|
Record 1
from database: MEDLINE
 Return
To Top
- Title
- Effect of butter, mono- and
polyunsaturated fatty acid-enriched
butter, trans fatty acid margarine, and
zero trans fatty acid margarine on serum
lipids and lipoproteins in healthy men.
- Author
- Wood R; Kubena K; OBrien B; Tseng S;
Martin G
- Address
- Department of Biochemistry and
Biophysics, Texas A&M University,
College Station 77843-2128.
- Source
- J Lipid Res, 1993 Jan, 34:1, 1-11
- Abstract
- The effect of diets containing 50% of
fat calories from butter, butter
enriched with mono- and polyunsaturated
fatty acids, and margarines with and
without trans fatty acids on the serum
lipids of 38 healthy men in a
free-living condition have been
determined. Serum lipid responses to the
high level of individual dietary fats
were unexpectedly small. The butter diet
produced a small, but significant rise
(5%) in the total serum cholesterol and
low density lipoprotein
(LDL)-cholesterol, relative to all other
diets. Enrichment of butter with either
olive oil (50/50) or sunflower oil
(50/50) failed to reduce serum lipid
levels below habitual diet values. Hard
margarine, containing 29% trans fatty
acids, caused a decrease in
apolipoprotein A-I and B levels, but did
not change total serum cholesterol or
LDL-cholesterol levels, relative to
habitual diet values. A soft margarine,
high in linoleate, with no trans fatty
acids reduced total cholesterol,
LDL-cholesterol, and apolipoprotein B
significantly, relative to all diets.
Soft margarine high density lipoprotein
(HDL)-cholesterol levels remained
unchanged, but apolipoprotein A-I values
were decreased relative to habitual and
butter diets. The quantities of
saturated fatty acids and the sum of
monounsaturated and polyunsaturated
fatty acids consumed on the hard and
soft margarines were equal; therefore,
the different response of serum
cholesterol and LDL-cholesterol between
these two diets is attributable to the
trans fatty acids in the hard margarine.
The data indicate that trans fatty acids
are not metabolically equivalent to the
natural cis isomers and that they affect
the serum lipid profile adversely.
- Language of Publication
- English
- Unique Identifier
- 93187543
Return
To Top
- MeSH Heading (Major)
- Dietary Fats|*AD; Lipids|*BL;
Lipoproteins|*BL
- MeSH Heading
- Adult; Apolipoproteins|BL; Butter;
Comparative Study; Fatty Acids|BL; Fatty
Acids, Monounsaturated|AD/CH; Fatty
Acids, Unsaturated|AD/CH; Human; Male;
Margarine; Middle Age; Phospholipids|BL;
Stereoisomerism; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-2275
- Country of Publication
- UNITED STATES
Record 2
from database: MEDLINE
Return
To Top
- Title
- The role of fatty acid saturation on
plasma lipids, lipoproteins, and
apolipoproteins: I. Effects of whole
food diets high in cocoa butter, olive
oil, soybean oil, dairy butter, and milk
chocolate on the plasma lipids of young
men [see comments]
- Author
- Kris Etherton PM; Derr J; Mitchell DC;
Mustad VA; Russell ME; McDonnell ET;
Salabsky D; Pearson TA
- Address
- Department of Nutrition, Pennsylvania
State University, University Park 16802.
- Source
- Metabolism, 1993 Jan, 42:1, 121-9
- Abstract
- The present studies were conducted to
evaluate the cholesterolemic effects of
whole-food diets high in stearic acid.
In study no. 1, normocholesterolemic
young men were fed diets high in stearic
acid provided by cocoa butter (CB);
oleic acid provided by olive oil (OO);
linoleic acid provided by soybean oil
(SO); and myristic acid (and lauric
acid) provided by dairy butter (B). In
study no. 2, different subjects with
similar baseline characteristics were
fed diets high in stearic acid provided
by milk chocolate (C), CB, CB+B (4:1,
MIX), and myristic (and lauric) acid
provided by B. Both studies used a
randomized, crossover, double-blind
experimental design, and experimental
subjects (n = 18 for study no. 1 and n =
15 for study no. 2) in each study
consumed every diet for 26 days with a
1-month wash-out period between each
experimental period. The diets provided
37% of calories from fat, of which 81%
was provided by the test fat. Ten ounces
(280 g) C was provided daily by the C
diet. In study no. 1, the B diet was
hypercholesterolemic, whereas the SO
diet was hypocholesterolemic, compared
with the other diets. The OO and SO
diets were hypocholesterolemic compared
with the CB diet. Low-density
lipoprotein (LDL) cholesterol levels, in
general, paralleled the changes in
plasma total cholesterol levels. SO
significantly decreased apolipoprotein (apo)
B levels compared with the other diets.
Plasma very-low density lipoprotein (VLDL)
cholesterol, high-density lipoprotein
(HDL) cholesterol, and apo A-I levels
were unaffected by the experimental
diets.(ABSTRACT TRUNCATED AT 250 WORDS)
- Language of Publication
- English
- Unique Identifier
- 93188717
Return
To Top
- MeSH Heading (Major)
- Apolipoproteins|*ME; Dietary Fats|*PD;
Fatty Acids|*BL; Lipids|*BL
- MeSH Heading
- Adult; Butter; Cacao; Comparative
Study; Double-Blind Method; Human;
Lipoproteins|BL; Male; Plant Oils|PD;
Soybean Oil|PD; Support, Non-U.S. Gov't
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0026-0495
- Country of Publication
- UNITED STATES
Record 3
from database: MEDLINE
Return
To Top
- Title
- Low-fat (41%) butter use decreases
butter lipid intake over 4-week trials
in healthy persons.
- Author
- Slama G; Rossi F; Bellisle F; Fiquet
P; Chappuis AS; Desplanque N; Laffitte A
- Address
- Department of Diabetes, HÈotel-Dieu,
Paris, France.
- Source
- Appetite, 1995 Oct, 25:2, 127-31
- Abstract
- All members of 18 families (n = 75;
ages from 1 to 65 years) participated in
a cross-over study of butter usage. Two
types of butter were compared: regular
(82%) fat) and low-fat (41%) butter.
Butter was supplied to the families by
the laboratory for use in raw (spread)
form over two successive periods of 5
weeks (first week served as training).
No other butter was allowed. The number
of consumers (75) remained constant
throughout the study. Over four
consecutive weeks, the families consumed
as much low-fat as regular butter (10.70
+/- 1 g versus 10.06 +/- 1.17 g per day
per person). However, lipid intake from
butter was significantly reduced during
the low-fat butter period as compared to
the regular butter period (4.39 +/- 0.41
g versus 8.25 +/- 0.96 g per day per
person, p = 0.0005). Since previous
studies showed that nutrient-specific
compensatory intake is unlikely, it is
suggested that use of low-fat butter can
facilitate a reduction in fat intake
over extended periods of time in healthy
persons.
- Language of Publication
- English
- Unique Identifier
- 96119669
Return
To Top
- MeSH Heading (Major)
- Butter|*; Diet, Fat-Restricted|*;
Dietary Fats|*AD
- MeSH Heading
- Adolescence; Adult; Aged; Child;
Child, Preschool; Cross-Over Studies;
Female; Follow-Up Studies; Human;
Infant; Male; Middle Age; Support,
Non-U.S. Gov't
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0195-6663
- Country of Publication
- ENGLAND
Record 4
from database: MEDLINE
Return
To Top
- Title
- 65Copper absorption by women fed
intrinsically and extrinsically labeled
goose meat, goose liver, peanut butter
and sunflower butter.
- Author
- Johnson PE; Stuart MA; Hunt JR; Mullen
L; Starks TL
- Address
- United States Department of
Agriculture, Grand Forks Human Nutrition
Research Center, ND 58202.
- Source
- J Nutr, 1988 Dec, 118:12, 1522-8
- Abstract
- Absorption of stable 65Cu incorporated
intrinsically or extrinsically into
foods was studied in women fed a diet
marginal in Cu content. Isotopic
enrichment was 73.1 +/- 1.0 atom percent
65Cu in goose breast meat, 74.9 +/- 0.5
atom percent in goose liver, and 55-69.5
atom percent in two crops of peanuts.
Seven women were fed a basal diet
containing 1.25 mg Cu/d. At 4-wk
intervals, they were fed test meals over
a 3-d period; each set of meals
contained one of the labeled test foods
in amounts with similar copper content.
Absorption of 65Cu from intrinsically
labeled liver was (mean +/- SD) 65 +/-
4%; extrinsic liver, 65 +/- 10%; E/I =
1.00 +/- 0.16. 65Cu absorption from
intrinsically labeled goose breast meat
was 54 +/- 6%; extrinsic meat, 52 +/-
10%; E/I = 0.97 +/- 0.18. 65Cu
absorption from intrinsically labeled
peanut butter was 58 +/- 15%; extrinsic
peanut butter, 54 +/- 10%; E/I = 0.93
+/- 0.11. 65Cu absorption from
extrinsically labeled sunflower butter
was 50 +/- 2%. There were no differences
in absorption of intrinsic and extrinsic
Cu from these foods. Absorption of Cu
was significantly higher from goose
liver than from goose meat or sunflower
butter (P less than 0.05). With a
dietary intake of 1.25 +/- 0.20 mg Cu/d,
Cu balance, exclusive of surface losses,
was essentially zero (0.01 +/- 0.13
mg/d) in the seven subjects.
- Language of Publication
- English
- Unique Identifier
- 89094516
Return
To Top
- MeSH Heading (Major)
- Copper|AD/*PK; Dietary Fats|*AD/ME;
Dietary Proteins|*AD/ME
- MeSH Heading
- Animal; Biological Availability; Diet;
Feces|AN; Female; Food Analysis; Geese;
Helianthus; Human; Intestinal
Absorption; Isotopes|AD; Meat Products;
Middle Age; Peanuts;
Spectrophotometry|MT; Spectrum Analysis,
Mass
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-3166
- Country of Publication
- UNITED STATES
Record 5
from database: MEDLINE
Return
To Top
- Title
- Effect of butter, mono- and
polyunsaturated fatty acid-enriched
butter, trans fatty acid margarine, and
zero trans fatty acid margarine on serum
lipids and lipoproteins in healthy men.
- Author
- Wood R; Kubena K; OBrien B; Tseng S;
Martin G
- Address
- Department of Biochemistry and
Biophysics, Texas A&M University,
College Station 77843-2128.
- Source
- J Lipid Res, 1993 Jan, 34:1, 1-11
- Abstract
- The effect of diets containing 50% of
fat calories from butter, butter
enriched with mono- and polyunsaturated
fatty acids, and margarines with and
without trans fatty acids on the serum
lipids of 38 healthy men in a
free-living condition have been
determined. Serum lipid responses to the
high level of individual dietary fats
were unexpectedly small. The butter diet
produced a small, but significant rise
(5%) in the total serum cholesterol and
low density lipoprotein
(LDL)-cholesterol, relative to all other
diets. Enrichment of butter with either
olive oil (50/50) or sunflower oil
(50/50) failed to reduce serum lipid
levels below habitual diet values. Hard
margarine, containing 29% trans fatty
acids, caused a decrease in
apolipoprotein A-I and B levels, but did
not change total serum cholesterol or
LDL-cholesterol levels, relative to
habitual diet values. A soft margarine,
high in linoleate, with no trans fatty
acids reduced total cholesterol,
LDL-cholesterol, and apolipoprotein B
significantly, relative to all diets.
Soft margarine high density lipoprotein
(HDL)-cholesterol levels remained
unchanged, but apolipoprotein A-I values
were decreased relative to habitual and
butter diets. The quantities of
saturated fatty acids and the sum of
monounsaturated and polyunsaturated
fatty acids consumed on the hard and
soft margarines were equal; therefore,
the different response of serum
cholesterol and LDL-cholesterol between
these two diets is attributable to the
trans fatty acids in the hard margarine.
The data indicate that trans fatty acids
are not metabolically equivalent to the
natural cis isomers and that they affect
the serum lipid profile adversely.
- Language of Publication
- English
- Unique Identifier
- 93187543
Return
To Top
- MeSH Heading (Major)
- Dietary Fats|*AD; Lipids|*BL;
Lipoproteins|*BL
- MeSH Heading
- Adult; Apolipoproteins|BL; Butter;
Comparative Study; Fatty Acids|BL; Fatty
Acids, Monounsaturated|AD/CH; Fatty
Acids, Unsaturated|AD/CH; Human; Male;
Margarine; Middle Age; Phospholipids|BL;
Stereoisomerism; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-2275
- Country of Publication
- UNITED STATES
Record 6
from database: MEDLINE
Return
To Top
- Title
- The role of fatty acid saturation on
plasma lipids, lipoproteins, and
apolipoproteins: I. Effects of whole
food diets high in cocoa butter, olive
oil, soybean oil, dairy butter, and milk
chocolate on the plasma lipids of young
men [see comments]
- Author
- Kris Etherton PM; Derr J; Mitchell DC;
Mustad VA; Russell ME; McDonnell ET;
Salabsky D; Pearson TA
- Address
- Department of Nutrition, Pennsylvania
State University, University Park 16802.
- Source
- Metabolism, 1993 Jan, 42:1, 121-9
- Abstract
- The present studies were conducted to
evaluate the cholesterolemic effects of
whole-food diets high in stearic acid.
In study no. 1, normocholesterolemic
young men were fed diets high in stearic
acid provided by cocoa butter (CB);
oleic acid provided by olive oil (OO);
linoleic acid provided by soybean oil
(SO); and myristic acid (and lauric
acid) provided by dairy butter (B). In
study no. 2, different subjects with
similar baseline characteristics were
fed diets high in stearic acid provided
by milk chocolate (C), CB, CB+B (4:1,
MIX), and myristic (and lauric) acid
provided by B. Both studies used a
randomized, crossover, double-blind
experimental design, and experimental
subjects (n = 18 for study no. 1 and n =
15 for study no. 2) in each study
consumed every diet for 26 days with a
1-month wash-out period between each
experimental period. The diets provided
37% of calories from fat, of which 81%
was provided by the test fat. Ten ounces
(280 g) C was provided daily by the C
diet. In study no. 1, the B diet was
hypercholesterolemic, whereas the SO
diet was hypocholesterolemic, compared
with the other diets. The OO and SO
diets were hypocholesterolemic compared
with the CB diet. Low-density
lipoprotein (LDL) cholesterol levels, in
general, paralleled the changes in
plasma total cholesterol levels. SO
significantly decreased apolipoprotein (apo)
B levels compared with the other diets.
Plasma very-low density lipoprotein (VLDL)
cholesterol, high-density lipoprotein
(HDL) cholesterol, and apo A-I levels
were unaffected by the experimental
diets.(ABSTRACT TRUNCATED AT 250 WORDS)
- Language of Publication
- English
- Unique Identifier
- 93188717
Return
To Top
- MeSH Heading (Major)
- Apolipoproteins|*ME; Dietary Fats|*PD;
Fatty Acids|*BL; Lipids|*BL
- MeSH Heading
- Adult; Butter; Cacao; Comparative
Study; Double-Blind Method; Human;
Lipoproteins|BL; Male; Plant Oils|PD;
Soybean Oil|PD; Support, Non-U.S. Gov't
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0026-0495
- Country of Publication
- UNITED STATES
Record 7
from database: MEDLINE
Return
To Top
- Title
- Effects of partially hydrogenated fish
oil, partially hydrogenated soybean oil,
and butter on serum lipoproteins and
Lp[a] in men.
- Author
- Almendingen K; Jordal O; Kierulf P;
Sandstad B; Pedersen JI
- Address
- Institute for Nutrition Research,
University of Oslo, Norway.
- Source
- J Lipid Res, 1995 Jun, 36:6, 1370-84
- Abstract
- We have compared the effects of
partially hydrogenated fish oil (PHFO-diet),
partially hydrogenated soybean oil (PHSO-diet),
and butterfat (butter-diet) on serum
lipids and lipoprotein[a] in 31 young
men. The three test margarines, which
contributed 78% of total fat in the
diets, were produced from 70% of
butterfat, PHSO, or PHFO, each with 30%
of soybean oil. Fat provided about 35%
of energy, and trans fatty acids 0.9%,
8.5%, and 8.0% of energy in the butter-,
the PHSO-, and the PHFO-diet,
respectively. Dietary cholesterol was
balanced by the addition of dried egg
powder to the PHSO- and the butter-diet;
thus all diets contained 420 mg dietary
cholesterol per 10 MJ per day. The
subjects consumed all three test diets
for 19-21 days in a random order
(crossover design). The serum levels of
total and LDL-cholesterol were
significantly elevated on the PHFO-diet
(mean values 5.42 and 3.94 mmol/L,
respectively) compared to the PHSO-diet
(5.11 and 3.58 mmol/L, respectively) but
not different from those on the
butter-diet (5.32 and 3.81 mmol/L,
respectively). LDL-cholesterol was
significantly reduced on the PHSO-diet
compared to the butter-diet. The level
of HDL-cholesterol was significantly
lower on the PHFO-diet (0.98 mmol/L)
when compared to the butter-diet (1.05
mmol/L) and with border-line
significance compared to the PHSO-diet
(1.05 mmol/L). The ratio of LDL- to
HDL-cholesterol was significantly higher
on the PHFO-diet (4.20) when compared to
both other test diets (3.85 and 3.65,
respectively). No significant
differences in triglyceride values were
observed. Lp[a] increased and apoA-I
decreased significantly after
consumption of both the PHSO-diet and
the PHFO-diet, compared to the
butter-diet. In conclusion, our results
indicate that consumption of PHFO may
unfavorably affect lipid risk indicators
for coronary heart disease at least to
the same extent as butterfat. To what
extent the observed effects are due to
the content of monoene trans, diene
trans, or to the long chain saturated
fatty acids in PHFO remains to be
elucidated.
- Language of Publication
- English
- Unique Identifier
- 95395394
Return
To Top
- MeSH Heading (Major)
- Butter|*; Dietary Fats|AD/*PD; Fish
Oils|AD/CH/*PD; Lipoprotein(a)|*BL;
Lipoproteins|*BL; Soybean Oil|AD/CH/*PD
- MeSH Heading
- Adult; Apolipoprotein A-I|ME;
Apolipoproteins B|BL; Comparative Study;
Cross-Over Studies; Human;
Hydrogenation; Lipoproteins, HDL
Cholesterol|BL; Lipoproteins, LDL
Cholesterol|BL; Male; Middle Age;
Support, Non-U.S. Gov't;
Triglycerides|BL
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0022-2275
- Country of Publication
- UNITED STATES
Record 8
from database: MEDLINE
Return
To Top
- Title
- Are butter and cheese rich in
monounsaturates beneficial in
hyperlipidaemic patients?
- Author
- OCallaghan D; Stanton A; Rafferty S;
Canton M; Murphy J; Harrington D;
Connolly B; Horgan J
- Address
- Department of Cardiology, Beaumont
Hospital, Dublin, Ireland.
- Source
- J Cardiovasc Risk, 1996 Oct, 3:5,
441-5
- Abstract
- BACKGROUND: Reduction in intake of
dairy products has long been recommended
to reduce blood lipids. The value of
monounsaturated fatty acids is
increasingly recognized. METHODS: We
evaluated the effects of a
monounsaturate-rich butter and cheese
(B) produced by modifying the bovine
diet on blood lipid levels of patients
with type IIa hyperlipidaemia. We
compared their effects with those of
normal butter and cheese (A) and
polyunsaturate-rich spread and cheese
(C). Using a double cross-over design,
we studied 30 patients of mean age 56.4
years (23 men, one woman excluded) over
6-week periods. RESULTS: Approximately
35.5 g/day butter/cheese were consumed;
no changes in serum total cholesterol,
triglycerides, low-density lipoprotein,
lipoprotein (a) or cholesterol:
high-density lipoprotein (HDL) ratio
were observed. HDL levels were higher in
B(1.31 mmol/l) than in C (1.22 mmol/l; P
< 0.05) and similar to those in A
(1.28 mmol/l). HDL2 levels were higher
in patients fed diet A(0.23 mmol/l) than
they were in those fed diet C (0.19 mmol/l;
P < 0.05) and similar to those in
patients fed diet B (0.20 mmol/l). Serum
HDL3 was significantly higher in
patients fed diet B (1.11 mmol/l) than
in those fed diet C (1.03 mmol/l; P <
0.05) but similar to that in patients
fed diet A (1.06 mmol/l). CONCLUSIONS:
Moderate intake of modified dairy
products may be of value and deserves
further evaluation.
- Language of Publication
- English
- Unique Identifier
- 97200324
Return
To Top
- MeSH Heading (Major)
- Cholesterol|*BL; Dietary Fats,
Unsaturated|*AD; Hypercholesterolemia|BL/*DH;
Lipoproteins, HDL|*BL; Lipoproteins,
LDL|*BL
- MeSH Heading
- Butter; Cheese; Cross-Over Studies;
Female; Human; Male; Margarine; Middle
Age
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL
TRIAL; JOURNAL ARTICLE
- ISSN
- 1350-6277
- Country of Publication
- ENGLAND
Record 9
from database: MEDLINE
Return
To Top
- Title
- Association of trans fatty acids
(vegetable ghee) and clarified butter
(Indian ghee) intake with higher risk of
coronary artery disease in rural and
urban populations with low fat
consumption.
- Author
- Singh RB; Niaz MA; Ghosh S; Beegom R;
Rastogi V; Sharma JP; Dube GK
- Address
- Heart Research Laboratory, Medical
Hospital and Research Centre, Moradabad,
India.
- Source
- Int J Cardiol, 1996 Oct, 56:3, 289-98;
discussion 299-300
- Abstract
- These cross-sectional surveys included
1769 rural (894 men and 875 women) and
1806 urban (904 men and 902 women)
randomly selected subjects between 25-64
years of age from Moradabad in North
India. The total prevalence of coronary
artery disease based on clinical history
and electrocardiogram was significantly
higher in urban compared to rural men
(11.0 vs. 3.9%) and women (6.9 vs.
2.6%), respectively. Food consumption
patterns showed that important
differences in relation to coronary
artery disease were higher intake of
total visible fat, milk and milk
products, meat, eggs, sugar and jaggery
in urban compared to rural subjects.
Prevalence of coronary artery disease in
relation to visible fat intake showed a
higher prevalence rate with higher
visible fat intake in both sexes and the
trend was significant for total
prevalence rates both for rural and
urban men and women. Subgroup analysis
among urban (694 men and 694 women) and
rural (442 men and 435 women) subjects
consuming moderate to high fat diets
showed that subjects eating trans fatty
acids plus clarified butter or those
consuming clarified butter as total
visible fat had a significantly higher
prevalence of coronary artery disease
compared to those consuming clarified
butter plus vegetable oils in both rural
(9.8, 7.1 vs. 3.0%) and urban (16.2,
13.5 vs. 11.0%) men as well as in rural
(9.2, 4.5 vs. 1.5%) and urban (10.7, 8.8
vs. 6.4%) women. Univariate and
multivariate regression analysis with
adjustment for age showed that
sedentariness in women, body mass index
in urban men and women, milk and
clarified butter plus trans fatty acids
in both rural and urban in both sexes
were significantly associated with
coronary artery disease. It is possible
that lower intake of total visible fat
(20 g/day), decreased intake of milk,
increased physical activity and
cessation of smoking may benefit some
populations in the prevention of
coronary artery disease.
- Language of Publication
- English
- Unique Identifier
- 97066594
Return
To Top
- MeSH Heading (Major)
- Coronary Disease|*EP/PC; Dietary
Fats|*AE; Food Habits|*; Rural
Population|*; Urban Population|*
- MeSH Heading
- Adult; Analysis of Variance; Butter;
Comparative Study; Cross-Sectional
Studies; Diet, Fat-Restricted; Female;
Human; India|EP; Life Style; Male;
Middle Age; Multivariate Analysis; Odds
Ratio; Plant Oils; Prevalence; Risk
Factors; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0167-5273
- Country of Publication
- IRELAND
Record 10
from database: MEDLINE
Return
To Top
Return
To Menu Position #10
- Title
- Impaired fibrinolytic activity induced
by ingestion of butter: effect of
increased plasma lipids on the
fibrinolytic activity.
- Author
- Kozima Y; Urano T; Serizawa K; Takada
Y; Takada A
- Address
- Department of Internal Medicine,
Hamamatsu University School of Medicine,
Shizuoka-ken, Japan.
- Source
- Thromb Res, 1993 Apr, 70:2, 191-202
- Abstract
- To investigate the effects of the
increased plasma lipid level on
fibrinolysis, we measured the levels of
fibrinolytic components in serially
obtained plasma samples from healthy
volunteers after the intake of different
amounts of butter. Plasma triglyceride
level increased significantly after
butter intake compared to the control
group. Eight hours after the intake of
100g of butter, plasminogen activator
inhibitor 1 (PAI-1) level in plasma was
significantly higher and euglobulin clot
lysis time was significantly prolonged
compared to those of the control group.
There was no effect on plasma tissue
plasminogen activator level. These
results suggest that the temporary
increase in plasma triglyceride level
induced high PAI-1 level, resulting in
impaired fibrinolytic activity. The
effect of temporary hyperlipidemia on
platelet function was also analyzed and
revealed that the response of platelets
to ADP and collagen was lower in the
butter intake group compared to those of
the control.
- Language of Publication
- English
- Unique Identifier
- 9331077
| | | |
