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Record 1
from database: MEDLINE
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- Title
- The need for special foods and sugar
substitutes by individuals with diabetes
mellitus.
- Author
- Talbot JM; Fisher KD
- Address
-
- Source
- Diabetes Care, 1978 Jul, 1:4, 231-40
- Abstract
- The need for special dietary products
marketed for use by individuals with
diabetes mellitus and the safety and
efficacy of certain nutritive sweetener
substitutes for sucrose are reviewed.
Special foods for individuals with
diabetes mellitus are not necessary to
achieve the dietary objectives
recommended by leading United States and
European authorities. They can be
achieved conveniently and at minimum
expense through enlightened choices of
commonly available food items. At
present, specific and unique
characteristics of food products with
special therapeutic properties for diets
of diabetic individuals cannot be
delineated or defined on rational
nutritional grounds. Such terms as
"diet", "dietetic",
and "diabetic" on food labels
have no uniform meaning for consumers,
and diabetologists have observed that
patients tend to consume such foods
without regard to their energy content.
Some consumers regard the
reduced-calorie and low-calorie prepared
food products as convenient in diets for
weight reduction and diabetes although
their use in dietary management of
diabetes has no therapeutic basis other
than weight reduction and maintenance.
When fed as pure substances to fasted
subjects, the nonglucose carbohydrate
nutritive sweeteners, fructose, xylitol,
and sorbitol, are absorbed relatively
slowly and produce less postprandial
hyperglycemia and insulin response than
sucrose or glucose. Adequate studies of
their long-term effectiveness when
ingested as part of mixed meals have not
been conducted. Although these sucrose
substitutes are generally considered
safe, the significance of recent
information on possible carcinogenicity
of oral xylitol in long-term feeding
studies has not been fully evaluated. In
view of the lack of certain essential
information on the long-term
effectiveness of various diets in
preventing or mitigating the chronic
debilitating complication of diabetes,
suggestions for future research are
included.
- Language of Publication
- English
- Unique Identifier
- 81113517
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- MeSH Heading (Major)
- Diabetic Diet|*; Food, Formulated|*;
Sweetening Agents|AE/ME/*TU
- MeSH Heading
- Blood Glucose|ME; Dietary
Carbohydrates|TU; Energy Intake;
Fructose|TU; Human; Sorbitol|TU;
Support, U.S. Gov't, P.H.S.; Xylitol|TU
- Publication Type
- JOURNAL ARTICLE; REVIEW
- ISSN
- 0149-5992
- Country of Publication
- UNITED STATES
Record 2
from database: MEDLINE
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- Title
- Influence of treatment with diet alone
on oral glucose-tolerance test and
plasma sugar and insulin levels in
patients with maturity-onset diabetes
mellitus.
- Author
- Doar JWH; Wilde CE; Thompson ME;
Sewell PFJ
- Address
-
- Source
- Lancet, 1975 Jun, 1:7919, 1263-6
- Abstract
- Oral glucose-tolerance test (O.G.T.T.)
plasma sugar and insulin levels were
measured in 118 newly diagnosed
maturity-onset diabetic patients before
and after treatment with diet alone for
periods of 2 and 6 months. The results
of glucose-tolerance tests carried out
during treatment could be predicted from
the initial test and the weight
reduction between the tests. This
prediction was not improved by the
addition of further variables, including
age, obesity, and plasma-insulin levels
during the first test. The change in
O.C.T.T. plasma-insulin between the
first and second tests was predicted by
the result of the initial tests, the
improvement of glucose tolerance between
the two tests, and the degree of weight
reduction. 95% of the group achieved
some improvement of glucose tolerance
after 2 months of dietary treatment, and
59% of the group achieved adequate
diabetic control by this time. It is
concluded that treatment with diet alone
should be the first-line management for
patients with newly diagnosed
maturity-onset diabetes mellitus.
- Language of Publication
- English
- Unique Identifier
- 75173885
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- MeSH Heading (Major)
- Blood Glucose|*AN; Diabetes
Mellitus|BL/*DH/DI; Diabetic Diet|*;
Insulin|*BL
- MeSH Heading
- Adult; Age Factors; Aged; Body Weight;
Glucose Tolerance Test; Human; Middle
Age; Remission, Spontaneous; Time
Factors
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0140-6736
- Country of Publication
- ENGLAND
Record 3
from database: MEDLINE
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- Title
- Beta-adrenoceptor-blocking drugs and
blood sugar control in diabetes
mellitus.
- Author
- Wright AD; Barber SG; Kendall MJ;
Poole PH
- Address
-
- Source
- Br Med J, 1979 Jan, 1:6157, 159-61
- Abstract
- The effects on diabetic control of the
relative cardioselective beta-blocker
metoprolol and the non-selective drug
propranolol were compared in 20
hypertensive diabetic patients receiving
diet alone or diet and oral
hypoglycaemic agents. Each drug was
given for one month in a double-blind,
cross-over study. Fasting, noon, and
mid-afternoon blood sugar concentrations
rose by 1.0-1.5 mmol/l (18-27 mg/100
ml). The rise with propranolol was not
significantly greater than with
metoprolol. In a few patients the rise
was clinically important. The small
overall change observed in diabetic
control should not deter the use of
beta-blockers in non-insulin-dependent
diabetics, provided control is carefully
monitored at the onset of treatment.
- Language of Publication
- English
- Unique Identifier
- 79125266
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- MeSH Heading (Major)
- Blood Glucose|*ME; Diabetes
Mellitus|*BL/CO; Metoprolol|*PD/TU;
Propanolamines|*PD; Propranolol|*PD/TU
- MeSH Heading
- Adult; Aged; Clinical Trials;
Comparative Study; Double-Blind Method;
Female; Human; Hypertension|CO/DT; Male;
Middle Age
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0007-1447
- Country of Publication
- ENGLAND
Record 4
from database: MEDLINE
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- Title
- Hormonal profile, blood sugar control
and HLA patterns in long-term insulin
dependent diabetes with and without
vascular disease.
- Author
- Larkins RG; Martin FI; Heding LG; Tait
BD
- Address
-
- Source
- Aust N Z J Med, 1978 Oct, 8:5, 465-71
- Abstract
- Nineteen insulin dependent diabetics
with onset at 30 years of age or less
and duration of diabetes of greater than
25 years were divided into two groups on
the basis of the presence or absence of
clinically evident vascular disease. The
patients without vascular disease were
characterised by a later mean age of
onset, lower fasting growth hormone
concentration, and a lower frequency of
the unusual HLA pattern B8 without A1
compared to the diabetics with vascular
complications. The level of blood
glucose control assessed over the last
15 years, insulin antibody titres,
plasma glucagon levels and plasma
cholesterol did not differ between the
two groups. Residual beta cell activity
was found in only one of the 19
patients. Although this study does not
exclude an effect of the degree of blood
glucose control or persistence of beta
cell function in the early stages of
diabetes on the subsequent development
of vascular disease, it suggests that
genetic factors, age of onset and plasma
growth hormone levels may be more
important.
- Language of Publication
- English
- Unique Identifier
- 79123624
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- MeSH Heading (Major)
- Blood Glucose|*ME; Diabetes
Mellitus|DT/GE/*ME; Diabetic
Angiopathies|GE/*ME; HLA Antigens|*;
Insulin|*TU; Somatotropin|*BL
- MeSH Heading
- Adult; Age Factors; Female; Human;
Islets of Langerhans|PP; Male; Middle
Age
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0004-8291
- Country of Publication
- AUSTRALIA
Record 5
from database: MEDLINE
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- Title
- Sugar intake and diabetes mellitus.
- Author
- Walker AR
- Address
-
- Source
- S Afr Med J, 1977 Jun, 51:23, 842-51
- Abstract
- Within the last century the prevalence
and mortality rates of diabetes and
other degenerative diseases have
increased considerably. Simultaneously,
there have been marked alterations in
the types and amounts of food consumed.
One of the most conspicuous dietary
changes has been the very considerable
rise in sugar intake. Some regard this
change specifically as the factor most
responsible for the increase in
diabetes. In this review, the
relationship between rises in sugar
intake and prevalences of diabetes and
the bearing of sugar intake on obesity
are discussed. There is not enough
evidence that a high intake of sugar
specifically promotes the development of
diabetes, but this does not imply that
sugar intake is unimportant. Because of
the high prevalence of obesity in some
populations, restriction of sugar intake
is as important as other dietary
restrictions.
- Language of Publication
- English
- Unique Identifier
- 77216329
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- MeSH Heading (Major)
- Diabetes Mellitus|EP/*ET/MO; Dietary
Carbohydrates|*AE; Sucrose|*AE
- MeSH Heading
- Adult; Aged; Animal; Europe; Female;
Glucose|ME; Human; Israel; Male; Mice;
Middle Age; Obesity|EP; Rats; South
Africa; United States
- Publication Type
- JOURNAL ARTICLE; REVIEW
- ISSN
- 0038-2469
- Country of Publication
- SOUTH AFRICA
Record 6
from database: MEDLINE
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- Title
- A random blood sugar diabetes
detection survey.
- Author
- Abernethy MH; Andre C; Beaven DW;
Taylor HW; Welsh G
- Address
-
- Source
- N Z Med J, 1977 Aug, 86:593, 123-6
- Abstract
- In a co-operative study undertaken
between various groups in the community,
3212 persons were screened at the
Agricultural and Pastoral Summer Show in
Christchurch. The mean glucose value was
88.4 mg/dl (4.9mmol/l) which roughly
equates to 91 mg/dl (5.1mmol/l) plasma
value. There was a standard deviation of
19.5mg/dl (1.08mmol/l) the 22.5
percentile was 63mg (3.5mmol/l), the
97.5 percentile was 125 (6.5mmol/l). One
hundred and twenty persons of the total
of 3212 were advised to contact their
family doctors as a result of higher
than normal blood sugar levels on the
day. Twenty-five probable diabetics were
diagnosed.
- Language of Publication
- English
- Unique Identifier
- 78093017
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- MeSH Heading (Major)
- Blood Glucose|*AN; Diabetes
Mellitus|EP/*PC; Health Education|*;
Mass Screening|*
- MeSH Heading
- Adult; Aged; Human; Infant; Middle
Age; New Zealand
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0028-8446
- Country of Publication
- NEW ZEALAND
Record 7
from database: MEDLINE
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- Title
- Diet and oral antidiabetic drugs and
plasma sugar and insulin levels in
patients with maturity-onset diabetes
mellitus.
- Author
- Doar JW; Thompson ME; Wilde CE; Sewell
PF
- Address
-
- Source
- Br Med J, 1976 Feb, 1:6008, 498-500
- Abstract
- A longitudal study was carried out to
separate the effects of treatment with
diet from those of treatment with
glibenclamide and phenformin on the oral
glucose tolerance test (OGTT) plasma
sugar and insulin levels in 118 patients
with maturity-onset diabetes mellitus.
Both drugs improved glucose tolerance
and random blood sugar levels more than
diet alone. The improved glucose
tolerance with both drugs was due to a
combination of a reduced fasting plasma
sugar level and an improved tolerance to
the glucose load. Treatment with
glibenclamide increased insulin
secretion but phenformin had no
significant effect. Mean body weight
fell slightly during phenformin
administration, whereas a small but
insignificant rise in patients receiving
glibenclamide.
- Language of Publication
- English
- Unique Identifier
- 76137253
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- MeSH Heading (Major)
- Glyburide|*TU; Phenformin|*TU
- MeSH Heading
- Blood Glucose|AN; Body Weight;
Comparative Study; Female; Glucose
Tolerance Test; Human; Insulin|BL; Male;
Middle Age
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0007-1447
- Country of Publication
- ENGLAND
Record 8
from database: MEDLINE
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- Title
- Plasminogen activation in diabetes
mellitus: normalization of blood sugar
levels improves impaired enzyme kinetics
in vitro.
- Author
- Geiger M; Binder BR
- Address
-
- Source
- Thromb Haemost, 1985 Aug, 54:2, 413-4
- Abstract
- We have demonstrated previously that
fibrin enhanced plasmin formation by the
vascular plasminogen activator was
significantly impaired, when components
isolated from the plasma of three
uncontrolled diabetic patients (type I)
were used to study plasminogen
activation in vitro. In the present
study it can be demonstrated that
functional properties of the vascular
plasminogen activators as well as of the
plasminogens from the same three
diabetic patients are significantly
improved after normalization of blood
sugar levels and improvement of HbA1c
values. Most pronounced the Km of
diabetic vascular plasminogen activator
in the presence of fibrin returned to
normal values, and for diabetic
plasminogen the prolonged lag period
until maximal plasmin formation occurred
was shortened to almost control values.
From these data we conclude that the
observed abnormalities of in vitro
fibrinolysis are not primarily
associated with the diabetic disease,
but might be secondary to metabolic
disorders caused by diabetes.
- Language of Publication
- English
- Unique Identifier
- 86097629
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- MeSH Heading (Major)
- Blood Glucose|*ME; Diabetes
Mellitus|BL/*EN; Plasminogen|*BI
- MeSH Heading
- Adult; Enzyme Activation; Female;
Human; In Vitro; Kinetics; Male;
Plasmin|AI/ME; Plasminogen Activators|BL;
Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0340-6245
- Country of Publication
- GERMANY, WEST
Record 9
from database: MEDLINE
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- Title
- Artificial endocrine pancreas
(closed-loop-system for blood sugar
control in diabetes mellitus):
introduction to the subject.
- Author
- Pfeiffer EF
- Address
- Universitat Ulm, Medizinische Klinik
und Poliklinik, F.R.G.
- Source
- Artif Organs, 1988 Aug, 12:4, 310-9
- Abstract
- Clearly, continuous blood glucose
monitoring by portable instruments is
the only and absolute prerequisite for
unprejudiced evaluation of the various
strategies for substitution of insulin
deficiency in any form of diabetes
mellitus. Continuous blood or tissue
glucose monitoring remain the
prerequisite for reestablishing a
satisfactory feedback control mechanism
between insulin secretion and blood
glucose concentration in any nondiabetic
patient. Loss of first-phase insulin
secretion produces defects in regulation
of carbohydrate metabolism, as in type
II diabetic human subjects. All efforts
to solve this important problem are
justified.
- Language of Publication
- English
- Unique Identifier
- 89025212
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- MeSH Heading (Major)
- Blood Glucose|*ME; Diabetes Mellitus,
Insulin-Dependent|BL/*DT; Diabetes
Mellitus, Non-Insulin-Dependent|BL/*DT;
Insulin Infusion Systems|*
- MeSH Heading
- Animal; Blood Glucose Self-Monitoring|IS;
Human; Insulin|BL
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0160-564X
- Country of Publication
- UNITED STATES
Record 10
from database: MEDLINE
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- Title
- Patients' participation in medical
care: effects on blood sugar control and
quality of life in diabetes.
- Author
- Greenfield S; Kaplan SH; Ware JE Jr;
Yano EM; Frank HJ
- Address
- Department of Medicine, University of
California, Los Angeles.
- Source
- J Gen Intern Med, 1988 Sep, 3:5,
448-57
- Abstract
- To maximize disease control, patients
must participate effectively in their
medical care. The authors developed an
intervention designed to increase the
involvement of patients in medical
decision making. In a 20-minute session
just before the regular visit to a
physician, a clinic assistant reviewed
the medical record of each experimental
patient with him/her, guided by a
diabetes algorithm. Using systematic
prompts, the assistant encouraged
patients to use the information gained
to negotiate medical decisions with the
doctor. A randomized trial was conducted
in two university hospital clinics to
compare this intervention with standard
educational materials in sessions of
equal length. The mean pre-intervention
glycosylated hemoglobin (HbA1) values
were 10.6 +/- 2.1% for 33 experimental
patients and 10.3 +/- 2.0% for 26
controls. After the intervention the
mean levels were 9.1 +/- 1.9% in the
experimental group (p less than 0.01)
and 10.6 +/- 2.22% for controls.
Analysis of audiotapes of the visits to
the physician showed the experimental
patients were twice as effective as
controls in eliciting information from
the physician. Experimental patients
reported significantly fewer function
limitations. The authors conclude that
the intervention is feasible and that it
changes patient behavior, improves blood
sugar control, and decreases functional
limitations.
- Language of Publication
- English
- Unique Identifier
- 89011051
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- MeSH Heading (Major)
- Diabetes Mellitus|BL/*PX/TH; Patient
Participation|*
- MeSH Heading
- Clinical Trials; Consumer
Satisfaction; Female; Hemoglobin A,
Glycosylated|AN; Human; Male; Middle
Age; Patient Education;
Physician-Patient Relations; Quality of
Life; Random Allocation; Support, U.S.
Gov't, P.H.S.
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0884-8734
- Country of Publication
- UNITED STATES
Record 11
from database: MEDLINE
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- Title
- Use of an alpha-glucosidase inhibitor
to synchronize sugar absorption with
delayed insulin secretion in a patient
with non-insulin-dependent diabetes
mellitus.
- Author
- Okada S; Ishii K; Tanokuchi S; Hamada
H; Ichiki K; Ota Z
- Address
- Third Department of Internal Medicine,
Okayama University Medical School,
Japan.
- Source
- J Int Med Res, 1996 Jan, 24:1, 164-8
- Abstract
- The case of a 67-year-old women with
non-insulin-dependent diabetes mellitus
is described. Diabetes was first
diagnosed when the woman was aged 55; a
diet of 1440 kcal daily was recommended
and 500 mg tolbutamide daily was
prescribed. Hypoglycaemia was improved
for a while but the blood-sugar
concentration gradually increased until
a tolbutamide dose of 2000 mg/day was
needed. The patient eventually came to
an out-patient clinic for diabetes
control due to continuous hyperglycaemia.
Her diabetes proved difficult to
control, probably due, in part, to
excessive eating and lack of exercise,
despite appropriate education and
glibenclamide treatment. After 15
months, an alpha-glycosidase inhibitor,
at a dosage of 0.75 mg/day, was added to
the treatment with glibenclamide at 7.5
mg/day and the glycosylated haemoglobin
level was reduced to normal levels
within 2 months. After a further 6
months the glibenclamide dose was
reduced to 3.75 mg/day with no ill
effects during the subsequent 4 weeks,
up to the present day.
- Language of Publication
- English
- Unique Identifier
- 96231167
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- MeSH Heading (Major)
- alpha-Glucosidases|*AI; Diabetes
Mellitus, Non-Insulin-Dependent|*DT/*PP;
Enzyme Inhibitors|AD/*TU; Insulin|*SE
- MeSH Heading
- Aged; Blood Glucose|ME; Case Report;
Female; Glyburide|AD; Hemoglobin A,
Glycosylated|ME; Human
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0300-0605
- Country of Publication
- ENGLAND
Record 12
from database: MEDLINE
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- Title
- A randomized clinical trial comparing
behavior modification and individual
counseling in the nutritional therapy of
non-insulin-dependent diabetes mellitus:
comparison of the effect on blood sugar,
body weight, and serum lipids.
- Author
- Rabkin SW; Boyko E; Wilson A; Streja
DA
- Address
-
- Source
- Diabetes Care, 1983 Jan, 6:1, 50-6
- Abstract
- To determine whether a group behavior
modification approach might be
preferable to individual counseling in
the nutritional therapy of
non-insulin-dependent diabetes mellitus,
40 adults younger than 65 yr of age with
diabetes mellitus who were not receiving
insulin were randomized to either a
program of individualized dietary review
and recommendations or a program of
group meetings aimed at controlling the
signals leading to overeating and
noncompliance with a diabetic dietary
regimen. Statistically significant (P
less than 0.05) decreases in body
weight, sum skin-fold thickness, fasting
serum glucose, and serum triglycerides
but not LDL-C or HDL-C were observed.
The individual counseling group had a
greater amount of weight loss than the
behavior modification group. There were
no significant (P greater than 0.05)
differences between the two groups with
respect to the biochemical outcome
variables. Patient characteristics
assessed at entry--namely anxiety,
internal versus external locus of
control and perceived disease severity,
and compliance with advice--were
significantly associated with weight
loss in the behavior modification group
while only the latter index was of value
in the individual counseling group.
Thus, our use of these programs does not
identify a clear advantage of either
approach in the nutritional therapy of
non-insulin-dependent diabetic patients.
- Language of Publication
- English
- Unique Identifier
- 83181968
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- MeSH Heading (Major)
- Behavior Therapy|*; Blood Glucose|*AN;
Body Weight|*; Counseling|*; Diabetes
Mellitus|*DH; Lipids|*BL
- MeSH Heading
- Adult; Cholesterol|BL; Clinical
Trials; Comparative Study; Human;
Lipoproteins, HDL|BL; Lipoproteins,
LDL|BL; Middle Age; Random Allocation;
Support, Non-U.S. Gov't;
Triglycerides|BL
- Publication Type
- CLINICAL TRIAL; JOURNAL ARTICLE;
RANDOMIZED CONTROLLED TRIAL
- ISSN
- 0149-5992
- Country of Publication
- UNITED STATES
Record 13
from database: MEDLINE
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- Title
- Sugar constituents of the seromucoid
in insulin-dependent diabetes.
- Author
- Turyna B; Sarnecka Keller M; Ciba T
- Address
-
- Source
- Exp Clin Endocrinol, 1984 Mar, 83:1,
87-92
- Abstract
- Seromucoid glycoproteins reveal
different carbohydrate composition in
diabetic patients as compared with
normal subjects. An increased glucose
content is the most characteristic
feature of seromucoid found in diabetic
patients. The amounts of proteins,
neutral sugars, amino-sugars and sialic
acids in seromucoid correlate with
diabetic microangiopathy.
- Language of Publication
- English
- Unique Identifier
- 84208371
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- MeSH Heading (Major)
- Carbohydrates|*AN; Diabetes Mellitus,
Insulin-Dependent|*ME; Orosomucoid|*AN
- MeSH Heading
- Adult; Female; Human; Male; Sialic
Acids|AN; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0232-7384
- Country of Publication
- GERMANY, EAST
Record 14
from database: MEDLINE
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- Title
- Effects of sugar alcohols and
disaccharides in inducing the hexagonal
phase and altering membrane properties:
implications for diabetes mellitus.
- Author
- Bryszewska M; Epand RM
- Address
- Department of Biochemistry, McMaster
University Health Sciences Centre,
Hamilton, Canada.
- Source
- Biochim Biophys Acta, 1988 Sep, 943:3,
485-92
- Abstract
- A number of sugars lowered the bilayer
to hexagonal phase transition
temperature of
dielaidoylphosphatidylethanolamine.
Disaccharides had the greatest effect
followed by sugar alcohols. The
monosaccharides, glucose and galactose
had no effect on this phase transition
temperature. The sugars promoted vesicle
leakage only under conditions where the
lipid was near its hexagonal phase
transition temperature. Leakage from
lipids in the bilayer state was
inhibited by the sugars. Polyols, such
as sorbitol, promote hexagonal phase
formation and alter membrane
permeability. These membrane effects may
contribute to the damage caused by
sorbitol accumulation in certain tissues
of diabetic patients.
- Language of Publication
- English
- Unique Identifier
- 88326959
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- MeSH Heading (Major)
- Cell Membrane|*DE/ME; Diabetes
Mellitus|*ME; Disaccharides|*PD; Lipid
Bilayers|*ME; Sugar Alcohols|*PD
- MeSH Heading
- Calorimetry, Differential Scanning;
Fluoresceins; Human; Nuclear Magnetic
Resonance; Phosphatidylethanolamines|ME;
Support, Non-U.S. Gov't; Temperature
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0006-3002
- Country of Publication
- NETHERLANDS
Record 15
from database: MEDLINE
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- Title
- Metabolic changes induced by sugar in
relation to coronary heart disease and
diabetes.
- Author
- Yudkin J
- Address
- University of London.
- Source
- Nutr Health, 1987, 5:1-2, 5-8
- Abstract
- The effects on the biochemistry and
physiology of the human body of diets
differing only in the ratio of the two
major carbohydrates, starch and sugars
are discussed and related to the
epidemiology of coronary heart disease
and diabetes.
- Language of Publication
- English
- Unique Identifier
- 88039786
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- MeSH Heading (Major)
- Coronary Disease|ET/*ME; Diabetes
Mellitus|ET/*ME; Dietary
Carbohydrates|*ME
- MeSH Heading
- Blood Glucose|ME; Human; Platelet
Adhesiveness
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW,
TUTORIAL
- ISSN
- 0260-1060
- Country of Publication
- ENGLAND
Record 16
from database: MEDLINE
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- Title
- Control of blood sugar in
insulin-dependent diabetes: comparison
of an artificial endocrine pancreas,
continuous subcutaneous insulin
infusion, and intensified conventional
insulin therapy.
- Author
- Rizza RA; Gerich JE; Haymond MW;
Westland RE; Hall LD; Clemens AH;
Service FJ
- Address
-
- Source
- N Engl J Med, 1980 Dec, 303:23, 1313-8
- Abstract
- We compared the ability of closed-loop
intravenous insulin infusion (i.e., an
artificial "pancreas"),
open-loop continuous subcutaneous
insulin infusion, and intensified
conventional insulin therapy (preprandial
injections of regular insulin, with
injection of long-acting zinc-suspension
insulin before breakfast) to bring the
hyperglycemia of insulin-dependent
diabetic subjects to a level comparable
to that of normal, nondiabetic subjects.
The mean circadian levels of plasma
glucose, mean amplitude of glycemic
excursions, and M values (defined in
Methods) did not significantly differ
among the three regimens. Although these
levels in the diabetic subjects
approximated those in the normal
subjects, the levels of plasma insulin,
mean amplitude of glycemic excursions,
and M values were significantly higher
than those in normal subjects (P <
0.01). Therefore, at least on a
short-term basis, all three regimens can
produce comparable, nearly normal levels
of blood sugar in such patients;
moreover, closed-loop devices can be
used to determine insulin requirements
for conventional therapy.
- Language of Publication
- English
- Unique Identifier
- 81052117
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- MeSH Heading (Major)
- Blood Glucose|*ME; Diabetes
Mellitus|BL/*DT; Insulin|*AD/TU
- MeSH Heading
- Adult; Comparative Study; Female;
Human; Injections, Intravenous|IS;
Injections, Subcutaneous; Insulin,
Lente|AD; Male; Middle Age; Support,
Non-U.S. Gov't; Support, U.S. Gov't,
P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0028-4793
- Country of Publication
- UNITED STATES
Record 17
from database: MEDLINE
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- Title
- The effect of sugar cereal with and
without a mixed meal on glycemic
response in children with diabetes.
- Author
- Wang SR; Chase HP; Garg SK; Hoops SL;
Harris MA
- Address
- Barbara Davis Center for Childhood
Diabetes, Department of Pediatrics,
University of Colorado Health, Sciences
Center, Denver 80262.
- Source
- J Pediatr Gastroenterol Nutr, 1991
Aug, 13:2, 155-60
- Abstract
- The effect of sucrose consumption on
glycemic control in children with
insulin-dependent diabetes mellitus is
unclear. Eight young subjects, 7-16
years of age, with a duration of
diabetes of 2-8 years participated in
this study. All subjects consumed four
different breakfasts--oatmeal (OM)
alone, oatmeal-sucrose (OMS),
oatmeal-protein (OMP), and oatmeal with
protein and sucrose (OMPS)--on four
different days. Addition of sucrose
resulted in a slightly greater area
under the tolerance curve in 50% of the
subjects; however, in 38% of subjects,
the area decreased. The peak glucose
level was lowest for OM, but there was
no statistical difference in the peak
levels of the four test meals. The most
significant effect on glucose response
was a delay in the peak time when
protein was added to the meals. Peak
times for OM and OMS (mean of 38 min)
when fed alone were significantly (p
less than 0.05, ANOVA) shorter when
compared to the peak time for OMP and
OMPS (mean of 54 min). The average
recovery time for OMP was longest. Other
indices (tolerance index and change of
rise in blood glucose) measured were not
significantly different among the test
meals. This study demonstrates that
adding limited sucrose to OM cereal has
little effect on the blood glucose
response in children with diabetes.
Addition of protein and fat clearly
delays the glycemic response.
- Language of Publication
- English
- Unique Identifier
- 92045188
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- MeSH Heading (Major)
- Blood Glucose|*ME; Diabetes Mellitus,
Insulin-Dependent|*BL; Dietary Fats|*AD;
Dietary Proteins|*AD; Sucrose|*AD
- MeSH Heading
- Adolescence; Cereals; Child; Female;
Human; Male; Random Allocation; Support,
Non-U.S. Gov't; Support, U.S. Gov't,
P.H.S.
- Publication Type
- CLINICAL TRIAL; CONTROLLED CLINICAL
TRIAL; JOURNAL ARTICLE
- ISSN
- 0277-2116
- Country of Publication
- UNITED STATES
Record 18
from database: MEDLINE
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- Title
- A clinical study on treatment of
vascular complications of diabetes with
the sugar--reducing and
pulse--invigorating capsule.
- Author
- Lin L; Zhang H; Gao Q; Ma J
- Address
- Guang'anmen Hospital, China Academy of
Traditional Chinese Medicine, Beijing.
- Source
- J Tradit Chin Med, 1994 Mar, 14:1, 3-9
- Abstract
- The capsule is effective in
replenishing qi, nourishing yin,
activating blood, and resolving stasis.
It can correct abnormalities in blood
rheology, improve fat metabolism,
enhance functioning of the islets of
Langerhans, lower blood sugar, and
alleviate clinical symptoms. Efficacious
also against the chief vascular
complications of diabetes, it helps in
abating myocardial anoxia, improving
left heart function, stimulating blood
circulation to the brain, resisting
coagulation and resolving thrombosis,
also dilating the arteries of the legs.
It is of some benefit in early diabetic
retinopathy and renal diseases.
- Language of Publication
- English
- Unique Identifier
- 94254501
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- MeSH Heading (Major)
- Cerebrovascular Disorders|*DT;
Diabetes Mellitus,
Non-Insulin-Dependent|*DT; Diabetic
Angiopathies|*DT; Drugs, Chinese
Herbal|*TU
- MeSH Heading
- Adult; Aged; Capsules; Diabetic
Nephropathies|DT; Diabetic
Retinopathy|DT; Female; Human; Male;
Middle Age
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0254-6272
- Country of Publication
- CHINA
Record 19
from database: MEDLINE
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- Title
- Depression and diabetes mellitus. A
study of the relationship between serum
cortisol and blood sugar levels in
patients with endogenous depression.
- Author
- Rihmer Z; Arató M
- Address
-
- Source
- Neuropsychobiology, 1982, 8:6, 315-8
- Abstract
- The relationship between serum
cortisol and fasting blood sugar levels
in 39 female patients with endogenous
depression was studied. Serum cortisol
levels were determined in two post-dexamethasone
blood samples during the dexamethasone
suppression test. There were no
significant differences between the
blood sugar levels of suppressors
(patients with low serum cortisol level)
and non-suppressors (patients with high
serum cortisol level). There was no
correlation between the serum cortisol
levels and blood sugar values in these
two groups either. Although numerous
reports claim to have found a
relationship between endogenous
depression and diabetes mellitus, our
data do not imply a direct relationship
between serum cortisol and blood glucose
levels of endogenously depressed
patients.
- Language of Publication
- English
- Unique Identifier
- 83142030
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- MeSH Heading (Major)
- Blood Glucose|*ME; Depressive
Disorder|*BL; Diabetes Mellitus|*BL;
Hydrocortisone|*BL
- MeSH Heading
- Dexamethasone|DU; Female; Human;
Middle Age
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0302-282X
- Country of Publication
- SWITZERLAND
Record 20
from database: MEDLINE
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- Title
- Diabetes mellitus and hypertension
based on the family history and 2-h
postprandial blood sugar in the Ann-Lo
district (northern Taiwan).
- Author
- Lin JD; Shieh WB; Huang MJ; Huang HS
- Address
- Division of Endocrinology and
Metabolism, Chang Gung Memorial
Hospital, Taipei, Taiwan, Republic of
China.
- Source
- Diabetes Res Clin Pract, 1993 Apr,
20:1, 75-85
- Abstract
- From July 1988 to June 1990, we
performed an epidemiological study on
the prevalence of hypertension and
diabetes mellitus (DM) in the Ann-Lo
district, a suburban area of Northern
Taiwan. One third of the population in
the district was randomly sampled. A
total of 9087 persons were screened with
67.4% participating. Following
completion of the questionnaire blood
pressure, 2 h postprandial blood sugar
were determined. DM was defined when the
blood sugar was over 200 mg/dl or the
subject had a diabetic history.
Hypertension was defined if the systolic
blood pressure was over 160 mmHg or the
diastolic blood pressure over 95 mmHg.
Statistical comparisons were performed
with a chi-square test, analysis of
covariance, stepwise multiple regression
and Pearson correlation matrix. In this
study, the prevalence rate of DM was
2.6% and of hypertension was 6.4%. For
those patients 40 years or older, the
prevalence rate for DM was 8.0% and for
hypertension was 19.7%. The prevalence
of hypertension was 24.8% in overt
diabetes and 5.2% in the normal
subjects. Analysis of the data between
risk factors of DM revealed that DM
correlated with age, body mass index,
hypertension, smoking, family history of
DM and correlated negatively with
education. Hypertension correlated with
gender, alcohol intake and smoking,
sugar level, age and body mass index.
The prevalence rate of diabetes and
hypertension were quite high in the
district and this study pointed out the
important risk factors for hypertension
and DM in Taiwan.
- Language of Publication
- English
- Unique Identifier
- 93345286
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- MeSH Heading (Major)
- Blood Glucose|*ME; Blood Pressure|*;
Diabetes Mellitus|*EP/GE/PC;
Hypertension|*EP/GE/PC; Medical History
Taking|*
- MeSH Heading
- Adolescence; Adult; Aged; Analysis of
Variance; Comparative Study; Demography;
Eating; Family; Female; Human; Male;
Mass Screening; Middle Age; Prevalence;
Questionnaires; Regression Analysis;
Support, Non-U.S. Gov't; Taiwan|EP
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0168-8227
- Country of Publication
- NETHERLANDS
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