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Record 1
from database: MEDLINE
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- Title
- Effects of a high-protein and low-fat
diet vs a low-protein and high-fat diet
on blood glucose, serum lipoproteins,
and cholesterol metabolism in noninsulin-dependent
diabetics.
- Author
- Andersén E; Hellström P; Kindstedt
K; Hellström K
- Address
-
- Source
- Am J Clin Nutr, 1987 Feb, 45:2, 406-13
- Abstract
- Six middle-aged patients with
noninsulin-dependent diabetes and six
normoglycemic control subjects were fed
protein-rich and fat-poor (diet A) or
protein-poor and fat-rich food (diet B).
The patients were hyperglycemic, VLDL
triglycerides levels were higher, and
HDL cholesterol levels lower than
corresponding findings in control
subjects. Bile acid formation and
biliary lipid composition did not differ
between the two groups, but net steroid
balance in the patients was elevated by
a factor of approximately 2. A switch
from diet A to diet B in control
subjects was associated with an increase
in HDL cholesterol and decreases in bile
acid synthesis and net steroid balance.
Lipoprotein pattern in the patients
remained unchanged, and effects on total
bile acid production and steroid balance
were less consistent. It is suggested
that the response in the patients
reflected diabetes-associated
abnormalities in lipid metabolism.
- Language of Publication
- English
- Unique Identifier
- 87124596
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- MeSH Heading (Major)
- Diabetes Mellitus, Non-Insulin-Dependent|BL/CO/*DH;
Diabetic Diet|*; Dietary Fats|*AD;
Dietary Proteins|*AD;
Hyperlipoproteinemia|*DH/ET
- MeSH Heading
- Adult; Aged; Blood Glucose|ME;
Cholesterol|ME; Comparative Study;
Female; Human; Lipoproteins|BL; Male;
Middle Age; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9165
- Country of Publication
- UNITED STATES
Record 2
from database: MEDLINE
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- Title
- Hypocaloric high-protein diet improves
glucose oxidation and spares lean body
mass: comparison to hypocaloric
high-carbohydrate diet.
- Author
- Piatti PM; Monti F; Fermo I;
Baruffaldi L; Nasser R; Santambrogio G;
Librenti MC; Galli Kienle M; Pontiroli
AE; Pozza G
- Address
- Istituto Scientifico San Raffaele,
Dipartimento di Chimica e Biochimica
Medica, Milano, Italy.
- Source
- Metabolism, 1994 Dec, 43:12, 1481-7
- Abstract
- The aim of the study was to
investigate the effects of two
hypocaloric (800-kcal) diets on body
weight reduction and composition,
insulin sensitivity, and proteolysis in
25 normal glucose-tolerant obese women.
The two diets had the following
composition: 45% protein, 35%
carbohydrate (CHO), and 20% fat (HP
diet, 10 subjects), and 60% CHO, 20%
protein, and 20% fat (HC diet, 15
subjects); both lasted 21 days. A
euglycemic hyperinsulinemic (25 mU/kg/h)
clamp lasting 150 minutes combined with
indirect calorimetry was performed
before and after the diet. Both diets
induced a similar decrease in body
weight and fat mass (FM), whereas
fat-free mass (FFM) decreased only after
the HC diet. 3-Methylhistidine
(3-CH3-HIS) excretion was reduced by 48%
after the HP diet and remained unchanged
after the HC diet (P < .05). A
significant correlation was found
between the changes in FFM and in
3-CH3-HIS excretion after the diet (rs =
.50, P < .02). Blood glucose remained
unchanged, while insulin decreased in
both diets. Free fatty acids (FFA)
significantly increased only after the
HC diet (P < .05). During the clamp
period, glucose disposal and glucose
oxidation significantly increased after
the HP diet and significantly decreased
after the HC diet. Opposite results were
found when measuring lipid oxidation. In
conclusion, our experience suggests that
(1) a hypocaloric diet providing a high
percentage of natural protein can
improve insulin sensitivity; and (2)
conversely, a hypocaloric
high-polysaccharide-CHO diet decreases
insulin sensitivity and is unable to
spare muscle tissue.
- Language of Publication
- English
- Unique Identifier
- 95082609
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- MeSH Heading (Major)
- Body Composition|*PH; Diet,
Reducing|*; Dietary Carbohydrates|*AD;
Dietary Proteins|*AD; Glucose|*ME;
Obesity|*DH
- MeSH Heading
- Adult; Body Mass Index; Energy
Intake|PH; Female; Glucose Clamp
Technique; Human; Insulin Resistance|PH;
Lipid Peroxidation|PH;
Oxidation-Reduction; Proteins|ME; Weight
Loss|PH
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL
TRIAL; JOURNAL ARTICLE
- ISSN
- 0026-0495
- Country of Publication
- UNITED STATES
Record 3 from database: MEDLINE
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- Title
- Protein turnover in acid maltase
deficiency before and after treatment
with a high protein diet.
- Author
- Umpleby AM; Wiles CM; Trend PS; Scobie
IN; Macleod AF; Spencer GT; Sonksen PH
- Address
-
- Source
- J Neurol Neurosurg Psychiatry, 1987
May, 50:5, 587-92
- Abstract
- A patient with acid maltase deficiency
was treated with a high protein diet for
7 months. Protein turnover expressed in
terms of lean body mass was shown to be
increased in this patient before the
diet but was markedly reduced following
the diet. The patient improved
clinically whilst on the diet both
subjectively and in terms of mobility,
breathing and reduced peripheral
cyanosis at rest.
- Language of Publication
- English
- Unique Identifier
- 87225009
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- MeSH Heading (Major)
- Dietary Proteins|*AD; Glucan
1,4-alpha-Glucosidase|*DF; Glucosidases|*DF;
Glycogen Storage Disease|*DH; Glycogen
Storage Disease Type II|*DH/EN; Muscle
Proteins|*ME
- MeSH Heading
- Adult; Case Report; Glucose Tolerance
Test; Human; Leucine|BL; Male; Support,
Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-3050
- Country of Publication
- ENGLAND
Record 4 from database: MEDLINE
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- Title
- Renal hemodynamic effects of a
short-term high protein and low protein
diet in patients with renal disease.
- Author
- Wetzels JF; Hoitsma AJ; Berden JH;
Koene RA
- Address
- Department of Medicine, University
Hospital Nijmegen, The Netherlands.
- Source
- Clin Nephrol, 1988 Jul, 30:1, 42-7
- Abstract
- The renal hemodynamic effects of
short-term protein loading and short
term protein restriction were studied in
patients with renal disease. Eleven
patients adhered to a high protein diet
(1.8 g/kg/day) and, subsequently, to a
low protein diet (0.6 g/kg/day) for four
weeks each. Renal hemodynamics were
studied at the end of the respective
dietary periods. Glomerular filtration
rate (inulin clearance) did not change
significantly (delta %: -1.5 +/- 5.4%;
mean +/- s.e.m.), whereas endogenous
creatinine clearance was lower on the
low protein diet (delta %: -7.8 +/-
2.8%; p less than 0.02), suggesting an
interference with the tubular secretion
of creatinine. Effective renal plasma
flow was significantly lower on the low
protein diet (223.7 +/- 47.6 ml/min vs
282.1 +/- 67.1 ml/min; delta %: -15.4
+/- 4.9%; p less than 0.02). As a
result, filtration fraction increased
from 0.18 +/- 0.01 on the high protein
diet to 0.22 +/- 0.02 on the low protein
diet (p less than 0.01). The low protein
diet caused a significant decrease in
protein excretion from 4.0 +/- 0.9 g/24
h to 3.1 +/- 0.7 g/24 h (p less than
0.02). Our study demonstrates that renal
hemodynamic responses to more sustained
protein loading and protein restriction
differ from the reported responses to
acute protein loading. Different
mechanisms may be involved. In this
light it is doubtful if the renal
hemodynamic response to acute protein
loading can predict a beneficial effect
of protein restriction.
- Language of Publication
- English
- Unique Identifier
- 89090265
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- MeSH Heading (Major)
- Dietary Proteins|*AD; Kidney|*PP;
Kidney Diseases|ME/*PP
- MeSH Heading
- Adult; Creatinine|UR; Female;
Glomerular Filtration Rate; Hemodynamics;
Human; Insulin|ME; Male; Middle Age;
Proteinuria|ME; Renal Circulation;
Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0301-0430
- Country of Publication
- GERMANY, WEST
Record 5 from database: MEDLINE
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- Title
- High protein vs high carbohydrate
hypoenergetic diet for the treatment of
obese hyperinsulinemic subjects.
- Author
- Baba NH; Sawaya S; Torbay N; Habbal Z;
Azar S; Hashim SA
- Address
- Department of Food Technology and
Nutrition and the Division of
Endocrinology, American University of
Beirut, Beirut, Lebanon. nahla@aub.edu.lb
- Source
- Int J Obes Relat Metab Disord, 1999
Nov, 23:11, 1202-6
- Abstract
- OBJECTIVE: To test the hypothesis that
hyperinsulinemic obese subjects would
respond differently to changes in the
composition of hypoenergetic diets.
DESIGN: A 4-week randomized dietary
intervention trial. SUBJECTS: Thirteen
male obese hyperinsulinemic
normoglycemic subjects were divided into
two groups and fed hypoenergetic diets
providing 80% of their resting energy
expenditure (REE). One group received a
high-protein diet (HP; 45% protein, 25%
carbohydrates, and 30% fat as percent of
dietary energy) and the other a
high-carbohydrate diet (HC; 12% protein,
58% carbohydrates and 30% fat).
MEASUREMENTS: Anthropometry, body
composition, fasting serum insulin and
lipids, and REE were performed before
and after the feeding period. RESULTS:
Weight loss was higher in the HP than HC
group (8.3+/-0.7 vs 6.0+/-0.6 kg,
P<0. 05). There was a decrease in
body fat in both groups, whereas body
water decreased significantly more in
the HP group. REE decreased more in the
HC than the HP group (-384.3+/-84.6 vs
-132.3+/-51.0 kcal, P<0.05). Serum
total cholesterol, triglycerides and LDL
cholesterol decreased significantly to a
similar extent in both diet groups,
while HDL cholesterol was decreased
significantly only in the HP group. Mean
fasting insulin decreased significantly
in both diet groups and reached the
normal range only in the HP group.
CONCLUSION: A low-carbohydrate (LC), HP
hypoenergetic diet could be the diet
composition of choice for a
weight-reducing regimen in obese
hyperinsulinemic subjects.
- Language of Publication
- English
- Unique Identifier
- 20047272
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- MeSH Heading (Major)
- Dietary Carbohydrates|*AD; Dietary
Proteins|*AD; Hyperinsulinemia|BL/CO/*DH;
Obesity|BL/CO/*DH
- MeSH Heading
- Basal Metabolism; Body Composition;
Cholesterol|BL; Dietary Fats|AD; Energy
Intake; Energy Metabolism; Human;
Lipoproteins, HDL Cholesterol|BL;
Lipoproteins, LDL Cholesterol|BL; Male;
Support, Non-U.S. Gov't;
Triglycerides|BL; Weight Loss
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0307-0565
- Country of Publication
- ENGLAND
Record 6 from database: MEDLINE
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- Title
- Urinary calcium and calcium balance in
young women affected by high protein
diet of soy protein isolate and adding
sulfur-containing amino acids and/or
potassium.
- Author
- Kaneko K; Masaki U; Aikyo M; Yabuki K;
Haga A; Matoba C; Sasaki H; Koike G
- Address
- Faculty of Eduction, Yokohama National
University, Japan.
- Source
- J Nutr Sci Vitaminol (Tokyo), 1990
Apr, 36:2, 105-16
- Abstract
- The effects of sulfur-containing amino
acids (SAA) and potassium (K) on urinary
excretion and retention of calcium (Ca)
of 27 young Japanese women were studied.
A basal diet low in protein level (50 g
per day) was fortified by meat or soy
protein isolate (SPI) to a protein level
of 100 g per day, and effects of
addition of apple to these high protein
diets, and addition of SAA and/or
potassium (K) to the high SPI diet,
especially on urinary Ca excretion, were
studied. The addition of meat which
increased protein intake to 100 g caused
the increase in apparent absorption and
urinary excretion of Ca with increased
excretion of urinary sulfur (S),
phosphate, ammonia, and titratable acids
(TA), whereas addition of SPI did not.
The addition of apple to high meat diet
decreased absorption and urinary
excretion of Ca. Urinary Ca, S, K,
ammonia, and TA excretion increased by
the addition of SAA to high SPI diet in
a manner similar to the meat diet.
Consequently, SAA-supplemented diet had
a significantly negative effect on Ca
retention. In SPI+SAA,K diet period,
urinary K excretion markedly increased,
and increments in urinary Ca, ammonia,
and TA excretion were reversed. These
changes observed in SPI+SAA, K diet
period were similar to those by adding
apple to meat diet without any effect on
Ca absorption. The results suggest that
the hypercalciuria induced by high meat
diet is mainly caused by high content of
SAA and may be reversed by the ingestion
of K-rich foodstuffs, and soy protein
does not induce hypercalciuria because
of it contains less SAA than animal
protein.
- Language of Publication
- English
- Unique Identifier
- 90354911
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- MeSH Heading (Major)
- Amino Acids, Sulfur|*PD; Calcium|ME/*UR;
Dietary Proteins|AD/*PD;
Potassium|*PD/UR; Vegetable Proteins|AD/*PD
- MeSH Heading
- Absorption; Adult; Ammonia|UR;
Creatinine|UR; Diet; Feces|AN; Female;
Fruit; Human; Hydrogen-Ion
Concentration; Japan; Meat;
Phosphates|UR; Sulfur|UR; Urine
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0301-4800
- Country of Publication
- JAPAN
Record 7 from database: MEDLINE
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- Title
- Satiety related to 24 h diet-induced
thermogenesis during high
protein/carbohydrate vs high fat diets
measured in a respiration chamber.
- Author
- Westerterp Plantenga MS; Rolland V;
Wilson SA; Westerterp KR
- Address
- Department of Human Biology,
Maastricht University, The Netherlands.
- Source
- Eur J Clin Nutr, 1999 Jun, 53:6,
495-502
- Abstract
- OBJECTIVE: Assessment of a possible
relationship between perception of
satiety and diet-induced thermogenesis,
with different macronutrient
compositions, in a controlled situation
over 24 h. DESIGN: Two diets with
different macronutrient compositions
were offered to all subjects in
randomized order. SETTING: The study was
executed in the respiration chambers at
the department of Human Biology,
Maastricht University. SUBJECTS:
Subjects were eight females, ages 23-33
y, BMI 23+/-3 kg/m2, recruited from
University staff and students.
INTERVENTIONS: Subjects were fed in
energy balance, with
protein/carbohydrate/fat: 29/61/10 and
9/30/61 percentage of energy, with fixed
meal sizes and meal intervals, and a
fixed activity protocol, during 36 h
experiments in a respiration chamber.
The appetite profile was assessed by
questionnaires during the day and during
meals. Diet induced thermogenesis was
determined as part of the energy
expenditure. RESULTS: Energy balance was
almost complete, with non-significant
deviations. Diet-Induced-Thermogenesis (DIT)
was 14.6+/-2.9%, on the high
protein/carbohydrate diet, and
10.5+/-3.8% on the high fat diet (P <
0.01). With the high protein/high
carbohydrate diet, satiety was higher
during meals (P < 0.001; P <
0.05), as well as over 24 h (P <
0.001), than with the high fat diet.
Within one diet, 24 h DIT and satiety
were correlated (r = 0.6; P < 0.05).
The difference in DIT between the diets
correlated with the differences in
satiety (r = 0.8; P < 0.01).
CONCLUSION: In lean women, satiety and
DIT were synchronously higher with a
high protein/high carbohydrate diet than
with a high fat diet. Differences (due
to the different macronutrient
compositions) in DIT correlated with
differences in satiety over 24 h.
- Language of Publication
- English
- Unique Identifier
- 99330381
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- MeSH Heading (Major)
- Dietary Carbohydrates|AD/ME/*PD;
Dietary Fats|AD/ME/*PD; Dietary
Proteins|AD/ME/*PD; Satiation|*DE
- MeSH Heading
- Adult; Analysis of Variance; Area
Under Curve; Calorimetry, Indirect;
Comparative Study; Diet; Energy Intake;
Energy Metabolism; Female; Human;
Hunger; Oxygen Consumption;
Questionnaires
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0954-3007
- Country of Publication
- ENGLAND
Record 8 from database: MEDLINE
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- Title
- The effects of a high-animal- and a
high-vegetable-protein diet on mineral
balance and bowel function of young men.
- Author
- Van Dokkum W; Wesstra A; Luyken R;
Hermus RJ
- Address
- Department of Human Nutrition,
TNO-CIVO Toxicology and Nutrition
Institute, Zeist, The Netherlands.
- Source
- Br J Nutr, 1986 Sep, 56:2, 341-8
- Abstract
- 1. Twelve young men were given for
periods of 20 d, each of three mixed
diets, namely a low-protein (LP) diet
(9% total energy as protein, 67% of
animal origin), a high-animal-protein
(HA) diet (16% total energy as protein,
67% of animal origin) and a
high-vegetable-protein (HV) diet (16%
total energy as protein, 67% of
vegetable origin). Retention of calcium,
magnesium, iron, zinc and copper as well
as various bowel function indices were
investigated during each dietary period.
2. Neither the HA diet nor the HV diet
changed the retention of the minerals
considerably. Only Fe balance decreased
significantly on the HV diet. 3.
Substituting the HV diet for the HA diet
resulted in significant increases in
faecal wet weight (17 g/d), defaecation
frequency (0.12 stools/d), faecal
volatile fatty acids (2.6 mmol/d) and a
decrease in faecal bile acids (128 mumol/d).
4. It is concluded that a HV diet,
rather than a HA diet is to be
recommended with respect to bowel
function, whereas the HV diet does not
necessarily have a significant influence
on mineral retention.
- Language of Publication
- English
- Unique Identifier
- 88050747
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- MeSH Heading (Major)
- Dietary Proteins|*PD; Intestines|*PH;
Meat|*; Minerals|AN/*ME; Vegetables|*
- MeSH Heading
- Adult; Calcium|UR; Defecation; Fatty
Acids, Volatile|AN; Feces|AN; Human;
Male
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0007-1145
- Country of Publication
- ENGLAND
Record 9 from database: MEDLINE
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- Title
- Increased clearance of propranolol and
theophylline by high-protein compared
with high-carbohydrate diet.
- Author
- Fagan TC; Walle T; Oexmann MJ; Walle
UK; Bai SA; Gaffney TE
- Address
-
- Source
- Clin Pharmacol Ther, 1987 Apr, 41:4,
402-6
- Abstract
- The objective of this study was to
determine whether changes in dietary
protein and carbohydrate influence the
oral clearance of propranolol, a
high-clearance drug, and theophylline, a
low-clearance drug. Six normal subjects
studied in a clinical research center
each received a single oral dose of
propranolol, 80 mg, and theophylline, 5
mg/kg, after having been on each of two
well-defined diets for a period of 10
days. When the diet was altered from
high carbohydrate/low protein to low
carbohydrate/high protein, the oral
clearance of propranolol increased by
74% +/- 20% (mean +/- SE; range 9% to
156%; P less than 0.01) with no change
in plasma half-life or plasma binding.
This dietary change resulted in an
increase in theophylline clearance of
32% +/- 6% (range 18% to 50%; P less
than 0.02) and a corresponding decrease
in plasma half-life of 26% +/- 6% (range
6% to 42%; P less than 0.05) with no
alteration in the apparent volume of
distribution. These observations
reemphasize the importance of diet in
drug disposition and suggest that the
clearance of high-clearance drugs like
propranolol is more susceptible than the
clearance of low-clearance drugs to
dietary manipulations, effects that may
have to be considered in drug therapy.
- Language of Publication
- English
- Unique Identifier
- 87160344
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- MeSH Heading (Major)
- Dietary Carbohydrates|*PD; Dietary
Proteins|*PD; Propranolol|BL/*ME;
Theophylline|BL/*ME
- MeSH Heading
- Administration, Oral; Adult;
Biological Availability; Comparative
Study; Female; Human; Kinetics; Male;
Mass Fragmentography; Support, U.S.
Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0009-9236
- Country of Publication
- UNITED STATES
Record 10 from database: MEDLINE
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- Title
- Cloning of rat uncoupling protein-3
and uncoupling protein-2 cDNAs: their
gene expression in rats fed high-fat
diet.
- Author
- Matsuda J; Hosoda K; Itoh H; Son C;
Doi K; Tanaka T; Fukunaga Y; Inoue G;
Nishimura H; Yoshimasa Y; Yamori Y;
Nakao K
- Address
- Department of Medicine and Clinical
Science, Kyoto University Graduate
School of Medicine, Japan.
- Source
- FEBS Lett, 1997 Nov, 418:1-2, 200-4
- Abstract
- In order to elucidate energy balance
in the skeletal muscle, we cloned cDNA
of a homologue of uncoupling protein (UCP)
from rat skeletal muscle. We also cloned
rat UCP-2 cDNA from rat brown adipose
tissue (BAT). The UCP cloned from rat
skeletal muscle showed 57% and 72%
identity with rat UCP-1 and UCP-2. The
mRNA was expressed abundantly in the
skeletal muscle, moderately in the BAT,
and slightly in the white adipose tissue
(WAT) with a major band at 2.5 kb and a
minor band at 2.8 kb, while the UCP-2
gene expression was widely detected in
the whole body with substantial levels
in the WAT and with slight levels in the
skeletal muscle and BAT. The rat UCP
cloned in the present study showed 86%
identity with the recently cloned human
UCP-3, which was also expressed
abundantly in the skeletal muscle with a
signal of 2.4 kb. Therefore, the rat UCP
was considered to be rat UCP-3. In rats
fed high-fat diet the UCP-3 gene
expression was augmented 2-fold in the
skeletal muscle while UCP-2 mRNA levels
were increased significantly (1.6-fold)
in the epididymal WAT. Augmented
expression of UCPs may provide defense
against high-fat induced obesity and
impairment of glucose metabolism.
- Language of Publication
- English
- Unique Identifier
- 98074937
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- MeSH Heading (Major)
- Adipose Tissue|*ME; Carrier
Proteins|*BI/CH; Dietary Fats|*; Gene
Expression Regulation|*; Muscle,
Skeletal|*ME; Proteins|*BI/CH;
Transcription, Genetic|*
- MeSH Heading
- Amino Acid Sequence; Animal; Brown
Fat|ME; Cloning, Molecular; DNA,
Complementary; Epididymis; Human; Male;
Molecular Sequence Data; Organ
Specificity; Rats; RNA, Messenger|BI;
Sequence Alignment; Sequence Homology,
Amino Acid; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0014-5793
- Country of Publication
- NETHERLANDS
Record 11 from database: MEDLINE
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- Title
- Weight reduction with a high protein,
low carbohydrate, calorie-restricted
diet: effects on blood pressure, glucose
and insulin levels.
- Author
- Nobels F; van Gaal L; de Leeuw I
- Address
-
- Source
- Neth J Med, 1989 Dec, 35:5-6, 295-302
- Abstract
- A clear relationship exists between
obesity and hypertension. In this study,
blood pressure was examined in 215 obese
patients. Significant positive
correlations were demonstrated between
the mean arterial pressure (MAP) and
age, body weight, body mass index (BMI),
fasting and 2 h postprandial glucose and
postprandial insulin concentrations.
Using a stepwise multiple regression
analysis, it was clear that body weight,
age and glycaemic parameters were the
most important determinants of arterial
blood pressure. During a period of 6
months, 113 patients were treated with a
high protein, low carbohydrate,
calorie-restricted diet. This resulted
in a mean weight loss of 17 +/- 7.9 kg
and a considerable drop in MAP, and in
fasting and postprandial glucose and
insulin concentrations. None of the
patients who were hypertensive before
treatment (n = 17) remained so
afterwards. We can conclude that: (1)
changes in blood pressure are always
accompanied by changes in the same
direction of one or more of the
parameters of glucose homeostasis, which
suggests a common link; (2) The dietary
approach to obesity therapy successfully
lowers blood pressure and helps to
rectify the abnormalities in glucose
metabolism.
- Language of Publication
- English
- Unique Identifier
- 90245170
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- MeSH Heading (Major)
- Blood Glucose|*AN; Blood Pressure|*;
Diet, Reducing|*; Insulin|*BL;
Obesity|BL/*DH/PP
- MeSH Heading
- Adolescence; Age Factors; Body Mass
Index; Body Weight; Energy Intake;
Female; Food, Formulated; Human;
Hypertension|PP; Male; Prospective
Studies; Weight Loss
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0300-2977
- Country of Publication
- NETHERLANDS
Record 12 from database: MEDLINE
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- Title
- The effect of a high protein diet on
leucine and alanine turnover in acid
maltase deficiency.
- Author
- Umpleby AM; Trend PS; Chubb D;
Conaglen JV; Williams CD; Hesp R; Scobie
IN; Wiles CM; Spencer G; Sönksen PH
- Address
- Department of Medicine, St Thomas'
Hospital, London, UK.
- Source
- J Neurol Neurosurg Psychiatry, 1989
Aug, 52:8, 954-61
- Abstract
- Leucine and alanine production rate
was measured in 5 patients with acid
maltase deficiency in the postabsorptive
state, following 6 months on a normal
diet with placebo and 6 months on an
isocaloric high protein diet (16-22%
protein). Whole body leucine production
rate, a measure of protein degradation,
expressed in terms of lean body mass was
significantly greater than in five
control subjects. Following the high
protein diet, leucine production rate
was decreased in four of the five
patients but this was not statistically
significant. Alanine production rate
expressed in terms of lean body mass was
significantly greater than in control
subjects. After the high protein diet,
alanine production rate and
concentration were significantly
decreased (p less than 0.05). There were
no significant improvements in any of
the clinically relevant variables
measured in these patients. It is
possible that a larger increase in
protein intake over a longer time period
may have a clinical effect.
- Language of Publication
- English
- Unique Identifier
- 90011123
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- MeSH Heading (Major)
- Alanine|*BL; Dietary Proteins|*AD;
Glucan 1,4-alpha-Glucosidase|*DF;
Glycogen Storage Disease Type II|*DH/EN;
Leucine|*BL
- MeSH Heading
- Adult; Clinical Trials; Female;
Follow-Up Studies; Glucose Tolerance
Test; Human; Lactates|BL; Male; Middle
Age; Random Allocation; Support,
Non-U.S. Gov't
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL
TRIAL; JOURNAL ARTICLE
- ISSN
- 0022-3050
- Country of Publication
- ENGLAND
Record 13 from database: MEDLINE
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- Title
- Effect of a high-protein,
very-low-calorie diet on resting
metabolism, thyroid hormones, and energy
expenditure of obese middle-aged women.
- Author
- Barrows K; Snook JT
- Address
-
- Source
- Am J Clin Nutr, 1987 Feb, 45:2, 391-8
- Abstract
- A 4-6 mo study was conducted to
examine effects of a very-low-calorie,
high-protein diet and realimentation on
energy expenditure, resting metabolic
rate (RMR), and serum thyroid hormones
of obese women aged 30-54 yr. Fifteen
healthy women, greater than or equal to
126% ideal body weight, were placed on
the diet (420 kcal/day) and lost an
average of 1.1 kg/wk until a
predetermined goal weight was attained.
RMR, triiodothyronine (T3), and reverse
T3 decreased significantly (p less than
0.05). Thyroxine remained unchanged.
Upon gradual realimentation onto solid
foods, all metabolic parameters
increased significantly within 5 wk
toward pre-diet baseline values, but RMR
(kcal/h) and T3 values remained
significantly below pre-study values.
Estimates of mean energy expenditure,
utilizing a technique based on energy
intake and body composition changes,
averaged 1719 kcal/day during the diet
period.
- Language of Publication
- English
- Unique Identifier
- 87124594
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- MeSH Heading (Major)
- Diet, Reducing|*; Dietary
Proteins|*AD; Energy Intake|*; Energy
Metabolism|*; Obesity|*DH/ME
- MeSH Heading
- Adult; Basal Metabolism; Female;
Human; Middle Age; Support, Non-U.S.
Gov't; Thyroid Hormones|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9165
- Country of Publication
- UNITED STATES
Record 14 from database: MEDLINE
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- Title
- Effect of a high-protein,
very-low-calorie diet on body
composition and anthropometric
parameters of obese middle-aged women.
- Author
- Barrows K; Snook JT
- Address
-
- Source
- Am J Clin Nutr, 1987 Feb, 45:2, 381-90
- Abstract
- Effects of a very-low-calorie (420
kcal/day), high-protein diet (70 g/day)
and realimentation on weight and body
composition of 15 obese, middle-aged
women were examined in a 4-6 mo study.
Mean weight loss was 20.5 kg (1.1
kg/wk). Fat accounted for 83% and lean
body mass (LBM) for 17% of total body
weight loss. Multiple regression
equations estimated from anthropometric
measures were developed to predict the
body density of obese individuals both
before and after weight loss. Best
predictors of body density in obese
women before and after weight loss were
circumference measurements in the trunk
area. Nine previously published
population specific and generalized
equations for predicting body fat in
women were not strongly enough
correlated with body fat values obtained
by densitometry in this study to be of
use clinically.
- Language of Publication
- English
- Unique Identifier
- 87124593
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- MeSH Heading (Major)
- Body Composition|*; Diet, Reducing|*;
Dietary Proteins|*AD; Energy Intake|*;
Obesity|*DH
- MeSH Heading
- Adipose Tissue|AH; Adult;
Anthropometry|MT; Densitometry; Female;
Human; Middle Age; Regression Analysis;
Support, Non-U.S. Gov't; Vital Capacity
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9165
- Country of Publication
- UNITED STATES
Record 15 from database: MEDLINE
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- Title
- Rapid catch-up growth of children fed
a high-protein diet during convalescence
from shigellosis.
- Author
- Kabir I; Malek MA; Mazumder RN; Rahman
MM; Mahalanabis D
- Address
- International Centre for Diarrheal
Disease Research, Dhaka, Bangladesh.
- Source
- Am J Clin Nutr, 1993 Mar, 57:3, 441-5
- Abstract
- Sixty-nine children age 2-5 y,
convalescing from shigellosis in a
randomized clinical trial were fed
either a high-protein diet containing
628 kJ.kg-1.d-1 with 15% of total energy
as protein, or a standard-protein diet
that was isoenergetic but with 7.5% of
total energy as protein for 21 d.
Children fed the high-protein diet
showed a significant increase in height
(1.02 +/- 0.44 cm; mean +/- SD) compared
with the children who were fed the
standard-protein diet (0.69 +/- 0.34 cm;
P < 0.001). Similarly, increases in
body weight were 1.25 +/- 0.48 vs 0.86
+/- 0.48 kg for the high-protein and the
standard-protein diet, respectively (P
< 0.001). The mean increases of serum
proteins were also significantly higher
in the high-protein group (P < 0.01).
These results indicate that increasing
the protein content of the diet during
convalescence from shigellosis in
children leads to more rapid catch-up
growth.
- Language of Publication
- English
- Unique Identifier
- 93175379
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- MeSH Heading (Major)
- Dietary Proteins|AD/*TU; Growth|*
- MeSH Heading
- Aging; Bangladesh; Blood Proteins|ME;
Body Height; Child, Preschool;
Dysentery, Bacillary|DH; Energy Intake;
Female; Human; Male; Support, Non-U.S.
Gov't; Support, U.S. Gov't, Non-P.H.S.;
Weight Gain
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0002-9165
- Country of Publication
- UNITED STATES
Record 16 from database: MEDLINE
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- Title
- Plasma levels of branched chain amino
acids in patients on regular
hemodialysis before and after including
a high-protein supplement in their diet.
- Author
- Vuzelov E; Krivoshiev S; Ribarova F;
Boyadjiev N
- Address
- Department of Hemodialysis, University
Hospital Tsaritsa Yoanna, Sofia,
Bulgaria.
- Source
- Folia Med (Plovdiv), 1999, 41:4, 19-22
- Abstract
- Chronic renal failure (CRF) patients
on hemodialysis have low plasma level of
the branched chain amino acids (BCAA)
leucine, isoleucine, and valine. The
abnormalities in the plasma amino acid
pool can be corrected with appropriate
high-protein supplements. The present
study was designed to evaluate the
effect of a balanced protein nutritional
supplement on the plasma level of BCAA.
Twenty eight CRF patients who received
hemodialysis treatment three times in a
week were enrolled in the trial. The
initial plasma levels of BCAA were as
follows--leucine 15.46 +/- 3.88 mcg/ml,
isoleucine 9.08 +/- 1.97 mcg/ml, and
valine 24.05 +/- 5.06 mcg/ml. For a
period of 6 months the patients received
a balanced nutritional supplement
(58-59% total protein content, leucine--8.6,
isoleucine--4.8, and valine--5.7 g/100 g
protein) on the day of hemodialysis at a
dose 1.0 g/kg body weight. Three months
after beginning of supplementation the
plasma level of BCAA was found to be
elevated--leucine by 36% (P < 0.001),
valine by 30% (P < 0.001), and
isoleucine by 27% (P < 0.001). The
body mass index of the patients was also
above the initial values. The plasma
BCAA levels were maintained high until
the sixth month from the beginning of
trial and even a month after withdrawal
of the supplement. The results obtained
allow us to recommend inclusion of
protein supplements with balanced amino
acid content in the diet of these
patients.
- Language of Publication
- English
- Unique Identifier
- 20247924
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- MeSH Heading (Major)
- Amino Acids, Branched-Chain|*BL;
Dietary Proteins|*AD/TU; Dietary
Supplements|*; Hemodialysis|*
- MeSH Heading
- Adult; Female; Human; Male; Middle Age
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0204-8043
- Country of Publication
- BULGARIA
Record 17 from database: MEDLINE
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- Title
- A metabolic ward study of a high
protein, very-low-energy diet.
- Author
- Wilson JH; Lamberts SW; Swart GR
- Address
-
- Source
- Int J Obes, 1983, 7:4, 345-52
- Abstract
- Seven obese women were placed on a
liquid formula diet providing 560 kcal
(2.4 MJ) and 70 g protein daily and
studied under metabolic ward conditions
for four weeks. The diet was well
tolerated and hunger sensations were
minimal. Mean weight loss was 10.47 kg
for the four weeks. A positive nitrogen
balance was achieved within two weeks in
most patients, but despite this serum
prealbumin levels fell as did the
excretion of 3-methylhistidine in the
urine. Plasma beta-hydroxybutyrate and
urate levels rose during the first two
weeks but remained constant thereafter.
The characteristic decrease in plasma
triiodothyronine levels and increase in
reverse triiodothyronine levels seen
with fasting and other very-low-calorie
diets were also observed with this diet.
Potassium losses were minimal and no
changes in electrocardiograms were seen.
This diet would appear to be an
acceptable, effective and safe means of
achieving rapid weight loss in obesity.
- Language of Publication
- English
- Unique Identifier
- 84031264
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- MeSH Heading (Major)
- Diet, Reducing|*; Dietary
Proteins|*AD; Obesity|*DH
- MeSH Heading
- Adult; Body Weight;
Electrocardiography; Female; Human;
Hydroxybutyrates|BL; Methylhistidines|UR;
Nitrogen|UR; Potassium|BL; Prealbumin|AN;
Triiodothyronine|BL; Uric Acid|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0307-0565
- Country of Publication
- ENGLAND
Record 18 from database: MEDLINE
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- Title
- Double-blind study of the addition of
high-protein soya milk v. cows' milk to
the diet of patients with severe
hypercholesterolaemia and resistance to
or intolerance of statins [see comments]
- Author
- Sirtori CR; Pazzucconi F; Colombo L;
Battistin P; Bondioli A; Descheemaeker K
- Address
- Center E. Grossi Paoletti, Institute
of Pharmacological Sciences, University
of Milan, Italy. cesare.sirtori@unimi.it
- Source
- Br J Nutr, 1999 Aug, 82:2, 91-6
- Abstract
- Total substitution of soyabean protein
for animal protein in the diet has been
repeatedly shown to lower plasma
cholesterol levels in
hypercholesterolaemic individuals. A
new, highly palatable, high-protein soya
drink may allow replacement of a
significant percentage of animal protein
in the diet. The soya drink was given,
within a crossover design v. a cows'
milk preparation of similar composition
and taste, to twenty-one severely
hypercholesterolaemic patients (mean
baseline plasma cholesterol 8.74 mmol/l)
with a history of resistance to or
intolerance of statin treatment. Each
dietary supplement was given for 4
weeks, with a 4-week interval between
treatments, Plasma lipid levels were
monitored every 2 weeks during each
dietary sequence. The concomitant
dietary treatment, which had been
followed for a long time by all
patients, was carefully monitored
throughout the study. The soya
supplementation reduced plasma total
cholesterol level by 6.5%, when given
first, and by 7.4% when given after
cows' milk. When given first, cows' milk
resulted in a small, non-significant
reduction of plasma cholesterol level
(-3.9%), and when given after soya, it
changed total plasma cholesterol to a
minimal extent (-1.6%). Changes in total
and LDL-cholesterol levels after 2 and 4
weeks of soya v. cows' milk treatment
were, thus, respectively -6.1, -7.0 and
-6.2, -7.8% (both P < 0.05). These
first data from a double-blind study
confirm a significant
cholesterol-lowering effect of soyabean
protein, even when only partly replacing
animal protein in the diet, in
individuals with extreme plasma
cholesterol elevations.
- Language of Publication
- English
- Unique Identifier
- 20207883
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- MeSH Heading (Major)
- Cholesterol|*BL;
Hypercholesterolemia|BL/*DH; Milk|*; Soy
Proteins|*TU
- MeSH Heading
- Adult; Aged; Analysis of Variance;
Animal; Cross-Over Studies; Dietary
Supplements; Double-Blind Method;
Female; Human; Hydroxymethylglutaryl-CoA
Reductase Inhibitors|CT; Lipoproteins,
LDL Cholesterol|BL; Male; Middle Age;
Support, Non-U.S. Gov't
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0007-1145
- Country of Publication
- ENGLAND
Record 19 from database: MEDLINE
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- Title
- A high protein, low calorie liquid
diet in the treatment of very obese
adolescents: long-term effect on lean
body mass.
- Author
- Brown MR; Klish WJ; Hollander J;
Campbell MA; Forbes GB
- Address
-
- Source
- Am J Clin Nutr, 1983 Jul, 38:1, 20-31
- Abstract
- The use of Optifast-70, a high protein
liquid diet, when used in the range of
500 to 700 cal over 5 months in very
obese adolescents, was associated with
weight loss of 20 to 25% of initial
weight of which 70 to 75% of the loss
was due to fat. No significant side
effects were noted. Twenty-four hour
electrocardiographic monitoring showed
no significant changes, and linear
growth continued. Lean body mass loss
was 36% of the weight lost during the
first 5 wks, but was only 10% of the
weight lost during the next few months.
Two adolescent males had negative
phosphorus and nitrogen balances over
the first 4 wk, implying that males may
have slightly higher phosphorus,
nitrogen, and calorie requirements.
- Language of Publication
- English
- Unique Identifier
- 83227962
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- MeSH Heading (Major)
- Body Composition|*; Diet|*; Dietary
Proteins|*AD; Energy Intake|*;
Obesity|*DH/ME/PP
- MeSH Heading
- Adolescence; Child; Female; Human;
Male; Support, Non-U.S. Gov't; Support,
U.S. Gov't, Non-P.H.S.; Support, U.S.
Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9165
- Country of Publication
- UNITED STATES
Record 20 from database: MEDLINE
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- Title
- Effects of a high protein
very-low-energy diet on ambulatory
subjects with special reference to
nitrogen balance.
- Author
- Apfelbaum M; Baigts F; Giachetti I;
Serog P
- Address
-
- Source
- Int J Obes, 1981, 5:2, 117-30
- Abstract
- Forty young healthy ambulatory
volunteers were given a very-low-energy
diet (2.34 MJ, 560 kcal) containing 70 g
of proteins of good biological value, 36
g carbohydrates, 2 g potassium, 0.5 g
sodium, polyvitamins and 21 water. The
nitrogen balance reached equilibrium on
the 8th day. No risk factors were found.
These results were compared with 4000
cases collected over 12 years. The
latter were given a protein diet with
neither salt nor carbohydrates. The
addition of salts and carbohydrates
resulted only in an increase of the
subjects' comfort. The analysis of
deaths occurring in the U.S.A. after
protein diets lead to the conclusion
that these very probably linked to the
duration of the protein diet, the poor
biological value of proteins provided,
the insufficiency in potassium intake.
The conditions for a safe use of a
very-low-energy diet, are a large intake
of proteins of good biological value, a
large intake of potassium and probably
small intake of carbohydrates and
sodium.
- Language of Publication
- English
- Unique Identifier
- 81191148
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- MeSH Heading (Major)
- Diet, Reducing|*AE; Dietary
Proteins|AD/*PD; Nitrogen|*UR
- MeSH Heading
- Adolescence; Adult;
Electrocardiography; Energy Intake;
Female; Human; Lipids|BL; Male;
Natriuresis; Nutritive Value;
Potassium|UR; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0307-0565
- Country of Publication
- ENGLAND
Record 21 from database: MEDLINE
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- Title
- Toxic optic neuropathy after
concomitant use of melatonin, zoloft,
and a high-protein diet.
- Author
- Lehman NL; Johnson LN
- Address
- Neuro-ophthalmology Unit, Mason Eye
Institute, University of
Missouri-Columbia, USA.
- Source
- J Neuroophthalmol, 1999 Dec, 19:4,
232-4
- Abstract
- Melatonin is a neuromodulating hormone
found in the pineal gland and retina. It
is involved in light-dark circadian
rhythms and mediates retinal processes
in a manner antagonistic to that of
dopamine. Zoloft (sertraline) is an
antidepressant drug that blocks the
reuptake of serotonin at the neural
synapse. Serotonin is the natural
precursor of melatonin. A 42-year-old
woman sought treatment for visual acuity
loss, dyschromatopsia, and altered light
adaptation. Neuro-ophthalmologic
examination was otherwise normal except
for evolving bilateral cecocentral
scotomas. She had taken Zoloft for 4
years and began a high-protein diet with
melatonin supplementation 2 weeks before
onset of visual symptoms. Visual acuity
and color vision improved within 2
months after melatonin and the
high-protein diet were discontinued.
Combined use of melatonin, Zoloft, and a
high-protein diet may have resulted in
melatonin/dopamine imbalance in the
retina, manifesting as a toxic optic
neuropathy. Physicians and patients
should be alerted to this potential drug
interaction.
- Language of Publication
- English
- Unique Identifier
- 20074385
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- MeSH Heading (Major)
- Antidepressive Agents|*AE; Dietary
Proteins|*AD/*AE; Melatonin|*AE; Optic
Nerve Diseases|*CI/CO/DI/PP; Sertraline|*AE
- MeSH Heading
- Adaptation, Ocular|DE; Adult; Case
Report; Color Vision Defects|ET; Female;
Human; Magnetic Resonance Imaging; Optic
Nerve|PA; Scotoma|ET; Support, Non-U.S.
Gov't; Visual Acuity|DE
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 1070-8022
- Country of Publication
- UNITED STATES
Record 22 from database: MEDLINE
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- Title
- Randomized controlled trial of a low
animal protein, high fiber diet in the
prevention of recurrent calcium oxalate
kidney stones.
- Author
- Hiatt RA; Ettinger B; Caan B;
Quesenberry CP Jr; Duncan D; Citron JT
- Address
- Division of Research, Kaiser
Permanente Medical Care Program,
Oakland, CA 94611-5714, USA.
- Source
- Am J Epidemiol, 1996 Jul, 144:1, 25-33
- Abstract
- Low protein diets are commonly
prescribed for patients with idiopathic
calcium nephrolithiasis, who account for
> 80% of new diagnoses of kidney
stones. This dietary advice is supported
by metabolic studies and epidemiologic
observational studies but has not been
evaluated in a controlled trial. Using
1983-1985 data from three Northern
California Kaiser Permanente Medical
Centers, the authors randomly assigned
99 persons who had calcium oxalate
stones for the first time to a low
animal protein, high fiber diet that
contained approximately 56-64 g daily of
protein, 75 mg daily of purine
(primarily from animal protein and
legumes), one-fourth cup of wheat bran
supplement, and fruits and vegetables.
Intervention subjects were also
instructed to drink six to eight glasses
of liquid daily and to maintain adequate
calcium intake from dairy products or
calcium supplements. Control subjects
were instructed only on fluid intake and
adequate calcium intake. Both groups
were followed regularly for up to 4.5
years with food frequency
questionnaires, serum and urine
chemistry analysis, and abdominal
radiography; and they were urged to
comply with dietary instructions. In the
intervention group of 50 subjects,
stones recurred in 12 (7.1 per 100
person-years) compared with two (1.2 per
100 person-years) in the control group;
both groups received a mean of 3.4
person-years of follow-up (p = 0.006).
After adjustment for possible
confounding effects of age, sex,
education, and baseline protein and
fluid intake, the relative risk of a
recurrent stone in the intervention
group was 5.6 (95% confidence interval
1.2-26.1) compared with the control
group. The authors conclude that advice
to follow a low animal protein, high
fiber, high fluid diet has no advantage
over advice to increase fluid intake
alone.
- Language of Publication
- English
- Unique Identifier
- 96259460
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- MeSH Heading (Major)
- Calcium Oxalate|*CH; Diet,
Protein-Restricted|*; Dietary Fiber|*AD;
Kidney Calculi|BL/CH/*DH/UR
- MeSH Heading
- Adult; Female; Fluid Therapy;
Follow-Up Studies; Human; Male;
Recurrence; Risk; Risk Factors; Support,
Non-U.S. Gov't
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0002-9262
- Country of Publication
- UNITED STATES
Record 23 from database: MEDLINE
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- Title
- Urinary calcium loss in elderly men on
a vegetable:animal (1:1) high-protein
diet.
- Author
- Moriguti JC; Ferriolli E; Marchini JS
- Address
- Division of General Internal and
Geriatric Medicine, Department of
Internal Medicine, School of Medicine of
RibeirÃao Preto, SÃao Paulo
University, RibeirÃao Preto, SP Brazil.
- Source
- Gerontology, 1999 Sep, 45:5, 274-8
- Abstract
- BACKGROUND: A high purified protein
intake has been shown to induce urinary
calcium loss. However, these findings
could not be reproduced with a
high-protein meat diet. Also, most
studies have been carried out in young
subjects and the applicability of their
results to the elderly population on a
mixed vegetable:animal diet remains
unclear. OBJECTIVES: To study whether a
mixed vegetable:animal high-protein
intake increases urinary calcium loss in
elderly volunteers, as has been shown
for younger subjects on a purified
high-protein intake. METHODS: Eight male
volunteers, with ages ranging from 66 to
88 years, recruited from the University
Hospital Geriatric Medicine Outpatients
Clinic, were studied. 24-hour urinary
calcium, phosphorus, and creatinine were
measured during a period of usual
protein intake (approximately 0.6
g/kg/day) and during 7 days of
vegetable:animal (1:1) high-protein
intake (2 g/kg/day). Calcium and
phosphorus intake were adjusted to be
kept constant (1 g/day of each) during
the whole study. RESULTS: Mean calcium
urinary levels did not change
significantly during the study (1.89 and
1.83 mmol/24 h during the usual and
high-protein diet, respectively).
Urinary phosphorus and creatinine levels
also remained stable throughout the
entire study. CONCLUSIONS: This study
has not detected any increased calcium
urinary excretion in male elderly
volunteers submitted to the mixed
vegetable:animal high-protein diet.
Therefore, it does not support the
suggestion that a high-protein intake is
a risk factor for urinary calcium loss
in elderly men.
- Language of Publication
- English
- Unique Identifier
- 99391727
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- MeSH Heading (Major)
- Calcium|*UR; Dietary Proteins|*AD
- MeSH Heading
- Age Factors; Aged; Aged, 80 and over;
Ascorbic Acid|BL; Beta Carotene|BL; Body
Mass Index; Calcium, Dietary|AD;
Creatine|DE/UR; Folic Acid|BL; Human;
Male; Phosphorus, Dietary|AD; Skinfold
Thickness; Support, Non-U.S. Gov't;
Vitamin A|BL
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE
- ISSN
- 0304-324X
- Country of Publication
- SWITZERLAND
Record 24 from database: MEDLINE
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- Title
- Urinary calcium loss in elderly men on
a vegetable:animal (1:1) high-protein
diet.
- Author
- Moriguti JC; Ferriolli E; Marchini JS
- Address
- Division of General Internal and
Geriatric Medicine, Department of
Internal Medicine, School of Medicine of
RibeirÃao Preto, SÃao Paulo
University, RibeirÃao Preto, SP Brazil.
- Source
- Gerontology, 1999 Sep, 45:5, 274-8
- Abstract
- BACKGROUND: A high purified protein
intake has been shown to induce urinary
calcium loss. However, these findings
could not be reproduced with a
high-protein meat diet. Also, most
studies have been carried out in young
subjects and the applicability of their
results to the elderly population on a
mixed vegetable:animal diet remains
unclear. OBJECTIVES: To study whether a
mixed vegetable:animal high-protein
intake increases urinary calcium loss in
elderly volunteers, as has been shown
for younger subjects on a purified
high-protein intake. METHODS: Eight male
volunteers, with ages ranging from 66 to
88 years, recruited from the University
Hospital Geriatric Medicine Outpatients
Clinic, were studied. 24-hour urinary
calcium, phosphorus, and creatinine were
measured during a period of usual
protein intake (approximately 0.6
g/kg/day) and during 7 days of
vegetable:animal (1:1) high-protein
intake (2 g/kg/day). Calcium and
phosphorus intake were adjusted to be
kept constant (1 g/day of each) during
the whole study. RESULTS: Mean calcium
urinary levels did not change
significantly during the study (1.89 and
1.83 mmol/24 h during the usual and
high-protein diet, respectively).
Urinary phosphorus and creatinine levels
also remained stable throughout the
entire study. CONCLUSIONS: This study
has not detected any increased calcium
urinary excretion in male elderly
volunteers submitted to the mixed
vegetable:animal high-protein diet.
Therefore, it does not support the
suggestion that a high-protein intake is
a risk factor for urinary calcium loss
in elderly men.
- Language of Publication
- English
- Unique Identifier
- 99391727
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- MeSH Heading (Major)
- Calcium|*UR; Dietary Proteins|*AD
- MeSH Heading
- Age Factors; Aged; Aged, 80 and over;
Ascorbic Acid|BL; Beta Carotene|BL; Body
Mass Index; Calcium, Dietary|AD;
Creatine|DE/UR; Folic Acid|BL; Human;
Male; Phosphorus, Dietary|AD; Skinfold
Thickness; Support, Non-U.S. Gov't;
Vitamin A|BL
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE
- ISSN
- 0304-324X
- Country of Publication
- SWITZERLAND
Record 25 from database: MEDLINE
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- Title
- Respiratory insufficiency in acid
maltase deficiency: the effect of high
protein diet.
- Author
- Demey HE; Van Meerbeeck JP; Vandewoude
MF; Prové AM; Martin JJ; Bossaert LL
- Address
- Department of Intensive Care,
University of Antwerp UIA, University
Hospital, Belgium.
- Source
- JPEN J Parenter Enteral Nutr, 1989
May, 13:3, 321-3
- Abstract
- A 27-yr-old woman with the myopathic
form of acid maltase deficiency (AMD)
developed severe respiratory
insufficiency after a crash diet
resulting in a 6-kg weight loss. While
being maintained on home ventilation, an
hypercaloric high-protein,
low-carbohydrate diet (1800-2000 cal;
28% carbohydrates, 55% fat, 17% protein
with 1.7 g protein/kg body weight) was
instituted. This ameliorated her
condition up to a level where useful
life was possible and ventilation could
be diminished.
- Language of Publication
- English
- Unique Identifier
- 89342802
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- MeSH Heading (Major)
- Diet Fads|*AE; Dietary Proteins|*AD;
Glucan 1,4-alpha-Glucosidase|*DF;
Glycogen Storage Disease Type II|*TH;
Respiratory Insufficiency|*ET
- MeSH Heading
- Adult; Case Report; Female; Human
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0148-6071
- Country of Publication
- UNITED STATES
Record 26 from database: MEDLINE
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- Title
- Effects of a high-protein diet in acid
maltase deficiency.
- Author
- Padberg GW; Wintzen AR; Giesberts MA;
Sterk PJ; Molenaar AJ; Hermans J
- Address
- Department of Neurology, State
University of Leiden, The Netherlands.
- Source
- J Neurol Sci, 1989 Mar, 90:1, 111-7
- Abstract
- The effects of a high-protein diet
were studied in 5 adult cases of acid
maltase deficiency. Measurements of
muscle strength, pulmonary function and
3-methylhistidine excretion revealed no
improvement consistently attributable to
the diet.
- Language of Publication
- English
- Unique Identifier
- 89257435
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- MeSH Heading (Major)
- Dietary Proteins|*TU; Glucan
1,4-alpha-Glucosidase|*DF; Muscular
Diseases|DH/*EN/PP
- MeSH Heading
- Female; Human; Male; Middle Age; Vital
Capacity
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-510X
- Country of Publication
- NETHERLANDS
Record 27 from database: MEDLINE
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- Title
- Improvement in protein absorption with
a small-peptide-based diet in patients
with high jejunostomy.
- Author
- Cosnes J; Evard D; Beaugerie L; Gendre
JP; Le Quintrec Y
- Address
- Service d'Hepatogastroenterologie et
de Nutrition, HÈopital Rothschild,
Paris, France.
- Source
- Nutrition, 1992 Nov, 8:6, 406-11
- Abstract
- We compared urinary and fecal
excretions of fluid, electrolytes, and
nutrients in six patients with a high
jejunostomy during three randomized
consecutive 3-day periods of total
enteral nutrition with three diets
differing only by the degree of
hydrolysis of the protein moiety: whole
proteins, their hydrolysate (63%
nitrogen as small peptides with <
1000 M), and the two mixed together.
Daily nitrogen absorption was
significantly enhanced with the
small-peptide and mixed diets (14.3 +/-
3.4 and 13.1 +/- 2 g, respectively)
compared with the whole protein diet
(10.9 +/- 2.4 g, p = 0.012).
Concomitantly, blood urea nitrogen and
urinary urea excretion increased with
the small-peptide diet. Apparent
absorption of fat and calories, fecal
weight, and urinary and fecal excretions
of sodium, potassium, calcium, and
magnesium remained unchanged. We
conclude that a small-peptide-based diet
may be beneficial in patients with
short-bowel syndrome.
- Language of Publication
- English
- Unique Identifier
- 93136601
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- MeSH Heading (Major)
- Dietary Proteins|AD/*ME; Intestinal
Absorption|*; Jejunostomy|*/AE;
Peptides|AD/*ME; Short Bowel Syndrome|ET/*ME
- MeSH Heading
- Aged; Blood Urea Nitrogen; Dietary
Fats|ME; Energy Intake; Enteral
Nutrition; Female; Human; Male; Middle
Age; Minerals|ME; Nitrogen|ME; Urea|UR
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0899-9007
- Country of Publication
- UNITED STATES
Record 28 from database: MEDLINE
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- Title
- The effect of a high protein-low
calorie diet on the energy expenditure
of obese adolescents.
- Author
- Stallings VA; Pencharz PB
- Address
- Division of Gastroenterology and
Nutrition, Children's Hospital of
Philadelphia, PA 19104.
- Source
- Eur J Clin Nutr, 1992 Dec, 46:12,
897-902
- Abstract
- Resting energy expenditure (REE), and
body composition, as fat-free mass (FFM)
and fat mass, were determined in seven
obese adolescents before and after
weight loss of a mean 13.5 kg on an
approximately 800 kcal/d (3349 kJ), high
protein reducing diet regimen. Ideal
body weight decreased from 166% to 142%
in 8 weeks. There were no significant
changes in total body potassium (TBK),
extracellular water (ECW), intracellular
water (ICW) or total body water (TBW)
with weight loss. The REE (kcal/d) fell
from 2034 +/- 392 (8514 +/- 1641 kJ) to
1762 +/- 453 (7376 +/- 1896 kJ) with
weight loss (P < 0.05). However, when
the REE was expressed as kcal/body
weight there was no difference between
before and after weight loss, 21.4 +/-
2.8 (90 +/- 21 kJ) and 21.6 +/- 4.5 (90
+/- 19 kJ). Similarly, when REE was
examined in relation to FFM (kcal/kg)
before and after weight loss, there were
also no significant differences: 34.6
+/- 5.1 (145 +/- 21 kJ) and 32.1 +/- 7.9
(134 +/- 33 kJ).
- Language of Publication
- English
- Unique Identifier
- 93130840
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- MeSH Heading (Major)
- Adolescent Nutrition|*; Diet,
Reducing|*ST; Dietary Proteins|*AD;
Energy Intake|*; Energy Metabolism|*;
Obesity|*DH/ME/PC
- MeSH Heading
- Adolescence; Body Composition; Body
Height; Body Weight; Child; Evaluation
Studies; Female; Human; Male; Support,
Non-U.S. Gov't; Weight Loss
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0954-3007
- Country of Publication
- ENGLAND
Record 29 from database: MEDLINE
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- Title
- High protein diet complements resin
therapy of familial
hypercholesterolemia.
- Author
- Wolfe BM; Giovannetti PM
- Address
- Department of Medicine, University of
Western Ontario, London.
- Source
- Clin Invest Med, 1992 Aug, 15:4,
349-59
- Abstract
- The intermediate-term effects on
plasma lipoprotein lipids of
substituting meat and dairy protein for
carbohydrate in the diets of five
subjects (three women, two men) with
familial hypercholesterolemia receiving
cholestyramine (mean dose, 18 g/d) were
studied. Subjects were randomly
allocated to either the high or low
protein diets (mean 27 versus 10% of
energy as protein, 25% as fat, and 48
versus 65% as carbohydrate) for 4 to 5
weeks and then switched to the other
diet for another 4 to 5 weeks. Mean
fasting plasma HDL cholesterol rose
significantly by 17 +/- 3% (1.11 +/-
0.12 vs 0.95 +/- 0.11 mmol/L, p less
than 0.005, n = 5), whereas total
triglycerides fell by 23 +/- 2% (1.7 +/-
0.3 vs 2.2 +/- 0.3 mmol/L, p less than
0.005, n = 5), VLDL triglycerides fell
by 28 +/- 5% (0.88 +/- 0.15 vs 1.18 +/-
0.19 mmol/L, p less than 0.02, n = 5),
VLDL cholesterol fell by 32 +/- 7% (0.39
+/- 0.08 vs 0.56 +/- 0.09 mmol/L, p less
than 0.01, n = 5), the ratio of LDL
cholesterol: HDL cholesterol by 19 +/-
5% (4.7 +/- 0.7 vs 5.7 +/- 0.7, p less
than 0.05) and that of total
cholesterol: HDL cholesterol by 16 +/-
5% (6.6 +/- 0.5 vs 8.0 +/- 0.7, p less
than 0.05) on the high versus low
protein diet. Increasing dietary protein
intake at the expense of carbohydrate
may be useful in treating
hypoalphalipoproteinemia and/or
hypertriglyceridemia in patients with
familial hypercholesterolemia.
- Language of Publication
- English
- Unique Identifier
- 92386813
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- MeSH Heading (Major)
- Cholestyramine|*TU; Dietary
Proteins|*AD; Hypercholesterolemia,
Familial|*TH
- MeSH Heading
- Adult; Cholesterol|BL; Dietary
Carbohydrates|AD; Energy Intake; Female;
Human; Lipoproteins, HDL Cholesterol|BL;
Lipoproteins, LDL Cholesterol|BL;
Lipoproteins, VLDL|BL; Male; Middle Age;
Support, Non-U.S. Gov't;
Triglycerides|BL
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0147-958X
- Country of Publication
- CANADA
Record 30 from database: MEDLINE
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- Title
- Indications that branched chain amino
acids, in addition to glucagon, affect
the glomerular filtration rate after a
high protein diet in insulin-dependent
diabetes.
- Author
- Rudberg S; Dahlqvist G; Aperia A;
Lindblad BS; Efendic S; Skottner A;
Persson B
- Address
- Department of Pediatrics St. GÂoran's
Hospital, Stockholm, Sweden.
- Source
- Diabetes Res, 1991 Mar, 16:3, 101-9
- Abstract
- Hormonal changes and whole blood free
amino acid levels and their relation to
renal function were measured in 12
insulin-dependent diabetic patients
after two 10-day periods with a diet
consisting of 10% and 20% respectively
of the energy as protein. The patients
were 15-21 years old and mean duration
of diabetes was 12 (5-20) years.
Glomerular filtration rate, renal plasma
flow, and albumin excretion rate were
measured together with plasma
concentrations of glucagon, growth
hormone, insulin-like growth factor 1
(IGF-1), somatostatin, serum insulin and
free amino acids in blood. Glomerular
filtration rate was 123 +/- 3
ml/min/1.73 m2 on high protein diet and
113 +/- 3 ml/min/1.73 m2 on low protein
diet (p = 0.02). Renal plasma flow was
unchanged. Glucagon, IGF-1, branch
chained amino acids (BCAA), tyrosine,
phenylalanine, lysine, and methionine
were increased after the high protein
diet. Growth hormone, somatostatin,
insulin, and other amino acids remained
unchanged. The increase in glomerular
filtration rate was significantly
correlated to the increase in glucagon,
isoleucine, and valine (glucagon r =
0.71, p = 0.01, isoleucine r = 0.59, p =
0.04, valine r = 0.62, p = 0.03). In a
multiple regression model the increase
in glomerular filtration correlated most
strongly to the increase in isoleucine,
followed by valine and glucagon.
Together these variables explained 88%
of the total variance of the change in
glomerular filtration rate (r2 = 0.88, p
= 0.001). Albumin excretion rate was
correlated to IGF-1 (r = 0.86, p less
than 0.001) on the high protein
diet.(ABSTRACT TRUNCATED AT 250 WORDS)
- Language of Publication
- English
- Unique Identifier
- 92200780
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- MeSH Heading (Major)
- Amino Acids, Branched-Chain|*BL;
Diabetes Mellitus, Insulin-Dependent|BL/*PP;
Dietary Proteins|*; Glomerular
Filtration Rate|*; Glucagon|*BL
- MeSH Heading
- Adolescence; Adult; Albuminuria;
Biological Markers|BL; Blood Glucose|ME;
Blood Pressure; Circadian Rhythm;
Eating; Female; Hexosamines|BL; Human;
Insulin-Like Growth Factor I|ME; Male;
Renal Circulation; Somatotropin|BL;
Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0265-5985
- Country of Publication
- SCOTLAND
Record 31 from database: MEDLINE
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- Title
- Effect of a high protein diet in
patients with the nephrotic syndrome.
- Author
- Mansy H; Goodship TH; Tapson JS;
Hartley GH; Keavey P; Wilkinson R
- Address
- Department of Nephrology, Freeman
Hospital, University of Newcastle upon
Tyne, U.K.
- Source
- Clin Sci, 1989 Oct, 77:4, 445-51
- Abstract
- 1. Twelve patients with the nephrotic
syndrome were prescribed for 4 week
periods a normal protein diet (NPD)
containing 1 g of protein/kg ideal body
weight. They were then prescribed for
further 4 week periods in random order
diets with high (HPD) and low (LPD)
protein contents, respectively 2.0 and
0.5 g/kg ideal body weight. 2.
Compliance was confirmed by dietary
history and measurement of urinary
excretion. 3. Serum albumin was the same
on all diets. Twenty-four hour urinary
protein excretion increased
progressively with increasing dietary
protein (LPD 6.1 g. NPD 8.2 g. HPD 9.2
g). Recumbent plasma renin activity and
serum phosphate were significantly
increased on HPD (plasma renin activity:
LPD 5.7, NPD 4.6, HPD 8.2 pmol of
angiotensin I min-1 1(-1); serum
phosphate: LPD 1.27, NPD 1.26, HPD 1.41
mmol/l). 4. There was no evidence of
protein-induced hyperfiltration or
hyperperfusion:
51Cr-ethylenediaminetetra-acetate and
[125I]iodohippurate clearances were
similar on all three diets. 5. Since
proteinuria, increased plasma renin
levels and hyperphosphataemia may
contribute to progression of renal
failure and because HPD did not improve
hypoalbuminaemia, the use of HPD in the
nephrotic syndrome should be abandoned.
6. Until it can be established that LPD,
which is accompanied by the least
proteinuria, does not, with long-term
feeding, lead to malnutrition, NPD
should be used in the treatment of the
nephrotic syndrome.
- Language of Publication
- English
- Unique Identifier
- 90031380
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- MeSH Heading (Major)
- Dietary Proteins|*AD; Nephrotic
Syndrome|*DH/ME
- MeSH Heading
- Adult; Aged; Blood Proteins|ME;
Creatinine|BL; Female; Human; Male;
Middle Age; Phosphates|ME; Serum
Albumin|ME; Support, Non-U.S. Gov't;
Urea|BL
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0143-5221
- Country of Publication
- ENGLAND
Record 32 from database: MEDLINE
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- Title
- Beneficial effects of high protein
diet in treatment of mild diabetes.
- Author
- Seino Y; Seino S; Ikeda M; Matsukura
S; Imura H
- Address
-
- Source
- Hum Nutr Appl Nutr, 1983 Jun, 37 A:3,
226-30
- Abstract
- The effects of a high protein diet on
blood glucose and plasma insulin levels
in mild diabetic patients were
investigated. Fifteen untreated diabetic
patients were given a balanced diet for
ten days; they were then divided into
two groups: nine received a high protein
diet for eight days while the other six
received a high carbohydrate diet for
the same period. At the beginning of the
study, blood glucose rose significantly
following oral glucose loading, while an
impaired insulin response was observed.
After the balanced diet period, fasting
blood glucose decreased significantly
and the insulin response improved
slightly. Following the high protein
diet, glucose intolerance was abated
considerably and the insulin response
was augmented significantly, however,
following the high carbohydrate diet
there was no significant difference in
glucose or insulin response to oral
glucose loading from the measurements
taken after the balanced diet period.
The high protein diet produced a
relative improvement in plasma insulin
responses for the blood glucose levels
attained following the meal. It was
concluded that a high protein diet is a
beneficial therapy for mild diabetic
patients.
- Language of Publication
- English
- Unique Identifier
- 83265118
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- MeSH Heading (Major)
- Diabetes Mellitus|BL/*DH; Dietary
Proteins|*AD
- MeSH Heading
- Adult; Aged; Circadian Rhythm; Female;
Glucose Tolerance Test; Human;
Insulin|BL; Male; Middle Age; Time
Factors
- Publication Type
- JOURNAL ARTICLE
- Country of Publication
- ENGLAND
Record 33 from database: MEDLINE
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- Title
- Changes in intraventricular septal
thickness, left ventrical wall thickness
and left ventricular volume in obese
adolescents on a high protein weight
reducing diet.
- Author
- Archibald EH; Stallings VA; Pencharz
PB; Duncan WJ; Williams C
- Address
- Hospital for Sick Children, Department
of Pediatrics, University of Toronto,
Ontario, Canada.
- Source
- Int J Obes, 1989, 13:3, 265-9
- Abstract
- Ten obese adolescents (153 percent
ideal body weight) underwent significant
weight reduction over a two to three
month period using a low calorie, low
carbohydrate, protein diet. The subjects
lost a mean of 13.9 +/- 4.3 kg,
representing a decrease of 15.5 +/- 5.0
percent of initial body weight. Serial
measures of intraventricular septal
thickness (ST), left ventricular wall
thickness (LVWT) and left ventricular
volume (LVV) were determined by standard
m-mode echocardiographic methods over 14
weeks to determine the effect of weight
reduction on these indicators of cardiac
size. The ST changed over the study
period from 8.2 +/- 1.9 mm to 7.3 +/-
2.0 mm; the LVWT from 7.6 +/- 1.8 mm to
6.3 +/- 1.1 mm; and the LVV from 47.1
+/- 4.0 mm to 42.0 +/- 2.8 mm. These
numerical decreases were not
significantly different. Over this study
period, the diet allowed weight loss
with no apparent effect on the cardiac
size (ST, LVWT, LVV) as measured by
echocardiography in these obese
adolescents.
- Language of Publication
- English
- Unique Identifier
- 89358443
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- MeSH Heading (Major)
- Myocardium|*PA; Obesity|*DH/PA
- MeSH Heading
- Adolescence; Cardiac Volume; Child;
Diet, Reducing; Echocardiography;
Female; Heart Ventricle; Human; Male;
Support, Non-U.S. Gov't; Weight Loss
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0307-0565
- Country of Publication
- ENGLAND
Record 34 from database: MEDLINE
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- Title
- Specific dynamic action of a
high-protein diet and its significance
for thermoregulation in the golden
hamster.
- Author
- Simek V
- Address
-
- Source
- Physiol Bohemoslov, 1975 Sep, 24:5,
421-4
- Abstract
- As a result of the specific dynamic
action of a high-protein diet the
resting metabolism of golden hamsters
within the zone of thermoneutrality is
increased on a average by 40%. The
specific dynamic action diminishes
markedly, with declining environmental
temperature. It is concluded from this
results that part of the heat produced
by the specific dynamic action of a
high-protein diet leads to a rise in the
lower critical temperature in the zone
of thermoneutrality by 2 degrees C.
- Language of Publication
- English
- Unique Identifier
- 76053573
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- MeSH Heading (Major)
- Body Temperature Regulation|*DE;
Dietary Proteins|*AD; Hamsters|*PH
- MeSH Heading
- Adaptation, Physiological; Animal;
Environmental Exposure; Human; Male;
Mice; Oxygen Consumption; Rabbits;
Swine|PH
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0369-9463
- Country of Publication
- CZECHOSLOVAKIA
Record 35 from database: MEDLINE
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- Title
- Absorption of macronutrients from a
high-protein diet in children during
convalescence from shigellosis.
- Author
- Kabir I; Malek MA; Mahalanabis D;
Rahman MM; Khatun M; Wahed MA; Majid N
- Address
- International Centre for Diarrhoeal
Disease Research, Dhaka, Bangladesh.
- Source
- J Pediatr Gastroenterol Nutr, 1994
Jan, 18:1, 63-7
- Abstract
- Absorption of macronutrients and
energy intake were determined in 29
children aged 24-59 months, during
convalescence from acute shigellosis. A
72 h metabolic balance study was
performed to determine the absorption of
carbohydrate, fat, and protein. Eighteen
children received a high-protein (5
g/kg/day) diet, and 11 children received
a standard-protein (2.5 g/kg/day) diet.
The mean +/- SD energy intake was 612
+/- 38 kJ/kg/day for children receiving
the high-protein diet, compared with 633
+/- 50 kJ/kg/day for the
standard-protein group. The coefficient
of carbohydrate absorption was 89 and
92% for the high-protein and
standard-protein diets, respectively (p
= 0.059). The coefficient of protein
absorption was 80 and 71% for the
high-protein and standard-protein
groups, respectively, and was
significantly higher in the high-protein
group (p < 0.01). Absorption of fat
was similar in both groups. The results
of the study show better absorption of
protein from a high-protein diet during
convalescence, which may have a positive
impact on catch-up growth of children
suffering from shigellosis.
- Language of Publication
- English
- Unique Identifier
- 94172518
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- MeSH Heading (Major)
- Dietary Proteins|*AD/ME; Dysentery,
Bacillary|*DH/ME; Intestinal
Absorption|*
- MeSH Heading
- Child, Preschool; Dietary
Carbohydrates|AD/ME; Dietary Fats|AD/ME;
Energy Intake; Feces; Human; Male;
Nitrogen|ME/UR; Support, U.S. Gov't,
Non-P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0277-2116
- Country of Publication
- UNITED STATES
Record 36 from database: MEDLINE
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- Title
- High protein, saturated fat and
cholesterol diet, and low levels of
serum lipids in colorectal cancer.
- Author
- Trichopoulou A; Tzonou A; Hsieh CC;
Toupadaki N; Manousos O; Trichopoulos D
- Address
- Department of Nutrition and
Biochemistry, Athens School of Public
Health; University of Athens, Greece.
- Source
- Int J Cancer, 1992 May, 51:3, 386-9
- Abstract
- In a case-control study probing the
role of diet on the occurrence of
colorectal cancer and undertaken in
Athens, Greece, sera were collected from
100 cases and 100 controls, and serum
total cholesterol,
high-density-lipoprotein (HDL)
cholesterol and triglycerides were
determined. The biochemical results were
analyzed in conjunction with nutrient
intakes and a dietary score that
summarizes in a linear way the dietary
contrast between high-risk (high
protein, saturated fat and dietary
cholesterol; low vegetable) and low-risk
(low protein, saturated fat and
cholesterol; high vegetable) patterns.
Cases with colorectal cancer had
significantly (p less than 0.001) and
substantially lower values of serum
total cholesterol and particularly HDL
cholesterol, but these associations did
not reflect dietary practices, since
protein intake and, to a lesser (and
nonsignificant) extent, saturated fat
and dietary cholesterol intake were
higher among cases than among controls.
In absolute terms, the dietary effect
(as summarized in the linear dietary
score) is more evident among persons
with low serum total cholesterol and HDL
cholesterol than among those with high
levels of these serum lipids. These
results indicate that a diet beneficial
with respect to the risk of coronary
heart disease is also likely to reduce
the risk of colorectal cancer, even
though low levels of serum total
cholesterol and particularly HDL
cholesterol represent important
independent correlates of clinically
overt colorectal cancer.
- Language of Publication
- English
- Unique Identifier
- 92275849
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- MeSH Heading (Major)
- Cholesterol|*BL; Colonic Neoplasms|*BL;
Food Habits|*; Rectal Neoplasms|*BL
- MeSH Heading
- Aged; Case-Control Studies;
Cholesterol, Dietary|AD; Dietary Fats|AD;
Dietary Proteins|AD; Fatty Acids|AD;
Female; Human; Lipoproteins, HDL
Cholesterol|BL; Male; Middle Age;
Support, Non-U.S. Gov't;
Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0020-7136
- Country of Publication
- UNITED STATES
Record 37 from database: MEDLINE
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- Title
- Absence of cardiac arrhythmias during
a very-low-calorie diet with high
biological quality protein.
- Author
- Linet OI; Butler D; Caswell K; Metzler
C; Reele SB
- Address
-
- Source
- Int J Obes, 1983, 7:4, 313-20
- Abstract
- Fourteen women who were at least 50 lb
(22.7 kg) overweight entered the 15 week
study which included 4 weeks of 1200 cal
(5028 J) balanced diet followed by 7
weeks on a very-low-calorie diet (VLCD)
and 4 weeks of refeeding. During the
VLCD high biological quality protein
(poultry, fish) and recommended
supplements of vitamins, minerals and
water were used. With the exception of
week 5 and 14, 25-h Holter monitorings
were done weekly. During the initial 4
weeks, 2 patients showed disturbances of
cardiac rhythm and were discharged from
the study. Twelve patients completed the
trial without any clinically significant
changes in cardiac rhythm. The 12 lead
ECGs remained normal in all patients
throughout the study. The average weight
loss was 46 lb (20.9 kg) and the whole
program was well tolerated. It is
concluded that seven weeks of VLCD with
high biological quality protein and
recommended supplements appears to be a
safe method for weight reduction for
severely obese patients.
- Language of Publication
- English
- Unique Identifier
- 84031260
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- MeSH Heading (Major)
- Arrhythmia|*ET; Diet, Reducing|*;
Obesity|*DH
- MeSH Heading
- Adult; Blood Pressure; Body Weight;
Dietary Proteins|AD;
Electrocardiography; Female; Human;
Middle Age; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0307-0565
- Country of Publication
- ENGLAND
Record 38 from database: MEDLINE
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- Title
- A hypocaloric high-protein diet as
primary therapy for adults with
obesity-related diabetes: effective
long-term use in a community hospital.
- Author
- Fitz JD; Sperling EM; Fein HG
- Address
-
- Source
- Diabetes Care, 1983 Jul, 6:4, 328-33
- Abstract
- The use of reducing diets as the sole
therapy for the long-term management of
obese diabetic patients has been
generally unsuccessful. Most previous
attempts took place with a few patients
in university hospital clinical research
centers. We placed 36 such patients on a
hypocaloric high-protein food diet,
consisting of 1.7-2.0 g protein/kg ideal
body wt, during admission to a community
hospital. After beginning this diet,
patients could be weaned from
sliding-scale regular insulin in an
average of 1.9 days. Patients remained
on this diet after discharge (mean
hospital stay = 4.3 days), and complex
carbohydrates were gradually added up to
80 g daily. Outpatient long-term
management consisted of alternating
biweekly visits to a sole nurse
practitioner or physician or to a group
discussion meeting. Follow-up averaged
41 wk, during which eight patients (22%)
had sustained weight loss throughout and
remained euglycemic. Twenty patients
(56%) initially lost weight (average:
23% of ideal body weight), then
plateaued weight, but have also remained
euglycemic. Only eight patients, (22%)
required insulin. Side effects of the
diet were not serious in any patient; no
one had myocardial irritability or serum
potassium less than 2.9 meq/L. This
hypocaloric high-protein diet thus
appears to be a generally successful
means of weaning obese diabetic adult
patients from insulin. This can be done
rapidly, safely, and permanently in the
community. Such diet therapy appears to
require minimal laboratory and hospital
resources that are available to all
health care providers.
- Language of Publication
- English
- Unique Identifier
- 84003858
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- MeSH Heading (Major)
- Diabetes Mellitus|*DH; Diabetes
Mellitus, Non-Insulin-Dependent|*DH;
Dietary Proteins|AD/AE/*TU; Obesity in
Diabetes|*DH
- MeSH Heading
- Adult; Blood Glucose|AN; Diet,
Reducing; Female; Human; Male; Middle
Age; Time Factors; Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0149-5992
- Country of Publication
- UNITED STATES
Record 39 from database: MEDLINE
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- Title
- Increased height gain of children fed
a high-protein diet during convalescence
from shigellosis: a six-month follow-Up
study.
- Author
- Kabir I; Rahman MM; Haider R; Mazumder
RN; Khaled MA; Mahalanabis D
- Address
- International Centre for Diarrhoeal
Disease Research, Bangladesh (ICDDR,B)
Dhaka 1000, Bangladesh.
- Source
- J Nutr, 1998 Oct, 128:10, 1688-91
- Abstract
- The impact of dietary supplementation
on catch-up growth was evaluated in 69
malnourished children ages 24-60 mo
after recovery from shigellosis. They
were fed either a high-protein (HP) diet
with 15% of energy as protein, or a
standard-protein (SP) diet with 7.5%
energy as protein, for 3 wk in a
metabolic study ward. Children were
followed up bi-weekly for 6 mo by
trained health assistants when
anthropometric measurements and
information of any illness were
collected. Thirty-one children in the HP
group and 28 children in the SP group
completed 6-mo follow-up. The increase
in height (mean +/- SD) was 5.3 +/- 1.0
cm vs. 4.1 +/- 1.1 cm for HP and SP
groups, respectively (P < 0.001),
whereas increase in body weight was 1.39
+/- 0.58 and 1.29 +/- 0.72 kg for
children fed HP and SP, respectively (P
= 0.59). The proportion of children who
were severely stunted (< -2 SD
height-for-age) decreased from 45 to 29%
in the HP group compared to 50 to 46% in
the SP group (P < 0.05) at 6-mo
follow-up. The number of diarrheal
episodes per child tended to be lower in
the HP vs. SP than in the SP group (1.9
vs. 2.3, P = 0.41). These results
demonstrate that feeding an HP diet to
the malnourished children during
recovery from shigellosis enhanced
linear growth with a modest reduction in
diarrheal morbidity during the 6-mo
follow-up period.
- Language of Publication
- English
- Unique Identifier
- 98445499
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- MeSH Heading (Major)
- Body Height|*DE; Convalescence|*;
Dietary Proteins|AD/*TU; Dysentery,
Bacillary|DT/PC/*PP; Growth|*DE
- MeSH Heading
- Amdinocillin Pivoxil|TU; Anthropometry;
Anti-Infective Agents, Quinolone|TU;
Bangladesh; Child, Preschool;
Comparative Study; Female; Human; Male;
Nalidixic Acid|TU; Nutritional Status;
Penicillins|TU; Support, Non-U.S. Gov't;
Support, U.S. Gov't, Non-P.H.S.
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0022-3166
- Country of Publication
- UNITED STATES
Record 40 from database: MEDLINE
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- Title
- Effect of a weight-reducing
high-protein diet on the body
composition of obese adolescents.
- Author
- Archibald EH; Harrison JE; Pencharz PB
- Address
-
- Source
- Am J Dis Child, 1983 Jul, 137:7,
658-62
- Abstract
- The effect of a three-month period on
a high-protein reducing diet on body
composition was studied in 17 obese
adolescents, aged 12.5 to 17.4 years.
Body composition was assessed by
estimating fat-free body mass from four
skin-fold thicknesses, total body
potassium by natural potassium 40
abundance, and total body nitrogen by
prompt gamma ray analysis. Weight loss
was 15% of initial body weight. Total
body nitrogen loss was only 4.8% (not
significant), while total body potassium
fell by 13.2%. Change in fat-free body
mass estimated from skin-fold
thicknesses constituted approximately
44% of the total weight lost. There was
no correlation between changes in total
body potassium and total body nitrogen,
suggesting that total body potassium
cannot be used to predict total body
nitrogen in a changing nutritional
state.
- Language of Publication
- English
- Unique Identifier
- 83228019
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- MeSH Heading (Major)
- Body Composition|*; Diet,
Reducing|*AE; Dietary Proteins|*AD;
Obesity|*TH
- MeSH Heading
- Adipose Tissue|AH; Adolescence;
Female; Human; Male; Nitrogen|AN;
Potassium|AD/AN; Skinfold Thickness;
Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-922X
- Country of Publication
- UNITED STATES
Record 41 from database: MEDLINE
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- Title
- Further studies of the effect of a
high protein diet as meat on calcium
metabolism.
- Author
- Spencer H; Kramer L; DeBartolo M;
Norris C; Osis D
- Address
-
- Source
- Am J Clin Nutr, 1983 Jun, 37:6, 924-9
- Abstract
- Previous studies in this Unit have
shown that a high protein intake, given
as meat, did not induce hypercalciuria,
except for the initial and temporary
increase in two subjects. In the present
investigation the long-term effect of a
high meat diet on calcium metabolism was
studied for 78 to 132 days in four adult
males and the short-term effect for 18
to 30 days in three subjects. Calcium
and phosphorus balances and calcium
absorption studies, using 47Ca as the
tracer, were carried out. During the
long-term high meat intake and during
the short-term high meat studies, there
was no significant change of the urinary
or fecal calcium nor of the calcium
balance. There was also no significant
change of the intestinal absorption of
calcium during the high meat intake.
These long- and short-term studies have
confirmed our previous results that a
high protein intake, given as meat, does
not lead to hypercalciuria and does not
induce calcium loss.
- Language of Publication
- English
- Unique Identifier
- 83201039
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- MeSH Heading (Major)
- Calcium|*ME; Dietary Proteins|AD/*PD
- MeSH Heading
- Adult; Human; Intestinal Absorption;
Male; Meat; Middle Age; Phosphorus|ME;
Support, Non-U.S. Gov't; Support, U.S.
Gov't, Non-P.H.S.; Time Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9165
- Country of Publication
- UNITED STATES
Record 42 from database: MEDLINE
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- Title
- Metabolic adaptation to a low
carbohydrate-high protein
('traditional') diet in Australian
Aborigines.
- Author
- ODea K; Spargo RM
- Address
-
- Source
- Diabetologia, 1982 Dec, 23:6, 494-8
- Abstract
- We have investigated plasma glucose
and insulin responses to 75 g glucose in
12 young, full-blood Aborigines before
and after 2 weeks on a diet derived
almost exclusively from seafood. This
diet was low in fat, extremely low in
carbohydrate and high in protein and was
representative of the diet consumed by
these people in their traditional
lifestyle during those times of the year
when very little vegetable food was
available. After an initial weight loss
which was probably due to glycogen, salt
and water losses associated with the
dietary change, body weights stabilised
by the end of the first week. Total
triglyceride concentrations in fasting
plasma fell from 1.32 +/- 0.33 before
the diet to 0.61 +/- 0.08 mmol/l after
it, while total cholesterol, which was
low initially, did not fall
significantly. There was a small but
significant improvement in glucose
tolerance and a small reduction in
insulin response indicating that the
Aborigines had adapted effectively to
the very low carbohydrate-high protein
diet in the 2 week period. The insulin
response to 50 g protein also fell
significantly after the seafood diet.
The results suggest that glucose
tolerance is not determined solely by
the carbohydrate content of the diet,
but rather by the availability of
carbohydrate either directly or
indirectly in precursor form as dietary
protein.
- Language of Publication
- English
- Unique Identifier
- 83106193
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- MeSH Heading (Major)
- Australoid Race|*; Blood Glucose|*AN;
Dietary Carbohydrates|*AD; Dietary
Proteins|*AD; Insulin|*AN
- MeSH Heading
- Adaptation, Physiological; Adult;
Australia; Body Weight; Cholesterol|BL;
Female; Glucose Tolerance Test; Human;
Male; Support, Non-U.S. Gov't;
Triglycerides|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0012-186X
- Country of Publication
- GERMANY, WEST
Record 43 from database: MEDLINE
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- Title
- Insulin-like growth factor-I and high
protein diet decrease calpain-mediated
proteolysis in murine muscular
dystrophy.
- Author
- Wingertzahn MA; Zdanowicz MM; Slonim
AE
- Address
- Department of Pediatrics, North Shore
University Hospital-New York University
School of Medicine, Manhasset 11030,
USA.
- Source
- Proc Soc Exp Biol Med, 1998 Jul,
218:3, 244-50
- Abstract
- In muscular dystrophy (MD) the
imbalance between muscle protein
synthesis and degradation may be an
important factor leading to muscle
wasting. The three major pathways of
muscle proteolysis identified in
skeletal muscle are: the lysosomal
cathepsin pathway, the calcium-dependent
calpain pathway, and the ATP-dependent
ubiquitin pathway. Insulin-like growth
factor I (IGF-I) and a high-protein diet
(HPD) have been shown to reduce
proteolysis in skeletal muscle. We
examined the effect of 6 weeks of
recombinant human IGF-I (rhIGF-I) alone
or in combination with HPD treatment on
the proteolytic pathways in skeletal
muscle of 129 ReJ dystrophic (dy) mice.
(A group of normal (Norm) nondystrophic
(129 J) mice were included as controls).
Untreated dy mice exhibited increased
net proteolysis (P < 0.05), elevated
net calpain activity (P < 0.01), and
increased ubiquitin levels when compared
to control mice (P < 0.05). Our
evidence suggests that HPD and rhIGF-I
decrease proteolysis in the 129 ReJ dy
mouse. This effect appears attributable,
at least in part, to reduced calpain-mediated
myofibrillar breakdown (P < 0.05) due
to decreased calpain autolysis or
increased calpastatin levels. In
contrast to calpain, cathepsin B
activity was increased in HPD and rhIGF-I
+ HPD-treated dy muscle (P < 0.05)
and unaltered in the rhIGF-I treated
animals. Levels of free and
protein-conjugated ubiquitin were also
increased in rhIGF-I, and rhIGF-I + HPD
treated dyanimals (P < 0.05). The
amelioration of muscle wasting in the
129 ReJ dy model by HPD and/or rhIGF-I
may have potential implications in the
treatment of human MD.
- Language of Publication
- English
- Unique Identifier
- 98311278
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- MeSH Heading (Major)
- Calpain|*ME; Dietary Proteins|*AD/TU;
Insulin-Like Growth Factor I|*PD/TU;
Muscular Dystrophy, Animal|EN/*TH
- MeSH Heading
- Animal; Blotting, Western; Cathepsin
B|ME; Human; Male; Mice; Mice, Mutant
Strains; Muscle Proteins|ME; Muscle,
Skeletal|EN; Recombinant Proteins|PD/TU;
Support, Non-U.S. Gov't; Ubiquitin|ME
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0037-9727
- Country of Publication
- UNITED STATES
Record 44 from database: MEDLINE
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- Title
- Vitamin B-6 requirement and status
assessment of young women fed a
high-protein diet with various levels of
vitamin B-6.
- Author
- Huang YC; Chen W; Evans MA; Mitchell
ME; Shultz TD
- Address
- Department of Food Science and Human
Nutrition, Washington State University,
Pullman 99164-6376, USA.
- Source
- Am J Clin Nutr, 1998 Feb, 67:2, 208-20
- Abstract
- The vitamin B-6 requirement of young
women consuming a constant high-protein
diet (1.55 g/kg body wt) and the effect
of various ratios of vitamin B-6 to
protein on this requirement were
studied. Eight women were fed a
lactoovovegetarian basal diet containing
0.45 mg vitamin B-6 (2.66 micromol as
pyridoxine) and 30 micromol carnitine
for 92 d. The protocol consisted of
successive baseline adjustment (9 d),
depletion (27 d), and repletion (two
21-d and then one 14-d) periods. Vitamin
B-6 intakes were 1.60, 0.45, 1.26, 1.66,
and 2.06 mg, resulting in ratios of
vitamin B-6 (in mg) to protein (in g)
for the five periods of 0.016, 0.005,
0.013, 0.017, and 0.021, respectively.
Direct and indirect as well as short-
and long-term vitamin B-6 status
measures were assessed weekly.
Regression analysis revealed that the
amount of dietary vitamin B-6 required
to normalize urinary 4-pyridoxic acid,
plasma pyridoxal-P, erythrocyte
pyridoxal-P and pyridoxal, and
erythrocyte alanine and aspartate
aminotransferase activity coefficients
to predepletion baseline values was 1.94
mg vitamin B-6/d (0.019 mg vitamin B-6/g
protein). This study suggests that the
current vitamin B-6 recommended dietary
allowance of 1.6 mg/d based on 0.016
mg/g protein is not an adequate intake
and may require reevaluation.
- Language of Publication
- English
- Unique Identifier
- 98119456
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- MeSH Heading (Major)
- Dietary Proteins|*AD/ME;
Pyridoxine|*AD/BL/ME
- MeSH Heading
- Adult; Female; Human; Linear Models;
Nutrition Assessment; Nutrition Policy;
Nutritional Requirements; Pyridoxic
Acid|UR; Support, U.S. Gov't, Non-P.H.S.
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE
- ISSN
- 0002-9165
- Country of Publication
- UNITED STATES
Record 45 from database: MEDLINE
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- Title
- Rapid catch-up growth of children fed
a high-protein diet during convalescence
from shigellosis.
- Author
- Kabir I; Malek MA; Mazumder RN; Rahman
MM; Mahalanabis D
- Address
- International Centre for Diarrheal
Disease Research, Dhaka, Bangladesh.
- Source
- Am J Clin Nutr, 1993 Mar, 57:3, 441-5
- Abstract
- Sixty-nine children age 2-5 y,
convalescing from shigellosis in a
randomized clinical trial were fed
either a high-protein diet containing
628 kJ.kg-1.d-1 with 15% of total energy
as protein, or a standard-protein diet
that was isoenergetic but with 7.5% of
total energy as protein for 21 d.
Children fed the high-protein diet
showed a significant increase in height
(1.02 +/- 0.44 cm; mean +/- SD) compared
with the children who were fed the
standard-protein diet (0.69 +/- 0.34 cm;
P < 0.001). Similarly, increases in
body weight were 1.25 +/- 0.48 vs 0.86
+/- 0.48 kg for the high-protein and the
standard-protein diet, respectively (P
< 0.001). The mean increases of serum
proteins were also significantly higher
in the high-protein group (P < 0.01).
These results indicate that increasing
the protein content of the diet during
convalescence from shigellosis in
children leads to more rapid catch-up
growth.
- Language of Publication
- English
- Unique Identifier
- 93175379
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- MeSH Heading (Major)
- Dietary Proteins|AD/*TU; Growth|*
- MeSH Heading
- Aging; Bangladesh; Blood Proteins|ME;
Body Height; Child, Preschool;
Dysentery, Bacillary|DH; Energy Intake;
Female; Human; Male; Support, Non-U.S.
Gov't; Support, U.S. Gov't, Non-P.H.S.;
Weight Gain
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0002-9165
- Country of Publication
- UNITED STATES
Record 46 from database: MEDLINE
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- Title
- Adaptability of pancreatic enzymes
activity to various food nutritive
values in man. Influence of high protein
diet.
- Author
- Bucko A; Kopec Z; Ovecka M; Grunt J
- Address
-
- Source
- Nahrung, 1982, 26:1, 59-64
- Abstract
- The effect of varying dietary protein
content on the activity of human
pancreatic proteinases was studied in
healthy volunteers. Following the
consumption of food with a higher
protein content, proteinases activities
in duodenal aspirate after pancreozymin
and secretin stimulation showed an
increasing trend only for a period of 14
days and then returned to their original
values. Chymotrypsin is more sensitive
and its activity increased
significantly. Trypsin activity
increased without statistical
significance. No evidence of changing
other parameter (volume, bicarbonate
concentration, amylase and lipase
activities) was observed.
- Language of Publication
- English
- Unique Identifier
- 82173142
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- MeSH Heading (Major)
- Chymotrypsin|*SE; Dietary
Proteins|*PD; Pancreas|DE/*EN; Trypsin|*SE
- MeSH Heading
- Adult; Cholecystokinin|PD; Diet;
Duodenum|SE; Human; Male; Nutritive
Value; Secretin|PD
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0027-769X
- Country of Publication
- GERMANY, EAST
Record 47 from database: MEDLINE
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- Title
- Increased excretion of a brain
depressor amine in infantile coeliac
disease and in healthy infants on a high
protein milk diet.
- Author
- Lindblad BS; Rafter JJ
- Address
-
- Source
- Acta Paediatr Scand, 1980 Sep, 69:5,
643-6
- Abstract
- Urinary excretion of piperidine, a
heterocyclic pressor amine of gut
bacterial origin and nicotine-like
activity in the brain, has been
estimated by a gas chromatography method
in healthy men and women, in normal
breast-fed and formula-fed infants and
in infants with untreated coeliac
disease. The excretion of piperidine
cannot usually be detected during the
first week of life. The amount present
in urine increases upon weaning with
higher excretion in formula-fed than in
breast-fed infants at four to six months
of age. When premature infants fed on
human milk are weaned, the urinary
content of piperidine rises from
undetectable amounts to normal for age.
The high content present in untreated
coeliac disease may be responsible for
the initial mental depression commonly
seen in this disease and suggests that
piperidine is one of the
"auto-intoxicating" substances
arising from the bacterial decomposition
of protein postulated by Metchnikoff in
1903 but hitherto unidentified.
- Language of Publication
- English
- Unique Identifier
- 81203557
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- MeSH Heading (Major)
- Celiac Disease|*ME; Milk Proteins|*ME;
Piperidines|*ME/UR
- MeSH Heading
- Adult; Brain|ME; Depression|CI;
Female; Human; Infant; Infant Nutrition;
Infant, Newborn; Infant, Premature;
Intestine, Small|ME; Male; Support,
Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0001-656X
- Country of Publication
- SWEDEN
Record 48 from database: MEDLINE
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- Title
- Improved energy kinetics following
high protein diet in McArdle's syndrome.
A 31P magnetic resonance spectroscopy
study.
- Author
- Jensen KE; Jakobsen J; Thomsen C;
Henriksen O
- Address
- Department of Magnetic Resonance,
Hvidovre Hospital, Copenhagen, Denmark.
- Source
- Acta Neurol Scand, 1990 Jun, 81:6,
499-503
- Abstract
- A patient with McArdle's syndrome was
examined using bicycle ergometry and 31P
NMR spectroscopy during exercise. The
patients working capacity was
approximately half the expected capacity
of controls. Muscle energy kinetics
improved significantly during
intravenous glucose infusion and after 6
weeks of high protein diet. During
intravenous infusion of amino acids, no
changes in working capacity could be
detected. No decrease was seen in
intracellular muscle pH during aerobic
exercise. A significant decrease in
muscle pH during aerobic exercise was
detected in all controls.
- Language of Publication
- English
- Unique Identifier
- 91021893
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- MeSH Heading (Major)
- Dietary Proteins|*AD/ME; Energy
Metabolism|*PH; Exercise Test|*MT;
Glycogen Storage Disease Type V|*DH/PP;
Nuclear Magnetic Resonance|*MT;
Phosphates|*ME
- MeSH Heading
- Adult; Case Report; Human;
Hydrogen-Ion Concentration; Male; Muscle
Contraction|PH; Muscles|PP;
Phosphocreatine|ME
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0001-6314
- Country of Publication
- DENMARK
Record 49 from database: MEDLINE
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- Title
- Preservation of peripheral nerve
function in severe uremia during
treatment with low protein high calorie
diet and surplus of essential amino
acids.
- Author
- Bergström J; Lindblom U; Norée LO
- Address
-
- Source
- Acta Neurol Scand, 1975 Feb, 51:2,
99-109
- Abstract
- Twelve patients with severe chronic
renal failure (serum creatinine 7.0-27
mg %), and marked uremic symptoms on a
40 g protein diet, were treated with a
caloric-rich diet containing 16-20 g
protein, supplemented with the 8
essential amino acids (1.1-2.2 g N) and
histidine (0.23-0.45 g N)in the form of
tablets for periods between 3 and 34
months. During the treatment the serum
urea-N fell, and the uremic symptoms
subsided or diminished without the
patient exhibiting signs of
malnutrition. The nerve function was
followed with quantitative and
semiquantitative neurological tests
(among others, determination of
vibratory perception thresholds and
nerve conduction times). Initially all
patients but 2 had signs of neuropathy
as measured by these methods. During the
course of treatment no deterioration of
peripheral nerve function was recorded
in any of the patients, several of whom
had had serum creatinine conceptrations
above 15 mg % for long periods. We
conclude that conservative treatment
with N-poor diet in far advanced chronic
renal failure may prevent the further
development of peripheral neuropathy
provided that adequatecaloried and
essential amino acids (2-3 times the
minimal requirements) are supplied. The
results suggest that, in addition to
uremic toxines, malnutrition is a factor
of importance for the developments of of
uremic neuropathy.
- Language of Publication
- English
- Unique Identifier
- 75105851
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- MeSH Heading (Major)
- Kidney Failure, Chronic|BL/*DH;
Peripheral Nerves|*PP; Uremia|BL/*DH/PP
- MeSH Heading
- Adult; Amyloidosis|DH; Blood Urea
Nitrogen; Creatinine; Dietary
Proteins|TU; Female;
Glomerulonephritis|DH/PP; Histidine|TU;
Human; Kidney, Polycystic|DH; Male;
Middle Age; Neural Conduction;
Pyelonephritis|DH
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0001-6314
- Country of Publication
- DENMARK
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