English
Unique Identifier
97149888

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MeSH Heading (Major)
Diabetes Mellitus|CO/*PP; Heart Rate|*PH; Myocardial Ischemia|CO/*PP
MeSH Heading
Aged; Circadian Rhythm|PH; Electrocardiography, Ambulatory; Female; Human; Male; Middle Age; Prognosis; Time Factors

Publication Type
JOURNAL ARTICLE
ISSN
0047-1828
Country of Publication
JAPAN

Record 8 from database: MEDLINE
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Title
Determinants for coronary heart disease in non-insulin-dependent diabetes mellitus: lessons from the diabetes intervention study.
Author
Hanefeld M; Schmechel H; Julius U; Schwanebeck U
Address
Department of Clinical Metabolic Research, Medical Faculty, Technical University Dresden, Germany.
Source
Diabetes Res Clin Pract, 1996 Feb, 30 Suppl:, 67-70
Abstract
In NIDDM a clustering of established coronary risk factors, e.g. the metabolic syndrome is responsible for excessive incidence of myocardial infarction. The harmful effects of these risk factors are aggravated by poor glucose control. Hyperinsulinaemia is associated with a higher level of risk factors for coronary heart disease. Individuals with subsequent myocardial infarction exhibit higher levels of serum insulin at entry. However, insulin in multivariate analysis was no independent risk factor. Perfect control of blood glucose, triglycerides and blood pressure was associated with a lower incidence of coronary heart disease. By extrapolation an integrated approach to correct the anomalies of the metabolic syndrome seems to be necessary to prevent macroangiopathy and improve life expectancy.
Language of Publication
English
Unique Identifier
96252128

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MeSH Heading (Major)
Coronary Disease|*; Diabetes Mellitus, Non-Insulin-Dependent|*PP
MeSH Heading
Clinical Trials; Human; Insulin|BL; Multicenter Studies; Myocardial Infarction; Risk Factors

Publication Type
JOURNAL ARTICLE
ISSN
0168-8227
Country of Publication
IRELAND

Record 9 from database: MEDLINE
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Title
Diabetes and coronary heart disease in American Indians: The Strong Heart Study.
Author
Howard BV; Lee ET; Fabsitz RR; Robbins DC; Yeh JL; Cowan LD; Welty TK
Address
Medlantic Research Institute, Washington, DC 20010, USA.
Source
Diabetes, 1996 Jul, 45 Suppl 3:, S6-13
Abstract
Coronary heart disease (CHD) is the leading cause of death among American Indians. However, information on the prevalence of CHD and its association with known risk factors is limited. The purpose of the Strong Heart Study is to quantify CHD and its risk factors among three geographically diverse groups of American Indians. The population consists of 4,549 adults between 45 and 74 years of age in 13 Indian communities in Arizona, Oklahoma, and South and North Dakota. The phase I examination (1989-1991) revealed very high prevalence rates of diabetes that ranged from 33 to 72% in men and women in the three centers. Prevalence rates of definite myocardial infarction (MI) and definite CHD were higher in men than in women in all three centers (P < 0.0001) and in those with diabetes (P = 0.002 and P = 0.0003 in women and men respectively). Diabetes was associated with a relatively greater increase in prevalence of MI (prevalence rate = 3.8 vs. 1.9) and CHD (prevalence rate = 4.6 vs. 1.8) in women than in men. Logistic regression analysis indicated that the prevalence of CHD among American Indians was significantly related to age, diabetes, hypertension, albuminuria, percentage of body fat, smoking, high concentrations of plasma insulin, and low concentrations of HDL cholesterol. Lower prevalence rates of CHD were found in Arizona despite higher rates of diabetes, obesity, hypertension, and albuminuria; these lower rates may be in part related to lower smoking frequency and lower concentrations of total and LDL cholesterol. These findings from the baseline Strong Heart Study examination emphasize the relative importance of diabetes and its associated variables as risk factors for CHD among American Indian populations.
Language of Publication
English
Unique Identifier
96289825

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MeSH Heading (Major)
Coronary Disease|*EP; Diabetes Mellitus|*EP
MeSH Heading
Adult; Aged; Female; Fibrinogen|AN; Human; Indians, North American; Lipoproteins|BL; Male; Middle Age; Obesity|CO; Odds Ratio; Regression Analysis; Risk Factors; Smoking; Socioeconomic Factors; Tobacco

Publication Type
JOURNAL ARTICLE; MULTICENTER STUDY
ISSN
0012-1797
Country of Publication
UNITED STATES

Record 10 from database: MEDLINE
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Title
Diabetes and the heart: coronary heart disease.
Author
Jarrett J
Address
 
Source
Clin Endocrinol Metab, 1977 Jul, 6:2, 389-402
Abstract
1. Diabetics have a greater risk of experiencing and of dying from a CHD event than age matched non-diabetics. 2. The excess risk is particularly notable in insulin dependent female diabetics who seem to lose the usual 'protection' accorded to women. 3. The cause or causes of the excess risk are not known. There are a variety of 'risk factors' observed in diabetics which, in sum, may contribute. 4. At least in insulin-dependent diabetics some cardiac morbidity and mortality may also be due, not to coronary heart disease, but to a cardiomyopathy secondary to intramural obstructive vascular disease and/or disordered myocardial metabolism. 5. No therapy has yet been convincingly proved to reduce (or to increase) the risk of cardiac morbidity or mortality. Nevertheless, in treating diabetics there is an a priori case for using diets designed to lower plasma lipid levels as well as the blood sugar, for early treatment of hypertension and for discouraging cigarette smoking.
Language of Publication
English
Unique Identifier
77244722

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MeSH Heading (Major)
Coronary Disease|*/BL/CO/EP/MO; Diabetic Angiopathies|*/BL/CO/EP/MO
MeSH Heading
Adolescence; Adult; Age Factors; Cholesterol|BL; Female; Human; Hypertension|CO/EP; Male; Middle Age; Obesity|CO; Risk; Sex Factors; Smoking; Triglycerides|BL

Publication Type
JOURNAL ARTICLE; REVIEW
ISSN
0300-595X
Country of Publication
ENGLAND

Record 11 from database: MEDLINE
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Title
Prevalence of coronary heart disease in subjects with normal and impaired glucose tolerance and non-insulin-dependent diabetes mellitus in a biethnic Colorado population. The San Luis Valley Diabetes Study.
Author
Rewers M; Shetterly SM; Baxter J; Marshall JA; Hamman RF
Address
Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine, Denver.
Source
Am J Epidemiol, 1992 Jun, 135:12, 1321-30
Abstract
The prevalence of coronary heart disease was studied in 1984-1988 in 1,092 individuals with normal glucose tolerance, 173 individuals with impaired glucose tolerance, and 429 individuals with non-insulin-dependent diabetes mellitus, who were age 25-74 years and were from a biethnic community in the San Luis Valley, Colorado. Glucose tolerance was classified using the World Health Organization criteria, and coronary heart disease prevalence was assessed using the Rose Questionnaire and a resting electrocardiogram. Compared with normal glucose tolerance, coronary heart disease was significantly more prevalent in diabetic non-Hispanic white women (odds ratio (OR) for all end points combined = 3.2, 95% confidence interval (Cl) 1.8-5.5) and men (OR = 1.9, 95% Cl 1.1-3.3) and in diabetic Hispanic women (OR = 1.7, 95% Cl 1.1-2.5), but not men (OR = 1.0, 95% Cl 0.6-1.7). Among diabetic men, the prevalence of possible myocardial infarction was lower in Hispanics than in non-Hispanic whites (OR = 0.4, 95% Cl 0.2-0.7). Similar patterns of coronary heart disease were observed in individuals with impaired glucose tolerance. The paradoxically low prevalence of coronary heart disease in Hispanics with non-insulin-dependent diabetes mellitus, especially men, may be due to unknown protective factors, increased case fatality, or competing mortality in this group.
Language of Publication
English
Unique Identifier
92377784

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MeSH Heading (Major)
Coronary Disease|CO/*EH; Diabetes Mellitus, Non-Insulin-Dependent|*CO; Glucose Tolerance Test|*; Hispanic Americans|*; Whites|*
MeSH Heading
Adult; Aged; Colorado|EP; Comparative Study; Cross-Sectional Studies; Female; Human; Male; Middle Age; Prevalence; Risk Factors; Support, U.S. Gov't, P.H.S.

Publication Type
JOURNAL ARTICLE
ISSN
0002-9262
Country of Publication
UNITED STATES

Record 12 from database: MEDLINE
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Title
The level of autoantibodies against oxidized LDL is not associated with the presence of coronary heart disease or diabetic kidney disease in patients with non-insulin-dependent diabetes mellitus.
Author
Leinonen JS; Rantalaiho V; Laippala P; Wirta O; Pasternack A; Alho H; Jaakkola O; Ylä Herttuala S; Koivula T; Lehtimäki T
Address
Medical School, University of Tampere, and Department of Clinical Chemistry, Tampere University Hospital, Finland. bljale@uta.fi
Source
Free