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Record 1
from database: MEDLINE
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- Title
- Effects of a high-protein and low-fat
diet vs a low-protein and high-fat diet
on blood glucose, serum lipoproteins,
and cholesterol metabolism in noninsulin-dependent
diabetics.
- Author
- Andersén E; Hellström P; Kindstedt
K; Hellström K
- Address
-
- Source
- Am J Clin Nutr, 1987 Feb, 45:2, 406-13
- Abstract
- Six middle-aged patients with
noninsulin-dependent diabetes and six
normoglycemic control subjects were fed
protein-rich and fat-poor (diet A) or
protein-poor and fat-rich food (diet B).
The patients were hyperglycemic, VLDL
triglycerides levels were higher, and
HDL cholesterol levels lower than
corresponding findings in control
subjects. Bile acid formation and
biliary lipid composition did not differ
between the two groups, but net steroid
balance in the patients was elevated by
a factor of approximately 2. A switch
from diet A to diet B in control
subjects was associated with an increase
in HDL cholesterol and decreases in bile
acid synthesis and net steroid balance.
Lipoprotein pattern in the patients
remained unchanged, and effects on total
bile acid production and steroid balance
were less consistent. It is suggested
that the response in the patients
reflected diabetes-associated
abnormalities in lipid metabolism.
- Language of Publication
- English
- Unique Identifier
- 87124596
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- MeSH Heading (Major)
- Diabetes Mellitus, Non-Insulin-Dependent|BL/CO/*DH;
Diabetic Diet|*; Dietary Fats|*AD;
Dietary Proteins|*AD;
Hyperlipoproteinemia|*DH/ET
- MeSH Heading
- Adult; Aged; Blood Glucose|ME;
Cholesterol|ME; Comparative Study;
Female; Human; Lipoproteins|BL; Male;
Middle Age; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0002-9165
- Country of Publication
- UNITED STATES
Record 2
from database: MEDLINE
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- Title
- Hypocaloric high-protein diet improves
glucose oxidation and spares lean body
mass: comparison to hypocaloric
high-carbohydrate diet.
- Author
- Piatti PM; Monti F; Fermo I;
Baruffaldi L; Nasser R; Santambrogio G;
Librenti MC; Galli Kienle M; Pontiroli
AE; Pozza G
- Address
- Istituto Scientifico San Raffaele,
Dipartimento di Chimica e Biochimica
Medica, Milano, Italy.
- Source
- Metabolism, 1994 Dec, 43:12, 1481-7
- Abstract
- The aim of the study was to
investigate the effects of two
hypocaloric (800-kcal) diets on body
weight reduction and composition,
insulin sensitivity, and proteolysis in
25 normal glucose-tolerant obese women.
The two diets had the following
composition: 45% protein, 35%
carbohydrate (CHO), and 20% fat (HP
diet, 10 subjects), and 60% CHO, 20%
protein, and 20% fat (HC diet, 15
subjects); both lasted 21 days. A
euglycemic hyperinsulinemic (25 mU/kg/h)
clamp lasting 150 minutes combined with
indirect calorimetry was performed
before and after the diet. Both diets
induced a similar decrease in body
weight and fat mass (FM), whereas
fat-free mass (FFM) decreased only after
the HC diet. 3-Methylhistidine
(3-CH3-HIS) excretion was reduced by 48%
after the HP diet and remained unchanged
after the HC diet (P < .05). A
significant correlation was found
between the changes in FFM and in
3-CH3-HIS excretion after the diet (rs =
.50, P < .02). Blood glucose remained
unchanged, while insulin decreased in
both diets. Free fatty acids (FFA)
significantly increased only after the
HC diet (P < .05). During the clamp
period, glucose disposal and glucose
oxidation significantly increased after
the HP diet and significantly decreased
after the HC diet. Opposite results were
found when measuring lipid oxidation. In
conclusion, our experience suggests that
(1) a hypocaloric diet providing a high
percentage of natural protein can
improve insulin sensitivity; and (2)
conversely, a hypocaloric
high-polysaccharide-CHO diet decreases
insulin sensitivity and is unable to
spare muscle tissue.
- Language of Publication
- English
- Unique Identifier
- 95082609
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- MeSH Heading (Major)
- Body Composition|*PH; Diet,
Reducing|*; Dietary Carbohydrates|*AD;
Dietary Proteins|*AD; Glucose|*ME;
Obesity|*DH
- MeSH Heading
- Adult; Body Mass Index; Energy
Intake|PH; Female; Glucose Clamp
Technique; Human; Insulin Resistance|PH;
Lipid Peroxidation|PH;
Oxidation-Reduction; Proteins|ME; Weight
Loss|PH
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL
TRIAL; JOURNAL ARTICLE
- ISSN
- 0026-0495
- Country of Publication
- UNITED STATES
Record 3 from database: MEDLINE
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- Title
- Protein turnover in acid maltase
deficiency before and after treatment
with a high protein diet.
- Author
- Umpleby AM; Wiles CM; Trend PS; Scobie
IN; Macleod AF; Spencer GT; Sonksen PH
- Address
-
- Source
- J Neurol Neurosurg Psychiatry, 1987
May, 50:5, 587-92
- Abstract
- A patient with acid maltase deficiency
was treated with a high protein diet for
7 months. Protein turnover expressed in
terms of lean body mass was shown to be
increased in this patient before the
diet but was markedly reduced following
the diet. The patient improved
clinically whilst on the diet both
subjectively and in terms of mobility,
breathing and reduced peripheral
cyanosis at rest.
- Language of Publication
- English
- Unique Identifier
- 87225009
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- MeSH Heading (Major)
- Dietary Proteins|*AD; Glucan
1,4-alpha-Glucosidase|*DF; Glucosidases|*DF;
Glycogen Storage Disease|*DH; Glycogen
Storage Disease Type II|*DH/EN; Muscle
Proteins|*ME
- MeSH Heading
- Adult; Case Report; Glucose Tolerance
Test; Human; Leucine|BL; Male; Support,
Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-3050
- Country of Publication
- ENGLAND
Record 4 from database: MEDLINE
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- Title
- Renal hemodynamic effects of a
short-term high protein and low protein
diet in patients with renal disease.
- Author
- Wetzels JF; Hoitsma AJ; Berden JH;
Koene RA
- Address
- Department of Medicine, University
Hospital Nijmegen, The Netherlands.
- Source
- Clin Nephrol, 1988 Jul, 30:1, 42-7
- Abstract
- The renal hemodynamic effects of
short-term protein loading and short
term protein restriction were studied in
patients with renal disease. Eleven
patients adhered to a high protein diet
(1.8 g/kg/day) and, subsequently, to a
low protein diet (0.6 g/kg/day) for four
weeks each. Renal hemodynamics were
studied at the end of the respective
dietary periods. Glomerular filtration
rate (inulin clearance) did not change
significantly (delta %: -1.5 +/- 5.4%;
mean +/- s.e.m.), whereas endogenous
creatinine clearance was lower on the
low protein diet (delta %: -7.8 +/-
2.8%; p less than 0.02), suggesting an
interference with the tubular secretion
of creatinine. Effective renal plasma
flow was significantly lower on the low
protein diet (223.7 +/- 47.6 ml/min vs
282.1 +/- 67.1 ml/min; delta %: -15.4
+/- 4.9%; p less than 0.02). As a
result, filtration fraction increased
from 0.18 +/- 0.01 on the high protein
diet to 0.22 +/- 0.02 on the low protein
diet (p less than 0.01). The low protein
diet caused a significant decrease in
protein excretion from 4.0 +/- 0.9 g/24
h to 3.1 +/- 0.7 g/24 h (p less than
0.02). Our study demonstrates that renal
hemodynamic responses to more sustained
protein loading and protein restriction
differ from the reported responses to
acute protein loading. Different
mechanisms may be involved. In this
light it is doubtful if the renal
hemodynamic response to acute protein
loading can predict a beneficial effect
of protein restriction.
- Language of Publication
- English
- Unique Identifier
- 89090265
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- MeSH Heading (Major)
- Dietary Proteins|*AD; Kidney|*PP;
Kidney Diseases|ME/*PP
- MeSH Heading
- Adult; Creatinine|UR; Female;
Glomerular Filtration Rate; Hemodynamics;
Human; Insulin|ME; Male; Middle Age;
Proteinuria|ME; Renal Circulation;
Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0301-0430
- Country of Publication
- GERMANY, WEST
Record 5 from database: MEDLINE
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- Title
- High protein vs high carbohydrate
hypoenergetic diet for the treatment of
obese hyperinsulinemic subjects.
- Author
- Baba NH; Sawaya S; Torbay N; Habbal Z;
Azar S; Hashim SA
- Address
- Department of Food Technology and
Nutrition and the Division of
Endocrinology, American University of
Beirut, Beirut, Lebanon. nahla@aub.edu.lb
- Source
- Int J Obes Relat Metab Disord, 1999
Nov, 23:11, 1202-6
- Abstract
- OBJECTIVE: To test the hypothesis that
hyperinsulinemic obese subjects would
respond differently to changes in the
composition of hypoenergetic diets.
DESIGN: A 4-week randomized dietary
intervention trial. SUBJECTS: Thirteen
male obese hyperinsulinemic
normoglycemic subjects were divided into
two groups and fed hypoenergetic diets
providing 80% of their resting energy
expenditure (REE). One group received a
high-protein diet (HP; 45% protein, 25%
carbohydrates, and 30% fat as percent of
dietary energy) and the other a
high-carbohydrate diet (HC; 12% protein,
58% carbohydrates and 30% fat).
MEASUREMENTS: Anthropometry, body
composition, fasting serum insulin and
lipids, and REE were performed before
and after the feeding period. RESULTS:
Weight loss was higher in the HP than HC
group (8.3+/-0.7 vs 6.0+/-0.6 kg,
P<0. 05). There was a decrease in
body fat in both groups, whereas body
water decreased significantly more in
the HP group. REE decreased more in the
HC than the HP group (-384.3+/-84.6 vs
-132.3+/-51.0 kcal, P<0.05). Serum
total cholesterol, triglycerides and LDL
cholesterol decreased significantly to a
similar extent in both diet groups,
while HDL cholesterol was decreased
significantly only in the HP group. Mean
fasting insulin decreased significantly
in both diet groups and reached the
normal range only in the HP group.
CONCLUSION: A low-carbohydrate (LC), HP
hypoenergetic diet could be the diet
composition of choice for a
weight-reducing regimen in obese
hyperinsulinemic subjects.
- Language of Publication
- English
- Unique Identifier
- 20047272
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- MeSH Heading (Major)
- Dietary Carbohydrates|*AD; Dietary
Proteins|*AD; Hyperinsulinemia|BL/CO/*DH;
Obesity|BL/CO/*DH
- MeSH Heading
- Basal Metabolism; Body Composition;
Cholesterol|BL; Dietary Fats|AD; Energy
Intake; Energy Metabolism; Human;
Lipoproteins, HDL Cholesterol|BL;
Lipoproteins, LDL Cholesterol|BL; Male;
Support, Non-U.S. Gov't;
Triglycerides|BL; Weight Loss
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0307-0565
- Country of Publication
- ENGLAND
Record 6 from database: MEDLINE
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- Title
- Urinary calcium and calcium balance in
young women affected by high protein
diet of soy protein isolate and adding
sulfur-containing amino acids and/or
potassium.
- Author
- Kaneko K; Masaki U; Aikyo M; Yabuki K;
Haga A; Matoba C; Sasaki H; Koike G
- Address
- Faculty of Eduction, Yokohama National
University, Japan.
- Source
- J Nutr Sci Vitaminol (Tokyo), 1990
Apr, 36:2, 105-16
- Abstract
- The effects of sulfur-containing amino
acids (SAA) and potassium (K) on urinary
excretion and retention of calcium (Ca)
of 27 young Japanese women were studied.
A basal diet low in protein level (50 g
per day) was fortified by meat or soy
protein isolate (SPI) to a protein level
of 100 g per day, and effects of
addition of apple to these high protein
diets, and addition of SAA and/or
potassium (K) to the high SPI diet,
especially on urinary Ca excretion, were
studied. The addition of meat which
increased protein intake to 100 g caused
the increase in apparent absorption and
urinary excretion of Ca with increased
excretion of urinary sulfur (S),
phosphate, ammonia, and titratable acids
(TA), whereas addition of SPI did not.
The addition of apple to high meat diet
decreased absorption and urinary
excretion of Ca. Urinary Ca, S, K,
ammonia, and TA excretion increased by
the addition of SAA to high SPI diet in
a manner similar to the meat diet.
Consequently, SAA-supplemented diet had
a significantly negative effect on Ca
retention. In SPI+SAA,K diet period,
urinary K excretion markedly increased,
and increments in urinary Ca, ammonia,
and TA excretion were reversed. These
changes observed in SPI+SAA, K diet
period were similar to those by adding
apple to meat diet without any effect on
Ca absorption. The results suggest that
the hypercalciuria induced by high meat
diet is mainly caused by high content of
SAA and may be reversed by the ingestion
of K-rich foodstuffs, and soy protein
does not induce hypercalciuria because
of it contains less SAA than animal
protein.
- Language of Publication
- English
- Unique Identifier
- 90354911
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- MeSH Heading (Major)
- Amino Acids, Sulfur|*PD; Calcium|ME/*UR;
Dietary Proteins|AD/*PD;
Potassium|*PD/UR; Vegetable Proteins|AD/*PD
- MeSH Heading
- Absorption; Adult; Ammonia|UR;
Creatinine|UR; Diet; Feces|AN; Female;
Fruit; Human; Hydrogen-Ion
Concentration; Japan; Meat;
Phosphates|UR; Sulfur|UR; Urine
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0301-4800
- Country of Publication
- JAPAN
Record 7 from database: MEDLINE
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- Title
- Satiety related to 24 h diet-induced
thermogenesis during high
protein/carbohydrate vs high fat diets
measured in a respiration chamber.
- Author
- Westerterp Plantenga MS; Rolland V;
Wilson SA; Westerterp KR
- Address
- Department of Human Biology,
Maastricht University, The Netherlands.
- Source
- Eur J Clin Nutr, 1999 Jun, 53:6,
495-502
- Abstract
- OBJECTIVE: Assessment of a possible
relationship between perception of
satiety and diet-induced thermogenesis,
with different macronutrient
compositions, in a controlled situation
over 24 h. DESIGN: Two diets with
different macronutrient compositions
were offered to all subjects in
randomized order. SETTING: The study was
executed in the respiration chambers at
the department of Human Biology,
Maastricht University. SUBJECTS:
Subjects were eight females, ages 23-33
y, BMI 23+/-3 kg/m2, recruited from
University staff and students.
INTERVENTIONS: Subjects were fed in
energy balance, with
protein/carbohydrate/fat: 29/61/10 and
9/30/61 percentage of energy, with fixed
meal sizes and meal intervals, and a
fixed activity protocol, during 36 h
experiments in a respiration chamber.
The appetite profile was assessed by
questionnaires during the day and during
meals. Diet induced thermogenesis was
determined as part of the energy
expenditure. RESULTS: Energy balance was
almost complete, with non-significant
deviations. Diet-Induced-Thermogenesis (DIT)
was 14.6+/-2.9%, on the high
protein/carbohydrate diet, and
10.5+/-3.8% on the high fat diet (P <
0.01). With the high protein/high
carbohydrate diet, satiety was higher
during meals (P < 0.001; P <
0.05), as well as over 24 h (P <
0.001), than with the high fat diet.
Within one diet, 24 h DIT and satiety
were correlated (r = 0.6; P < 0.05).
The difference in DIT between the diets
correlated with the differences in
satiety (r = 0.8; P < 0.01).
CONCLUSION: In lean women, satiety and
DIT were synchronously higher with a
high protein/high carbohydrate diet than
with a high fat diet. Differences (due
to the different macronutrient
compositions) in DIT correlated with
differences in satiety over 24 h.
- Language of Publication
- English
- Unique Identifier
- 99330381
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- MeSH Heading (Major)
- Dietary Carbohydrates|AD/ME/*PD;
Dietary Fats|AD/ME/*PD; Dietary
Proteins|AD/ME/*PD; Satiation|*DE
- MeSH Heading
- Adult; Analysis of Variance; Area
Under Curve; Calorimetry, Indirect;
Comparative Study; Diet; Energy Intake;
Energy Metabolism; Female; Human;
Hunger; Oxygen Consumption;
Questionnaires
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0954-3007
- Country of Publication
- ENGLAND
Record 8 from database: MEDLINE
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- Title
- The effects of a high-animal- and a
high-vegetable-protein diet on mineral
balance and bowel function of young men.
- Author
- Van Dokkum W; Wesstra A; Luyken R;
Hermus RJ
- Address
- Department of Human Nutrition,
TNO-CIVO Toxicology and Nutrition
Institute, Zeist, The Netherlands.
- Source
- Br J Nutr, 1986 Sep, 56:2, 341-8
- Abstract
- 1. Twelve young men were given for
periods of 20 d, each of three mixed
diets, namely a low-protein (LP) diet
(9% total energy as protein, 67% of
animal origin), a high-animal-protein
(HA) diet (16% total energy as protein,
67% of animal origin) and a
high-vegetable-protein (HV) diet (16%
total energy as protein, 67% of
vegetable origin). Retention of calcium,
magnesium, iron, zinc and copper as well
as various bowel function indices were
investigated during each dietary period.
2. Neither the HA diet nor the HV diet
changed the retention of the minerals
considerably. Only Fe balance decreased
significantly on the HV diet. 3.
Substituting the HV diet for the HA diet
resulted in significant increases in
faecal wet weight (17 g/d), defaecation
frequency (0.12 stools/d), faecal
volatile fatty acids (2.6 mmol/d) and a
decrease in faecal bile acids (128 mumol/d).
4. It is concluded that a HV diet,
rather than a HA diet is to be
recommended with respect to bowel
function, whereas the HV diet does not
necessarily have a significant influence
on mineral retention.
- Language of Publication
- English
- Unique Identifier
- 88050747
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- MeSH Heading (Major)
- Dietary Proteins|*PD; Intestines|*PH;
Meat|*; Minerals|AN/*ME; Vegetables|*
- MeSH Heading
- Adult; Calcium|UR; Defecation; Fatty
Acids, Volatile|AN; Feces|AN; Human;
Male
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0007-1145
- Country of Publication
- ENGLAND
Record 9 from database: MEDLINE
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- Title
- Increased clearance of propranolol and
theophylline by high-protein compared
with high-carbohydrate diet.
- Author
- Fagan TC; Walle T; Oexmann MJ; Walle
UK; Bai SA; Gaffney TE
- Address
-
- Source
- Clin Pharmacol Ther, 1987 Apr, 41:4,
402-6
- Abstract
- The objective of this study was to
determine whether changes in dietary
protein and carbohydrate influence the
oral clearance of propranolol, a
high-clearance drug, and theophylline, a
low-clearance drug. Six normal subjects
studied in a clinical research center
each received a single oral dose of
propranolol, 80 mg, and theophylline, 5
mg/kg, after having been on each of two
well-defined diets for a period of 10
days. When the diet was altered from
high carbohydrate/low protein to low
carbohydrate/high protein, the oral
clearance of propranolol increased by
74% +/- 20% (mean +/- SE; range 9% to
156%; P less than 0.01) with no change
in plasma half-life or plasma binding.
This dietary change resulted in an
increase in theophylline clearance of
32% +/- 6% (range 18% to 50%; P less
than 0.02) and a corresponding decrease
in plasma half-life of 26% +/- 6% (range
6% to 42%; P less than 0.05) with no
alteration in the apparent volume of
distribution. These observations
reemphasize the importance of diet in
drug disposition and suggest that the
clearance of high-clearance drugs like
propranolol is more susceptible than the
clearance of low-clearance drugs to
dietary manipulations, effects that may
have to be considered in drug therapy.
- Language of Publication
- English
- Unique Identifier
- 87160344
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- MeSH Heading (Major)
- Dietary Carbohydrates|*PD; Dietary
Proteins|*PD; Propranolol|BL/*ME;
Theophylline|BL/*ME
- MeSH Heading
- Administration, Oral; Adult;
Biological Availability; Comparative
Study; Female; Human; Kinetics; Male;
Mass Fragmentography; Support, U.S.
Gov't, P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0009-9236
- Country of Publication
- UNITED STATES
Record 10 from database: MEDLINE
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- Title
- Cloning of rat uncoupling protein-3
and uncoupling protein-2 cDNAs: their
gene expression in rats fed high-fat
diet.
- Author
- Matsuda J; Hosoda K; Itoh H; Son C;
Doi K; Tanaka T; Fukunaga Y; Inoue G;
Nishimura H; Yoshimasa Y; Yamori Y;
Nakao K
- Address
- Department of Medicine and Clinical
Science, Kyoto University Graduate
School of Medicine, Japan.
- Source
- FEBS Lett, 1997 Nov, 418:1-2, 200-4
- Abstract
- In order to elucidate energy balance
in the skeletal muscle, we cloned cDNA
of a homologue of uncoupling protein (UCP)
from rat skeletal muscle. We also cloned
rat UCP-2 cDNA from rat brown adipose
tissue (BAT). The UCP cloned from rat
skeletal muscle showed 57% and 72%
identity with rat UCP-1 and UCP-2. The
mRNA was expressed abundantly in the
skeletal muscle, moderately in the BAT,
and slightly in the white adipose tissue
(WAT) with a major band at 2.5 kb and a
minor band at 2.8 kb, while the UCP-2
gene expression was widely detected in
the whole body with substantial levels
in the WAT and with slight levels in the
skeletal muscle and BAT. The rat UCP
cloned in the present study showed 86%
identity with the recently cloned human
UCP-3, which was also expressed
abundantly in the skeletal muscle with a
signal of 2.4 kb. Therefore, the rat UCP
was considered to be rat UCP-3. In rats
fed high-fat diet the UCP-3 gene
expression was augmented 2-fold in the
skeletal muscle while UCP-2 mRNA levels
were increased significantly (1.6-fold)
in the epididymal WAT. Augmented
expression of UCPs may provide defense
against high-fat induced obesity and
impairment of glucose metabolism.
- Language of Publication
- English
- Unique Identifier
- 98074937
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- MeSH Heading (Major)
- Adipose Tissue|*ME; Carrier
Proteins|*BI/CH; Dietary Fats|*; Gene
Expression Regulation|*; Muscle,
Skeletal|*ME; Proteins|*BI/CH;
Transcription, Genetic|*
- MeSH Heading
- Amino Acid Sequence; Animal; Brown
Fat|ME; Cloning, Molecular; DNA,
Complementary; Epididymis; Human; Male;
Molecular Sequence Data; Organ
Specificity; Rats; RNA, Messenger|BI;
Sequence Alignment; Sequence Homology,
Amino Acid; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0014-5793
- Country of Publication
- NETHERLANDS
Record 11 from database: MEDLINE
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- Title
- Weight reduction with a high protein,
low carbohydrate, calorie-restricted
diet: effects on blood pressure, glucose
and insulin levels.
- Author
- Nobels F; van Gaal L; de Leeuw I
- Address
-
- Source
- Neth J Med, 1989 Dec, 35:5-6, 295-302
- Abstract
- A clear relationship exists between
obesity and hypertension. In this study,
blood pressure was examined in 215 obese
patients. Significant positive
correlations were demonstrated between
the mean arterial pressure (MAP) and
age, body weight, body mass index (BMI),
fasting and 2 h postprandial glucose and
postprandial insulin concentrations.
Using a stepwise multiple regression
analysis, it was clear that body weight,
age and glycaemic parameters were the
most important determinants of arterial
blood pressure. During a period of 6
months, 113 patients were treated with a
high protein, low carbohydrate,
calorie-restricted diet. This resulted
in a mean weight loss of 17 +/- 7.9 kg
and a considerable drop in MAP, and in
fasting and postprandial glucose and
insulin concentrations. None of the
patients who were hypertensive before
treatment (n = 17) remained so
afterwards. We can conclude that: (1)
changes in blood pressure are always
accompanied by changes in the same
direction of one or more of the
parameters of glucose homeostasis, which
suggests a common link; (2) The dietary
approach to obesity therapy successfully
lowers blood pressure and helps to
rectify the abnormalities in glucose
metabolism.
- Language of Publication
- English
- Unique Identifier
- 90245170
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- MeSH Heading (Major)
- Blood Glucose|*AN; Blood Pressure|*;
Diet, Reducing|*; Insulin|*BL;
Obesity|BL/*DH/PP
- MeSH Heading
- Adolescence; Age Factors; Body Mass
Index; Body Weight; Energy Intake;
Female; Food, Formulated; Human;
Hypertension|PP; Male; Prospective
Studies; Weight Loss
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0300-2977
- Country of Publication
- NETHERLANDS
Record 12 from database: MEDLINE
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- Title
- The effect of a high protein diet on
leucine and alanine turnover in acid
maltase deficiency.
- Author
- Umpleby AM; Trend PS; Chubb D;
Conaglen JV; Williams CD; Hesp R; Scobie
IN; Wiles CM; Spencer G; Sönksen PH
- Address
- Department of Medicine, St Thomas'
Hospital, London, UK.
- Source
- J Neurol Neurosurg Psychiatry, 1989
Aug, 52:8, 954-61
- Abstract
- Leucine and alanine production rate
was measured in 5 patients with acid
maltase deficiency in the postabsorptive
state, following 6 months on a normal
diet with placebo and 6 months on an
isocaloric high protein diet (16-22%
protein). Whole body leucine production
rate, a measure of protein degradation,
expressed in terms of lean body mass was
significantly greater than in five
control subjects. Following the high
protein diet, leucine production rate
was decreased in four of the five
patients but this was not statistically
significant. Alanine production rate
expressed in terms of lean body mass was
significantly greater than in control
subjects. After the high protein diet,
alanine production rate and
concentration were significantly
decreased (p less than 0.05). There were
no significant improvements in any of
the clinically relevant variables
measured in these patients. It is
possible that a larger increase in
protein intake over a longer time period
may have a clinical effect.
- Language of Publication
- English
- Unique Identifier
- 90011123
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- MeSH Heading (Major)
- Alanine|*BL; Dietary Proteins|*AD;
Glucan 1,4-alpha-Glucosidase|*DF;
Glycogen Storage Disease Type II|*DH/EN;
Leucine|*BL
- MeSH Heading
- Adult; Clinical Trials; Female;
Follow-Up Studies; Glucose Tolerance
Test; Human; Lactates|BL; Male; Middle
Age; Random Allocation; Support,
Non-U.S. Gov't
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL
TRIAL; JOURNAL ARTICLE
- ISSN
- 0022-3050
- Country of Publication
- ENGLAND
Record 13 from database: MEDLINE
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- Title
- Effect of a high-protein,
very-low-calorie diet on resting
metabolism, thyroid hormones, and energy
expenditure of obese middle-aged women.
- Author
- Barrows K; Snook JT
- Address
-
- Source
- Am J Clin Nutr, 1987 Feb, 45:2, 391-8
- Abstract
- A 4-6 mo study was conducted to
examine effects of a very-low-calorie,
high-protein diet and realimentation on
energy expenditure, resting metabolic
rate (RMR), and serum thyroid hormones
of obese women aged 30-54 yr. Fifteen
healthy women, greater than or equal to
126% ideal body weight, were placed on
the diet (420 kcal/day) and lost an
average of 1.1 kg/wk until a
predetermined goal weight was attained.
RMR, triiodothyronine (T3), and reverse
T3 decreased significantly (p less than
0.05). Thyroxine remained unchanged.
Upon gradual realimentation onto solid
foods, all metabolic parameters
increased significantly within 5 wk
toward pre-diet baseline values, but RMR
(kcal/h) and T3 values remained
significantly below pre-study values.
Estimates of mean energy expenditure,
utilizing a technique based on energy
intake and body composition changes,
averaged 1719 kcal/day during the diet
period.
- Language of Publication
- English
- Unique Identifier
- 87124594
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- MeSH Heading (Major)
- Diet, Reducing|*; Dietary
Proteins|*AD;
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