- Results for your query:on May 28, 2000
- Words in title only: germanium
- Words in abstract only: organic germanium
- Published in 1957 through 1999
- Only select references with abstracts available
- Show references published in English only
Documents: 1 to 12 of 12
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NLM database Documents
Record 1 from database: MEDLINE
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- Title
- Inhibition of senile amyloidosis of mice by biscarboxyethyl germanium
sesqui-oxide.
- Author
- Kuga N; Oboshi S; Sato H; Sato R
- Address
-
- Source
- Acta Pathol Jpn, 1976 Jan, 26:1, 63-71
- Abstract
- A mouse strain, ICR/SLC, was involved in spontaneous amyloidosis with high
incidence. The amyloid deposition in this strain was seen mainly in the
mucosal propria of duodenum and terminal ileum, liver, spleen, adrenal
cortices, and renal glomeruli. The mice, orally administered more than 300
mg/kg of organic germanium for 22 months since 5 weeks old, did not develop
amyloidosis. Half of the mice, given 30 mg/kg of organic germanium for 22
months developed amyloidosis. The mice given 5% carboxymethylcellulose, the
solvent of organic germanium, were affected with systemic amyloidosis with
high frequency. The results showed that the organic germanium successfully
inhibited the occurrence of senile amyloidosis with dose response. The agent
did not have any apparent relation to the incidence of hepatic cell
carcinoma or pulmonary adenoma which is frequently combined with aged mice.
Although the actual mechanism involved is not clear, the evidence of the
inhibition of senile amyloidosis by organic germanium may give a light to
elucidate the pathogenesis of amyloidosis.
- Language of Publication
- English
- Unique Identifier
- 76202414
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- MeSH Heading (Major)
- Amyloidosis|PA/*PC; Germanium|*TU
- MeSH Heading
- Animal; Female; Kidney|PA; Liver|PA; Male; Mice; Myocardium|PA; Propionic
Acids|TU
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0001-6632
- Country of Publication
- JAPAN
Record 2 from database: MEDLINE
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- Title
- Effect of germanium on 1,2-dimethylhydrazine-induced intestinal cancer in
rats.
- Author
- Jao SW; Lee W; Ho YS
- Address
- Department of Surgery, National Defense Medical Center, Taipei,
Taiwan,Republic of China.
- Source
- Dis Colon Rectum, 1990 Feb, 33:2, 99-104
- Abstract
- Through recent research, the trace element, germanium, was found to have
an anticancer effect. The purpose of this research was to determine the
effect of germanium on 1,2-dimethylhydrazine-induced intestinal cancer in
rats. Ninety-six 8-week-old Sprague-Dawley male rats were divided into 4
groups, with 24 rats in each group. All received dimethylhydrazine, 20 mg/kg
body weight, subcutaneously, once a week for 20 weeks. Except for one
control group, the other three groups were subdivided into six groups and
administered three different kinds of germanium (inorganic germanium,
organic germanium, and natural organic germanium) one month before and
during dimethylhydrazine treatment, and during dimethylhydrazine treatment,
respectively. Twenty-four weeks after carcinogen exposure, all surviving
animals were sacrificed and examined for intestinal tumors. The number and
location of the tumors were recorded and the pathology examined. The
incidence of intestinal cancer in the control group (dimethylhydrazine only)
was 91 percent; in groups provided with inorganic germanium one month before
and during dimethylhydrazine treatment, and during dimethylhydrazine
treatment only, it was 91 and 78 percent; in groups provided with organic
germanium one month before and during dimethylhydrazine treatment, and
during dimethylhydrazine treatment only, it was 64 and 64 percent; in groups
provided with natural organic germanium one month before and during
dimethylhydrazine treatment and during dimethylhydrazine treatment only, it
was 50 and 45 percent. From these results, the authors conclude that natural
organic germanium has the best prevention effect for intestinal cancer in
this animal model (P less than 0.01), followed by organic germanium (P less
than 0.05). Inorganic germanium has no effect. However, there is no
difference in the cancer prevention effect of germanium provided one month
before and during dimethylhydrazine treatment, and during dimethylhydrazine
treatment only.
- Language of Publication
- English
- Unique Identifier
- 90126120
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- MeSH Heading (Major)
- Germanium|*TU; Intestinal Neoplasms|CI/*DT/PC
- MeSH Heading
- Adenocarcinoma|CI/DT/PC; Adenocarcinoma, Mucinous|CI/DT/PC; Animal;
Carcinogens; Dimethylhydrazines; Male; Rats; Rats, Inbred Strains; Support,
Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0012-3706
- Country of Publication
- UNITED STATES
Record 3 from database: MEDLINE
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- Title
- Effect of organic germanium compound (Ge-132) on experimental osteoporosis
in rats.
- Author
- Fujii A; Kuboyama N; Yamane J; Nakao S; Furukawa Y
- Address
- Department of Pharmacology, Nihon University School of Dentistry, Chiba,
Japan.
- Source
- Gen Pharmacol, 1993 Nov, 24:6, 1527-32
- Abstract
- 1. The therapeutic effect of organic germanium compound,
2-carboxyethylgermaniumsesquioxide (Ge-132), for experimental osteoporosis
was studied using ovariectomized rats maintained on a low calcium containing
diet. 2. Serum calcitonin (sCT) level was decreased and serum parathyroid
hormone (sPTH) level was increased by ovariectomy and the decrement and
increment rates, respectively, were reduced by administration of Ge-132.
Thus, the sCT/sPTH ratio was greater in the groups given Ge-132, indicating
that the resorption was somehow inhibited by Ge-132. 3. The transverse
strength of femur bone was significantly enhanced by Ge-132. 4. A trend was
found in the group given Ge-132 for a larger femur cortical bone index. 5.
The relative femur bone wet weight was greater in the group given Ge-132. 6.
These results indicate that Ge-132 prevents decreased bone strength, and
affects the femur cortical bone index, and bone mineral mass caused by
osteoporosis.
- Language of Publication
- English
- Unique Identifier
- 94156120
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- MeSH Heading (Major)
- Germanium|*TU; Organometallic Compounds|*TU; Osteoporosis|*DT/ME/PA
- MeSH Heading
- Animal; Bone Density|DE; Calcitonin|BL; Calcium|DF/ME; Calcium, Dietary;
Female; Femur|ME/PA; Organ Weight|DE; Ovariectomy; Parathyroid Hormones|BL;
Phosphorus|ME; Rats; Rats, Wistar
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0306-3623
- Country of Publication
- ENGLAND
Record 4 from database: MEDLINE
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- Title
- Interaction of germanium (Ge) with biosilicification in the freshwater
sponge Ephydatia mülleri: evidence of localized membrane domains in the
silicalemma.
- Author
- Simpson TL; Garrone R; Mazzorana M
- Address
-
- Source
- J Ultrastruct Res, 1983 Nov, 85:2, 159-74
- Abstract
- In the presence of germanium (Ge) the needle-shaped silica spicules of the
freshwater sponge Ephydatia m ulleri are very short and thin and possess
bulbs with large spines. SEM-coupled X-ray analyses confirm the
incorporation of Ge into the silica. A small number of bulbs are susceptible
to erosion by HNO3 and hypochlorite and although the chemical basis of such
erosion is presently unknown it suggests the presence of an organic matrix
within the bulbs and/or an incomplete polymerization of the silica. Addition
of Ge to control media in which silicification is newly initiated increases
the incidence of erosion and results in centrally located eroded areas of
the silica and discontinuities in its deposition. Removal of Ge from such
newly forming structures results in a partial recovery of normal morphology
(spine development and thickening of the silica) but only in the central
region surrounding the bulbs. Both results establish the presence of a
central, active region for silicification and further support the view that
there is a distal spreading, away from this center, of transported forms of
silica. Secondary centers may also be present. The newly assembled organic
core of control structures is associated with tubular elements possibly
derived from the surrounding membrane. In such newly silicifying structures
the spicule tips contain oriented material in the form of "rays."
Both of these new observations increase the likelihood of the presence of an
organic matrix within the silica.
- Language of Publication
- English
- Unique Identifier
- 84188635
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- MeSH Heading (Major)
- Germanium|*ME; Porifera|*ME/UL; Silicon Dioxide|*ME
- MeSH Heading
- Animal; Membranes|ME; Microscopy, Electron, Scanning; Support, Non-U.S.
Gov't; Support, U.S. Gov't, Non-P.H.S.
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0022-5320
- Country of Publication
- UNITED STATES
Record 5 from database: MEDLINE
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- Title
- Hazard assessment of germanium supplements.
- Author
- Tao SH; Bolger PM
- Address
- Center for Food Safety and Applied Nutrition, Food and Drug
Administration, Washington, DC 20204, USA.
- Source
- Regul Toxicol Pharmacol, 1997 Jun, 25:3, 211-9
- Abstract
- Germanium-containing dietary supplements became popular in the 1970s in
Japan and later in other countries, as elixirs for certain diseases (e.g.,
cancer and AIDS). Germanium is not an essential element. Its acute toxicity
is low. However, at least 31 reported human cases linked prolonged intake of
germanium products with renal failure and even death. Signs of kidney
dysfunction, kidney tubular degeneration, and germanium accumulation were
observed. Other adverse effects were anemia, muscle weakness, and peripheral
neuropathy. Recovery of renal function is slow and incomplete even long
after germanium intake was stopped. The total dose of ingested germanium (as
dioxide, carboxyethyl germanium sesquioxide, germanium-lactate-citrate, or
unspecified forms) varied from 15 to over 300 g; the exposure duration
varied from 2 to 36 months. In laboratory animals, elevated germanium in
tissues and impaired kidney and liver function were observed in a life-time
drinking water (5 ppm germanium) study. Other toxicities associated with
ingested germanium products in human cases were also demonstrated in animal
studies with germanium dioxide and sometimes other germanium compounds.
Based on the evidence of persistent renal toxicity associated with germanium
dioxide, the lack of conclusive findings of differential nephrotoxicity of
organic germanium compounds, and the possibility of contamination of the
organic germanium products with inorganic germanium, it is clear that
germanium products present a potential human health hazard.
- Language of Publication
- English
- Unique Identifier
- 97380534
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- MeSH Heading (Major)
- Food, Fortified|*; Germanium|*AE/PD/TO; Kidney|*DE; Liver|*DE
- MeSH Heading
- Administration, Oral; Adolescence; Adult; Anemia|CI; Animal; Antimutagenic
Agents|AE/PD/TO; Antineoplastic Agents|AE/PD/TO; Child; Child, Preschool;
Female; Human; Kidney Failure|CI; Lethal Dose 50; Male; Middle Age; Muscle
Weakness|CI; Neurons|DE; Organometallic Compounds|AE/PD/TO; Risk Assessment
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
- ISSN
- 0273-2300
- Country of Publication
- UNITED STATES
Record 6 from database: MEDLINE
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- Title
- Mutagenicity, carcinogenicity and teratogenicity of germanium compounds.
- Author
- Gerber GB; Léonard A
- Address
- Teratogenicity and Mutagenicity Unit, Catholic University of Louvain,
Brussels, Belgium.
- Source
- Mutat Res, 1997 Dec, 387:3, 141-6
- Abstract
- The metalloid germanium has found widespread application in electronics,
nuclear sciences and in medicine. General toxicity of germanium is low,
except for the tetrahydride germane, and few observations on toxicity of
germanium in man exist. Germanium is not carcinogenic and even appears to
inhibit cancer development and, in the form of the organic germanium
compound, spirogermanium, to destroy cancer cells. Germanium compounds have
no mutagenic activity and may, under certain conditions, inhibit the
mutagenic activity of other substances. High doses of germanium may result
in an increased embryonic resorption, but possible malformations have been
reported only after administration of dimethyl germanium oxide to pregnant
animals. Germanium may thus be considered an element of rather low risk to
man.
- Language of Publication
- English
- Unique Identifier
- 98102883
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- MeSH Heading (Major)
- Carcinogens|*TO; Germanium|CH/ME/*TO; Mutagens|*TO
- MeSH Heading
- Animal; Female; Human; Pregnancy
- Publication Type
- JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
- ISSN
- 0027-5107
- Country of Publication
- NETHERLANDS
Record 7 from database: MEDLINE
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- Title
- Accumulation of germanium in the tissues of a long-term user of germanium
preparation died of acute renal failure.
- Author
- Nagata N; Yoneyama T; Yanagida K; Ushio K; Yanagihara S; Matsubara O;
Eishi Y
- Address
-
- Source
- J Toxicol Sci, 1985 Nov, 10:4, 333-41
- Abstract
- Acute renal failure developed in a patient accompanied by systemic
manifestations such as myopathy and skin rash. The patient, a middle aged
house wife, had been taking 600 mg of germanium (Ge) preparation daily for
18 months as an elixir. The main component of the preparation was GeO2 and
some organic compound was also present. Histological study of the kidney
post mortem showed foamy cell transformation of glomerular epithelia,
degeneration of tubular epithelia with red blood cell casts and urate
crystals, and a mild proliferation of mesangial matrix. Analysis of the
tissue content of Ge, prompted by her history, revealed an increased
accumulation of the metal. As compared to a non-user died of liver
cirrhosis, the concentration of the metal was higher particularly in the
spleen (183X), thyroid gland (175X), psoas muscle (93X), jejunum (76X), and
renal cortex (69X). So far, neither accumulation of Ge in humal tissue nor
systemic toxicity of the Ge in human has been reported. The relevance of
massive accumulation of Ge to the renal failure as well as to other systemic
manifestations the patient presented remains to be clarified.
- Language of Publication
- English
- Unique Identifier
- 86171879
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- MeSH Heading (Major)
- Germanium|AD/AE/*ME; Kidney Failure, Acute|*CI/PA
- MeSH Heading
- Case Report; Female; Human; Kidney|PA; Tissue Distribution
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0388-1350
- Country of Publication
- JAPAN
Record 8 from database: MEDLINE
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- Title
- Effect of organic germanium compound (Ge-132) on experimental osteoporosis
in rats.
- Author
- Fujii A; Kuboyama N; Yamane J; Nakao S; Furukawa Y
- Address
- Department of Pharmacology, Nihon University School of Dentistry, Chiba,
Japan.
- Source
- Gen Pharmacol, 1993 Nov, 24:6, 1527-32
- Abstract
- 1. The therapeutic effect of organic germanium compound,
2-carboxyethylgermaniumsesquioxide (Ge-132), for experimental osteoporosis
was studied using ovariectomized rats maintained on a low calcium containing
diet. 2. Serum calcitonin (sCT) level was decreased and serum parathyroid
hormone (sPTH) level was increased by ovariectomy and the decrement and
increment rates, respectively, were reduced by administration of Ge-132.
Thus, the sCT/sPTH ratio was greater in the groups given Ge-132, indicating
that the resorption was somehow inhibited by Ge-132. 3. The transverse
strength of femur bone was significantly enhanced by Ge-132. 4. A trend was
found in the group given Ge-132 for a larger femur cortical bone index. 5.
The relative femur bone wet weight was greater in the group given Ge-132. 6.
These results indicate that Ge-132 prevents decreased bone strength, and
affects the femur cortical bone index, and bone mineral mass caused by
osteoporosis.
- Language of Publication
- English
- Unique Identifier
- 94156120
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- MeSH Heading (Major)
- Germanium|*TU; Organometallic Compounds|*TU; Osteoporosis|*DT/ME/PA
- MeSH Heading
- Animal; Bone Density|DE; Calcitonin|BL; Calcium|DF/ME; Calcium, Dietary;
Female; Femur|ME/PA; Organ Weight|DE; Ovariectomy; Parathyroid Hormones|BL;
Phosphorus|ME; Rats; Rats, Wistar
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0306-3623
- Country of Publication
- ENGLAND
Record 9 from database: MEDLINE
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- Title
- Determination of germanium in human specimens: comparative study of atomic
absorption spectrometry and microwave-induced plasma mass spectrometry.
- Author
- Shinohara A; Chiba M; Inaba Y
- Address
- Department of Epidemiology and Environmental Health, Juntendo University
School of Medicine, Tokyo, Japan.
- Source
- J Anal Toxicol, 1999 Nov, 23:7, 625-31
- Abstract
- The determination methods of germanium (Ge) in biological specimens such
as blood plasma, erythrocytes, urine, hair, nail, and other organs were
established using graphite furnace atomic absorption spectrometry (GFAAS)
and microwave-induced plasma mass spectrometry (MIP-MS). The detection
limits of Ge standard solution were 3 ng/mL with GFAAS and 0.05 ng/mL with
MIP-MS. The detection limits in organ samples depended on the type of
samples and sampling amounts: 3-30 ng/g by GFAAS and 0.05-0.5 ng/g by
MIP-MS. The sensitivity of GFAAS was lower than that of MIP-MS; however, it
was adequate for determining Ge concentrations in specimens from patients
who had ingested Ge. Samples were digested by a simple wet-ashing procedure
using nitric acid and perchloric acid. To avoid the interfering effects of
coexisting elements and perchloric acid residue, an extraction method using
organic solvent was tried. When using MIP-MS, extraction was not necessary;
however, both dilution and addition of an internal standard were needed.
Special attention was required for iron-rich samples because a molecular ion
of 56Fe16O was observed at nm/z72 where 2Ge was monitored. The results of Ge
concentrations in human samples obtained by these methods agreed well.
Interfering effects of perchloric acid, which was used for digestion and
which remained in samples, were observed in both methods. Hair and nail
samples from people who had ingested Ge were useful for monitoring Ge in the
body. Hair samples were useful for determining past exposure to Ge when the
distribution patterns from the scalp to the end of the strand were analyzed.
In control subjects, Ge concentrations in the listed specimens and organs
were lower than 0.1 microg/g or mL, and these low levels of Ge were able to
be determined by MIP-MS in combination with the extraction method.
- Language of Publication
- English
- Unique Identifier
- 20061300
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- MeSH Heading (Major)
- Germanium|*AN/PK; Spectrophotometry, Atomic Absorption|*MT; Spectrum
Analysis, Mass|*MT
- MeSH Heading
- Aged; Comparative Study; Female; Human; Male; Microwaves; Middle Age;
Sensitivity and Specificity; Tissue Distribution
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0146-4760
- Country of Publication
- UNITED STATES
Record 10 from database: MEDLINE
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- Title
- Induction of interferon and activation of NK cells and macrophages in mice
by oral administration of Ge-132, an organic germanium compound.
- Author
- Aso H; Suzuki F; Yamaguchi T; Hayashi Y; Ebina T; Ishida N
- Address
-
- Source
- Microbiol Immunol, 1985, 29:1, 65-74
- Abstract
- After oral administration of an organic germanium compound, Ge-132 (300
mg/kg), a significant level of interferon (IFN) activity was detected in the
sera of mice at 20 hr and it reached a maximum of 320 U/ml at 24 hr. This
IFN activity was lost after heat- or acid-treatment, suggesting that the
induced IFN is of gamma-nature. The molecular weight of this IFN was
estimated to be 50,000 daltons by gel filtration. The NK activity of spleen
cells was increased 24 hr after the oral administration of Ge-132, and
cytotoxic macrophages were induced in the peritoneal cavity by 48 hr. In the
mice receiving an intraperitoneal (ip) injection of trypan blue or
carrageenan 2 days before oral administration of Ge-132, neither induction
of IFN nor augmentation of NK activity occurred, and X-ray irradiation of
mice also rendered the mice incapable of producing IFN, all indicating that
both macrophages and lymphocytes are required for this IFN induction. Both
NK and cytotoxic macrophages appeared 18 hr after ip administration of the
induced IFN with a titer as low as 20 U/ml. These facts suggest that both
the augmentation of NK activity and activation of macrophages in mice after
oral administration of Ge-132 are mediated by the induced IFN.
- Language of Publication
- English
- Unique Identifier
- 85187651
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- MeSH Heading (Major)
- Antineoplastic Agents|*PD; Germanium|*PD; Interferons|*BI/PD; Killer
Cells, Natural|*DE; Macrophage Activation|*DE; Organometallic Compounds|*PD
- MeSH Heading
- Administration, Oral; Animal; Heat; Hydrogen-Ion Concentration;
Immunosuppressive Agents|PD; Mice; Mice, Inbred Strains; Whole-Body
Irradiation
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0385-5600
- Country of Publication
- JAPAN
Record 11 from database: MEDLINE
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- Title
- Protection against concanavalin A-induced murine liver injury by the
organic germanium compound, propagermanium.
- Author
- Ishiwata Y; Yokochi S; Hashimoto H; Ninomiya F; Suzuki T
- Address
- Developmental Research Department, Sanwa Kagaku Kenkyusho Co. Ltd, Mie,
Japan.
- Source
- Scand J Immunol, 1998 Dec, 48:6, 605-14
- Abstract
- Propagermanium (3-oxygermylpropionic acid polymer) is an organic germanium
compound that activates the immune system. In this study, we investigated
the action of propagermanium on T-cell-mediated murine hepatic injury
induced by concanavalin A (Con A). Oral administration of propagermanium
inhibited the development of liver injury about 10 h after ConA injection.
Histological analysis demonstrated that propagermanium attenuated the extent
of liver damage compared with controls, reducing infiltration by leucocytes,
especially CD11b-positive cells. Infiltration by CD4-positive cells was not
affected. Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma are
crucial for the development of hepatitis in this model. Propagermanium
treatment induced significant inhibition of subsequent TNF-alpha production
about 10 h after Con A injection, without affecting IFN-gamma, interleukin
(IL)-10, IL-4 and IL-12 production. This effect on TNF-production coincided
with the inhibition of aminotransferase activity late in the progression of
Con A-induced liver injury. These facts suggest that this compound affects
the macrophages (Mphi) function in the liver sinusoid. Therefore, Mphi were
cultured with liver sinusoidal endothelial cells (SEC) and the effect of
propagermanium on TNF-alpha production in the presence of IFN-gamma was
determined. TNF-alpha production was reduced significantly in the coculture
of Mphi and SEC when Mphi was treated with propagermanium. These results
might explain the mechanisms by which propagermanium inhibits Con-A-induced
liver injury. That is, propagermanium improves hepatitis through mechanisms
including the reduced production of TNF-alpha, without modification of Th1-
and Th2-cell function.
- Language of Publication
- English
- Unique Identifier
- 99089890
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- MeSH Heading (Major)
- Germanium|*PD; Hepatitis, Toxic|IM/PA/*PC; Interferon Inducers|*PD;
Liver|*IN; Organometallic Compounds|*PD
- MeSH Heading
- Animal; Antibodies|IM; Cells, Cultured; Coculture; Concanavalin A;
Endothelium, Vascular|CY; Female; Interferon Type II|BL; Macrophages|ME;
Mice; Mice, Inbred BALB C; Rats; Rats, Inbred F344; Tumor Necrosis Factor|AN/IM
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0300-9475
- Country of Publication
- ENGLAND
Record 12 from database: MEDLINE
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- Title
- Inhibition of tumor growth and metastasis in association with modification
of immune response by novel organic germanium compounds.
- Author
- Sato I; Yuan BD; Nishimura T; Tanaka N
- Address
-
- Source
- J Biol Response Mod, 1985 Apr, 4:2, 159-68
- Abstract
- The effects of two novel organic germanium compounds,
1-phenyl-2-carbamoylethylgermanium sesquisulfide (PCAGeS) and
1-phenyl-2-carbamoylethylgermanium sequioxide (PCAGeO), on transplantable
murine tumors and immune responses were studied. Both drugs showed low
toxicity for mice. In culture, neither substance displayed significant
cytotoxicity against murine tumor cells L1210 leukemia, L5178Y lymphoma, or
IMC carcinoma. Growth of subcutaneously transplanted IMC carcinoma or Meth-A
fibrosarcoma was markedly reduced by oral administration of PCAGeS. PCAGeO
exhibited a similar but smaller effect on the tumor growth. Pulmonary
metastasis of Lewis lung carcinoma was inhibited by oral or intraperitoneal
treatment with PCAGeS. The activity of cyclophosphamide or Adriamycin
against L1210 leukemia was significantly potentiated by oral administration
of PCAGeS. PCAGeS enhanced the delayed-type hypersensitivity response to
sheep red blood cells (SRBC) of mice or restored the response suppressed by
ascitic IMC carcinoma, but did not significantly affect the formation of
antibody to SRBC. PCAGeO similarly stimulated the DTH reaction. Phagocytic
activity of peritoneal macrophages was enhanced by oral treatment of mice
with PCAGeS. The results suggest that PCAGeS and PCAGeO display
tumor-inhibitory activity by modification of the immune mechanism.
- Language of Publication
- English
- Unique Identifier
- 85209937
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- MeSH Heading (Major)
- Antineoplastic Agents|PD/*TU; Germanium|PD/TO/*TU; Neoplasms,
Experimental|*DT/IM; Organometallic Compounds|PD/TO/*TU
- MeSH Heading
- Animal; Antibody Formation|DE; Comparative Study; Cyclophosphamide|TU;
Doxorubicin|TU; Drug Synergism; Female; Fibrosarcoma|DT; Hypersensitivity,
Delayed; Leukemia L1210|DT; Lung Neoplasms|SC; Macrophages|DE; Male; Mice;
Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR;
Phagocytosis|DE; Support, Non-U.S. Gov't
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0732-6580
- Country of Publication
- UNITED STATES
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Karl pledges that every personal message will get a personal answer. When you provide your mail address, we will send you free information including our free catalog and a cassette tape lecture by Karl Loren about heart disease, no charge, by mail, even if outside the US.
You can select particular information you would like to receive, along with the free cassette tape and catalog.
You can reach Vibrant Life in many ways, including by mail to
Vibrant Life, 2808 N. Naomi St., Burbank, CA 91504.
Within the US and Canada, use
the toll free number: (800) 523-4521,
the local number: (818) 558-1799,
the FAX: (818) 558-7299,
eMail to kimberly@oralchelation.com
or any one of the hundreds of message forms throughout the 50 web sites.
Vibrant Life normally ships the same day we get an order.
There are message forms on each of the 100,000+ pages on this and other sites where you can communicate with Vibrant Life.
Check out our companion site, at: http://www.oralchelation.net
where Karl's 2000 page book is published. Karl Loren is the author and
webmaster for this BOOK, as well as
for another web site about ORAL CHELATION.
His personal philosophical articles are at PHILOSOPHY.
Copyright © May 20, 2008 6:25 AM by Karl Loren on behalf of Vibrant Life, ALL RIGHTS RESERVED.
Permission is granted for non-commercial downloading, copying, distribution or redistribution on two conditions:
One, that some form of copyright notice is included in every copy distributed or copied,
showing the copyright belonging to Vibrant Life, Burbank, CA, at
www.oralchelation.com .
The second condition is that the material is not to be used for any purpose contrary to
the purposes and objectives of this site.
This permission does not extend to materials on this site which are copyrighted by others.
