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	2. Excerpt from the Director's File of the Clinic By Dr. Shigeru Makiuchi     Many of the patients visiting the organic germanium clinic have undergone length. v treatment at university hospitals or national, public or private hospitals, without experiencing any improvement in their condition. In general. they are people who have heard of germanium from friends or relatives :  who themselves have experienced cures or remissions, or at least an improvement in their respective diseases by the intake of organic germanium.     Gradually, the effects of the organic germanium, sometimes almost bordering on the miraculous, are becoming widely known and recognized, and the number of doctors favoring an "organic germanium treatment" has increased throughout Japan.  Accordingly, the number of patients calling on the Organic Germanium Clinic by recommendation of such doctors constantly increases. Unfortunately, however, not a few patients have distorted ideas about this compound. Hence, I wish to clarify some points as a doctor at the organic germanium clinic.     To begin with. organic germanium is now available in different preparations to facilitate its administration in various  disorders: (I ) in capsules, (2) in granules packed in alluvial, (3) in injection solution (for hypodermic, intramuscular and intravenous injection), (4) in suppositories, (5) in cream form, (6) in solution contained in vials as a drip for eye, ear and nose.     Regarding the toxicity of organic ~ germanium, the results of tests have shown organic germanium to be nontoxic and completely harmless. These tests on acute and subacute toxicity, deformity and accumulation were carried out by a  professor and his research staff at the laboratory of a renowned university and by an authoritative research institute entrusted to undertake this task.     A large number of patients entertain erroneous ideas with regard to the side effects of organic germanium. While it has been prescribed by many doctors to a large number of patients during the last eight years as a test treatment agent, no side effects have been observed either clinically or biochemical.     When viewed from the patients' viewpoint,  however. symptoms that may be suspected as being side effects, do appear. Such symptoms are especially liable to appear in patients with liver and kidney disorders, in allergic people, in those who are susceptible to bronchial asthma and hives and in patients suffering from stomach and intestinal disorders, constipation, chronic articular rheumatism and gout.     This is one of the characteristic actions of organic germanium.  Toxic elements, products of decomposition, waste matter and, foreign matter generated in the body, which are injurious to health or which obstruct disease curing processes, are discharged with the, urine, feces and also through the pores of the skin. In such cases, the volume of urine may increase, the feces may become softer and even watery and the frequency of discharge may increase to several times the usual amount. Unlike the effects generally known as diarrhea,  however, no abdominal pains accompany this process. Furthermore, when such matters are discharged through the skin by insensible perspiration, rash accompanied by itching appears. This symptom differs according to constitution, age, diet, duration of the disorder, existing condition of disorder and the dosage of organic germanium. Such phenomena are observed more frequently in patients with larger amounts of internal toxic elements. However, since these are the effects of organic germanium, the symptoms disappear within three days to two weeks when administration is in progress or when the dosage is controlled under instruction of the, doctor in charge. Having overcome these effects, the patient will feel fine. For example, when a patient suffering from gout or chronic arthritis takes organic germanium, the pain may intensify when the pain causing substance (uric acid in the case of gout) is removed  from the joint, but when administration is continued, the pain will be reduced within a few days to a few weeks. If treatment is suspended because of the pain the administration up to this point will become meaningless.     People with all sorts of ailments visit the organic Germanium Clinic. Thus, data on countless cases accumulate, a few of which, should be cited: Atopic dermatitis (8-year-old boy, weighing 21 kg) : Typical symptoms appeared all over his body a few months after birth. He was examined by specialists at different hospitals, underwent many sorts of treatment, including adrenocortical steroid treatment, without any effect. As later severe itching occurred, he was continually scratching himself. This had given rise to a complication in the form of acute inflammation and rash, swellings, local feverishness and pain became prominent.     Organic germanium was prescribed four times a day after each meal and before going to bead at the rate of 20 mg per 1 kg body weight. In addition, germanium cream was rubbed on the affected areas once immediately after rising in the morning and once before retiring at night.     After two months of treatment his condition improved around the elbows and knees, and he stopped scratching himself. Administration of germanium is being continued. Retrobulbar neuritis (state of total blindness) (32-year-old woman, weighing 50 kg) : Her eyesight began to decline about a year ago, and gradually she became almost totally blind so that she could not distinguish between day and night. She underwent treatment at well known ophthalmic hospitals without any effect.     The patient accompanied by her father was told at the Organic Germanium Clinic that it was doubtful whether any effect could be expected, since all the physicians attending her had given up the idea of Cure. On the insistence of father and daughter, who refused to give up, treatment was started orally twice a day, once after breakfast and once after supper, at the rate of 40 mg per I kg body weight. In addition, she was told to use one drop of the eye lotion eight times and more per day.     The result was that the patient became able to distinguish between day and night within one month. Her visual acuity improved to 0.1. in  two months, to 0.4 in three months and after six months to 1.0.  Needless to say, the patient and her family were delighted, saying the improvement was miraculous. Sub acute myelo-optico-neuropathy (SMON) (50-year-old woman, weighing 48 kg) : Acute sensory impediment appeared about 15 years ago, and because of a severe motor impediment in both lower legs, she began to experience difficulty in standing upright, walking becoming impossible. Obstruction of visual acuity gradually increased, her left eye becoming virtually blind. She had to use a wheelchair when she came for examination.     The sensory impediment in her lower legs was deep, muscular atrophy and decline of muscular strength became conspicuous and she showed the syndrome of the pyramidal tract. She also experienced urinary incontinence occasionally. On instruction, she twice daily took organic germanium capsules, once after breakfast and once after  supper, at the rate of 40 mg per 1 kg body weight. In addition, she was told to use germanium eye drops five times or more daily.     She started to walk again with the aid of crutches in about two months. When she visited the clinic three months  later, she was able to walk with only the help of a stick. Case of Nephrosis Syndrome (80-year-old man, weighing- 9 55 kg):  Edema appeared in the lower legs about a year ago, and he was treated at a public hospital for several months with adrenocortical steroid preparation, immunization depressors and others. but the edema grew worse expanding up to the abdomen and chest. It ultimately became an anasarca. Lasic and other diuretics were used, but the edema persisted. When he was brought to the Organic Germanium Clinic he was unable to walk. Examination showed his total serum protein content to be 5.8 g/dl, serum albumen content 2.7 g/dl, total cholesterol value 310 mg/dl and the urea nitrogen content 24 mg/dl (others omitted).     As the 24 hour value of urine protein could not be measured, the first early morning discharge was measured and showed 300-500 mg/dl. Blood pressure was 190- 120.     Organic germanium in capsules was prescribed three times daily to be taken after each meal, in a dosage of 30 mg per 1 kg body weight.  However, as the decline in edema was too slow even after two weeks, the dosage was increased to 40 mg per 1 kg body weight, with the same frequency of administration. As a result, the edema began to disappear first from the chest and then from the abdomen, and three weeks later it was only apparent in the lower part of the legs. His weight decreased to 51 kg, and after another two weeks the edema in both ]egs disappeared  completely, while his weight decreased to 49 kg.     Examination of the patient at this stage showed a total serum protein content of 6. I g/dl, serum albumen content of 4.2 gg/dl and urea nitrogen content of 21 mg/dl. The blood pressure was found to be normal. In addition to administration of germanium, the patient remains under observation as to his daily habits and diet. Case of Cerebellar Degeneration (25-year-old woman, weighing 48 kg): Difficulty in walking and speech impediment gradually developed about three years ago until she was no longer able to walk. Furthermore, she lost the ability to write. She had nystagmus, tinnitus and trembling limbs. Over a period of eight months she went from one specialist to another, to be told at ]ast that she suffered from cerebellar degeneration.  However, as the cause for this condition remained unclear she was told that there was no way to help her. When she at last came to our clinic, carried by her father and brother, she was a virtual cripple.     Organic germanium was prescribed orally at a dosage of 40 mg per 1 kg body weight, to be taken twice daily before breakfast and before supper. Within one month her speech impediment gradually declined and after five months her writing impediment, nystagmus and trembling of the limbs decreased. After ten months not only did her speech and writing impediments further decline, but she became capable of rising on her own and was even able to walk a short distance.  Tinnitus and trembling had completely disappeared. She continues germanium intake. Case of Hepatoma (56-year-old man, weighing 66 kg): Symptoms such as ]oss of appetite, loss of weight, general weariness and abdominal inflation began to appear from early June, 1977. He went for treatment at a hospital, but examination revealed liver cancer which was certified by liver puncture. liver scientigraphy, etc. He came to the Organic Germanium Clinic by recommendation of the hospital doctor in charge of his case. The result of the examination was a clear case of cancer of the liver and spleen, which could be felt at a distance of about six fingers from the costal bow. Abdominal dropsy and anemia were observed, but not jaundice.     Organic germanium, at 35 mg per I kg body weight, was prescribed three times daily before each meal. On August 3, the patient carried a letter from his attending physician requesting the doctor at the Organic Germanium Clinic to give the patient a daily intra-venous drip injection adding 5 % glucose to the germanium solution.  In addition to this daily intravenous injection (10 ml injection solution containing 200 mg organic germanium), germanium in capsules in a dosage of 60 mg per I kg body weight was prescribed to be taken three times daily before each meal. In addition, one suppository a day was used after evacuation. From September 2, intravenous injection solution was increased to 320 mg per day.     According to a report from the doctor in charge, the patient had been making good progress, when he caught a cold in mid November accompanied by fever. In early December an estimated 2,500 ml of abdominal dropsy was observed. Under these circumstances the daily injections were increased to 600 mg from December 15, accompanied by an oral intake and the use of suppositories in the same amount as before.     When the patient was again hospitalized on January 13, 1978, abdominal dropsy had disappeared and neither the liver tumor nor the spleen tumor could be tactically perceived. Examination on March 28 showed his condition to be almost normal. The doctor in charge conceded "no medicine that treats cancer so effectively has yet been developed. Moreover, the absence of side effects is amazing.  I am now wondering if it really has been cancer." The followings are the results of the biochemical serum tests ( excerpt ) :

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