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	6. Synthesis of Organic Germanium Compound To invent is not the conquest of nature. Man creates nothing, he merely uncovers things which were heretofore unknown. The synthesis of organic germanium has fulfilled a vision I have had since youth of doing something good for mankind. However, it was not an easy task. Research on the organic  germanium compound progressed smoothly at first. Working with germanium in organic form was not entirely new to me for I had previously met with considerable Success by extracting germanium from coal in the early 1950's. I had also succeeded in obtaining large quantities from liquefied coal gas. Previous research activities had been directed primarily at obtaining an inorganic ~ germanium of a high purity for use by the electronics industry.     To extract germanium from coal, I developed a process whereby the organic germanium in coal is removed at high temperature in a carbonization furnace. It is then liquefied by adjusting the pH and burned to eliminate miscellaneous organics. Afterwards, it is chlorianted and this chlorinated organic germanium is converted by hydrolysis into germanium oxide, a white powder, further reduced by hydrogen. Increased purity is achieved by zone melting, and finally a lump of cylindrical shaped silver-gray single crystals is produced.     The principal object of my research with germanium until that point had been to convert the organic germanium obtained from coal into an inorganic substance for the electronics industry     I was now faced with doing the reverse in converting inorganic germanium into an organic substance if it was to be of use in the field of biochemistry. I first thought that in order to obtain a germanium compound which is biochemically active, the synthetic germanium must be made with an affinity to living cells. My research staff and I studied the possibility of compounding germanium with either amino acid or nucleic acid. We attacked these and other possibilities from every angle, but our attempts failed. At the time, publications on germanium in Japanese or any other language were virtually nonexistent and ten years went by almost completely unnoticed while we were groping in the dark. In the meantime, the once flourishing coal industry had reached its zenith and began to decline from around 1959. With the decline, the royalties and research grants which I had been receiving from coal mining companies for my discoveries decreased sharply. Mv personal finances were also nearly exhausted, and it became increasingly difficult to run a research laboratory I often say, "Poverty and affliction are the mother of invention." Once I discussed this matter with Dr. Reppe, a German scientist who had been awarded the Nobel prize for his work in the chemistry of acetylene. He said, " Invention is made up of 90 % perspiration and 10 % gray matter.     Whilst trying to combat and resolve these difficulties I realized the danger of losing my creative spirit. I began to read fervently From Religion to Science by Bertrand Russell ; Einstein and the Order of Space; Zen and the Art of Archery by Eugen Herrigel; Dogen (about a Zen work), and several other books by Japanese authors. I made notes of the thoughts of great men and these supplied the thread that kept me from succumbing completely. The saying which sticks uppermost in mind, however, is "God may give you a chestnut but won't crack it and take it out of the shell for you."     In November, 1967, a member of my research staff who stayed on, walked into the room holding a test tube of white powder. Raising it slowly, and with an expression on his face which radiated the whole room, he uttered the words I had been waiting ten years to hear.  "Dr. Asai, the water-soluble organic germanium compound has at last been synthesized." For the first time in my life I shed tears of joy in deep silence as a man in ecstasy. They were tears of almost religious exaltation. The event proved to me that all of man's struggles are not in vain. The organic germanium compound synthesized on that day has changed my life, and as I hope you shall see, has done something good for everyone who has come in contact with it.

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